The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease
NIA - National Institute on Aging
About This Grant
Summary Alzheimer's disease, a leading cause of dementia, is characterized by synaptic dysfunction and aberrant neural activity contributing to cognitive decline, with mitochondria being an early target of amyloid pathology. This sets off a vicious cycle involving synapses, neural activity, and mitochondria, which may differ depending on age and brain region. This proposal seeks to investigate the interconnectedness of these factors in an age- dependent manner across multiple brain regions. By utilizing mouse models of Alzheimer's disease, the study aims to determine whether modulation of neural activity, synapses, or mitochondria could enhance neural plasticity in amyloidosis. Through a combination of in vivo and ex vivo approaches, the proposal aims to unravel the relationship between neural activity and synaptic abnormalities and test the efficacy of targeting Cyclophilin D, a component of the mitochondrial membrane permeability transition pore, in improving mitochondrial health and reversing synaptic and neural activity deficits.
Grant Summary
The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease is a NIA - National Institute on Aging grant providing up to $3.2M for university, nonprofit, healthcare org. Applications are due 2029-08-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $3.2M
2029-08-31
- 1Confirm your organization is eligible for The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease from NIA - National Institute on Aging, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIA - National Institute on Aging before the deadline.
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The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease: Frequently Asked Questions
Who is eligible for the The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease?
The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease is offered by NIA - National Institute on Aging and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease provide?
The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease provides up to $3.2M per award from NIA - National Institute on Aging. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease deadline?
Applications for The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease are due 2029-08-31 (open). Because deadlines can change, verify the date with the funder, NIA - National Institute on Aging, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease?
To apply for The Interplay of Neuronal Activity and Synaptic Abnormalities and their Restoration through Mitochondria in Alzheimer's Disease, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIA - National Institute on Aging.