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24 grants worth up to $19.8M match your search

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Boston University-Demographic and Social Determinants of Healthy Cognitive Aging Research Program (BU-SHARP)

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NIA - National Institute on Aging

Overall Abstract The Boston University-Quantitative Population Science and Healthy Cognitive Aging Research Program (BU-SHARP) will serve as a hub for interdisciplinary research on Alzheimer’s Disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD). BU-SHARP will concentrate on three research themes: (A) between and within-group patterning of AD/ADRD onset, progression, and consequences across persons with disabilities, underserved rural populations, and other populations disproportionately affected by AD/ADRD, (B) life course individual and interpersonal resources and mechanisms contributing to this patterning, and (C) modifiable influences on AD/ADRD onset, progression, and consequences in these populations. BU-SHARP will collaborate with initiatives across Boston University (BU), drawing on campus-wide strengths in demography, sociology, economics, epidemiology, data science, and related fields to stimulate interdisciplinary research. BU-SHARP will contribute to the future pipeline of AD/ADRD researchers via pilot funding and mentorship to early-stage investigators, enhancing access to data, methodological resources, and technical assistance. Bridging disciplinary divides to share quantitative methods will accelerate AD/ADRD research and generate new insights. BU-SHARP will provide an infrastructure and structured programs focused on enhancing research rigor and innovation (e.g., bi-weekly research accelerator meetings, technical assistance to pilot awardees and collaborators, curated speaker series on innovations in research methods relevant to AD/ADRD), effective research translation (e.g., expert guidance in translating research findings, fostering multiple dissemination channels for scientific findings), and mentorship and support of early-stage researchers (an emerging scholars pilot grant program, structured and individualized mentorship, curated professional development workshops), among other activities. The BU-SHARP Administrative Core will provide leadership and oversee all activities. The Program Development (Pilot) Core will fund 2 early career pilot projects annually (12 total across the 6-year grant), and provide structured mentorship and technical assistance. The Communications & Dissemination Core will collect, curate, and disseminate research findings, ensure cross-disciplinary sharing of research advances, and train a cohort of students to develop expertise in writing and reporting on AD/ADRD via a social science writing fellowship program and a public health journalism program at BU. Through these efforts, BU-SHARP will generate new insights into the behavioral and contextual risk and protective factors that influence cognitive aging and its consequences, contribute to the development of effective prevention strategies, and increase the pipeline of population science AD/ADRD researchers.

Up to $466K
2027-08-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Bridging the Gap: Advancing Rural Health Research with the Wear-IT Research Platform and Edge-of-Cloud Computing

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NCATS - National Center for Advancing Translational Sciences

Modified Project Summary/Abstract Section Although health disparities between rural and urban communities have been known for decades2–5, there is evidence individuals from rural areas are less likely to participate in translational research and clinical trials6. Rural communities face higher mortality than urban communities for the six leading causes of death in the US–heart disease, cancer, unintentional injuries, COVID-19, stroke, and chronic lower respiratory disease.20–23 This has been referred to as the ‘rural mortality penalty’ as rural areas show slower declines in mortality compared to urban areas.14,24 Barriers to research participation among rural populations include participation costs (e.g., travel time, monetary), limited Internet connectivity, and socio-cultural barriers (e.g., perceived lack of anonymity)6. NCATS’s More Treatments for All People More Quickly initiative outlines the need to develop effective treatments that can reach underserved populations, which highlights the need for a research tool that can collect data and administer interventions in the privacy of participants homes regardless of Internet connectivity. Given the ubiquity of smartphones (~90% ownership in rural areas), the planned research will test the Wear-IT app,7 a smartphone research platform that can reduce barriers for rural populations by 1) ensuring a fast and responsive experience even when Internet is limited; and 2) delivering automatic, personalized interventions. Wear-IT is unique in the mHealth space due to its on-device processing model which allows for real-time responsiveness when Internet is unavailable7 with data uploaded to the cloud for more computationally intense processing when a participant passively encounters better connectivity (e.g., travel to town, WiFi). Wear-IT can flexibly assess complex clinical targets through multi-modal ecological momentary assessments (EMA) including video, photo, geolocation, and survey responses. On-device processing of multi-modal EMA or sensor data (e.g., step count) also enables delivery of just-in-time adaptative interventions (JITAI)7, which aim to provide personalized information or support at the exact moment it is needed.8 The proposed study will demonstrate the translational and clinical utility of Wear-IT by assessing diet-related health behaviors in 100 rural families with children from the Appalachian region. Using Federal Communications Commission fixed and mobile Broadband coverage data, targeted recruitment will ensure half the families (n = 50) have at-home Broadband and half (n = 50) have poor/no at-home Internet. Parents will use the Wear-IT app for three weeks. During the 3-week period, parents will receive EMA prompts and JITAI messages related to the three diet-related health behaviors: 1) home food environment; 2) home meals; and 3) food shopping (Figure 1). Assessing the acceptability and feasibility of Wear-It in rural communities will help to increase rural representation in health research and clinical trials, which is the first step in addressing persistent health disparities in rural communities.

Up to $164K
2028-05-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Burden and Predictors of Neurocognitive Impairment Among HIV-Infected Patients with Meningitis in Rural, Northern Uganda

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FIC - John E. Fogarty International Center for Advanced Study in the Health Sciences

This IRSDA K-award will provide me with mentored research and career development training to build expertise in translating global health findings to benefit U.S. populations and underserved healthcare systems. I will learn to validate neurocognitive impairment (NI) screening tools and analyze inflammatory biomarkers that predict NI in meningitis patients with or without HIV in rural, northern Uganda, an area of high meningitis burden within Africa’s meningitis belt. Meningitis affects over 2.5 million people globally each year, and causes significant disability, with 20-32% of survivors experiencing long-term morbidity and 14-38% developing prolonged NI, yet data on NI burden in meningitis patients remain scarce. Despite evidence that inflammation in central nervous system infections is associated with NI, limited information is available about the biomarkers involved in NI development. This study seeks to fill the gaps in our understanding of the burden and pathogenesis of NI by identifying which brain injury biomarkers are expressed in patients with NI and can be used to predict NI development among meningitis patients with and without HIV. This study will be embedded within my primary mentor’s existing Meningitis Diagnosis and Treatment Program (MEN-DTP) at Lira Regional Referral Hospital in northern Uganda, which focuses on understanding mortality due to various meningitis etiologies in an area with high meningitis and HIV burden. Aim 1 is to validate neurocognitive assessment tools to determine the burden of NI among meningitis patients living with and without HIV, including follow-up for two years to assess long- and short-term NI burden. Aim 2 is to identify clinical parameters and immune/inflammatory biomarkers predictive of NI. Serum and CSF samples will be collected from meningitis patients who do or do not develop NI to identify biomarkers specifically associated with NI. Investigating immunologic and brain injury biomarkers will provide insights into inflammatory pathways activated by meningitis that lead to NI in those with or without HIV. Our neurocognitive assessments will help determine the true burden of NI and enable timely diagnoses and interventions. Our findings from this high-burden setting will inform neurocognitive assessment and early intervention strategies to improve care for meningitis patients that could be implemented in underserved U.S. populations and globally.

Up to $908K
2030-05-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Center for Aging with Serious Illness (CASI)

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NIGMS - National Institute of General Medical Sciences

This Phase I Centers of Biomedical Research Excellence (COBRE) proposal establishes the Center for Aging with Serious Illness (CASI) at Dartmouth Health (DH). The growing number of older adults living with chronic, serious illness represents one of the most pressing public health challenges in the United States. However, research addressing the unique needs of this population has not kept pace with its rapid expansion. Building a robust evidence base to improve the quality of life for this group is critical to advancing healthcare. To address this gap, it is essential that research be designed to navigate the complexities of providing care for older adults facing serious illness. The primary goal of this COBRE is to create the foundational infrastructure required to develop a multidisciplinary research program focused on aging with serious illness al DH, one of the most rural academic medical centers in the country. This program will provide expert mentorship, protected research time, and institutional support to recruit and nurture a critical mass of early-career clinician-scientists, facilitating their transition into independent researchers dedicated to improving care for older adults with serious illness. To achieve this overarching goal, CASI will pursue three specific aims: (1) Establish a robust framework that integrates research expertise and mentorship to formalize CASI and strengthen DH's research infrastructure, in collaboration with affiliate institutions; (2) Develop a structured pathway to support early-career clinicianscientists as Research Project Leaders (RPLs) and enhance their transition to independent investigators through tailored, milestone-driven research plans; and, (3) Ensure the success of RPLs and Pilot Project Leaders by providing comprehensive technical assistance through the Biostatistics, Ethics, Data Management, Research Design, and Community Engagement (BEDRoC) Core, which will serve the broader DH research community focused on improving care for older adults with serious illness. CASI will concentrate on building a network of experts who will conduct clinical, behavioral, and health services research to address the challenges faced by older adults with serious illness. Our investigators will focus on solving key issues in aging with serious illness and use their findings to inform healthcare policy and stakeholder decision-making. The initial three RPLs will focus on shared decision-making for surgery in older adults, palliative care for older patients with cancer, and management of osteoarthritis in older adults with multimorbidity. The BEDRoC Core will support CASI by: (1) Providing the three RPLs specialized expertise in statistical analysis, research ethics, and community engagement to aid in the planning and execution of their projects, and (2) Creating an innovative learning collaborative that provides workshops, tutorials, resources, and services to promote continuous researcher development. COBRE funding, combined with substantial institutional investment and plans to hire additional faculty, will lay a strong foundation for creating a self-sustaining, vibrant Center. This Center will foster independent investigators whose work will ultimately improve the care and quality of life for older adults.

Up to $2.4M
2031-03-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Characterizing the Quality of Evidence-based Prescribing for Hospitalized Veterans

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NIH

Significance to VA: Each year, hundreds of thousands of Veterans are hospitalized for new presentations and acute exacerbations of complex chronic conditions, such as cardiovascular, pulmonary, neurologic, and substance use disorders. For each of these conditions, there are medications with strong evidence for improving clinical outcomes when taken long-term. Use of evidence-based, long-term medications following hospitalization is often deficient, with disparities observed in prescribing by race, ethnicity, rurality, and socioeconomic status. To date, no studies have systematically assessed the quality and equity of evidence-based prescribing at hospital discharge, a critical time to initiate guideline-recommended care. The objectives of this proposal are to detect and understand determinants of quality and equity of prescribing for hospitalized Veterans and to identify evidence-based strategies to improve prescribing. This research has been developed in partnership with the National Hospital Medicine Program, Office of Health Equity, and Center for Medication Safety and aligns with HSR priorities to apply Learning Health Systems foundational methods to achieve the VA Quintuple Aims of improving outcomes and ensuring equity. Innovation and Impact: The proposal is innovative in three ways. First, this research moves beyond disease- specific silos to examine evidence-based prescribing as a cross-cutting concept for hospitalized Veterans. Second, this research evaluates prescribing quality with an explicit health equity lens and employing a novel pharmacoequity framework. Third, it will use a complementary set of rigorous health services research methods to understand the underlying mechanisms for gaps in the quality and equity of prescribing and develop strategies with stakeholders to close gaps. This proposal will provide hospital-specific metrics to frontline clinicians and administrators to guide quality improvement efforts to advance inpatient prescribing quality and equity. Specific Aims: Aim 1: To examine the association of sociodemographic factors with receipt of evidence-based medications at hospital discharge. Aim 2: To determine mechanisms by which Veterans do not receive evidence- based medications at hospital discharge. Aim 3: To identify stakeholder perceptions of hospital prescribing performance and barriers to and facilitators of discharge prescribing quality and equity. Methodology: Aim 1 will be a retrospective cohort study using electronic health record data from the VA Corporate Data Warehouse to assess national and hospital-level rates of evidence-based medication use for Veterans hospitalized from 2022 and 2024 for five common complex chronic conditions: alcohol use disorder, atrial fibrillation, cerebrovascular disease, chronic obstructive pulmonary disease, and heart failure. Aim 2 will be a chart review study of a sample of 1,000 Veterans identified in Aim 1 as not receiving evidence-based medications at hospital discharge, oversampling for sociodemographic groups with the largest disparities in care. Aim 3 will be a qualitative study of 75 semi-structured interviews with inpatient clinicians and VA hospital leaders to identify barriers to and facilitators of equitable, high-quality discharge prescribing, recruiting from VA hospitals that are high and low performing (by quality and equity metrics) based upon Aim 1 results. Path to Translation/Implementation: This project will yield critical evidence to guide research and quality improvement efforts to equitably improve care delivery for hospitalized Veterans. The sum impact of this proposal will be the foundational data needed to initiate a Learning Health System Translation-to-Policy Learning Cycle to urgently transform current prescribing practices and test the implementation of data-informed strategies to improve hospital discharge prescribing quality and equity. Findings from all aims will be synthesized and reviewed with Operations partners, Veterans, and a longitudinal Expert Stakeholder Panel of frontline hospital- based clinicians to inform the co-design of implementation strategies to increase prescribing of evidence-based therapies for hospitalized Veterans that will be studied in future QUERI and Merit proposals.

2029-12-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Clinical impact of geriatric emergency department accreditation (GEDA) on older adults with dementia

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NIA - National Institute on Aging

The growing number of older Americans who seek care in emergency departments (EDs) has increased awareness of the need for specialized geriatric emergency care. Since 2018, the Geriatric ED Accreditation (GEDA) program has promoted such care, and there now are >500 GEDA EDs, across the 3 levels: Gold (~6%), Silver (~11%), and Bronze (~83%). GEDA is particularly attentive to the care of vulnerable older adults, such as persons living with dementia (PLWD). PLWD are a large and growing population that has been shown to visit the ED more often than their cognitively intact counterparts. Alzheimer’s Disease and Related Dementias (ADRD) are often under-recognized during these ED visits, and PLWD have been shown to experience prolonged ED length-of-stay and avoidable hospitalizations. Over the past two years, members of the study team have performed foundational research on GEDA and now seek to investigate, among PLWD, if ED participation in GEDA leads to better emergency care processes and better clinical outcomes. We propose a mixed methods project that combines three population-based datasets from 2022-2024 (NEDI-USA for ED characteristics, including GEDA level; and HCUP SEDD/SID and Medicare for clinical outcomes), and performs qualitative research on ADRD-related ED care practices. The Aims investigate: (1) GEDA level and documentation of ADRD among PLWD. Clinician recognition of ADRD is a critical first step for improving the care of PLWD, yet our Preliminary Work shows that ~1/3 of ED visits by PLWD lack this coding. Hypothesis 1: Compared to non-GEDA EDs, GEDA Gold/Silver EDs are more likely to code ADRD among PLWD. (2) GEDA level and clinical outcomes among PLWD. Hypothesis 2: Compared to PLWD in non-GEDA EDs, those in GEDA Gold/Silver EDs are less likely to have prolonged ED LOS (8+ hours) and to be hospitalized. (3) Adoption and long-term implementation of GEDA practices that improve emergency care for PLWD. Guided by the Consolidated Framework for Implementation Research, we will conduct in-depth qualitative interviews with a purposive sample of ED physician and nurse leaders, based on GEDA level and key ED characteristics (e.g., annual ED visit volume, urban vs rural). Hypothesis 3a: GEDA EDs that successfully integrate ADRD-related care practices into their workflows demonstrate common organizational, cultural, and leadership characteristics. Hypothesis 3b: Specific factors affect the adoption and long-term implementation of ADRD-related care. This R01 project addresses major knowledge gaps and will advance interventional work, including future trials of ADRD-related ED care practices. The investigators have complementary expertise (e.g., emergency medicine, geriatrics, epidemiology, health services research, mixed methods) and a track record of successful collaboration in an exceptional research environment. Preliminary work confirms feasibility, with >90% power for clinically important associations. This 4-year R01 project advances the scientific priorities of NIA/NIH by developing strategies to improve the emergency care of older adults, especially those with ADRD.

Up to $679K
2030-03-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Clinician Research Education and Scientific Training (CREST) Program

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NIGMS - National Institute of General Medical Sciences

The Clinician Research Education and Scientific Training (CREST) MSTP will rigorously train MD/PhD students in laboratory, clinical, translational, and community research to ensure their development into successful, independent clinician-scientists. This new MSTP will build on the strong foundation established by the current institutionally-supported MD/PhD program at the University of Arkansas for Medical Sciences (UAMS) and its affiliated Arkansas Children’s Research Institute (ACRI) to uniquely address the need for clinician-scientists in Arkansas and the neighboring IDeA states of Mississippi, Louisiana and Oklahoma. This would be the only MSTP in a geographically isolated desert of 4 contiguous rural IDeA states, all of which have some of the worst health outcomes in the country. CREST will focus recruitment of top applicants from the mid-South region and also leverage a statewide pool of candidates from the University of Arkansas at Fayetteville (UAF) and 17 primarily undergraduate universities already linked with programs at UAMS/ACRI through the Arkansas IDeA Network of Biomedical Research Excellence (INBRE). Recognizing we are at a critical inflection point in training clinician- scientists in Arkansas and the surrounding states, UAMS recently established a new Office of Clinician-Scientist Development (OCSD). The OCSD will facilitate coordination between the CREST Program, existing T32 training programs, our Clinical and Translational Sciences Award (CTSA) and its affiliated Translational Research Institute (TRI), and other UAMS/ACRI IDeA programs, including multiple Centers of Biomedical Research Excellence (COBREs), and the strong population health research programs at UAMS/ACRI and UAF. This central coordination will promote synergies between programs to enhance opportunities for CREST students to pursue broad areas of biomedical research to address healthcare needs unique to the mid-South region. UAMS will provide critical institutional support to ensure full tuition, health insurance supplements, and stipend support for every MD/PhD student in every year of both the MD and PhD phases of training. We are requesting 4 MSTP slots per year in years 1-2, and 2 additional slots beginning in year 3 for a steady state of 10 funded slots, with matching institutional support for a total program size of 32 MSTP students. CREST leadership will utilize a multi- PI (MPI) approach that includes highly successful and complementary investigators well-versed in MD/PhD training. CREST mentoring will include an individualized Scholarship Oversight Committee and near-peer mentoring to support CREST students and ensure seamless integration of the MD and PhD phases of training. Mentoring will purposefully continue for 4 years after completion of the Program to ensure the development of CREST students as independent clinician-scientists. CREST will capitalize on established infrastructure to build a nationally recognized MSTP to train and promote retention of clinician-scientists in Arkansas and surrounding IDeA states, including incentivizing the return of graduates following residency and fellowship training. These clinician-scientists will change the paradigm in a region with particularly poor healthcare outcomes.

Up to $269K
2031-06-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

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NIA - National Institute on Aging

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Although, Alzheimer disease remains important there are greater contributions from vascular brain injury, systemic disease and dysfunction that indirectly affects the brain, and recently described, poorly understood brain pathologies. Vascular and lifestyle risk factors may contribute differently to risk of dementia in the oldest-old. Conversely, it is also important to learn what resilience factors permit persons to remain alive and cognitively normal as nonagenerians. Studies that enroll persons aged 85+, often lack information from when these individuals were middle-aged. Longitudinal cohort studies that enrolled participants between ages 45 and 70 years and followed them past age 80 years, till they died or developed dementia, would be ideal study samples, but each such cohort usually has only a small number of participants surviving beyond age 80. One solution is to combine data across multiple longitudinal studies with harmonizable protocols. The Cross-Cohort Collaboration Consortium (CCC) was established in 2018, as an offshoot of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. The Neurology working group within the CCC (led by MPIs Seshadri, Ikram, Dufouil, Debette, Satizabal) brought together 8 cohorts (RF1 AG059421) to study late life dementia. We now request a renewal of this grant to expand and continue the collaboration. We will add 5 new cohorts reaching 13 cohorts, to study 102,285 participants, 37,803 with brain MRI, and add a new MPI in Suchy-Dicey who will bring her experience working with AD in American Indians. We propose the following aims. Aim 1: To relate various risk factors, systemic illness and MRI markers in midlife (ages 45 to 70) to (a) the risk of late life dementia, and (b) the probability of reaching age 85 (+/- 5) years, alive and dementia free (‘wellderly’). Aim 2: To assess (a) the impact of multimorbidity examining how persons with two or more chronic conditions differ in life-expectancy and dementia risk and (b) to combine various risk and resilience factors, multimorbidity and MRI measures using artificial intelligence and machine learning to create parsimonious models that predict late-onset dementia and wellderly status. Aim 3: To examine the biological pathways underlying the observed associations using pathway analyses and structural equation modeling to explore the mediating role of plasma proteins. The proteins we study will include known biomarkers of amyloid, tau and neurodegeneration (Aβ40 Aβ42, p-tau181/217, NfL, GFAP) in 37,824 individuals, as well as an array of 3000+ plasma proteins in 38,067 persons (new assays on Olink Explore 3072 + available data) so we can identify previously unsuspected biology using Mendelian randomization methods to examine causality. Aim 4: We will investigate any effect modification by sex-, age-, race-, ethnicity-, urban or rural residence, menopause, APOE genotype on findings from Aims 1-3. We hope to uncover putative drug targets to reduce risk of late life dementia.

Up to $578K
2031-01-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Coiled-coil proteins as drivers of protein assemblies, and recruitment pathways for broadening biomedical participation

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NIGMS - National Institute of General Medical Sciences

PROJECT SUMMARY/ABSTRACT Liquid-liquid phase separation (PS) is thought to be the process by which the cell organizes many of its complex structures. While PS is typically associated with intrinsically disordered regions, regions with well-defined structures are also known to contribute, particularly if they can support multivalent transient interactions. Recently, coiled-coil proteins, which can lack elements typically associated with phase separation, have been identified as forming liquid condensates in cells. Examples include structural elements in the centrosome, spindle and Golgi, as well as proteins that help to initiate endocytosis. Motivated by those observations, we recently developed coarse-grained models that demonstrate that the transient interactions between small coiled-coil regions are sufficient to drive phase separation in silico, results which have been supported experimentally by synthetic biology collaborators. Taken together, these observations indicate that coiled-coil regions act as drivers of the intermolecular interactions that organize cells. However, the molecular details of the phase separation of coiled-coil proteins is still unclear. Coiled-coil regions have long confounded structural biology techniques because of their inherent plasticity. We hypothesize that coiled-coil mediated phase separate can arise from exactly those transient interaction that have confounded structural work. We propose phase separation is driven by individual labile coils that interact through their multimeric interfaces, or by interactions between stable and well defined coiled-coil structures and other parts of the protein. We have designed three aims, combining computational (Aim 1), biochemical, and cell biology approaches (Aims 2 and 3) to dissect the molecular mechanisms driving the assembly of condensates by proteins that initiate endocytosis (Aim 2) and organize the Golgi cisternae (Aim 3). Our long term goal is to understand the functional and medical importance of CC domains. In addition, we propose a comprehensive plan to improve the accessibility and quality of the biomedical profes- sional development and research training opportunities for students from historically marginalized populations. We will collaborate with Ft. Lewis College, which serves a significant Native and rural population, and has a relative lack of biomedical research opportunities for students. In addition, strengthening the cultural fluency of CU Boulder researchers will help reduce barriers faced by students coming to a primarily white and well-resourced school. We will (Aim 1) use virtual workshops to bring exposure and access of biomedical research to this community, will (Aim 2) host students for research intensive visits to the Colorado Front Range, and (Aim 3) will work to improve the cultural fluency of CU Boulder researchers to improve the quality of those research experiences.

Up to $537K
2031-02-28
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Collection of Traditional Ecological Knowledge Regarding Polar Bear Habitat Use in Chukotka, Russia

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National Park Service

This funding opportunity announcement is issued to provide public notice of the National Park Service, Alaska Region intent to fund a Cooperative Agreement without competition to the Alaska Nanuuq Commission - ANC. The intended Cooperative Agreement is a continuation of an existing project that was started in 2012. The project end date is May 30, 2014. The purpose is to conduct a habitat-use study for polar bears that builds on previous studies using traditional knowledge and local observers in several villages in Chukotka, Russia. In 2012, the ANC completed a polar bear habitat use study on the Alaska portion of the shared polar bear population. In order to get a more complete picture of the changing nature of these habitats, it is essential to include the Chukotka population. Scientists and Native leaders alike recognize that the most effective management of shared Bering/Chukchi polar bears and their habitat would require active cooperation among the governments and local Native people of the United States and Russia. The ANC will work with indigenous hunters organizations in Chukotka and gather reports on environmental changes in polar bear habitats in Russian. This project will cooperatively develop a report serving to update the report Traditional Knowledge of Chukotka Native Peoples Regarding Polar Bear Habitat Use, which was conducted by ANC and the National Park Service in 2003. Updating information gathered in the `90s. The ANC study in Chukotka will benefit a large number of Chukotka Natives, agencies, organizations, and governmental entities, including the NPS. This project is mutually beneficial and the knowledge exchange is a primary objective of the project. It contributes to the larger body of knowledge on the changing habitat of polar bears on both sides of the Bering Strait, and the long-term implications for this important species. The objectives of this cooperative agreement will be: To continue work and further develop the relationship between the ANC and Native organizations in Chukotka, with the NPS facilitating the exchange of information and the process of writing international agreements. -To gather information about polar bear habitat use through the observations of indigenous people in Chukotka. The NPS will act as a liaison when needed to facilitate exchanges, enhance communication, provide translation services when necessary, assist with organizing trainings and seminars, and provide logistical support. -To assist the Native organizations in their village outreach programs of conservation education and habitat protection of polar bear. -To update the habitat use study in Chukotka through the collection of interviews, data, and TEK in Chukotka villages -To provide a written report that will be shared by the SHBP with a vast network of interested parties through the SBHP website, Facebook page, and other distribution methods including participating communities and respondents. The National Park Service agrees to: 1. Using the network of contacts in Alaska and Russia (especially in Native communities), facilitate dissemination of project results to relevant communities and organizations in Alaska and Russia. Assist with the dissemination of information; working with local park units to post information, advertise presentations, and include in interpretive programs. 2. Use the network of contacts, the program website, and the program Facebook page to share information from the final and interim reports with the participating communities and participants, public, as well as targeted audiences through the development of distribution plan for final project materials and results. 3. Assist the ANC in strengthening their relationship with Native organizations in Chukotka, with the NPS facilitating the exchange of information and the process of writing international agreements. The SBHP has experience in writing successful agreements with Russian organizations, and will provide essential support to the ANC during the negotiation and finalization of an international agreement with a Russian Native organization. 4. The NPS will assist the ANC during their process of gathering information about polar bear habitat use through the observations of indigenous people in Chukotka. The SBHP will act as a liaison when needed to facilitate exchanges, enhance communication, provide translation services when necessary, assist with organizing trainings and seminars, and provide logistical support. 5. Provide technical assistance and expertise to the project including help with travel arrangements, and safety briefings related to project and geographic location. Also will provide translation and interpretation when necessary through our network of translators, as well as bilingual staff members. 6. The NPS will also support the ANC during meetings and conferences, including inter-Commission annual gathering. By attending relevant partner meetings, the NPS will support the mission and the objectives of the project by interacting and networking with other organizations in order to strengthen the liaison role. The NPS SBHP will also support the ANC by presenting information about the project to other interested parties, as well as at the annual gathering of ANC Commissioners. 7. Connect this project with the NPS network of projects aimed at indigenous and subsistence knowledge and share how this effort is structured and the final results, to inform other preservation efforts especially those working internationally. 8. Assign Elizabeth Shea, Program Specialist for the SBHP, NPS, as the Agreements Technical Representative (ATR) for the administration of this Cooperative Agreement; and as Liaison between the NPS and the ANC for the implementation of the program(s) identified within this agreement. The Alaska Nanuuq Commission agrees to: 1. Work directly with Native organizations on the Russian side to successfully accomplish the goals outlined under this project. 2. ANC will work directly with local organizations to coordinate all overall activities for the completion of the entire study within Chukotka. 3. Authors and editors for the Final report will be selected from the local Native organizations in Chukotka by the ANC. 4. ANC will work with chosen local organizations to incorporate the project s data and results in to the greater context of the Beringia Program to show the importance of subsistence aboriginal hunting and TEK in rural and urban communities within Chukotka. 5. The designated organizations in Chukotka will work with experts on the Russian side to provide the final draft of the overall report that includes the data, surveys and interviews conducted by the local surveyors. 6. Survey team will be headed by local Russian organizations that already have contacts with local surveyors, utilizing primarily team members from the original study, wherever possible. Technical Point of Contact: Elizabeth Shea 907-644-3606.

$47K
rolling
Environmentalsustainability

Free to search & build · $99 one-time to unlock the application pack · No subscription

Community Economic Development Projects

upcoming

Administration for Children and Families - OCS

The Office of Community Services (OCS) will award approximately $18.57 million in Community Economic Development (CED) discretionary funds to Community Development Corporations (CDC) to enhance job creation and business development for individuals with low income. Projects should be well-planned, financially viable, and innovative. CED awards will be made as part of a broader strategy to address objectives such as decreasing dependency on federal programs, chronic unemployment, and community deterioration in urban and rural areas. CED projects are expected to actively recruit individuals with low incomes to fill the positions created by CED-funded development activities, to assist those individuals in successfully maintaining employment, and to ensure that the businesses and jobs created remain viable for at least one year after the project period. CED projects can be non-construction or construction projects. In states with current projects, OCS encourages applicants to target rural and underserved areas.Furthermore, OCS encourages potential applicants to explore how proposed projects can be aligned and/or integrated with other OCS-funded programs and priorities to more comprehensively address the needs of rural and urban communities with high rates of poverty, unemployment, and substance-use disorder, as well as communities experiencing persistent poverty, as identified by US Department of Agriculture's Economic Research Service.

$100K – $800K
2026-07-17
social services

Free to search & build · $99 one-time to unlock the application pack · No subscription

Community Economic Development Projects

upcoming

Administration for Children and Families - OCS

<p>The Office of Community Services (OCS) will award approximately $18.57 million in Community Economic Development (CED) discretionary funds to Community Development Corporations (CDC) to enhance job creation and business development for individuals with low income. Projects should be well-planned, financially viable, and innovative. CED awards will be made as part of a broader strategy to address objectives such as decreasing dependency on federal programs, chronic unemployment, and community deterioration in urban and rural areas. CED projects are expected to actively recruit individuals with low incomes to fill the positions created by CED-funded development activities, to assist those individuals in successfully maintaining employment, and to ensure that the businesses and jobs created remain viable for at least one year after the project period. CED projects can be non-construction or construction projects. In states with current projects, OCS encourages applicants to target rural and underserved areas.<br><br>Furthermore, OCS encourages potential applicants to explore how proposed projects can be aligned and/or integrated with other OCS-funded programs and priorities to more comprehensively address the needs of rural and urban communities with high rates of poverty, unemployment, and substance-use disorder, as well as communities experiencing persistent poverty, as identified by US Department of Agriculture's Economic Research Service.</p>

$100K – $800K
2026-07-17
income_security_and_social_services

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Components of emergency department pediatric readiness associated with short-and long-term survival among injured children: a mixed method evaluation

open

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

Proposed Approach: We will use a mixed methods study design to identify the components of emergency department (ED) pediatric readiness most predictive of short- and long-term survival among children. This project will help EDs prioritize implementation of ED readiness to save pediatric lives. We will use existing research infrastructure, data science methods, the ability to follow children to one year, novel analytics, and an interdisciplinary team to address this critical public health need. Importance: Injury and acute illness are the leading causes of death in children. We have recently shown that high ED pediatric readiness in US trauma centers and general hospitals is independently associated with improved survival, but the components of ED readiness driving survival are unknown. It is also unclear whether other organizational factors or ED processes of care improve survival among children. Answers to these questions will guide EDs in prioritizing the implementation of ED readiness, especially in smaller hospitals and rural settings with limited resources and budgets. This project is designed to inform the national trauma center verification criteria, the national field triage guidelines, the National Pediatric Readiness Project, and the Emergency Medical Services for Children program. Objectives: There are three specific aims: Specific Aim 1: We will build two multi-state cohorts of children receiving emergency care and use machine learning to identify the components of ED pediatric readiness predictive of short- and long-term survival. Specific Aim 2. Empirically develop a global measure of ED pediatric readiness and compare it to the weighted Pediatric Readiness Score for predicting short- and long-term survival in children. Specific Aim 3: Use a positive deviance approach to identify ED pediatric readiness factors and processes of care associated with improved survival among children receiving emergency care. Study Design & Setting: We will build two cohorts of children using emergency services from 1/1/2018 to 12/31/2022 in 928 EDs in 11 states (ED cohort) and 678 trauma centers in 50 states (Trauma cohort). We will link state vital statistics death records to the cohorts to track outcomes to one year and assess 152 unique components of ED readiness using machine learning methods. We will also conduct 150 interviews in 30 hospitals across the US using positive deviance methods as a complement to the quantitative analyses. Participants: Injured children 0–17 years using emergency services, including 15.6 million children with ED visits, 606,810 hospitalized children, and 264,865 children admitted to US trauma centers. Outcome measures: We will evaluate in-hospital mortality (primary) and 1-year mortality (secondary) at the patient-level. We will also evaluate the observed versus expected mortality at the ED-level to facilitate the positive deviance analysis.

Up to $273K
2028-04-30
health research

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