Grants

National Park Service

Project Goals The goal is to collaborate towards a scientifically robust and credible inventory and monitoring program designed to detect change in natural resources within the parks of the Greater Yellowstone Network (GRYN) and other networks in the west. A. Project Goals: The overall goal of the project is for the GRYN to partner with NMSU to analyze over a decade of amphibian and wetland data from Yellowstone and Grand Teton National Parks. This work will specifically target the breeding salamander data. B. Project Objectives To determine the trend and relevant relationship of breeding salamanders to wetland habitat, hydrological periods, and weather patterns. This work will be valuable to informing park managers and the public about the dynamic nature of wetlands and how amphibians such as salamanders respond to changes in wetlands (i.e. how do salamanders respond when there are more dry wetlands on the landscape).

$1 – $30K

sciencetechnology

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Analysis of Contaminants of Emerging Concern in Herring Gull Eggs in the Great Lakes

Fish and Wildlife Service

The Contaminants of Emerging Concern (CEC) herring gull project will be a landscape scale project conducted within the Great Lakes basin to evaluate the status and trends of CECs through the analysis of herring gull eggs already collected from U.S. colonies. Dr. William Bowerman of the University of Maryland and formerly of Clemson University has led the U.S. egg collection program and coordinates the analyses of legacy contaminants (e.g. PCBs and DDT) in these eggs in conjunction with the Great Lakes Herring Gull Monitoring Program (GLHGMP). Through this ongoing partnership, the USFWS East Lansing Field Office (ELFO) Environmental Contaminants (EC) Program will analyze a representative sub-sample or aliquot of individually archived herring gull eggs and composites from selected colonies sampled in the U.S. since the inception of herring gull egg collection in the U.S. The list of analytes will be coordinated with Carleton University and Environment Canada based on their latest CEC findings in the eggs they have most recently analyzed for the GLHGMP. The analysis of CECs will initially include colonies of Isle Royale National Park and Grand Traverse Bay, as well as within U.S. Areas of Concern (AOCs) including: Saginaw Bay, River Raisin, and the St. Mary's River.

Environmentalsustainability

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Analysis of Immune Tolerance Mechanisms in T1D patients Receiving Sequential B Cell Depletion and T Cell Costimulatory Blockade

NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases

Project Summary Type 1 diabetes (T1D) is caused by an autoimmune attack on insulin-producing β-cells in the pancreatic islets of Langerhans. Although T cells drive β-cell destruction, B cells are important for disease pathogenesis. T1D patients with high T cell counts who are treated with B cell depletion therapy (Rituximab, RTX) tend to progress more quickly. Conversely, patients with elevated B cell counts who are treated with CTLA-4-Ig (Abatacept, ABA, which blocks T cell co-stimulation), progress more rapidly. These findings prompted the TN-25 TrialNet trial, in which sequential therapy with RTX and ABA is being compared to therapy with RTX and placebo. This design provides a unique opportunity to analyze T cell and B cell compartments before and after treatment and characterize tolerance mechanisms that may be restored by this potentially synergistic combination therapy. We hypothesize that sequential RTX and ABA treatment abrogates key co-stimulation signals delivered by (self)- antigen-presenting B cells to autoreactive T cells and vice versa. In Aim 1 we will determine if sequential RTX and ABA abrogates co-stimulation signals delivered by B cells to T cells. We will analyze islet-reactive T cells in tetramer binding and activation-induced marker assays. Simultaneously, we will measure cell surface protein expression and clonotypes using single cell RNA-seq and TCR-seq and evaluate CD4 and CD8 T cell populations as well as a novel population of KIR+CD8+ regulatory T cells for alterations in activation, specificity and gene signatures. In aim 2, we will determine if ABA-mediated limitation of T cell help leads to more profound B cell tolerance through clonal deletion. We will analyze recombinant antibodies cloned from autoreactive B cells at naïve and memory stages of development to evaluate defects in clonal recruitment, expansion and evolution. We will also investigate the trajectory of serum IgM and IgG autoantibodies over time and potential blocking effects of IgM on IgG. Taken together, these studies will identify how this novel combination therapy contributes to T cell and B cell tolerance in T1D.

Up to $5.6M

2029-06-30

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Analysis of innate responses and vaccination-induced serotype-specific B and T cell responses associated with protection against controlled human dengue virus challenge

NIAID - National Institute of Allergy and Infectious Diseases

Summary This proposal aims to define the vaccine-induced B cell responses, T cell responses, and innate responses that are associated with effective protection against dengue virus (DENV) infection. DENV has become the most important arbovirus worldwide with estimates of ~390 million dengue infections occurring annually, more than 2 million of which are classified as severe disease. Dengue is now endemic in more than 100 countries with approximately 2.5 billion people at risk for infection. Dengue was ranked third in infectious disease threats to the US military, highlighting the need for a dengue vaccine to protect U.S. service members deployed abroad. There are four distinct serotypes of DENV, and the goal of vaccines is to induce balanced immunity against all four serotypes, since unbalanced immunity across serotypes can lead to more severe dengue disease rather than protection. We will study immune responses to vaccines that were tested in a controlled human infection model (CHIM) of DENV infection. These vaccines contained either three of four dengue serotypes, and provided a range of protection against serotype 2 (DENV2) in the CHIM model. The first aim will define the impact of DENV vaccine serotype composition on specificity, function, and durability of serotype- specific memory B cell and monoclonal antibody (mAb) responses and on subsequent responses to DENV2 challenge. We hypothesize that vaccine serotype composition will determine the balance and function of serotype-specific and cross-reactive B cell responses after vaccination, as well as the proportions and neutralizing potency of serotype-specific and cross-reactive mAbs, and that these responses will dictate capacity to effectively prevent DENV2 infection after challenge. In the second aim, we will define the role of T cell function, including metabolic function, on control of challenge DENV2 and on specificity, phenotype and durability of DENV-specific memory B cell and neutralizing antibody responses. We hypothesize that vaccine- induced CD4 T cell phenotype, particularly expression of glucose transporter 1, and function promote effective B and CD8 T cell responses upon DENV challenge, and that CD8 T cell phenotype and function are correlated with control of DENV infection. In the third aim, we will dissect innate immune cell responses to DENV vaccination and challenge. We hypothesize that protective innate cell responses will promote robust CD4 T cell help and facilitate cross-reactive B cell responses. The results from this proposal will define the immune mechanisms underlying effective dengue protection, aid in interpretation of ongoing vaccine trials, and may inform design of next-generation dengue vaccines.

Up to $766K

2031-05-31

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Analysis of Late Pleistocene and Holocene Environmental Change and Landscape Evolution in White Sands National Monument

National Park Service

Analysis of Late Pleistocene and Holocene Environmental Change and Landscape Evolution in White Sands National Monument

$41K

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Analysis of the AgrA-mediated transcription regulation in Listeria monocytogenes

NIAID - National Institute of Allergy and Infectious Diseases

Abstract. Listeria monocytogenes is a low G+C Gram-positive bacterium that can cause severe disease in immunocompromised individuals, pregnant women, newborns, and the elderly. Pathogenic strains frequently use two-component regulatory systems to control the timing and level of virulence gene expression. In L. monocytogenes, a quorum-sensing-like two-component system, AgrCA, is involved in virulence, biofilm development, and adaptation to environment. It governs expression of dozens of listerial genes. The agr locus is highly expressed in laboratory media and during infection, and AgrA is, apparently, one of the most abundant transcriptional regulators in listerial cells. The functions of most AgrA-regulated genes and the mechanisms by which AgrA affects virulence and biofilm development remain unknown. Importantly, it is not even known which genes are directly regulated by AgrA and under which conditions the regulation occurs. We propose to determine the entire set of genes that are able to interact with AgrA directly either in vitro or in vivo. Using a novel approach, in vitro DNA affinity purification coupled with sequencing, we are able to visualize protein-binding sites on a genome-wide basis at near-single-nucleotide resolution and rank the sites according to their relative strengths. We now achieve similar, near-single-nucleotide resolution in ChIP- Seq experiments, which will be used to define sites that interact with AgrA in vivo. The precise information on the locations and relative strengths of AgrA-binding sites will provide the foundation for future research on the detailed mechanisms by which AgrA regulates individual genes. We have shown that the L. monocytogenes agr locus is the strongest target of regulation by CodY, a global transcriptional regulator of metabolism and virulence in most low G+C Gram-positive bacteria. CodY- mediated regulation of the agr locus is positive and direct. The agr locus is also subject to a very strong AgrA- mediated positive autoregulation, and requires binding of another transcriptional regulator, MouR, for its expression. The requirement for three direct positive regulators to achieve expression of a single locus above the low basal level is very unusual. The mechanisms of this triple regulation have not yet been determined. To begin unraveling this complex regulation, we will determine the modes of interaction of AgrA, CodY, and MouR with their binding sites and establish whether CodY and/or MouR are required for AgrA binding and activity at the agr locus and other AgrA-regulated genes. DNase I footprinting, high-resolution ChIP-Seq experiments, and transcription assays with purified proteins will be used as in vitro and in vivo approaches. L. monocytogenes is one of the deadliest foodborne pathogens in the United States. By revealing the mechanisms of transcriptional regulation of the agr locus and identifying the full complement of direct AgrA targets, we will be able to provide novel insight into how L. monocytogenes senses its environment and uses that information to modulate its physiology and the level of virulence.

Up to $248K

2028-04-30

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Analysis of the local and global responses in the placenta syncytiotrophoblast

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

ABSTRACT The multinucleated syncytiotrophoblast (STB) is a tissue-sized single cell that separates the maternal and fetal vasculature during pregnancy. The STB wraps around the villous trees of the placenta lobules, encasing them in a cell with billions of nuclei in a common cytoplasm. This giant single cell facilitates the exchange of nutrients, is essential for fetal immunoprotection, is the primary producer of pregnancy hormones, and performs critical metabolic roles. Further, the STB must simultaneously respond to gradients in oxygen, nutrients, maternal hormones, and pathogens that fluctuate in space and time. How does a single cell support these diverse homeostatic tasks and simultaneously respond to local stresses? We hypothesize that the multinucleate organization is fundamental to supporting the many demands of production, metabolism, and stress response required of a single STB cell. Recent work and our preliminary data show that individual nuclei within the STB indeed have distinct transcriptional programs despite all sharing the same cell cytoplasm. This indicates that STB nuclei are heterogeneous in activity and function. Notably, GO terms for each of the STB nuclear clusters show mutually exclusive expression of homeostatic STB functions or stress response genes. Therefore, nuclear individuality could both facilitate the myriad of STB functions and the insulation of the stress response by spatially clustering in different regions depending on local functions or conditions. Major gaps in knowledge include how different nuclear identities are spatially patterned in the tissue, how nuclear identities arise mechanistically, and the functional consequences of nuclear heterogeneity within the STB cell. Spatial organization of the STB is disrupted in multiple forms of preeclampsia, a pregnancy disease that stems from improper placentation in the first trimester or maternal inflammation. We predict that the systemic stress seen in preeclampsia perturbs the functional balance and spatial organization of homeostatic and stress response pathways in STB nuclei. The proposed experiments will analyze heterogeneous gene expression in healthy and preeclamptic placentas with the following aims: Aim 1: Dissect the spatial patterns of RNA expression and localization in the STB cell and Aim 2: Identify the function and mechanism of heterogeneous nuclear gene expression in the STB. We will apply state-of-the-art spatial transcriptomics on placentas from healthy and preeclamptic pregnancies to analyze gene expression patterning in different locations of the STB. Using super-resolution, live-cell imaging, and genetic manipulations of placenta organoids, we will determine the mechanisms generating specialized nuclear transcription and the functional consequences of heterogeneous nuclear gene expression. This work will establish a functional atlas of STB nuclear identity patterning in health and preeclampsia and act as a guide to discover molecular drivers of pregnancy disease.

Up to $694K

2031-03-31

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Analysis, Summary, and Public Archaeology Outreach of Artifacts from an Archaeological Field School at Fort Vancouver National Historic Site

National Park Service

United State Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This posting is to provide public notice of the NPS' intention to fund the following project activities without full and open competition: Task Agreement P15AC01490 under Cooperative Agreement H8W07110001 with Portland State University, a partner under the Pacific Northwest Cooperative Ecosystem Studies Unit, for the project titled, "Analysis, Summary, and Public Archaeology Outreach of Artifacts from an Archaeological Field School at Fort Vancouver National Historic Site."

$38K

humanities

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Analyze Forest Condition and Produce Floristic Guides

National Park Service

This project between the National Park Service-Cumberland Piedmont Network and the University of North Carolina at Chapel Hill-Herbarium will provide managers at 14 national park units with information on the condition of their forest ecosystems and floral guides suitable for public use.

$1 – $93K

sciencetechnology

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ANALYZING 14 YEARS OF LANDBIRD DATA FOR THE NORTHERN COLORADO PLATEAU I&M NETWORK

National Park Service

The Northern Colorado Plateau Network (NCPN) and the cooperator will analyze 14 years of avian monitoring data and conduct avian monitoring during the 2019 avian breeding seasons (May July). The NCPN includes landbird monitoring at 12 National Park units in Colorado, Utah, Wyoming, and Arizona. The Northern Colorado Plateau Network has been monitoring landbirds as a vital sign since 2005 using the status and trends of the breeding bird community as an indicator of ecosystem integrity, contributing to local and regional avian population monitoring programs, and to communicate to visitors and the public, the importance of NCPN parks as breeding bird habitat. The NCPN and University of Delaware will use the monitoring data to provide long-term population status and trend information for breeding landbirds in low-elevation riparian, pinyon-juniper, and sage shrubland.

$1 – $49K

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Analyzing Archaeological Materials from Redwood National Park to Investigate Historical Marine Environments

National Park Service

United State Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This funding opportunity is to provide public notice of NPS's intention to fund the following project activities without full and open competition. Task Agreement # P14AC01578 under Cooperative Agreement H8W07110001 with Washington State University, a partner under the Pacific Northwest Cooperative Ecosystem Studies Unit, for project titled "Analyzing Archaeological Materials from Redwood National Park to Investigate Historical Marine Environments"

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Analyzing caregiver linguistic input during a remote dialogic book-sharing interventions for toddlers with clefts.

NIDCD - National Institute on Deafness and Other Communication Disorders

PROJECT SUMMARY Cleft palate with or without cleft lip (CP±L) is among the most common congenital conditions, affecting approximately 1 in 450 infants worldwide and 1 in 1050 infants in the United States. While most children undergo early surgical repair, many continue to experience significant speech and language delays that impact social and academic development. Recent research has highlighted the potential of parent/caregiver-focused interventions in supporting language development in children with CP±L, but the specific mechanisms underlying these interventions are not yet fully understood. This goal of this study is to examine the mechanistic role of parent/caregiver's speech inputs in supporting language development in toddlers with CP±L. This study fills critical gaps by transcribing, coding, and analyzing observational data from a remote dialogic book-sharing (DBS) intervention for toddlers with CP±L (randomized controlled trial or RCT of the intervention, Book Sharing for Toddlers with Clefts – BOOST; NCT06338319). Unlike prior work relying on audio-only data, this research uniquely includes gestural communication, such as deictic gestures, which may act as compensatory strategies in children with impaired speech and are linked to vocabulary development. Through language sample analysis of video-recorded parent-child book-sharing interactions collected at five timepoints, we will examine how parent/caregiver language quantity (e.g., utterance frequency, speech rate, pause time) and responsiveness (e.g., contingent responses, conversational turns, deictic gestures, personalization, categorization, and temporal responses) change over the course of the intervention. We will also evaluate how these changes relate to expressive and receptive language improvements in children with CP±L. Clinically, this work will clarify caregiver-mediated mechanisms to enhance targeted interventions for children with CP±L and other language delays, improving long-term developmental outcomes. In line with the R15's dual goals, the project will build research infrastructure by training undergraduate and graduate students in developmental research methods, including transcription, coding, and data analysis. This training will provide hands-on interdisciplinary experience, strengthen research capacity at a primarily undergraduate institution, and foster a collaborative environment that integrates clinical and developmental science. By moving beyond traditional speech metrics to incorporate gesture and multidimensional responsiveness, this study advances understanding of parent input's role in language development for children with CP±L and lays a foundation for future research to refine and expand parent-mediated interventions. Chong R15

Up to $530K

2029-05-31

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Analyzing the Distribution, Effectiveness, and Implementation of Wildfire Smoke Exposure Reduction Strategies on Respiratory Health

NIEHS - National Institute of Environmental Health Sciences

PROJECT SUMMARY The objective of my proposal is to apply a novel, interdisciplinary approach with its combination of spatial analysis, implementation science, and exposure assessment to understand respiratory health and gaps in resource availability in the San Francisco Bay Area. My proposal builds on my past and current expertise in environmental engineering to use a systematic approach to assimilate across multiple data source to detect wildfire smoke risk changes due to exposure reduction strategies. I seek additional training to develop and apply innovative spatial and exposure analytical and qualitative methods to better characterize respiratory risk due to wildfire smoke exposure across all populations and identify specific factors influencing the success or implementation of strategies designed to increase community resilience. Due to evolving climate trends, environments in the western United States (U.S.) as well as more broadly across Canada have become drier and warmer resulting in more frequent and intense wildfire fire events. Year after year, wildfire smoke and particularly, wildfire-specific fine particulate matter (PM2.5) remain significant contributors to the air pollution burden on population health in the U.S. and beyond. While numerous guidance documents exist, especially in California, it unknown whether these strategies are adopted and enacted across communities and specifically in those most vulnerable to respiratory health outcomes. Historical patterns have led some communities to face higher risk for adverse respiratory outcomes and therefore these communities must be the public health priority when examining respiratory health effects of wildfire smoke and identifying effective risk reduction strategies. This proposal will advance the field of environmental health by applying spatial analysis to examine the distribution of risk reduction strategies and the factors driving these patterns (Aim 1); identifying individual, organizational, and societal factors that influence the presence of wildfire smoke risk reduction strategies using implementation research methods (Aim 2); and quantifying the impact of these strategies on the association between wildfire smoke and respiratory outcomes, with a focus on how effectiveness may vary based on community characteristics (Aim 3).The K99 training will enhance my research expertise through targeted coursework, mentorship, and active engagement in: (1) advanced spatial analysis; (2) implementation science and community-based participatory research; (3) quasi-experimental methods and epidemiology; and (4) career development. The skills gained through this award are essential to achieving my long-term goal of advancing multidisciplinary statistical and methodological approaches to quantify the respiratory health impacts of air pollution and exposure reduction strategies. This work will generate new scientific knowledge to improve understanding of respiratory health disparities and resource distribution, while equipping me with the expertise to plan and execute independent, innovative studies on the health effects of hazardous air pollutants using multi- dimensional analysis techniques.

Up to $118K

2028-03-31

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Ancestral Lands Conservation Corps

National Park Service

he FY19 Conservation Legacy ALCC NPS project will provide job and service opportunities for up to 70 young adults from up to 8 distinct rural, Native American communities. Critical back log maintenance projects on NPS units will be completed with the additional goal of building long term capacity, partnerships, resources, to ensure a strong workforce for the future. The project additionally will also engage up to 60 school aged children from Acoma and Zuni Pueblo with their local National Parks, to provide recreational and appropriate service opportunities, and opportunities for parks to historically connect to adjacent tribal communities.

$70K

employmentworkforce development

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Ancestral Lands Conservation Corps & Career Institute FY 2016

National Park Service

The FY 2016 ALCC & Career Institute project will engage Native American young people at twelve different Native American communities completing meaningful service projects on NPS units with the purpose of developing partnerships, resources, and long term capacity for future projects.

$1 – $530K

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Ancestry-Specific Genetic Influences and Potential Therapeutics for Ocular Disorders in the Million Veteran Program

NIH

Background and Innovation. The ability of Veterans to retain independence depends on their ability to perform visual tasks such as reading and driving. This independence is threatened by ocular disorders such as age-related macular degeneration (AMD) that result in central vision loss and are prevalent in the Veteran population. We currently lack a complete understanding of the risk factors that contribute to AMD onset and the basis for their marked variation between Veterans of European (EUR) or African (AFR) ancestry. Currently, we have insufficient treatment options to offer Veterans with AMD to slow or stop disease progression and vision loss. The VA Million Veteran Program (MVP) provides a powerful resource to address these shortcomings, by providing genetic data in the context of the de-identified but otherwise complete electronic health record (EHR) and other MVP-specific instruments (e.g., lifestyle survey). MVP is one of the largest biobanks in the world, with more than 1 million Veterans having been enrolled to date. Importantly, MVP has enrolled substantial numbers of Veterans of AFR and EUR ancestry, providing the opportunity to follow on our original observation that genetic variants that confer strong risk in EUR populations do have a comparable impact on individuals of AFR ancestry. MVP now provides whole genome sequence data for a considerable number of Veterans, which provide a critical next step to understand ancestry-specific differences in AMD risk. Aim 1 will use these to data to understand observations made during the current award period that alleles for genes such as CFH, which make strong contributions to risk for age-related macular degeneration (AMD) in EUR cohorts, are not linked to AMD in AFR populations. In Aim 2 we will use the MVP EHR data to determine if drugs already used in the care of Veterans impact AMD risk. We will follow our proven model wherein we documented that metformin decreases risk for AMD in both EUR and AFR Veterans. Significance and Impact to Veterans Healthcare. This project will (a) identify risk factors that drive AMD pathogenesis in diverse populations, thereby providing tools for early identification of the disease state based on EHR and genetic data and (b) identify medications already in the VA formulary that impact AMD risk. Path to Translation/Implementation. This project will provide a roadmap for early and effective diagnosis across the diverse ancestries that comprise the U.S. Veteran population. This project will provide insights into new therapeutic approaches for AMD, which can be rapidly incorporated into future clinical trials.

2029-09-30

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ancient DNA for Modern Genomics (aDMG) Coordination Center

National Institutes of Health

ancient DNA for Modern Genomics (aDMG) Coordination Center

Rolling

general

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ancient DNA for Modern Genomics (aDMG) Data Generation and Resource Center

National Institutes of Health

ancient DNA for Modern Genomics (aDMG) Data Generation and Resource Center

Rolling

general

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ancient DNA for Modern Genomics (aDMG) Research Projects (U01 Clinical Trials Not Allowed)

National Institutes of Health

<p>The National Human Genome Research Institute (NHGRI) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to establish an ancient DNA for Modern Genomics (aDMG) program. The goal of aDMG is to establish an ethical resource of ancient and historical human DNA (aDNA) data to advance studies about contemporary human traits and biology. This NOFO aims to solicit applications that will leverage existing and newly generated aDNA data from this consortium to advance the biological and epidemiological understanding of modern human diseases and health-related traits by integrating aDNA with modern human and other species’ data. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of ancient DNA and population genomics are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in DNA sequencing methods and technology, computational genomics and data science, human evolution, and ancient human populations will be encouraged and these investigators should also begin considering applying for this application.</p>

2028-02-01

Health

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ancient DNA for Modern Genomics (aDMG) Research Projects (U01 Clinical Trials Not Allowed)

National Institutes of Health

The National Human Genome Research Institute (NHGRI) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to establish an ancient DNA for Modern Genomics (aDMG) program. The goal of aDMG is to establish an ethical resource of ancient and historical human DNA (aDNA) data to advance studies about contemporary human traits and biology. This NOFO aims to solicit applications that will leverage existing and newly generated aDNA data from this consortium to advance the biological and epidemiological understanding of modern human diseases and health-related traits by integrating aDNA with modern human and other species data. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of ancient DNA and population genomics are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in DNA sequencing methods and technology, computational genomics and data science, human evolution, and ancient human populations will be encouraged and these investigators should also begin considering applying for this application.

2028-02-01

Healthhealthcare

Free to search & build · $99 one-time to unlock the application pack · No subscription

Ancient Highway Resurface

Newington

Ancient Highway Resurface

Up to $27K

Rolling

general

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Ancillary Studies to Major Ongoing NIDDK and NHLBI Clinical Research Studies (R01)

National Institutes of Health

-Purpose. This Funding Opportunity Announcement (FOA) solicits grant applications from qualified investigators to conduct ancillary studies of selected ongoing major clinical research studies, including clinical trials, epidemiological studies and disease databases, supported by the National Institute of Diabetes and Digestive and Kidney Diseases and the National Heart, Lung, and Blood Institute, National Institutes of Health (NIH). The objective is to introduce NIDDK-oriented ancillary studies into either NIDDK or NHLBI-funded parent studies, or NHLBI-oriented ancillary studies into NIDDK-funded parent studies. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant R01) award mechanism. -Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the number, quality, duration, and costs of the applications received.

foodnutrition

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Ancillary Studies to Ongoing Clinical Projects (RP1 Clinical Trial Not Allowed)

National Institutes of Health

This Notice of Funding Opportunity (NOFO) solicits applications that propose to conduct time-sensitive ancillary studies in conjunction with privately or publicly funded, active, ongoing clinical projects (parent projects). The parent project can be an interventional clinical trial, or a clinical study such as an observational study, or a disease-specific repository that will be actively collecting patient samples or clinical data. The parent project(s) should provide a cohort of well-characterized patients, infrastructure, data, and biological samples for the ancillary study. The objective of this NOFO is to provide a flexible mechanism to leverage currently funded resources and maximize the return on existing investments in parent projects. Successful ancillary studies will enhance the scientific content and value of the parent projects, improve the research community s understanding of a disease or organ system and thus may identify novel targets for diagnosis, treatment, and prevention of disease.

2026-10-15

Healthhealthcare

Free to search & build · $99 one-time to unlock the application pack · No subscription

Ancillary Studies to Ongoing Clinical Projects (RP1 Clinical Trial Not Allowed)