Search Grants — Free, No Account Required

The Eli's Park Project

Initiated and designed by the community it will serve, the Eli's Park Project at the Burke Gilman Playground Park, located at 5201 Sand Point Way NE, will renovate an underutilized green space into a park that is fully accessible to people of all ages, abilities and identities. This phase of funding will complete the art elements partially funded in the previous cycle and includes the fabrication and installation of 5 permanent art features. All contractors qualified through community hiring panels and public art calls. This project will be completed by December 30, 2022.

The Eli's Park Project

Led by Site Workshop and our design team, The Eli's Park Project will continue our partnership with Seattle Parks and Recreation in design development for the Burke-Gilman Playground Park located at 5201 Sandpoint Way NE. This phase will result in design documents including civil engineering reports and integrated art elements. This phase is estimated to be completed by February 2020.

Think Big, Wedgwood

The Think Big, Wedgewood community group, purpose for the project is to create a sense of unity in their neighborhood through art that communicates that Wedgwood welcomes all. Think Big Wedgewood will have a public design process and fabricate and hang light pole banners that will be non-commercial in nature & beautify the neighborhood. There will be roughly 25 banners along the 35th Ave business district between 75th & 95th in Wedgwood. The banners will be installed by SuperGraphics with the guidance of the Seattle Dept of Transportation Directors Pole Banner Permitting Guidelines, or the appropriate recommended contractor.

Calgary Foundation

Calgary Foundation provides grants for community well-being in the Calgary area including arts, education, environment, health, and social services.

California Arts Council

California Arts Council provides grants to support arts and cultural programming, artist fellowships, arts education, and community-based arts projects across CA.

California Arts Council

Artists in Schools (AiS) provides direct arts education experiences by placing professional artists in K-12 schools and community settings throughout California.

California Arts Council

The Organizational Support Program (OSP) provides multi-year general operating support to California arts organizations, strengthening their capacity to deliver arts and cultural programs statewide.

California Community Foundation

California Community Foundation provides grants to Los Angeles County nonprofits in areas including housing and homelessness, civic engagement, immigrant integration, and arts and culture.

Cambridge Hip-Hop Collective

Cambridge MA Arts Grants Grant #352

NIAID - National Institute of Allergy and Infectious Diseases

Project summary/abstract Despite effective antiretroviral therapy (ART), people with HIV (PWH) continue to have chronic inflammation and comorbidities driven by low-level viral transcription from integrated HIV proviruses. Silencing this residual HIV activity could reduce immune activation and improve long-term health. Our long-term goal is to develop therapies that suppress HIV expression and inflammation in PWH on ART. Topotecan (TPT), a Camptothecin analog that inhibits Topoisomerase I, potently suppresses HIV transcription in latently infected T cells. Notably, TPT appears to inhibit HIV independent of its Topoisomerase I activity, suggesting an alternative mechanism of action. We will evaluate new Camptothecin analogs as HIV “block- and-lock” agents. Our central hypothesis is that these compounds can stably suppress HIV without harming host cells. We will pursue three aims: 1) Determine the mechanisms by which TPT inhibits HIV gene expression; 2) Identify new Camptothecin analogs with HIV inhibitory function; 3) Determine the longevity of Camptothecin analog-induced HIV suppression and validate their function using samples from PWH ex vivo. First, we will define how TPT blocks HIV by mapping epigenetic changes at the viral promoter (via CUT&RUN), testing Tat dependence, and assessing post-transcriptional effects like RNA stability and nuclear export (Aim 1). Second, we will screen Camptothecin analogs—with and without Topoisomerase I activity—to identify compounds that suppress HIV at low doses without cytotoxicity. Lead candidates will be validated in primary cells, and their mechanisms and off-target effects will be characterized (Aim 2). Third, we will test whether these compounds can durably silence HIV in latency models and in cells from PWH ex vivo (Aim 3). Completion of these studies will clarify how Camptothecin analogs suppress HIV and assess their therapeutic potential. We expect this work will enable the development of novel “block-and-lock” drugs that reduce persistent inflammation and improve health outcomes in PWH on ART.

Canada Council for the Arts

Engage and Sustain supports arts organizations to strengthen their artistic practice, organizational resilience, and engagement with communities.

Canada Council for the Arts

The Canada Council invests $300M annually in arts. Explore and Create supports artistic practice and the creation, production, and dissemination of art across all disciplines.

Canadian Heritage

Canadian Heritage supports heritage conservation, cultural development, and promotion of arts and culture. Includes programs for museums, festivals, and cultural events.

National Institutes of Health

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NCI R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this Notice of Funding Opportunity (NOFO) will support creative educational activities with a primary focus on Courses for Skills Development. Applications are encouraged that propose innovative, state-of-the-art programs that address the cause, diagnosis, prevention, or treatment of cancer, rehabilitation from cancer, or the continuing care of cancer patients and the families of cancer patients.

National Institutes of Health

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NCI R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this Notice of Funding Opportunity (NOFO) will support creative educational activities with a primary focus on Curriculum or Methods Development. Applications are encouraged that propose innovative, state-of-the-art programs that address the cause, diagnosis, prevention, or treatment of cancer, rehabilitation from cancer, or the continuing care of cancer patients and the families of cancer patients.

National Institutes of Health

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NCI R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this Notice of Funding Opportunity (NOFO) will support creative educational activities with a primary focus on Curriculum or Methods Development. Applications are encouraged that propose innovative, state-of-the-art programs that address the cause, diagnosis, prevention, or treatment of cancer, rehabilitation from cancer, or the continuing care of cancer patients and the families of cancer patients.

National Institutes of Health

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NCI R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this Notice of Funding Opportunity (NOFO) will support creative educational activities with a primary focus on Research Experiences. Applications are encouraged that propose innovative, state-of-the-art programs that address the cause, diagnosis, prevention, or treatment of cancer, rehabilitation from cancer, or the continuing care of cancer patients and the families of cancer patients.

NCI - National Cancer Institute

PROJECT SUMMARY Multiple myeloma (MM) remains an incurable malignancy in most patients, who will eventually relapse and become refractory to existing therapies. There is thus a critical need for therapeutic innovations that maintain remission and preserve patient quality of life. The tumor microenvironment (TME) of MM is within hypoxic bone marrow, which is intriguing because membrane biogenesis for proliferation is limited by available cholesterol. The synthesis of cholesterol is energy- and oxygen-intensive, and limited supply leads to resource competition between constantly dividing tumor and hematopoietic cells. This nutrient tug-of-war between tumor and nontumor cells in the MM-TME is evidenced by high rates of anemia and infection in MM patients. Separately, altered immune cell behavior results in immunosuppression, which is common in advanced and relapsing MM, and therapeutically underserved. Epidemiolocal studies indicate that low levels of plasma cholesterol are linked with MM progression, likely reflecting the high demand for sterols in the TME. All cells can rapidly increase cellular sterol levels and stimulate membrane biosynthesis through uptake of cholesterol-rich low-density lipoprotein (LDL). Most recently, it has been published that LDL also transport small RNAs that promote macrophage polarization by activating an endosomal sensor of RNA, toll-like receptor 8 (TLR8). Researchers demonstrated that pharmacologic antagonism of TLR8 shifted the immune landscape within atherosclerotic plaques and reduced disease burden in hyperlipidemic mice. Taken together, LDL is a nutrient-dense particle capable of supporting cell proliferation, and a source of extracellular sRNA capable of modulating immune cell function. The goal of this Stephen I. Katz Early-Stage Investigator Grant is to 1) determine whether LDL’s canonical functions in lipid transport directly enable MM growth, progression and therapeutic resistance, and 2) investigate whether LDL’s transport of small RNAs indirectly enables MM progression through activation of TLR8 in host leukocytes to create an immunosuppressive TME. In agreement with the funding mechanism, this proposal represents an ambitious new direction for our laboratory supported by rigorous work in the literature and an ensemble of experienced collaborators and clinicians that reflect the tremendous environment for translational MM research at our institution. We will harness this translational power by using innovative approaches to humanize lipoprotein metabolism in proven pre-clinical models of MM, and by combining state-of-the-art bioinformatic, imaging, and single-cell immune profiling approaches, to test the therapeutic synergy of safe, effective, and FDA-approved, LDL-lowering drugs with standard-of-care chemotherapy. Mice are used in this study because it is not possible to fully recapitulate the complex patho-physiological state of myeloma disease, which involves multiple cells, tissues and organs, using cultured cell models. The validity of mice as an animal model for studying the pathophysiology and treatment of myeloma disease has been supported by extensive literature showing that cellular and molecular features of myeloma disease in mice are similar to those in humans. Upon completion, this award will fill a critical gap in knowledge of how LDL contributes to a pro-malignant TME, and more specifically how lipoprotein disequilibrium contributes to immunosuppression in MM. We envision that these data will be leveraged to open many new research opportunities for diagnostic and therapeutic approaches for MM, and perhaps, other malignancies.

Cape Cod Foundation

Cape Cod Foundation ($75M in assets) supports nonprofits in MA through grants focused on education, environment, health, arts. Awards range from $1,000 to $25,000.

Capital Region Community Foundation (Lansing)

Capital Region Community Foundation (Lansing) ($100M in assets) supports nonprofits in MI through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

Capoeira Life

The South Seattle Capoeira Academy, located at 2909 Rainier Ave S #103 will be rebuilt after sustaining damage due to a flood. The project will allow the rebuilding of their homebase into an even greater serving cultural art center that will improve safety, have a greater capacity for events and provide health and wellness to the community, and increase the impact to public benefit. The project is free and open to public participation. The project will be completed in summer of 2026.

NHLBI - National Heart Lung and Blood Institute

Project Summary Angina is one of the most common symptoms prompting coronary angiography, yet up to 50% of patients are found to have no significant obstructive coronary artery disease (CAD). Many of these individuals continue to experience chest pain without a clear diagnosis. In a substantial proportion of cases, symptoms are attributable to coronary microvascular dysfunction (MVD), an increasingly recognized contributor to myocardial ischemia, heart failure with preserved ejection fraction (HFpEF), obesity, and diabetes. Despite its high prevalence, MVD remains underdiagnosed and challenging to monitor noninvasively. Invasive coronary function testing (CFT) is the gold standard but is technically complex, carries procedural risk, and is limited to specialized centers. While positron emission tomography (PET) enables non-invasive quantification of myocardial blood flow (MBF) and myocardial perfusion reserve (MPR), its utility is constrained by cost, limited availability, radiation exposure, and moderate spatial resolution. Cardiac magnetic resonance (CMR) offers a promising, widely accessible alternative. Recent advances in quantitative perfusion mapping, Artificial Intelligence-driven image enhancement, and multiparametric tissue characterization have transformed stress CMR into a powerful tool for assessing perfusion and myocardial health with high spatial resolution. These capabilities position CMR to play a central role in the diagnosis and monitoring of MVD. This proposal leverages state-of-the-art CMR technology, cross-modality validation, invasive testing, and mechanistic phenotyping to: • Define and validate CMR-based diagnostic criteria for MVD using invasive CFT as the reference standard. • Evaluate the correlation and comparative diagnostic accuracy of CMR- versus PET-derived MBF and MPR for detecting MVD. • Assess whether GLP-1 receptor agonist (GLP-1RA) therapy improves coronary microvascular function independent of weight loss, using bariatric surgery as a comparator and serial quantitative CMR for longitudinal assessment. This work addresses a critical unmet need for non-invasive diagnostic tools and treatment monitoring in MVD, with the potential to expand precision cardiovascular care for an overlooked yet high-risk population.

Cartier Foundation

Funds contemporary art, environmental programs, and cultural projects globally.

NCI - National Cancer Institute

PROJECT SUMMARY CD8 T cells are powerful adaptive immune cells that have the ability to eradicate cancer cells. However, despite the presence of tumor-specific CD8 T cells (CD8 TST) tumors progress, suggesting that CD8 T cells become dysfunctional. While direct cytotoxic activity against cancer cells generally resides within the CD8 T cell compartment, CD4 T cells play important roles in priming and activation of naïve CD8 T cells in lymphoid tissues and enhancing CD8 T cell mobilization into peripheral tissues, including tumors. We recently investigated if and how tumor-specific CD4 T cells (CD4 TST) could be enlisted to overcome CD8 TST dysfunction/exhaustion in tumors (Espinosa et al., (2024)). Employing preclinical cancer models as well as human samples, we discovered that CD4 TST are critical during the effector phase within tumors: CD4 TST must co-engage with CD8 TST on the same dendritic cell (DC), forming a three-cell-cluster (triad) to license CD8 TST cytotoxicity and tumor destruction. Triad formation reprograms CD8 TST, preventing and even reversing CD8 TST dysfunction/exhaustion, ultimately leading to the elimination of large established tumors and long-term protection from recurrence. We showed that when triad formation is prevented in settings of immunotherapies, tumors progress even when equal numbers of CD8 and CD4 TST are present within tumors. Strikingly, we found that the presence of triads in tumors of patients treated with immune checkpoint blockade was associated with clinical responses. Thus, the unique spatial positioning and cell-cell interactions of CD4 T cells, CD8 T cells, and DC are critical for anti-tumor responses. These intriguing findings have now led us to ask how CD4 TST in immune cell triads license CD8 TST to kill cancer cells. Which transcription factors (TF) and polarization state(s) are required for CD4 TST effector function within triads? Which receptor/ligand and/or cytokine/chemokine signals mediate CD8 TST cytotoxicity? Which signals do DC provide to CD4 TST and/or CD8 TST? Are specialized DC subsets, phenotypes, or maturation states needed? In this application, we will leverage the power of preclinical cancer models and unique human samples, employ state-of-the-art technologies, and design and test innovative strategies to identify the critical molecular factors and signals within triads and test how they can be enforced for the treatment of cancer. This work will provide mechanistic insights into the immune cell interactions critical for tumor control and inform strategies to enhance immunotherapy responses.