Coiled-coil proteins as drivers of protein assemblies, and recruitment pathways for broadening biomedical participation
About This Grant
PROJECT SUMMARY/ABSTRACT Liquid-liquid phase separation (PS) is thought to be the process by which the cell organizes many of its complex structures. While PS is typically associated with intrinsically disordered regions, regions with well-defined structures are also known to contribute, particularly if they can support multivalent transient interactions. Recently, coiled-coil proteins, which can lack elements typically associated with phase separation, have been identified as forming liquid condensates in cells. Examples include structural elements in the centrosome, spindle and Golgi, as well as proteins that help to initiate endocytosis. Motivated by those observations, we recently developed coarse-grained models that demonstrate that the transient interactions between small coiled-coil regions are sufficient to drive phase separation in silico, results which have been supported experimentally by synthetic biology collaborators. Taken together, these observations indicate that coiled-coil regions act as drivers of the intermolecular interactions that organize cells. However, the molecular details of the phase separation of coiled-coil proteins is still unclear. Coiled-coil regions have long confounded structural biology techniques because of their inherent plasticity. We hypothesize that coiled-coil mediated phase separate can arise from exactly those transient interaction that have confounded structural work. We propose phase separation is driven by individual labile coils that interact through their multimeric interfaces, or by interactions between stable and well defined coiled-coil structures and other parts of the protein. We have designed three aims, combining computational (Aim 1), biochemical, and cell biology approaches (Aims 2 and 3) to dissect the molecular mechanisms driving the assembly of condensates by proteins that initiate endocytosis (Aim 2) and organize the Golgi cisternae (Aim 3). Our long term goal is to understand the functional and medical importance of CC domains. In addition, we propose a comprehensive plan to improve the accessibility and quality of the biomedical profes- sional development and research training opportunities for students from historically marginalized populations. We will collaborate with Ft. Lewis College, which serves a significant Native and rural population, and has a relative lack of biomedical research opportunities for students. In addition, strengthening the cultural fluency of CU Boulder researchers will help reduce barriers faced by students coming to a primarily white and well-resourced school. We will (Aim 1) use virtual workshops to bring exposure and access of biomedical research to this community, will (Aim 2) host students for research intensive visits to the Colorado Front Range, and (Aim 3) will work to improve the cultural fluency of CU Boulder researchers to improve the quality of those research experiences.
Grant Summary
Coiled-coil proteins as drivers of protein assemblies, and recruitment pathways for broadening biomedical participation is a NIGMS - National Institute of General Medical Sciences grant providing up to $537K for university, nonprofit, healthcare org. Applications are due 2031-02-28 (open). Check eligibility and apply with FindGrants.
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Up to $537K
2031-02-28
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Coiled-coil proteins as drivers of protein assemblies, and recruitment pathways for broadening biomedical participation: Frequently Asked Questions
Who is eligible for the Coiled-coil proteins as drivers of protein assemblies, and recruitment pathways for broadening biomedical participation?
Coiled-coil proteins as drivers of protein assemblies, and recruitment pathways for broadening biomedical participation is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Coiled-coil proteins as drivers of protein assemblies, and recruitment pathways for broadening biomedical participation provide?
Coiled-coil proteins as drivers of protein assemblies, and recruitment pathways for broadening biomedical participation provides up to $537K per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Coiled-coil proteins as drivers of protein assemblies, and recruitment pathways for broadening biomedical participation deadline?
Applications for Coiled-coil proteins as drivers of protein assemblies, and recruitment pathways for broadening biomedical participation are due 2031-02-28 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Coiled-coil proteins as drivers of protein assemblies, and recruitment pathways for broadening biomedical participation?
To apply for Coiled-coil proteins as drivers of protein assemblies, and recruitment pathways for broadening biomedical participation, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.