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The impact of sleep pressure and timing on hippocampal reactivation and replay

NINDS - National Institute of Neurological Disorders and Stroke

Abstract/Project Summary The circadian rhythm has strong effects on cognition and memory. There is also strong evidence that the activities of neurons during sleep are important for the memory function of the brain. Until recently, little was known about why delaying these activities for a prolonged period of wakefulness (commonly known as “sleep loss”) should have an enduring negative impact on memory, especially given the brain’s general capacity to restore itself during an eventual “recovery sleep”. Recently, by recording from large populations of hippocampal neurons in behaving and sleeping rodents, we found that the reactivation and replay of neuronal ensembles in the hippocampus during sharp-wave ripple events were significantly diminished during recovery sleep compared to in sleep immediately following behavior on a maze, suggesting that prolonged waking during the inactive cycle, when animals normally sleep, impairs the capacity of the hippocampus to generate the patterns widely considered most important for the consolidation of memories. However, key questions remain concerning how these sleep-dependent effects interact with the circadian cycle—known to impact learning and memory—and the optimal times and durations for waking and sleep for reactivations and replays that are critical to hippocampal function. In this proposal, we investigate how different periods of extended waking, at different phases of the circadian cycle, plus arousal enhanced by caffeine, impact hippocampal neuronal firing patterns during sharp-wave ripples, in both the awake state and the subsequent sleep. We further investigate the impact of enhancing these events by optogenetically prolonging their duration to test their impact on hippocampus-dependent memory. In sum, this work will help elucidate how sleep pressure and circadian timing interact to impact on hippocampal function and influence the systems-level firing patterns that are considered to support the hippocampal role in memory.

Up to $532K

2031-03-31

health research

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The impact of sleep pressure and timing on hippocampal reactivation and replay

The Impact of Social Isolation, Loneliness, and Support on Vascular Brain Injury: From Subclinical Small Vessel Disease to Stroke and Post-Stroke Outcomes.

The Impact of Social-Contextual Stressors on Psychopharmacological Mechanisms of Smoking Cessation and Relapse among Socioeconomically Disadvantaged Young Adults who Smoke Cigarettes

The impact of tau on RNA and translation in progressive supranuclear palsy

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The Impact of Trained Provider Teams on Diagnosis and Treatment of Eating Disorders in the Veterans Health Administration (VHA)

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The inhibitory mechanism underlying psychedelic disruption of visual processing

THE INTEGRATED STRESS RESPONSE IN GBM PATHOGENESIS AND RESPONSE TO THERAPY

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The International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia

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The interplay of protein secretion and lipid virulence factors in host immune suppression by Mycobacterium tuberculosis

The King Center

The Laidlaw Foundation

The Lawson Foundation

The Legacy of Childhood SES and Lead Exposure on Dementia Risk: ARIC-NCS Historical Census Linkage

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THE LIVING DECLARATION: A BIOGRAPHY OF AMERICA?S FOUNDING TEXT [NO TEXT IS AS ESSENTIAL AS THE DECLARATION OF INDEPENDEN...

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Grants

The impact of sleep pressure and timing on hippocampal reactivation and replay

The Impact of Social Isolation, Loneliness, and Support on Vascular Brain Injury: From Subclinical Small Vessel Disease to Stroke and Post-Stroke Outcomes.

The Impact of Social-Contextual Stressors on Psychopharmacological Mechanisms of Smoking Cessation and Relapse among Socioeconomically Disadvantaged Young Adults who Smoke Cigarettes

The impact of tau on RNA and translation in progressive supranuclear palsy

The impact of the use of digital tools outside school and for communication on educational outcomes and mental health

The Impact of Trained Provider Teams on Diagnosis and Treatment of Eating Disorders in the Veterans Health Administration (VHA)

The impacts of glutathione on Clostridioides difficile infection

The Implementation of Local Flavored Cigar Restrictions

The Influence of Obesity and Insulin Sensitivity on Reward Processing and Decision Making

The Influence of Religiosity and Spirituality on Health Risk Behaviors in Children and Adolescents (R01)

The inhibitory mechanism underlying psychedelic disruption of visual processing

THE INTEGRATED STRESS RESPONSE IN GBM PATHOGENESIS AND RESPONSE TO THERAPY

The interaction of X chromosome and sex hormonal effects in stroke and neuroinflammation

The International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia

The interplay among reproductive, molecular, and chronological age in relation to aging-related conditions in women: a longitudinal study

The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease

The interplay of protein secretion and lipid virulence factors in host immune suppression by Mycobacterium tuberculosis

The King Center

The Laidlaw Foundation

The Lawson Foundation

The Legacy of Childhood SES and Lead Exposure on Dementia Risk: ARIC-NCS Historical Census Linkage

The LINK Intervention: Using informatics and implementation science to reduce missed opportunities to prevent opioid overdose and HIV infection

The Little Yosemite Valley Backcountry Internship Program

THE LIVING DECLARATION: A BIOGRAPHY OF AMERICA?S FOUNDING TEXT [NO TEXT IS AS ESSENTIAL AS THE DECLARATION OF INDEPENDEN...