Grants

Community Oriented Policing Services

This solicitation is being announced as an open competition targeted at state law enforcement agencies authorized by law or by a state agency to engage in or to supervise anti-methamphetamine investigative activities. Funding is limited and this solicitation is expected to be very competitive. Strong applications should demonstrate a multijurisdictional reach and participation in interdisciplinary team structures (i.e., task forces). Strong applications should also include multi-year state level methamphetamine seizure data to support their proposal. The goals for this program are to Increase efforts to locate and investigate illicit methamphetamine activities including precursor diversion, laboratories, or traffickers; establish new or enhance existing multijurisdictional and interdisciplinary task forces to lead to the seizure of precursor chemicals, finished methamphetamine, laboratories, and laboratory dump seizures; increase the use of community policing strategies (including problem solving, partnerships, and organizational changes) to reduce the manufacture, distribution, and use of methamphetamine; and increase anti-methamphetamine collaboration efforts with federal, state, local, and/or tribal partners involved in prevention, intervention/treatment, identification of drug endangered children and enforcement activities. The COPS Office reserves the right to limit awards to one per state at the time of award announcement.

Community Oriented Policing Services

Community Policing Development (CPD) funds are used to advance the practice of community policing in law enforcement agencies through training and technical assistance, demonstration projects, the development of innovative community policing strategies, applied research, guidebooks, and best practices. The COPS Office, a federal provider of innovative, customer-focused resources that address the continuing and emerging needs of those engaged in enhancing public safety through community policing, has designed the CPD solicitation to address critical topics in the law enforcement field by building on the principles of community policing. The 2016 CPD program has been established to fund specific projects related to the following topic areas: (1) Microgrant Initiative for Law Enforcement; (2) Critical Response Technical Assistance; (3) Community Policing Emerging Issues Forums; (4) Community Policing Training, (5) Law Enforcement Led 21st Century Policing Demonstration Projects, (6) 21st Century Policing Implementation Projects and (7) Invitational Awards. There is up to $5.5 million in CPD funds, subject to the availability of funding, and the COPS Office aims to fund numerous projects. All awards are subject to the availability of appropriated funds and any modifications or additional requirements that may be imposed by law. Funding is limited, and we expect this solicitation to be very competitive. The COPS Office may make some awards from the CPD solicitation in the form of a cooperative agreement, which is the funding instrument used if the COPS Office anticipates ongoing substantial involvement in award activities. Cooperative agreement recipients will be responsible for day-to-day project management but should expect direct oversight and collaboration by the COPS Office in implementing the award. Examples of substantial federal involvement may include, but are not limited to, participating in the selection of key recipient personnel; providing feedback on deliverables before publication; approving all conference-related costs prior to obligation; and redirecting the work as appropriate.

Community Oriented Policing Services

CHP provides funding directly to law enforcement agencies to hire and/or rehire career law enforcement officers in an effort to increase their community policing capacity and crime prevention efforts. 2016 CHP grants will cover up to 75 percent of the approved entry-level salary and fringe benefits of each newly-hired and/or rehired, full-time sworn career law enforcement officer over the three-year (36 months) grant period, with a minimum 25 percent local cash match requirement and a maximum federal share of $125,000 per officer position. CHP grant funding will be based on your agency s current entry-level salary and fringe benefits for full-time sworn officers; any additional costs for higher than entry-level salaries and fringe benefits will be the responsibility of the grantee agency. All agencies requests will be capped at no more than five percent of their actual sworn force strength as reported at the time of updated application, up to a maximum of 25 officers. Agencies with a service population of 1 million or above may apply for up to 25 officer positions; agencies with a service population less than 1 million may apply for up to 15 officer positions. [The request of any agency with a sworn force less than or equal to 20 will be capped at one officer.] Funding under this program may be used to: Hire new officers, which includes filling existing officer vacancies that are no longer funded in your agency s budget. Rehire officers who have already been laid off from any jurisdiction as a result of state, local, or Bureau of Indian Affairs (BIA) budget reductions. The rehired officers must be rehired on or after the official grant award start date as it appears on your agency s award document. Documentation must be maintained showing the dates that the positions were laid off and rehired. Rehire officers who are (at the time of application) currently scheduled to be laid off by your jurisdiction on a specific future date as a result of state, local, or BIA budget reductions. Grantees will be required to continue funding the positions with local funding until the dates of the scheduled lay-offs. The dates of the scheduled lay-offs and the number of positions affected must be identified in the CHP application. CHP grants can be used to hire and or rehire School Resource Officers. Please note that the COPS Office requires that the officer(s) deployed into the SRO position(s) spend a minimum of 75 percent of their time in and around primary and/or secondary schools, working on youth-related activities. The time commitment of the funded officers must be above and beyond the amount of time that the agency devoted to the schools before receiving the grant. There must be an increase in the level of community policing activities performed in and around primary or secondary schools in the agency s jurisdiction as a result of the grant.

Coquille Public Library

This project is a collaborative partnership between the Coquille Public Library and the Oregon Digital Newspaper Program (ODNP) to digitize, archive, and make available online images of historic newspaper editions of the Coquille Valley Sentinel for the period 1923-1936.

NYC Department of Cultural Affairs

Cora Incorporated

NSF

The primary aim of this project is to develop a process for modeling the hydrodynamic flow of coral reefs using observations obtained using Light Detection and Ranging (LiDAR) mounted on unmanned aerial vehicles, or drones. Current methods involve deploying instrumentation in the water column, which is expensive, time-consuming, and prone to lost instrumentation. If successful, this new approach would enable water-flow models to be readily developed and continually used following a single high-resolution LiDAR survey of a reef. The proposed objectives will advance physical oceanography on reef systems, via hydrodynamical modeling that will readily lead into broad-scale heat budget modeling of reefs. This project will develop hydrodynamic models of wave-driven flow on shallow coral reefs, with constraints for the models coming entirely from data collected by unmanned aerial vehicles (UAVs, or “drones”). Past work with in-water instrumentation has demonstrated the effectiveness of hydrodynamic models to capture water flow across shallow reef flats when the pressure gradient from wave setup is measured alongside bathymetry and an estimate of hydrodynamic roughness. This current approach, while effective, requires extensive in-water instrument deployments and the method needs to be “tuned” to each stretch of reef because the hydrodynamic roughness needs to be calibrated in lieu of a more general way to measure it. This project leverages technological advances that allow high-resolution bathymetry and water level to be measured from LiDAR payloads carried by relatively small drones. There are three scientific objectives: (1) test whether sea level gradients and bathymetry derived from LiDAR data effectively constrain hydrodynamic models, (2) develop an AI algorithm to derive hydrodynamic roughness from high-resolution bathymetric point clouds, and (3) evaluate the utility of modeling coral reef water flow from only LiDAR based bathymetry and roughness combined with remote sensing products. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

NSF

Wildfires are increasing globally in both frequency and severity, including on tropical islands adjacent to coral reefs. Burned materials from urban and rural fires, such as ash, smoke, and toxic compounds, are delivered to the atmosphere and waterways during and after wildfires. The impacts of wildfires, therefore, extend to terrestrial and aquatic ecosystems adjacent to burn zones, as well as those thousands of miles away. Within the last decade, research has shown how wildfires can impact nutrient cycling and production in the ocean. Yet the impacts of wildfires on ecologically sensitive coral reefs are largely unknown. Coral reefs foster the highest biodiversity per unit area of any aquatic ecosystem, providing $3.4B per year to the US economy alone through fisheries, tourism, and storm protection. This project expands our understanding of wildfire disturbances in tropical ecosystems by characterizing the effects of ash deposition on coral reefs and their microbial communities. This work contributes to our understanding of how wildfire and nutrient pollution affect coral reefs and will serve to inform coastal communities of fire risks to reef ecosystems. This project evaluates the functional impact of ash deposition from terrestrial wildfires on tropical coral reef ecosystems. Until the last decade, fire events in tropical latitudes were largely limited to agricultural controlled burns. Unfortunately, large scale tropical wildfire disturbances are becoming increasingly prevalent as the result of drought and more frequent and intense heatwaves. Fire acts as a nutrient transformer and ecosystem subsidy, changing the chemical composition of parent material and releasing large quantities of particles to the atmosphere (aerosols) and waterways (burned detritus), including nearshore and open-ocean ecosystems. Wildfires and the deposition of burned materials are known to have acute and long-lasting effects on nutrient dynamics and biodiversity in freshwater ecosystems. Yet little is known about the impacts of wildfires on coral reef ecosystems, alone or in combination with covarying environmental stressors, such as thermal stress. Through a series of bottle remineralization and controlled mesocosm experiments in Hawaiʻi, this research: 1) characterizes how microbial community composition and carbon metabolism is impacted by pyrogenic ash deposition; 2) evaluates the functioning of the coral holobiont in response to pyrogenic ash and increased temperature, both separately and in tandem; and 3) develops a mechanistic model to predict how scenarios of wildfire ash deposition and warming affect coral reef community composition. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

Corbett Medical Foundation

Corbett Medical Foundation is an active grantmaking foundation based in Saratoga, WY. Focus: health. Contact the foundation directly for current funding opportunities.

Society of the Third Street Music School Settlement, Inc.

Core music and student performance programs

The Brooklyn Music School

Core program curriculum development

NSF

The Federal Demonstration Partnership (FDP) is a cooperative initiative involving 10 federal agencies and 217 recipient institutions managing federally-sponsored research funds. FDP works to reduce the administrative burdens associated with research grants and contracts. The goal is to increase research productivity by streamlining the administrative process for research while ensuring effective stewardship of and full accountability for federal funds. More specifically, FDP strives to maximize research performance per federal dollar by minimizing the monetary and time burdens associated with the administrative aspects of federally-sponsored research. The National Academies of Sciences, Engineering, and Medicine serves as the secretariat for FDP. FDP’s approximately 600 institutional and federal representatives work together at three annual meetings and in collaborative working groups where members exchange thoughts, ideas, and feedback on current and proposed research administration policies and processes; work towards reducing administrative burdens associated with federal research grants and contracts; identify potential improvements and initiatives; and demonstrate possible solutions. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

NIAID - National Institute of Allergy and Infectious Diseases

SUMMARY/ABSTRACT Type 1 diabetes (T1D) is characterized by the T cell-mediated destruction of the insulin producing b cells in the islets of Langerhans. Currently, there is no cure for T1D, highlighting the ongoing need for immunotherapies that effectively suppress b cell autoimmunity long-term for disease prevention and treatment. Recently, T follicular helper cells (Tfh) have been implicated in promoting the diabetogenic response. Notably, persistently high levels of Tfh correlate with nonresponsiveness to CTLA4-Ig therapy in T1D patients. This observation suggests that it is necessary to tolerize Tfh to effectively suppress T1D. With this in mind, we propose to exploit the inherent plasticity of Tfh to limit their fitness and function, while promoting Tfh conversion into functional regulatory T cells (Treg). To achieve this, we will evaluate the efficacy of coreceptor therapy (CoRT), using low-dose nondepleting (ND) Ab specific for CD4 to induce Tfh de-differentiation and conversion into Treg. Our prior work has demonstrated that high-dose CoRT has potent in vivo effects on the properties of murine and human effector T cells (Teff), restoring b cell tolerance in NOD mice, and blocking pathogenic Teff activity in humanized mice. This R21 proposal outlines two Specific Aims. In the first Aim, we will assess the efficacy of low-dose CoRT to promote de-differentiation of murine and human Tfh and subsequent conversion into Treg, as well as investigate mechanisms that regulate this process. In the second Aim we will define the pathogenic versus suppressor function of CoRT-induced, de-differentiated murine and human Tfh. Through this work, we aim to establish a novel approach to both selectively block the pathogenic activity of autoreactive Tfh, while enhancing protective immunoregulation. In addition to T1D, this approach will be applicable to other autoimmune diseases and pathologies where Tfh play a role.

NINDS - National Institute of Neurological Disorders and Stroke

NINDS is committed to providing well characterized cell sources to both academic and industry investigators to advance the study of neurological disorders. The specific objective of this contract is to receive, process, store, and distribute biological samples and associated phenotypic and genotypic data and manage and track all associated data and human subjects materials for National Institute of Neurological Disorders and Stroke (NINDS) to help facilitate or further develop treatments for neurological disorders.

OD - NIH Office of the Director

Coriell Institute for Medical Research Application to ORIP C06 Funding Opportunity Announcement PAR- 25-061, Biomedical Research Facilities. Project title: “Coriell Cell Engineering Center to Support National Biobanking Infrastructure” Project Summary/Abstract: Coriell Institute for Medical Research’s mission is to conduct and support research to benefit human health and help cure disease. A leader in biobanking, Coriell has hosted NIH biobanks since 1972, building and distributing world class sample collections, enabling biomedical research. Coriell’s biobank is committed to meeting the evolving needs of researchers by adopting new technologies as well as diversifying and including minorities and underrepresented populations in its biospecimen collections. Coriell scientists are supported by the NIH, NJ State, and other parties, in fields including but not limited to cancer and disease research, aging biology, biobanking, and personalized medicine. Coriell’s primary facility, 403 Haddon Avenue, Camden, NJ, is owned by, and resides on, the campus of Cooper University Hospital. There is limited room for growth and plans are underway for Coriell to relocate to a new headquarters building, on its own site in Camden, in approximately three years. If awarded, ORIP C06 funds would help create a >7,495 square foot Cell Engineering Center on the first floor of Coriell’s new facility, to enable expansion of biobanking infrastructure and product and service offerings. Of these offerings, stem cells offer unique insights into cell and developmental biology, disease etiology, and expedition of drug discovery. Advances in gene engineering and tools like 3D “mini-organ” models are revolutionizing research. Such tools also represent New Approach Models (NAMs) that complement and reduce the need for vertebrate animals in research. This Center will serve as a core laboratory, offering cancer cell lines, newly created iPSCs, differentiated cells, 3D organoid models, cell gene engineering, quality control, genomic/epigenomic profiling, and bioinformatic services, for NIH-funded scientists at Coriell, in the region, and across the country. This project epitomizes Coriell’s mission to support robust research by providing scientists a new generation of reproducible, highly characterized, high-quality biospecimens and services to accelerate the pace of biomedical discoveries. Coriell samples have been instrumental for elucidating mechanisms of diseases to allow new regenerative and precision medicine therapeutics. This Center will provide critical, affordable new products and services to support researchers. An experienced and collaborative team of dedicated professionals, with an expert Principal Investigator, Construction Project Manager, and Facility Manager will lead this project. This project is part of a larger new building investment which is already underway with an anticipated completion date of 2027-2028, and Coriell leadership commits to staffing and supporting this Center for 10+ years post-completion, using business tactics developed as an independent research institute for over 70 years. In addition to institutional, local and regional benefits, this project will have a substantial national impact. The Center will increase current capabilities >20 fold, support up to 30 scientists/technicians, and enable biobanking of new, needed sample types, supporting Coriell internal grants, contracts, and federally funded researchers, as well as scientists nationwide.

OD - NIH Office of the Director

Abstract Chemical threat agents can potentially be weaponized to cause mass casualties. The warfare agent sulfur mustard and its chemical analog nitrogen mustard (NM) cause severe injury to ocular tissues with acute epithelial defects, pain and delayed onset of keratitis. As yet, a comprehensive understanding of the cellular contributors and pathophysiological molecular mechanisms of corneal pathology and sensory dysfunction is lacking. Recently, we have described remarkable changes in citrullination, a protein posttranslational modification (PTM), manifests in NM-injured murine corneas. Citrullination is catalyzed by peptidyl arginine deiminases (PADs). Our preliminary findings show that PAD4 could be driving citrullination in the corneal epithelium and stroma, but its citrullinated targets have yet to be formally identified. In addition, it is still unclear how vesicant injury affects corneal sensory function and what molecular pathways in corneal Schwann cells (cSCs) contribute to axonal degeneration and regeneration. To study such complex facets of corneal pathology- structural integrity and sensory function – in this R01 grant proposal, we will investigate the epithelium and sensory system, using citrullinomics and transcriptomics approaches, respectively. Specifically in Aim 1, we will investigate what proteins are temporally altered by PAD4- driven citrullination to illuminate biological pathways and cellular processes affected by citrullinated proteins. These protein hits will be validated and assayed for function in human corneal epithelial cell culture experiments. In Aim 2, we will focus on a newly identified druggable target in cSCs whose pharmacological inhibition in NM injury promotes cSCs and axonal network regeneration and sensory recovery, and hence understanding this SC-target’s mechanisms in cSCs would be important. We will exploit a single nuclear RNA sequence analysis paradigm to pursue temporal transcriptomic changes occurring in injured corneas to illuminate novel effectors of this regenerative paradigm. Bioinformatic approaches will be used to interrogate these data to achieve a comprehensive overview of the pathways affected by citrullination mediated by PAD4 in the cornea, and a similar decoding of transcriptomic information for understanding cSC regenerative function. Ultimately, this two-pronged approach could illuminate new biomarkers and effectors of corneal injury and unravel repair mechanisms that have not been previously established.

NEI - National Eye Institute

ABSTRACT Traumatic brain injury (TBI) often leads to vision loss and damage to cranial dura mater (CDM), the outermost brain meningeal covering, which regulates the brain’s metabolic waste and cerebrospinal fluid outflow. The incidence of TBI- related disability in men is 2.2 times higher than in women, but reasons for this disparity remain unknown. CDM shares sensory innervation with cornea through trigeminal ganglion system forming anatomo- physiological link between easily accessible cornea and unreachable CDM. Our resent collaborative study identified a connection between corneal injury and alterations in the connective tissue and microvasculature of the CDM. Additional pilot data support these findings and show delayed time-dependent corneal damage in response to mild TBI. Importantly, we reveal the involvement of decorin, a small leucine-rich extracellular matrix proteoglycan, in cornea-CDM crosstalk post injury. Our recent novel in vivo findings and human clinical literature led us to hypothesis that TBI-induced insult to CDM leads to neuroinflammatory alterations in cornea via ophthalmic division of the trigeminal ganglion supplying sensory innervation to cornea and this pathological event is modulated by the decorin. The primary goal of the project is to identify mechanism of TBI/CDM-injury to cornea and test if decorin can serve as a therapeutic target to regulate this pathological process. The results of study will lead to identification of mechanisms mediating corneal dysfunction post TBI/CDM injury and uncovering of strategies for treating TBI/CDM-induced corneal damage resulting vision loss in vivo. The two Specific Aims will test novel hypothesis and accomplish goal of current project. Specific Aim 1 elucidates how TBI/CDM-injury alters neuroinflammatory responses in cornea in vivo using a well-established mouse model. Specific Aim 2 tests if decorin has therapeutic potential to regulate TBI/CDM-mediated pathological responses in cornea in vivo using decorin-knockout (loss-of-function) mouse model and insult to CDM. Our multidisciplinary team has cornea and CDM experts with experience in TBI/CDM-injury in vivo mouse model, and has established methods, published protocols, and vast expertise in corneal and CDM research with experience in clinical eye imaging, quantitative computer-based image analysis, and molecular techniques. The scientific impact of project is high as successful will (a) advance understanding of the anatomo-physiological connection between cornea and CDM provided by trigeminal system, (b) unveil neuroinflammatory link between cornea and CDM, (c) improve clinical diagnostic approach for pathophysiology of cornea and TBI disorders associated with the activation of trigeminal system, (d) fill knowledge gaps regarding the sex-based differences in anatomo-physiological connection between cornea and CDM, and (e) allow us to collect pilot data for R01 application to extend this research.

NEI - National Eye Institute

Scarring of the stroma, the central layer of the cornea, due to Injury or infection, and severe stromal thinning due to keratoconus, cause corneal blindness worldwide. Cornea transplantation is often the only cure for many of these conditions, but limited supply of donor tissue is a major concern. Cell therapy for the stroma, still under development, primarily uses limbal stem cells from donor corneas. Therefore, there is a critical need for treatment of the stroma that will be independent of donor tissues. To address this need, we recently developed human cornea organoids (HCOs) that mimic the fetal cornea. Generated from induced pluripotent stem cells (iPSC) the HCOs present a breakthrough model system of co-differentiating stromal keratocyte, epithelial and endothelial cells in a more cornea-like 3-dimensional extracellular matrix (ECM). Our single cell RNA sequence (scRNA-seq) study shows that HCOs harbor stromal progenitor and fetal corneal keratocyte-like cells which may have the desired long-lasting functionality in the cornea. In addition, we found that HCOs express ECM genes and produce a stroma rich in collagen type III, fibronectin, and other ECM components known to make up the immature corneal stroma. Additionally, as the TGF-𝛽 network is the master regulator of healthy and fibrotic ECM, this network must be specifically regulated in HCOs to maintain its regenerative ECM quality. Therefore, we hypothesize that the HCO is a novel stromal therapy resource and a corneal surrogate for identifying TGF-𝜷 signals that promote healthy but limit fibrotic ECM production. Our preliminary data shows that a mix of stem, progenitor and differentiating cells can be rapidly extracted from the HCO stroma without further monolayer culturing. Injected into decellularized donor corneas the HCO-stromal cells can integrate in the tissue. Second, the extracted ECM from HCOs promote migration in cell culture and corneal wound healing in the mouse. Importantly, as the HCO expresses all major receptors and transcription factors, it is feasible to investigate the TGF-𝛽 network in this model. Aim 1 will determine if extracted HCO-stromal cells will integrate and function in a decellularized donor cornea. Aim 2 will test whether the HCO-stromal cells or the extracted HCO-ECM promote scarless wound healing in the mouse. Aim 3 will identify specific TGF-𝛽 signals that underpin the immature ECM of HCOs. Our findings will develop the HCO as a promising donor tissue-free source of regenerative biomaterial and cells and identify regenerative TGF-𝛽 signals for future treatments of corneal scarring.

EDF

Cornell Industrial Hemp Working Capital

Regional Council Capital Fund - RC 2

Cornell University Capital

NYPA OFB Craft Bev Marketing

Cornell University Craft Beverage Working Capital

Cornell University

Education and Training Services

Upstate Revitalization Initiat Round 1

Cornell University Electron Storage Ring Capital

Regional Council Capital Fund - RC 2

Cornell University Greenhouse Capital

Sunnyside Community Services, Inc.

Youth