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A colourimetric early detectiondevice for premature rupture of membrane (PROM)

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NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

ABSTRACT Premature rupture of membranes (PROM) and preterm PROM (pPROM) affect up to 10% and 4% of pregnancies globally, respectively, leading to significant maternal and fetal health risks if not detected and managed promptly. These risks include maternal chorioamnionitis, neonatal sepsis, umbilical cord prolapse, placental abruption, and preterm labor. Current detection methods, such as the Nitrazine test and immunoassays for biomarkers like PAMG-1 and IGFBP-1, are effective but are often costly, invasive, and depend on the mother's ability to identify abnormal vaginal discharge. Such dependency on patient recognition is problematic, especially in persistent low-volume leakage where symptoms are easily mistaken for normal discharge, delaying diagnosis and treatment. These challenges are further compounded in rural or underserved areas, where limited access to healthcare can delay diagnosis and increase risks. Our research aims to develop a novel colorimetric detection system that functions as a vaginal insert for the early identification of premature rupture of membranes (PROM) and preterm PROM (pPROM). This insert is specifically designed to distinguish amniotic fluid from other vaginal discharges, offering an at-home, minimally invasive solution that integrates into a patient’s daily routine. By utilizing a pH-sensitive polymer, the device reacts to the presence of amniotic fluid by releasing a biocompatible dye, causing a visible color change in vaginal discharge. This allows for early detection, even with small leaks, enabling patients to seek timely medical care without frequent clinical visits. The system leverages the design of pessary devices, which are already widely used by pregnant women for long-term use, ensuring comfort and improving patient compliance. Placing the device close to the uterus maximizes contact with amniotic fluid while minimizing interference from other secretions. The device uses FDA-approved materials to ensure biocompatibility and safety for both mother and fetus. In contrast to costly and time-consuming biomarker assays, this solution provides a simple, cost-effective alternative by utilizing the pH difference between amniotic fluid and vaginal discharge. Ultimately, this system offers a user-friendly, accessible, and highly sensitive method to detect PROM and pPROM, improving maternal and fetal health outcomes, especially in low-resource settings. Aim 1: Optimize the formulation of a pH-responsive polymer with additives to ensure stability in an acidic vaginal environment while maintaining high sensitivity to amniotic fluid. Aim 2: Refine device designs, including geometric configurations and material placement, to enhance detection sensitivity and specificity, minimizing false positives and negatives. Aim 3: Assess the biocompatibility, stability, and effectiveness (i.e., sensitivity and selectivity) of the prototype devices for detecting amniotic fluid leakage using a mouse model

Up to $486K
2028-05-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

A pilot adaptive trial of FITtrack chatbot, nurse navigator, and peer navigator to promote FIT screening among rural residents.

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NCI - National Cancer Institute

Project Summary & Abstract Background: Rural residents experience higher colorectal cancer (CRC) incidence and mortality rates than their urban counterparts. Adherence to CRC screening is essential for early detection, timely treatment, and reduced mortality. The fecal immunochemical test (FIT) is a preferred screening method among rural populations due to its non-invasive nature, affordability, and at-home convenience. Patient navigation plays a crucial role in increasing FIT completion rates but faces structural and logistical challenges. While adaptive, stepped-care patient navigation interventions have been developed to improve scalability and cost-effectiveness, they have not been failed to account for individual sociodemographic factors and evolving patient needs in real time, and have not determined the optimal timing or type of person-led navigation. The primary goal of this study is to optimize a novel adaptive patient navigation model using a two-stage Sequential Multiple Assignment Randomized Trial (SMART) to promote FIT screening among rural residents. In Stage 1, this study will evaluate chatbot-based navigation (FITtrack) versus standard SMS reminders as an initial assistive tool and determine the optimal timing for introducing additional person-led support. In Stage 2, this study will assess the optimal type of person-led support, comparing nurse navigators and peer navigators. Specific Aims: 1) Evaluate the feasibility and acceptability of the digital intervention (4-week SMS reminders, 4-week FITtrack chatbot, and 12- week FIT track chatbot), supplemental person-led navigation (nurse vs. peer), and adaptive interventions (digital intervention plus person-led navigation); 2) Evaluate the preliminary effectiveness of these interventions; 3) Understand step-specific challenges and supports needed in completing FIT. Innovation: This study is highly innovative as it tailors to individual sociodemographic factors and real-time needs through the integration of AI- based chatbot technology, utilizes a novel trial design (i.e., SMART) to inform the development of an adaptive model, and directly addresses the unique challenges faced by rural residents. Significance: Aligned with PA- 25-295, this study accelerates priority initiatives by identifying optimal type and timing of digital and person- assisted navigation approaches to improve CRC screening adherence among rural populations. Ultimately, these findings will support the development of a scalable, adaptive, and cost-effective patient navigation intervention, advancing cancer prevention and early detection efforts in populations with high cancer burden.

Up to $381K
2028-04-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

A Sicangu-driven social network strategy for syphilis prevention

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NIAID - National Institute of Allergy and Infectious Diseases

Abstract This developmental research grant award (R21) requests funds to characterize the social and transmission networks of Rosebud Sioux Tribe (RST) (Sicangu Lakota Oyate) community members to mitigate ongoing and future syphilis epidemics among American Indian/Alaska Native (AI/AN) populations and move towards elimination of congenital syphilis: A Sicangu-driven social network strategy for syphilis prevention (S4). In addition to classic transmission networks, we include social networks that confer influence, social support, diffuse information/innovation and can lead to syphilis prevention interventions that the team has experience implementing. AI/AN individuals in South Dakota (SD) are one of the most syphilis impacted communities and are at increased risk of syphilis transmission, including congenital syphilis. In 2020, 3% of all AI/AN babies born in South Dakota had congenital syphilis. AI/AN individuals are more likely to live in rural areas with limited access to prenatal care and hospital obstetric units, creating barriers to timely identification and treatment of syphilis. Earlier this year, The Great Plains Tribes requested emergency assistance from the federal government to declare a public health emergency and address the syphilis epidemic. Critical to public health is improving syphilis prevention among AI/AN communities and their larger social networks. Network analysis traditionally focuses on transmission dynamics and potential for future epidemics. Contact tracing and other strategies do not, however, fully include the larger social network and data can be limited due to the stigma associated with providing names, as well as mistrust in government and healthcare providers, particularly for AI/AN individuals. Social network analysis that this team has expertise in, can illuminate multiple networks and develop metrics tied not only to disease transmission but to diffusion of information, and among highly marginalized groups such as people who use substances. The PI has a track record of collaborative work implementing participant network recruitment protocols such as the Social Network Strategy to be used in S4. The PI and site-PI are joined by additional experts in AI/AN Health, Indigenous community leaders and local community members engaging in Talking Circles in these contexts. Accordingly, we aim to: Characterize the social networks of RST community members and measure features of their network structure— assortativity, density and bridging – most relevant to syphilis transmission and network intervention; Explore individual (ie. age, education), contextual (ie employment type), network and structural (stigma, health care access) factors associated with syphilis seropositivity. We will collect survey data and biologic samples to model potential factors associated with historic and recent syphilis transmission and; Determine individual and social network level factors associated with syphilis prevention behaviors (ie. condom use, drug treatment, doxyPEP) and network intervention (ie. information sharing, proportion approving of syphilis prevention), which could lead to future network interventions.

Up to $418K
2028-03-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Acute Kidney Injury in Care Transitions: The ACT Pragmatic Trial

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NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases

PROJECT SUMMARY/ABSTRACT Acute kidney injury (AKI) is an abrupt loss of kidney function that affects 1 in 5 hospitalized patients. AKI survivors experience a 1.5-2.5-fold higher risk of chronic kidney disease (CKD), a 1.4-fold higher risk of cardiovascular disease, and 50% of affected individuals are readmitted within 1 year. Despite these grave sequelae, the care of non-dialysis-dependent AKI survivors is inadequate. One-third of patients fail to receive basic kidney health follow-up (i.e., laboratory assessment of kidney function and a visit with a clinician). 87% of AKI survivors use nephrotoxic medications in the 3 years after discharge, which independently increases the risk for CKD. These gaps are especially prominent in the 20% of AKI survivors from rural settings who experience health disparities including transportation barriers, a higher comorbidity burden, decreased health literacy, and reduced access to nephrology specialist care. Addressing these gaps in care facilitates prognostication, decision making, medication reconciliation and supportive care which can limit AKI complications. We therefore developed the AKI in Care Transitions (ACT) program, a multidisciplinary bundled care delivery model tailored to individual prognosis. AKI survivors are risk-stratified according to post-discharge prognosis. Those at the lowest risk are provided access to informational resources about AKI. Patients at moderate risk receive kidney health education before discharge from nurses and coordinated follow-up in primary care with a provider and a pharmacist in the 7-14 days after discharge. The highest-risk patients are provided with home monitoring technology (e.g., blood pressure cuff, tablet for symptom assessments) and followed remotely by nephrology specialists for up to 90 days. Pilot testing in an academic medical center demonstrated feasibility, a significant increase in timely and complete follow-up, improved medication reconciliation, and a decreased incidence of kidney disease progression. This proposal extends ACT to rural settings to address the overall goal of creating effective, patient-centered, scalable care delivery models that improve health outcomes for all AKI survivors. We will test the impact of ACT on health outcomes and processes of care (e.g., kidney disease progression, excess days in acute care, adverse drug events, guideline-concordant care) in rural patients using a pragmatic cluster randomized trial conducted in the Mayo Clinic Health System (MCHS; Aim 1). We will then richly characterize the rural AKI survivor experience including illness burden, treatment burden, and patient capacity (Aim 2a) and assess the impact of ACT (Aim 2b) using qualitative data gathered from rural patients at MCHS and the University of Maryland Medical System. This innovative proposal leverages digital health and the multidisciplinary team to improve outcomes and reduce health disparities for AKI survivors in rural settings.

Up to $796K
2031-01-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Adaptation and Validation of Tablet-based Cognitive Assessments for Diverse Populations in Cameroon

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NIA - National Institute on Aging

Project Abstract Dementia prevalence in Sub-Saharan Africa is projected to increase by over 300% within the next 25 years as the population aged 60 years and older triples to more than 235 million. Beyond the demographic transition and population growth, a major driver of these increases is the growing burden of communicable and non- communicable diseases, which contributes to disability and adverse brain health outcomes. Currently, there are limited data on Alzheimer's Disease and related dementias to inform healthcare and research policies within resource-strained health systems in SSA. This gap is especially evident in French-speaking African countries (30-40% of SSA), which are critically underrepresented in ADRD research. Indeed, our recent review highlights the cultural, ethnic, linguistic, and socioeconomical challenges to dementia research in this setting. In Cameroon, ADRD mortality has increased by over 130% in 20 years and ADRD represents 12.4% of outpatient neurology consultations. Our prior work highlights the urgent need to develop and validate scalable and accessible assessment tools for ADRD to establish a robust infrastructure to support dementia diagnosis, care, and research nationwide. The growing field of digital cognitive tools offers an innovative opportunity for developing easily accessible and highly accurate neuropsychological tools for cost- and time-efficient case identification. Standardized administration, automated scoring/interpretation, and cross platform integration features can address several challenges and support the development of dementia registries – a valuable resource for dementia research and care. The main objectives of this proposal are to culturally adapt and validate a brief multi-domain digital cognitive assessment tool in Cameroon and to develop and pilot the infrastructure needed for improved dementia care and research. Specifically, we plan to culturally adapt TabCAT-BHA digital cognitive assessment in Cameroon, evaluate demographic effects on performance and generate regression-based norms in a community representative sample of healthy adults in rural and urban areas (Aim 1). Concurrently, we will examine TabCAT-BHA’s diagnostic accuracy to detect mild cognitive impairment (MCI) and dementia in the existing BRAIN Cohort and examine its neuroanatomical validity to domain specific regional patterns of brain atrophy on MRI (Aim 2). Finally, as an exploratory aim, we will determine implementation barriers to cognitive testing and dementia diagnosis in a clinical setting in Cameroon to develop the infrastructure needed for improved dementia care and research (Aim 3). These proposed studies will begin to fill the data gap on dementia research in French-Speaking Sub-Saharan Africa (FS-SSA) and provide the first ever neuroimaging data in people living with dementia in Cameroon and set the stage for more comprehensive dementia studies in FS-SSA. For future research following this proposal, we anticipate that valid digital neuropsychological tools coupled with blood biomarkers that still need validation in this setting, could be a scalable and sustainable path for ADRD research, diagnosis and care (R01 proposal)

Up to $216K
2028-01-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Adapting a telehealth intervention for suicide prevention among patients with Alcohol Use Disorder in Tanzania

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NIMH - National Institute of Mental Health

Globally, alcohol use disorders (AUD) cause 3.3 million deaths each year and account for nearly 100 million disability-adjusted life years (DALYs). Alcohol use is also one of the most prominent risk factors for death by suicide, as people with AUD have a lifetime risk of suicide more than 7 times higher than the general population. Efforts to prevent suicide can reduce disruptions and fragility of the U.S. health system and serve as a public health good to benefit Americans. We are developing innovative approaches to bridge mental health and substance use treatment gaps, including telehealth and nurse-led counseling interventions with clear potential to reduce suicide in the United States and other settings. In our preliminary study, 7% of patients with AUD were experiencing suicidal thoughts or behavior. Despite this high comorbidity, routine screening and treatment for both suicide risk and alcohol use disorder are extremely rare in emergency care settings. Thus, there is a critical need for innovative, resource-efficient treatments for suicide prevention among people with AUD. In an earlier NIMH-funded study, our team adapted an evidence-based Motivational Interviewing intervention, MI-SafeCope, to develop IDEAS for Hope, a telehealth intervention for suicide prevention in HIV care. In the current grant, we will revisit this process by adapting MI-SafeCope to reduce suicide risk among people with AUD who are presenting for care in a Tanzanian Emergency Department. The resulting intervention, IDEAS-AUD, will address suicide risk with a four-pillared approach: reducing alcohol-related harm, building social support, enhancing emotional health, and meeting basic needs. The pillars are integrated with Motivational Interviewing-enhanced safety planning and referral for psychiatric care as appropriate. Intervention refinement in a low-cost, high-burden global setting has great potential for adaptation and implementation in the rural U.S., where mental health needs are high. The aims of this grant are to: 1) adapt IDEAS-AUD for the AUD population; 2) rigorously evaluate the acceptability and feasibility of IDEAS-AUD; and 3) develop our intervention package for a future implementation evaluation and a clinical trial in the rural U.S. In Aim 1 of the current study, we will identify drivers of suicide risk and desired intervention characteristics to prevent suicide in the AUD population. In Aim 2, we will adapt an evidence-based suicide prevention intervention to existing AUD care, guided by a community coalition. In Aim 3, we will pilot test the telehealth intervention to assess its feasibility and acceptability for reducing suicide risk in the AUD population. By the end of this proposed project, we will have a framework-guided, resource-adapted, piloted protocol for IDEAS-AUD, including screening tools, programmatic, and implementation components. The research is innovative, yet fundamentally essential, and supports NIH Strategic Objectives to prevent suicide across the lifespan, address mental health comorbidities such as AUD, and develop interventions that can be rapidly implemented to strengthen mental health outcomes in the U.S. and improve the health of Americans.

Up to $62K
2029-06-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Adapting and testing an evidence based digitally delivered healthy relationship and violence prevention intervention with Native American adolescents

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NINR - National Institute of Nursing Research

Dating violence (DV) is common among U.S. high school age adolescents and has significant and lifelong negative health consequences, including suicide behaviors. Native American (NA) adolescents are at increased risk for violence victimization and/or perpetration in their dating violence, given their high rates of violence exposure in their homes and communities. Key challenges for dating violence prevention are the lack of services, fear of stigma and discrimination, and limited trust in and access to skilled professionals. The Fort Peck Reservation is home to the Assiniboine and Sioux Tribes in rural Montana. The reservation community reports high rates of violence and suicide behavior with underfunded and limited health and social service, especially for adolescents. The wide range of negative health and social outcomes associated with violence experienced by reservation-based NA adolescents underscores the call for innovative and targeted behavioral health interventions using appropriate technology. myPlan Teen, is an evidence-based healthy relationship and dating violence prevention intervention for adolescents and is delivered through a secure and confidential web based and mobile app. myPlan Teen provides adolescents with immediate access to information about healthy and unhealthy behaviors, safety strategies tailored to their situation with links to youth friendly resources, to reduce confusion, feelings of isolation and stigma associated with unhealthy relationships. In our CDC funded randomized control trial (RCT) with a national sample of 609 adolescents aged 15-17, we found adolescents randomized to myPlan Teen had a significant increase in use and helpfulness of safety behaviors compared to control group (adolescent health website). Further adolescents who used myPlan Teen reported a significant reduction in physical/sexual violence perpetration and suicide behaviors compared to control group. To advance the relevance and use of myPlan Teen with NA adolescents, our interdisciplinary team in partnership with Tribal Health leaders and Youth Advisory Board (YAB) will adapt myPlan Teen by integrating culturally relevant content, including tribal identity and communal mastery for NA adolescents to build healthy relationships, develop safety skills and access culturally relevant resources. Following the adaptation process, the team will evaluate the effectiveness of the culturally adapted myPlan Teen app on health and safety outcomes with 550 NA adolescents. In addition, we will examine the mechanisms by which myPlan Teen improves health and safety outcomes. The study will advance violence prevention interventions with NA adolescents and inform future processes to adapt and disseminate a digital intervention with adolescents nationally.

Up to $2.0M
2029-02-28
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Algorithm-Enabled Engagement of Patients with Advanced Cancer (A-EPAC) to improve goals of care communication among Veterans with Advanced Stages of Cancer

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NIH

Background: Early goals of care (GoC) communication regarding prognosis, values, and care preferences improves patient mood and reduces the likelihood of intensive, unwanted care at the end-of-life for Veterans with cancer. In 2017, the VA National Center for Ethics in Health Care (NCEHC) launched the Life-Sustaining Treatment Decisions Initiative (LSTDI), a national program to promote GoC communication between clinicians and their patients. Despite LSTDI, 60% of Veterans with cancer still have no GoC communication or an LST documented note before death. Major barriers include reliance on oncology clinicians to identify appropriate Veterans and initiate these conversations in clinic. In response, we developed the Engagement of Patients with Advanced Cancer (EPAC) intervention – a 6-month telephone-based intervention in which trained lay health workers (LHWs) educate and empower Veterans with cancer to engage in GoC with their oncology clinical teams. To facilitate scale, we propose Algorithm-Enabled EPAC (A-EPAC), which uses the VA Care Assessment Needs (CAN) score to automatically identify patients with cancer who could benefit from EPAC. Significance: Connecting Veterans to the soonest/best care and promoting a culture of safety, learning, and knowledge translation are central to VA priorities. This proposals’ objective for early and equitable GoC communication is strongly aligned with VA’s strategic plan (Goal 2.1) and VHA Directive 1004.03, Advance Care Planning. The research addresses HSR priority topic areas of health care system organization and delivery through access, virtual care, and rural health (remote delivery); behavioral, social, and cultural determinants of health (tailored interventions to address equity); and, strategic methodology areas, including data science (algorithm-based eligibility) and implementation science (type 1 hybrid trial design). Innovation and Impact: Integrating high-tech automated algorithms with high-touch LHW interventions can overcome persistent barriers to GoC communication. Innovative methodologic aspects of this proposal, include: (1) recruitment of oncology sites, including the National Teleoncology Program (NTO), that serve racial and ethnic minorities, women, and Veterans in rural settings; (2) longitudinal assessment of patient mood and care preferences; and (3) decentralized clinical trial with remote recruitment and intervention activities. Specific Aims: 1) Determine whether A-EPAC improves LST documentation within 12 weeks more than usual care alone; 2) Determine whether A-EPAC reduces patient anxiety and depression more than usual care from baseline to 12 weeks; 3) Identify Veteran, clinician, and organizational factors associated with feasibility, adoption, acceptability, and A-EPAC fidelity using the Consolidated Framework for Implementation Research. Methodology: Our intent-to-treat randomized trial is conducted in collaboration with the NTO and the National VA Oncology Program (NOP). We will randomize 200 Veterans with cancer receiving care across 7 VA facilities that serve primarily Black, Latino or Hispanic, and/or rural-dwelling Veterans to either the A-EPAC intervention (algorithm-based identification and referral to EPAC for 6-months) or usual cancer care alone (cancer care provided by oncology teams at the local site). Participants will be followed for 12-months post-enrollment. Our primary outcome is LST documentation within 12 weeks post-enrollment. Secondary outcomes are patient anxiety and depression at 12 weeks measured by PROMIS® short forms. Exploratory outcomes include intensive end-of-life care, advance directive documentation, and acute care use. Using a quant-qual framework, we will conduct validated surveys with 60 Veterans with cancer and Veteran and clinician interviews at 6 months to identify factors associated with feasibility, adoption, acceptability, and A-EPAC fidelity. Next Steps/Implementation: Our collaboration with operational partners including the NTO, NOP, NCEHC, the Veterans Experience Center, and the VA Proactive Patient Centered Care Program founded and directed by MPI Patel, will support widespread dissemination across VA oncology settings.

2031-06-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Annual Program Statement for Public Diplomacy Programs (Public Diplomacy Grants Program)

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U.S. Mission to Tajikistan

Purpose of Public Diplomacy Grants: PDS Embassy Dushanbe invites proposals for programs that strengthen ties between the United States and Tajikistan in priority program areas (see below) in order to highlight shared values and promote bilateral cooperation. All proposed programs must include an American element, either through a connection with American expert/s, organization/s, or institutions/s, usage of American educational/informational resources, or any other activities that promote or contribute to increased mutual understanding between the people of the United States and people of Tajikistan. Competitive proposals will promote continued and sustainable cooperation between the people of the United States and Tajikistan even after the project concludes. Competitive proposals will include partnership with Tajik governmental bodies, and to organizations that have a demonstrated track record of implementing such programs. Examples of programs could include, but are not limited to: Academic or professional exchanges, lectures, seminars, trainings, speaker programs, or workshops; and Artistic, cultural, or sports workshops, masterclasses, joint performances, and/or exhibitions. PDS welcomes proposals that support one of the following priority program areas: TOPIC 1: Counter Gender-based Violence (GBV) Domestic violence (DV) and gender-based violence (GBV) remains a serious issue in Tajikistan and much of the world. In a USAID-funded survey in Tajikistan, 97% of men and 60% of women believed spousal abuse was justified. Cases of GBV and DV are underreported because victims wish to avoid humiliation, reprisal, or social stigmatization, or believe it may have been warranted. Further, authorities wishing to promote traditional gender roles frequently dismiss domestic violence as a family matter or only gave a warning or fine. Government resources for survivors are also limited. Project Audience(s) may include: Religiously or socially conservative communities, especially Tajik men (18-50 years old) High school students (14-18 years old.) Youth and emerging leaders (18-35 years old.) University teachers and students. Labor migrants and spouses of labor migrants. Tajik advocacy groups. Government bodies. Independent media including bloggers and vloggers Countering Gender-Based Violence Project Goal: Empower civil society and communities in Tajikistan to prevent and prosecute cases of Domestic Violence (DV) or Gender-Based Violence (GBV) through community-led initiatives. Project Objectives (may address one or more of the following): Messaging campaigns or awareness raising activities, such as sports diplomacy, should engage and target both men and women. Having men as the face of campaigns, or having men speak to men standing against GBV, demonstrates solidarity and emphasizes that eradicating gender-based violence is the collective responsibility of everyone, regardless of gender. Improve collaboration between civil society, independent media, and the government to identify and address gaps in existing laws and policies that criminalize GBV/DV, provide protections for victims, and establish legal frameworks for persecution. Raise awareness among vulnerable populations about laws, rights, and support services concerning early marriage, domestic abuse, harassment, divorce, alimony, and other civil rights. TOPIC 2: Promoting Women s Economic Empowerment and Entrepreneurship Due to the high rate of male labor migration and unemployment, more Tajik women are exploring ways to financially support their households and communities. However, women entrepreneurs' activities are highly dependent on the effectiveness of the business environment in the country. Moreover, the mountainous regions throughout the country challenge the development of entrepreneurship, as does lack of information, limited access to financing for starting a business, and other socio-economic conditions. Nevertheless, successful small business development creates new employment opportunities in Tajikistan and helps women support themselves and their families. Small businesses are fast becoming the main source of income for women in Tajikistan. Proposed projects should enhance women s participation, promotion, and longevity in the Tajik economy and ability to assume leadership positions. Projects should clearly support the protection of economic rights for women and increase respect for women s rights in society to improve their independence and proactive role in Tajik society. Project Audience(s) may include: Women from rural areas (including the spouses of labor migrants) and women entrepreneurs. Small businesses in rural areas. Business associations. Financial and government institutions. Tourism agencies (including guesthouse and small hotels). Community leaders and youth demonstrating leadership potential in these areas. Women s Economic Empowerment Project Goal: Increase the capacity of women from underserved, rural communities, including the spouses of labor migrants, to participate or increase their participation in the Tajik economy. Improve women's economic opportunities in Tajikistan by increasing the capacity of women to start, establish, or expand their own companies. Project Objectives (may address one or more of the following): Develop the business and technical skills of women in rural communities to increase employability, launch and/or improve their own businesses. Establish and conduct activities with a professional network for women from under-represented communities, including the spouses of labor migrants, to support mentorship relationships and collaborative initiatives among network members that go beyond the conclusion of project activities. o Projects could connect women s entrepreneurship in the development of tourism around newly recognized UNESCO heritage sites. o Increase awareness of tourism initiatives and employment opportunities centered around newly designated UNESCO heritage sites. o Projects could seek to increase participation of women from underserved and target communities in the fields of Science, Technology, Engineering, and Mathematics (STEM). Increase women s knowledge and understanding about their legal rights in society and how to advocate for the respect of those rights. o Increase women s knowledge and understanding about their legal rights in the workplace, including rights related to employment, equal pay, job security, and access to economic opportunities. o Equip Tajik women with the ability to advocate for the recognition and enforcement of these rights. Promote women s economic empowerment and entrepreneurship through support from start-up hubs, corporate social responsibility, and/or access to finance. Emphasis should be placed on strengthening chambers of commerce, entrepreneurs, and core private sector industries through interactions or linkages with U.S. counterparts. o Facilitate access to funding resources and financing opportunities for women entrepreneurs to launch and grow their businesses. o Strengthen organizational capacities of chambers of commerce to support business development of aspiring female entrepreneurs. o Facilitate interactions and linkages between women entrepreneurs, chambers of commerce, startup hubs, and private sector industries in Tajikistan and their U.S. counterparts. TOPIC 3: Sharing America with Tajikistan The United States values innovation, creativity, critical thinking, freedom of expression, democratic principles, economic growth, and security. The United States supports a sovereign and independent Tajikistan, which includes support for a well-informed, discerning public who can inoculate itself against disinformation. Both the United States and Tajikistan have rich cultural traditions as shown in literature and storytelling, theater and performing arts, film, music, dance, sport, and education. Educational, cultural, and other exchange activities are a great way to engage the public, especially at-risk youth and those with neutral views or misconceptions about the United States, in order to bridge our cultures, deepen understanding, and discuss topics of mutual importance. Proposed projects should strengthen understanding between the United States and Tajikistan and advance areas of mutual interest by leveraging the experiences and lessons learned from the United States, while respecting cultural differences. Project Audience(s) may include: Tajik audiences who have not had exposure to the United States before. Youth 16-35. Academia, professors, and teachers. Civil society, non-government organizations, and associations/organizations promoting shared values or areas of mutual interest. Information professionals (media outlets, managers, editors, journalists, influencers). Religious and community leaders. Entrepreneurs and business community advocacy organizations. National and subnational government officials. Project Goal: To share American values, such as freedom of expression, respect for human rights, and celebrate/promote respect for diversity and social inclusion, while also improving access to objective information and increase media literacy and critical thinking skills to analyze mis and disinformation aimed at the United States. Project Objectives (may address one or more of the following): Raise awareness about shared U.S.-Tajik values and partnerships through trainings, workshops, masterclasses, joint performances, or other projects by U.S. and/or Tajik experts. Increase access to American content by Tajik audiences (such as book translations) that promote U.S. democratic and rights-based values. Increase collaboration between local, state, and civil society actors/stakeholders on well-defined social issues affecting both the United States and Tajikistan by sharing U.S. models of government-community engagement, or by working with U.S. experts/peers. Increase the effectiveness of individuals, organizations, and coalitions working to advance and/or advocate for respect and the promotion of human rights. Strengthen the ability of Tajik media professionals to develop accurate and fact-based informational media campaigns through digital skills building and training initiatives based on U.S.-best practices. Increase production and publication of objective, fact-based and editorially diverse media content by Tajik media professionals. Increase critical thinking skills, especially for youth and publics with a neutral or view or misconceptions about the United States, to identify and critically analyze sources of misinformation and disinformation. In addition to the specific requirements listed above by program area, all proposals must: 1. Clearly indicate the primary activity area to which it is being submitted for consideration. 2. Focus on the key public diplomacy audiences and activities specified in the areas, provide programs for underserved geographic regions of Tajikistan, as well as non-elite schools (if applicable); 3. Clearly delineate how elements of their program will have a multiplier effect and be sustainable beyond the life of the grant; 4. Provide a traditional and/or social media plan for marketing program activities and outcome, if applicable 5. Identify the cities/districts in which activities will take place. 6. Identify specific outcomes to be achieved by the end of the grant period. 7. Identify any tools (surveys, beneficiary interviews, focus groups, etc.) that will be developed for Monitoring and Evaluation purposes. Applicants must also demonstrate competency to manage all financial aspects of the project, including participant costs and transparent arrangements of sub-grant relationships with partner organizations, if applicable.

$5K – $45K
rolling
other

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