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Grants $250,000 to $500,000

Large grants from $250,000 to $500,000 for major initiatives including research programs, community development projects, and public health interventions.

Open Grants

89

Amount Range

$250K-$500K

Top Grants $250,000 to $500,000

Showing 12 of 89 grants $250,000 to $500,000

12 grants on this page, worth up to $3.6M combined.

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Grant Details: Amounts and Deadlines

Grant NameFunderAmountDeadline
Region 4 Small Business Transportation Technical Assistance Center (SBTTAC)69A350 OSDBUUp to $250KOct 31, 2026
Advanced Development and Validation of Emerging Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed)National Institutes of HealthUp to $300KNov 10, 2026
Seattle FY 2021 – FY 2023 EDA Planning and Local Technical AssistanceDepartment of CommerceUp to $300KRolling / Open
Long-term health outcomes of people living with spina bifidaCenters for Disease Control - NCBDDD$100K - $300KOct 26, 2026
Animal Food Regulatory Program Standards Implementation Development and Maintenance, with Mutual Reliance Initiatives Clinical Trials Not AllowedFood and Drug AdministrationUp to $300KApr 1, 2027
CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed)National Institutes of HealthUp to $300KOct 16, 2026
CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R01 Clinical Trial Not Allowed)National Institutes of HealthUp to $300KNov 5, 2028
Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)National Institutes of Health$50K - $300KOct 19, 2027
Atlanta FY 2021 – FY 2023 EDA Planning and Local Technical AssistanceDepartment of CommerceUp to $300KRolling / Open
Chicago FY 2021 FY 2023 EDA Planning and Local Technical AssistanceDepartment of CommerceUp to $300KRolling / Open

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Frequently Asked Questions: Grants $250,000 to $500,000

Who awards grants in the $250K-$500K range?
Federal agencies (NIH, NSF, HUD, EPA, HRSA), large private foundations (Ford, Gates, Kresge, MacArthur), state agencies with federal pass-through funding, and some corporate foundations. Multi-year grants often have annual budgets in this range.
Do I need prior grant experience for grants this large?
Almost always. Funders awarding $250K+ expect a track record of successfully managing similar-sized grants. Organizations new to this level should start with smaller awards and build capacity, or partner with an experienced fiscal agent.

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