AVIT24 System for Next-Generation Sequencing and Spatial MultiOmics to Advance Genomics Research at USC
openNIGMS - National Institute of General Medical Sciences
Abstract:
The University of South Carolina (USC) Functional Genomics Core (FGC), supported by the NIGMS-funded
COBRE Center for Targeted Therapeutics, offers comprehensive genomics, transcriptomics, and epigenomics
services to a diverse research community. This includes NIH- and NSF-funded investigators across the USC
Columbia campus, regional campuses, the state of South Carolina, and out-of-state collaborators. The Core
currently depends on an aging Illumina NextSeq 500 platform for next-generation sequencing (NGS), which
presents significant limitations in throughput, operational efficiency, and cost-effectiveness. To address these
challenges and accommodate the growing demand for high-throughput and spatially resolved molecular profiling,
we propose acquiring the Element Biosciences AVITI24 system. This advanced platform significantly enhances
data quality, operational cost, and scalability for both small and large projects. Uniquely among NGS systems,
the AVITI24 integrates spatial transcriptomics and proteomics capabilities, enabling simultaneous spatial and
sequence-based analyses within a single instrument. This transformative capability will broaden access to
cutting-edge spatial multiomics technologies for a wide range of users, including early-stage investigators and
underrepresented researchers, while greatly improving the throughput, precision, and affordability of genomic
services. The acquisition of the AVITI24 will modernize the FGC’s sequencing infrastructure, support
interdisciplinary biomedical research programs, and allow NIH-funded investigators at USC and in South
Carolina to access new technologies. Overall, this instrument will significantly and sustainably enhance the
productivity and competitiveness of the USC research community and regional FGC partners.
Up to $395K
health research