Grants

Manchester

Cheney Rail/Trail Amenities

NHLBI - National Heart Lung and Blood Institute

PROJECT SUMMARY/ABSTRACT Duchenne muscular dystrophy (DMD) is a devastating X-linked skeletal and cardiac myopathy resulting from a defect in the gene coding for dystrophin. DMD myopathy leads to loss of ambulation, respiratory failure, cardiomyopathy (CM), and premature death. Since the discovery of the DMD gene nearly three decades ago, the field has been dominated by the expectation of a “cure”; this has not yet transpired. Gene therapies have been approved but the cardiac effects remain unknown. Supportive care advances have decreased death from respiratory failure but simultaneously unmasked the lethal and fully penetrant CM phenotype, which is now the leading cause of death in DMD. We have documented that DMD CM progresses from normal imaging to diastolic dysfunction with subtle strain abnormalities to manifest systolic dysfunction; these changes correspond pathologically with myocardial inflammation and progressive increase in myocardial fibrosis and fibrofatty infiltration. Guideline-directed medical therapy (GDMT) has become standard of care for patients with DMD, but individual response to these therapies is suboptimal and often only serves to minimally delay the inevitable progression to heart failure and early death. Sodium/glucose cotransporter-2 inhibitors (SGLT2i) have resulted in mortality benefits in adult CM patients. The mechanism of this beneficial effect is unknown. Several factors specific to DMD suggest that SGLT2i could have potential for DMD CM – 1) improved cardiac energetics and metabolism (specifically, switch from carbohydrate towards fatty acids, ketone bodies, and amino acids metabolism); 2) improved mitochondrial function and reduced oxidative stress; 3) anti-inflammatory; 4) myocardial fibrosis inhibition; 5) reduction in sarcoplasmic calcium leak; 6) improved sympathetic overdrive. Our prior work, funded by the NIH/NHLBI and the FDA, has created the DMD Cardiovascular Care Consortium (DMDCCC), a multi-center consortium of 9 institutions following over 1350 DMD patients. The primary goal of the DMDCCC is to discover surrogate outcome measures of CM for use in clinical trials and to leverage the DMDCCC infrastructure for future clinical trials for DMD CM. The central hypothesis of this proposal is that SGLT2 inhibition is safe and well-tolerated in DMD patients with early CM. Aim 1 will define the SGLT2i pharmacokinetic (PK) profile in pediatric DMD patients. Aim 2 will determine the safety and tolerability of SGLT2i in younger DMD patients with early CM. Aim 3 will evaluate the clinical efficacy and blood biomarker alterations as a result of SGLT2i therapy in DMD, with a goal of informing future, larger efficacy studies. This study performs a critical evaluation of the pharmacokinetics, safety, and tolerability of SGLT2i in DMD. The potential of SGLT2i’s in DMD is immense, but a more complete evaluation must be performed before equipoise is lost.

NIGMS - National Institute of General Medical Sciences

Project Summary Cherokee INSPIRE (Indigenous and Native Science Program for Igniting Research & Education) will provide multiple pathways to increase representation of American Indian and Alaska Native (AI/AN) students in science, technology, engineering, and mathematics (STEM)-related careers and research. Cherokee INSPIRE will be led by Cherokee Nation and their Sequoyah High School (SHS), a Bureau of Indian Education (BIE) school. Additional program partners include the University of Oklahoma Health Sciences Center (OUHSC), the Oklahoma State University Center for Health Sciences (OSU-CHS) - Office of American Indians in Medicine and Science, and the OSU College of Osteopathic Medicine (OSU-COM) at Cherokee Nation. OSU-COM at Cherokee Nation is the only tribally affiliated medical school in the nation. Cherokee INSPIRE aims to 1) develop a replicable science curricula that integrates Western Science and Indigenous Knowledge and Science (IKS), 2) implement hands-on research and STEM projects within core science classes that will include community mentorship and digital and Indigenous storytelling as novel modes of student learning, 3) establish a multilevel mentorship and research program. In Specific Aim 1, SHS teachers, students, and staff will partner with Indigenous community elders and experts in Indigenous science development to create curricula for their STEM courses that integrates IKS with Western Science, and which also aligns with Next Generation Science Standards (NGSS). Each year, an IKS theme will be selected to guide the transformation of courses in different subfields (biology, earth science, etc.). Digital storytelling, storyboarding, podcasting, and social media platforms will capture stories, experiences, and knowledge related to science, medicine, technology, and environmental balance, which will help inform and create educational resources for the curriculum. In Specific Aim 2, Cherokee INSPIRE students will conduct research and hands-on projects within core science classes, encouraging student-driven inquiry and critical thinking. Finaly, in Specific Aim 3, a formal mentorship program will be created using a Peer-Onsite-Distance (POD) model and incorporate students, teachers, faculty, and staff from SHS, OUHSC, OSU-CHS, OSU-COM at Cherokee Nation, as well as STEM professionals from various departments within the Cherokee Nation. Mentorship PODS will encompass multiple forms of mentorship interactions (peer-peer, near-peer, intergenerational, and reverse peer). Each semester, high school students in mentorship PODs will complete a scientific poster that will be presented at a newly developed Cherokee INSPIRE SHS Research Showcase. Fostering a greater AI/AN presence in STEM, with a specific eye toward creating communities of learning will impact current health and educational disparities. Tribal communities and health systems have designated these disparities as a high priority, and our proposed pathways with respective activities will provide immediate and long-term impacts via reciprocal mentorship networks, enhanced community partnerships, and integrated place-based curriculum.

Montgomery County MD / State of Maryland

Transportation

Hip Hop is Green

Hip Hop is Green will host the first annual, free-of-cost, Cherry Street Block Party: a one-day community celebration on September 6, 2025 on East Cherry Street between 24th and 26th Avenues. The purpose of the Cherry Street Block Party is to build community and social cohesion for local organizations, artists, chefs, and small businesses who focus on uplifting and empowering Black and Brown families in Seattle’s Central District. The CD is Seattle’s historically Black neighborhood and has faced ongoing waves of gentrification. Luckily, there is a growing community movement to reclaim the CD as a hub for Black culture and resilience. Hip Hop is Green will produce the event, working collaboratively with a roster of 16+ partner organizations. Programming will include food demos and samples, wellness workshops, booths with information about community programs, and live performances. This project will be completed by October 31, 2025.

Plymouth Housing Group

Construction of a rain garden on the Cherry St. hill climb of the 710 Cherry Street property to include benches and spaces for pedestrians, as well as education panels regarding storm water run-off, native plants, and green infrastructure.

City of Richmond

Cherrys Eye

Dorchester County

Chesapeake Grove Center

Dorchester County

Chesapeake Grove Center

Dorchester County

Chesapeake Grove Center

Talbot County, Maryland

Chesapeake Multicultural Center

Talbot County, Maryland

Chesapeake Multicultural Center

DECD

Cheshire Community Pool Aquatics Enhancements

Cheshire Health Foundation

Cheshire Health Foundation is an active grantmaking foundation based in Keene, NH. Focus: health. Contact the foundation directly for current funding opportunities.

Chester County Economic Development Foundation

Chester County Economic Development Foundation is an active grantmaking foundation based in Exton, PA. Focus: community development. Contact the foundation directly for current funding opportunities.

Chester Education Foundation

Chester Education Foundation is an active grantmaking foundation based in Chester, PA. Focus: general. Contact the foundation directly for current funding opportunities.

Chester Healthcare Foundation

Chester Healthcare Foundation is an active grantmaking foundation based in Chester, SC. Focus: health. Contact the foundation directly for current funding opportunities.

DOT

Chester Three Bridges Project

DOT

Chester Village Revitalization project

Chesterfield Cultural Arts Foundation

Chesterfield Cultural Arts Foundation is an active grantmaking foundation based in Chester, VA. Focus: arts. Contact the foundation directly for current funding opportunities.

Queen Anne's County

Chesterwye Facility

Queen Anne's County

Chesterwye Facility

GILLESPIE AUTOMOTIVE LLC

Commercial and Military and Private Vehicles and their Accessories and Components

State Treasurer's Office

Eligibility General Requirements -Must be a health facility as defined in the Authority's Act (Section 15432(d) of the California Government Code) -Must be a non-profit 501(c)(3) corporation or  public health facility (e.g., district hospital) as defined in the Authority's Act (Section 15432(e) of the California Government Code) -Must have been in existence for at least three years, providing the same types of services -Must demonstrate evidence of fiscal soundness and the ability to meet the terms of the proposed loan Use of Funds Funds may be used for: -Construction, remodeling, renovation, and/or improvements -Land acquisition -Acquisition of existing health facilities -Equipment and/or furnishings -Refunding of prior debt -Working capital for start-up facilities -Costs of bond issuances, feasibility studies & reimbursement of prior expenditures Loan Terms -Market determined fixed or variable rate interest rate, depending on maturity -No loan maximum -Maximum loan maturity typically 40 years -Loan security provisions and bond covenants that correspond with bond rating Fees -No application fee -Initial fee of 0.05% of the issue amount (maximum $100,000), set fee of $1,000 for smaller health systems and public health facilities -Annual administrative fee of 0.0175% of the bonds outstanding (maximum $150,000), maximum of $500 for small health systems and public health facilities Required Documentation -Three most recent fiscal years of audited financial statements