Grants

Cascade People’s Center

Add 3 new computers to the YMCA of Greater Seattle - Cascade People's Center to enable low income, homeless residents in the South Lake Union/Cascade neighborhood to have greater access to online services, such as healthcare, food stamps, housing, and transportation.

Oregon Business Development Department

Cascade Engineering Technologies, Inc

City of Gresham

Cascade Grndwater Dev: Manganese Water Trmnt Plant

Rockwood Water People’s Utility District

Cascade Grndwater Dev: Manganese Water Trmnt Plant

Cascade Music Foundation

Cascade Music Foundation is an active grantmaking foundation based in Seattle, WA. Focus: arts. Contact the foundation directly for current funding opportunities.

Cascade P-Patch

The Cascade P-Patch located at 310 Minor Ave N. will rebuild and relocate its existing tool shed. The group will also purchase new and safe garden equipment for all who use the P-Patch garden.

Cascade Neighborhood Council

The Cascade Recycled Arts Project is being led by an emerging group of low income residents and small businesses that wish to become a resource for participation in arts and cultural events in the Cascade neighborhood. Planned activities include a boat sailing in June, participation in National Night Out in August, summer movie nights, and a 'Snowflake Fest' in December. The group will also host a series of bi-monthly, arts and cultural, events in the park that will encourage and incorporate the theme of upcycling and recycling.

Cascade People’s Center

Replace obsolete computers in the computer lab and provide basic technology training for low income and homeless families in the South Lake Union neighborhood.

NIDA - National Institute on Drug Abuse

The US Deep South bears the highest burden of HIV, and the South is lagging behind in achieving Ending the HIV Epidemic (EHE) goals. People who use drugs (PWUD) like cocaine, meth, heroin, and fentanyl, are more likely to fall out at each step of the HIV care cascade. Contextual factors contribute to poorer HIV and substance use outcomes, neuroimmune dysfunction, and related chronic illness. The overarching goal of CASCADE (Carolina Addiction Science Coalition for Accelerating Discovery and Engagement) is to investigate the impacts of established and emerging drug use patterns and addiction treatment on the HIV prevention/care cascade in the South. As a community-academic-health system partnership, this proposal is a collaboration between Wake Forest University Health Sciences in Winston-Salem and Charlotte and multiple community organizations throughout Central and Western North Carolina. Leveraging the robust infrastructure of Atrium Health, one of the largest nonprofit health systems in the South, along with HIV and substance use service programs, we will enroll a status-neutral cohort of 1,000 persons who use stimulant and/or opioid drugs – 500 people with HIV (PWH) and 500 people at risk for HIV. Using an observational-implementation hybrid approach, our aims are to: (1) Recruit and retain the CASCADE Cohort to collect multilevel data harmonized with other NIDA-funded HIV cohorts for emerging and high-priority research; (2) Using a social-ecological framework, examine the effects of individual, community, and contextual factors on status-neutral HIV and substance use outcomes over time, investigate the neuroimmune mechanisms through which psychosocial stress affects neuropsychiatric outcomes, and identify structural modifiers (e.g., rural/urban setting) and potential resiliency factors (e.g., coping); and (3) Conduct mixed-methods assessments using implementation mapping to identify structural factors, organizational practices, and other contextual factors that influence the uptake of evidence-based HIV and substance use treatments in healthcare settings, and co-create and disseminate a set of multilevel strategies informed by user-centered design to improve service delivery. Through our application of cutting-edge biostatistics and data science methodologies, our findings will yield novel insights to accelerate scientific discoveries while also enhancing translation to clinical care and facilitating rapid dissemination. As the first NIDA HIV Cohort in the South, we will partner with our Community and Scientific Advisory Board, consisting of members from community organizations, health system administrators, public health officials, scientific leaders, and persons with lived experiences, to inform guidelines and practices in the Carolinas and beyond. CASCADE aligns with national priorities by addressing the growing burden of chronic illness and substance use through a pragmatic, science-based approach.

Cascadia College Foundation

Cascadia College Foundation is an active grantmaking foundation based in Bothell, WA. Focus: education. Contact the foundation directly for current funding opportunities.

Manchester

Case Cabin Improvements

New Horizons

Provide staff with laptops to help homeless and street involved youth to access employment, housing and educational opportunities. Develop a system for youth to check out the laptops and build their technology skills and empower them to leave the streets.

Granby

Case Street - Chipseal and Overlay

Granby

Case Street - Chipseal and Overlay

West Bronx Housing and Neighborhood Resource Center, Inc.

Local

DEPT OF DEFENSE.DEFENSE LOGISTICS AGENCY.DLA LAND.DLA LAND WARREN MICHIGAN.DLA LAND WARREN

CASE,ELECTRICAL-ELE

NHLBI - National Heart Lung and Blood Institute

PROJECT SUMMARY/ABSTRACT Among patients with asthma, a disease that afflicts over 300 million people globally, for over 50% their asthma is not well-controlled by current therapies. β-agonists are a cornerstone medication used to prevent and relieve acute bronchospasm in asthma patients. Unfortunately, excessive use of β-agonists can cause desensitization, internalization, and downregulation of the β2-adrenoceptor (β2AR), leading to tachyphylaxis (loss of clinical efficacy). β-agonists act by binding to the cognate G protein-coupled receptor on human airway smooth muscle (HASM), the β2AR. Activation of the β2AR prompts Gαs to stimulate adenylyl cyclase production of cAMP. Increased intracellular cAMP levels activate protein kinase A (PKA), which phosphorylates mediators of excitation-contraction coupling, leading to HASM cell relaxation and bronchodilation. The regulation of cAMP is canonically considered “switch-like”: the “on-switch” (adenylyl cyclase) is counteracted by phosphodiesterases (PDEs) that degrade cAMP to its inactive form, AMP. Our laboratory recently reported that β-agonist-evoked intracellular cAMP is also negatively regulated by transport of cAMP into the extracellular space via ATP- binding cassette subfamily member C1 (ABCC1). This effect was observed in receptor-dependent (i.e. β- agonist) and receptor-independent (i.e. adenylyl cyclase agonist) manners, suggesting this is a universal response to elevated intracellular cAMP levels. However, the mechanism by which ABCC1 is regulated and the contribution of ABCC1 to β2AR desensitization remain unknown. Our preliminary data indicate that Casein Kinase 2 (CK2), a highly conserved serine/threonine protein kinase, directly phosphorylates and regulates ABCC1 in response to β2AR activation. In addition, the timing of ABCC1 phosphorylation coincides with recruitment of MAPK, an important step in β2AR desensitization and a demonstrated regulator of CK2. Therefore, the overarching hypothesis is that MAPK and CK2 are critical in β2AR-evoked ABCC1 activation, leading to physiological outcomes of increased cAMP efflux and β2AR desensitization. Aim 1 will determine the contribution of CK2 and MAPK in homeostatic and β-agonist-induced ABCC1 activity in cultured HASM cells. In Aim 2, we will assess whether the MAPK-CK2-ABCC1 axis regulates β2AR desensitization and internalization. This research investigates a novel regulatory mechanism of cAMP signaling with the goal of identifying druggable targets that can split β2AR signaling mechanisms and inhibit the loss of clinical efficacy of β-agonists. Further, the proposed training will strengthen the Principal Investigator as an independent researcher in obstructive lung disease and cell signaling.

Center for Alternative Sentencing and Employment Services

Purchase desktop computers and monitors, a photocopier, printers, file cabinets, desks, waiting room chairs and tables, stackable classroom chairs, classroom and computer tables, meeting room table and chairs, therapy room pneumatic chairs, and desk guest

NYC Department of Cultural Affairs

Casita Maria, Inc.

Casper College Foundation

Casper College Foundation is an active grantmaking foundation based in Casper, WY. Focus: education. Contact the foundation directly for current funding opportunities.

EDF

Castelli America Capital

JDA

Castelli RE JDA

Castilleja School Foundation

Castilleja School Foundation is an active grantmaking foundation based in Palo Alto, CA. Focus: education. Contact the foundation directly for current funding opportunities.

New NY Broadband 15-16 Capital

Castle Cable Phase II Broadband Capital