Cardiac MRI Phenotyping of Coronary Microvascular Dysfunction
About This Grant
Project Summary Angina is one of the most common symptoms prompting coronary angiography, yet up to 50% of patients are found to have no significant obstructive coronary artery disease (CAD). Many of these individuals continue to experience chest pain without a clear diagnosis. In a substantial proportion of cases, symptoms are attributable to coronary microvascular dysfunction (MVD), an increasingly recognized contributor to myocardial ischemia, heart failure with preserved ejection fraction (HFpEF), obesity, and diabetes. Despite its high prevalence, MVD remains underdiagnosed and challenging to monitor noninvasively. Invasive coronary function testing (CFT) is the gold standard but is technically complex, carries procedural risk, and is limited to specialized centers. While positron emission tomography (PET) enables non-invasive quantification of myocardial blood flow (MBF) and myocardial perfusion reserve (MPR), its utility is constrained by cost, limited availability, radiation exposure, and moderate spatial resolution. Cardiac magnetic resonance (CMR) offers a promising, widely accessible alternative. Recent advances in quantitative perfusion mapping, Artificial Intelligence-driven image enhancement, and multiparametric tissue characterization have transformed stress CMR into a powerful tool for assessing perfusion and myocardial health with high spatial resolution. These capabilities position CMR to play a central role in the diagnosis and monitoring of MVD. This proposal leverages state-of-the-art CMR technology, cross-modality validation, invasive testing, and mechanistic phenotyping to: • Define and validate CMR-based diagnostic criteria for MVD using invasive CFT as the reference standard. • Evaluate the correlation and comparative diagnostic accuracy of CMR- versus PET-derived MBF and MPR for detecting MVD. • Assess whether GLP-1 receptor agonist (GLP-1RA) therapy improves coronary microvascular function independent of weight loss, using bariatric surgery as a comparator and serial quantitative CMR for longitudinal assessment. This work addresses a critical unmet need for non-invasive diagnostic tools and treatment monitoring in MVD, with the potential to expand precision cardiovascular care for an overlooked yet high-risk population.
Grant Summary
Cardiac MRI Phenotyping of Coronary Microvascular Dysfunction is a NHLBI - National Heart Lung and Blood Institute grant providing up to $848K for university, nonprofit, healthcare org. Applications are due 2031-03-31 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $848K
2031-03-31
- 1Confirm your organization is eligible for Cardiac MRI Phenotyping of Coronary Microvascular Dysfunction from NHLBI - National Heart Lung and Blood Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NHLBI - National Heart Lung and Blood Institute before the deadline.
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Cardiac MRI Phenotyping of Coronary Microvascular Dysfunction: Frequently Asked Questions
Who is eligible for the Cardiac MRI Phenotyping of Coronary Microvascular Dysfunction?
Cardiac MRI Phenotyping of Coronary Microvascular Dysfunction is offered by NHLBI - National Heart Lung and Blood Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Cardiac MRI Phenotyping of Coronary Microvascular Dysfunction provide?
Cardiac MRI Phenotyping of Coronary Microvascular Dysfunction provides up to $848K per award from NHLBI - National Heart Lung and Blood Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Cardiac MRI Phenotyping of Coronary Microvascular Dysfunction deadline?
Applications for Cardiac MRI Phenotyping of Coronary Microvascular Dysfunction are due 2031-03-31 (open). Because deadlines can change, verify the date with the funder, NHLBI - National Heart Lung and Blood Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Cardiac MRI Phenotyping of Coronary Microvascular Dysfunction?
To apply for Cardiac MRI Phenotyping of Coronary Microvascular Dysfunction, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NHLBI - National Heart Lung and Blood Institute.