Search Grants — Free, No Account Required

Health Resources and Services Administration

The purpose of the THCGME Program is to provide maintenance funding to support the training of residents in existing HRSA-supported primary care residency training programs in community-based ambulatory patient care centers. These programs will prepare residents to provide high-quality care, particularly in rural and medically vulnerable communities, and develop competencies to serve a wide range of populations and communities.

Environmental Protection Agency

The U.S. Environmental Protection Agency (EPA) is soliciting applications under the authority of the Clean Water Act (CWA) section 104(b)(8) to provide Technical Assistance and Training for Rural, Small and Tribal Municipalities and Wastewater Treatment Systems. The program supports small, rural, and Tribal communities efforts to identify water challenges, develop plans, build technical, financial, and managerial capacity, comply with CWA requirements, and access water infrastructure funding.Through this Notice of Funding Opportunity under the Clean Water Act, EPA will achieve greater protection of public health and the environment through an increase in trained water sector personnel, access to funding and financing for wastewater treatment facilities, and Clean Water Act compliance. This action advances the Administration s priorities, including to Make America Healthy Again, by improving water quality and reducing exposure risks, and enabling responsible economic growth for small, rural, and tribal communities through improved wastewater infrastructure. In partnership with States, Tribes, and local governments and grounded in sound science and the law, EPA will deliver cleaner water, stronger infrastructure, and long-term environmental stewardship for all Americans.The proposed activities support the Agency s Powering the Great American Comeback Initiative s Pillar 1: Clean Air, Land, and Water for Every American. Priority Areas identified in this opportunity are:(1) Technical assistance and training for rural, small, and Tribal municipalities for planning, developing and acquisition of financing/funding for eligible projects and activities. Technical assistance and training for rural, small, and Tribal publicly owned treatment works and decentralized wastewater systems to help improve water quality and to achieve and maintain compliance.(2) Technical assistance and training focused specifically on Tribes for planning, developing and acquisition of financing/funding, to help improve water quality and achieve and maintain compliance, and/or to support emerging contaminants project development.(3) Information dissemination, technical assistance and training focused specifically on decentralized wastewater treatment systems to support planning, development and acquisition of financing.Eligible entities for this grant program include nonprofit organizations and institutions of higher education that can provide technical assistance and training to rural, small, and Tribal municipalities, publicly owned wastewater treatment works, and decentralized wastewater treatment systems. Assisting systems with their technical, managerial, and financial capacity to achieve long-term compliance is a key priority for the Agency. Infrastructure construction projects such as repairing water or sewer lines, adding new equipment, or upgrading, retrofitting, or rehabilitating existing equipment are not eligible for funding under this announcement.

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

1 PROJECT SUMMARY 2 Children living in rural and underserved communities face persistent disparities in access 3 to early rehabilitation services due to geographic isolation, provider shortages, and 4 socioeconomic barriers. These challenges are especially detrimental during the first three years 5 of life, when early intervention has the greatest potential to improve developmental outcomes. 6 Physical therapy (PT) is a key component of early intervention for infants and toddlers with or at 7 risk for motor delays, yet many families face long waitlists or lack access to qualified providers. 8 ELEVATE (Early Learning & Engagement Via Access to Tele-coaching) is an innovative, 9 caregiver-delivered PT intervention delivered via telerehabilitation. This project will evaluate the 10 efficacy, acceptability, and caregiver engagement of ELEVATE for children aged 0–3 years with 11 or at risk for motor delays in rural communities. Forty-five children and caregivers will be recruited 12 from two rural sites in Ohio and Montana and randomized to immediate intervention or a waitlist 13 control group. The intervention includes twice-weekly telehealth PT sessions, and a structured 14 home program, delivered for 8 weeks. Primary outcomes include child motor function and 15 caregiver self-efficacy. Outcomes will be assessed at baseline, post-intervention, and at a 1- 16 month post-intervention follow-up. We will also assess acceptability through caregiver satisfaction 17 surveys and focus groups with both caregivers and community stakeholders. Finally, we will 18 explore caregiver and child engagement as a potential mechanism of motor and self-efficacy 19 change. Findings will provide critical outcome data to inform a future multi-site comparative 20 effectiveness trial evaluating ELEVATE versus usual care in underserved settings.

Tennessee Department of Economic and Community Development (ECD)

The Rural Economic Opportunity Fund supports economic development in Tennessee's rural communities through grants for infrastructure, site preparation, and community projects that attract investment and create jobs in distressed areas.

NIDA - National Institute on Drug Abuse

PROJECT SUMMARY Partly due to inaccurate beliefs about substance use disorder and inadequate public policies, the substance use epidemic has increased associated risks of infection with the Human Immunodeficiency Virus (HIV) and viral hepatitis (e.g., Hepatitis C Virus [HCV]) in rural regions of the United States. Identifying efficacious programs that are effective and scalable remains imperative. The proposed project, submitted in response to RFA-DA-25024, High Priority HIV and Substance Use Research, will examine the effectiveness of a virtual social intervention to increase HIV/HCV testing and prevention in rural areas of the US. The intervention convenes people with recent substance use and members of the community at large via Zoom to increase social integration, decrease negative beliefs, and improve pro-health norms in all involved. In addition to increasing social capital, the intervention provides remote access to testing and Naloxone (Narcan) and adapts to participants’ needs by promoting individual goal achievement within a group format and through an ad-hoc social platform. The research plan is supported by meticulously collected preliminary data establishing a large effect of the intervention on HIV testing, HCV testing, HIV prevention, and social integration as a composite primary outcome. The approach is also supported by impressive AI (Artificial Intelligence) data on the feasibility of developing an AI Co-Pilot to scale up this intervention by training and providing realtime assistance to community facilitators at a low cost. This five-year project will begin by preparing the infrastructure to conduct an implementation Cluster-Randomized Controlled Trial (C-RCT), including convening our Community Advisory Board (CAB) to cover at-risk rural counties and fine-tuning the AI Co-Pilot (Aim 1). We will enroll 700 participants from high-risk rural locations in the US, half using substances and the other half from the community at large, randomizing them to the AI-assisted intervention or a virtual supportgroup attention control, both with booster sessions (Aim 2). Over the next 6 months, we will measure the outcome of the intervention on a composite index of HIV and HCV testing, HIV prevention, and social integration, as well as each of those outcomes and mental health, substance use treatment seeking, substance use behaviors, and idiosyncratic goal achievement as supplementary outcomes. We will assess theoretical processes that mediate the intervention effects based on measures of norms, social support, goal session and implementation, and testing- and Narcan-kit requests. The project, which will document implementation outcomes, will be conducted by an interdisciplinary team with expertise in psychology, medicine, communication, public health, implementation science, computer science, and biostatistics, from the University of Pennsylvania and the University of North Carolina.

Texas Department of Agriculture

Supports rural Texas communities and agricultural enterprises through grants for infrastructure, market development, and rural economic development.

NIAID - National Institute of Allergy and Infectious Diseases

Project summary: With the growing prevalence of pediatric atopic dermatitis (AD) and subsequent food allergy, asthma and allergic rhinitis, there is an unmet need to identify early biomarkers to allow early disease-preventative interventions. Recent studies emphasize the heritable and environmental components of early-onset AD. DNA methylation (DNAm), a regulator of gene expression highly reactive to environmental exposures, is one potential mechanistic biomarker that that may work along the causal pathway. In our population birth cohort, the Wayne County, Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS), we identified differential cord-blood DNAm in children with early-onset AD compared to those without. Furthermore, we created a cord-blood poly-CpG score that differentiates those with early-onset AD, with a cross-validated AUC of 0.937. We aim to further investigate the connection between cord-blood DNAm and newborn blood spot DNAm, and early-onset AD in the context of established germline genetic and environmental AD risk factors. Using a rigorous framework, we will achieve this objective through the following Specific Aims: Aim 1: To identify and validate cord blood DNAm associated with early-onset AD in the context of in- utero environmental factors. We will use WGBS to identify and validate cord blood DNAm variation associated with early-onset AD in five birth cohorts spanning urban, suburban, and rural environments for early-onset AD and whether known AD-associated prenatal factors lie upstream in the causal pathway. We will also investigate whether methylation-based gestational age is associated with early-onset AD risk and the impact of the prenatal environment on this relationship. Leveraging our Henry Ford Health Eczema and Primary Care Clinics, we will also determine whether the cord-blood signatures for early-onset AD translate to newborn blood spot DNAm. Aim 2: To determine whether cord blood DNAm causally impacts risk of early-onset AD using Mendelian randomization. First, we will determine which of the 101 multi-ethnic GWAS established risk variants are cord blood methylation quantitative trait loci (mQTL) using an epigenome-wide analysis approach. Second, for those risk variants that are also mQTL, we will use these variants as instrumental variables to assess the causal relationship of the CpG sites with early-onset AD using one-sample Mendelian randomization methods. Aim 3: To determine the individual and joint contributions of DNAm, genetic, and prenatal environment scores to the prediction of early-onset AD. We will develop and validate poly-prenatal environmental risk scores (PERS) and poly-CpG risk scores (PCRS) for early-onset AD, and along with an existing polygenic risk score (PGRS) for AD, evaluate their separate and joint impact on early-onset AD prediction.

NCI - National Cancer Institute

PROJECT SUMMARY/ABSTRACT No changes are being made in this proposed supplement to the stated project summary. With the evolution of the Experimental Therapeutics Clinical Trials Network (ETCTN), the Johns Hopkins Translational Science Team (JHTST) supports 8 Affiliate Organizations (AO) under our Lead Academic Organization (LAO) with the goal to enhance and accelerate our collective contribution to the drug development efforts of the NCI. We have organized a comprehensive and cohesive infrastructure that can conduct high-quality clinical trials evaluating novel anticancer agents, in combinations, in molecularly selected patient populations, or rare tumor sites. Our infrastructure stems from the need to be clinically efficient, regulatory compliant and scientifically rigorous in our approach as we collaborate as network members within the ETCTN. Our infrastructure consists of seven experienced NCI-designated Cancer Centers: Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Emory Winship Cancer Institute, Georgetown Lombardi Comprehensive Cancer Center, Sidney Kimmel Cancer Center at Thomas Jefferson University (withdrawn), Memorial Sloan Kettering Cancer Center, University of Virginia Cancer Center, University of Wisconsin Carbone Cancer Center, University of Colorado Denver, University of Maryland Greenbaum Cancer Center, and most recently Wake Forest University. This collection of Centers brings together many unique discovery strengths, diverse patient volumes, and locations both urban and rural. We will focus on 4 specific aims: Aim 1- To lead and maintain a clinical trial consortium that will support cancer clinical trials from Phase 1 initiation through proof-of-activity and foster seamless Phase 2 clinical development of NCI CTEP IND agents; Aim 2- To actively participate and engage disease-focused clinical investigators in the ETCTN by promoting accrual to a range of ETCTN studies led by other LAO/AO members; Aim 3- To incorporate and implement innovative correlative and biological laboratory studies in the context of or as eligibility for participation in early phase clinical studies that enhance our understanding of determinants of toxicity and response that will be used for further definitive practice-changing clinical trial evaluation; and Aim 4- To train the next generation of investigators in drug development. With 9 centers within our consortium, we anticipate no problem in meeting the grant metrics of 100 accruals per year, submitting enough LOI concepts to have 6 new studies approved each year, functioning as a network by having Disease-Focused Clinical Investigators champion ETCTN studies at each site across disease sites, and to provide opportunities to engage and train early career investigators in drug development. We anticipate that our contributions within the ETCTN will impact the clinical care of cancer patients.

NCI - National Cancer Institute

In 2025, an estimated 80,350 people in the US will be diagnosed with non-Hodgkin lymphoma (NHL), and 19,390 will die from this cancer. NHL survival rates began improving in the 1990s with the advent of improved treatment strategies, leading to the current 5-year survival rate of 74%. These trends led to a growth in the number of NHL survivors, estimated at 808,413 as of January 1, 2024. To address the unmet health needs of this patient population, in 2002 we established the Molecular Epidemiology Resource, which was expanded nationally in 2015 as Lymphoma Epidemiology of Outcomes (LEO) cohort study. LEO enrollment is currently over 17,000 NHL participants (and >19,000 at the start of this grant), with <1% loss to follow-up and 73% alive and in follow-up. LEO abstracts pathology, demographic, address (to derive neighborhood variables), clinical, treatment and outcome data, and collects patient reported epidemiologic risk factors and quality of life (QoL) outcomes. Importantly, LEO enrollment (2015-2020) had similar distributions of participants by demographic and NHL subtype as the national Surveillance, Epidemiology, and End Results (SEER) registry, making LEO the largest and most representative prospective cohort of lymphoma outcomes reflecting NHL patients in the US. Cumulatively, LEO has supported numerous publications, prior and ongoing grants (NIH, foundation, industry), NCI Supplements, and career development awards. Under this funding mechanism, we propose to use the LEO cohort to drive the next generation of NHL prognosis and survivorship studies, define patient subgroups with poor outcomes in need of clinical trials, and identify unmet needs for long-term survivors. We will develop and validate novel clinical risk prediction models across NHL subtypes utilizing both the extensive existing LEO data and proposed ongoing follow-up. Our aims are: 1) To develop, validate, and disseminate new clinical models for early treatment failure (ETF) across the major NHL subtypes; 2) To define the intermediate and long-term outcomes and longitudinal QoL in NHL patients who achieve a functional cure with standard of care (SOC) management; and 3) To evaluate the impact of rurality and social determinants of health (SDOH) using individual and area-level measures on NHL outcomes in the context of clinical and lifestyle factors, comorbidities, frailty and QoL. To achieve these aims, we will leverage existing data from the LEO cohort and further annotate the cohort with new data on outcomes, longitudinal and pulse surveys, and external data sources. Maintenance of the cohort also will provide outcomes for ongoing and new studies utilizing the LEO biorepository, and completion of our proposed aims will provide validated clinical models to integrate with biologic studies. This proposal addresses key research questions in outcomes and survivorship for patients with NHL (an understudied cancer) and in understudied populations, including rural and adolescent and young adults. Our results will directly inform clinical guidelines and risk assessment, and support development of novel studies and interventions to improve the outcomes of NHL patients.

Department of Transportation

The synopsis for this grant opportunity is detailed below, following this paragraph. This grant opportunity is being funded by the American Recovery and Reinvestment Act of 2009, Pub. L. 111-5, 123 Stat.115 (Feb. 17, 2009) ( Recovery Act ). This synopsis contains all updates to this document that have been posted as of April 30, 2009. If updates have been made to the opportunity synopsis, update information is provided below the synopsis. All individuals and organizations potentially interested in this grant opportunity are responsible for frequently MONITORING this website AND the Department s TIGER Grants website for any AMENDMENTS to this notice. Such Amendments could contain crucial information. The Department s TIGER Grants website is http://www.dot.gov/recovery/ost/. Document Type: Grants Notice Funding Opportunity Number: DTOS59-09-RA-TIGER Opportunity Category: Discretionary Posted Date: May 1, 2009 Creation Date: May 1, 2009 Original Closing Date for Applications: To be determined. The Department is in the process of developing criteria and requirements for this program. Additional information will be available when the Department publishes a full announcement. Current Closing Date for Applications: To be determined. The Department is in the process of developing criteria and requirements for this program. Additional information will be available when the Department publishes a full announcement. Archive Date: November 30, 2010 Funding Instrument Type: Grant Category of Funding Activity: Surface Transportation Expected Number of Awards: To be determined. The number of awards will be determined after evaluating all Applications. Estimated Total Program Funding: $1,500,000,000. Of this amount, the Department may use an amount not to exceed $200,000,000 for the purpose of paying the subsidy and administrative costs of projects eligible for federal credit assistance under chapter 6 of title 23, United States Code, if the Department finds that such use of the funds would advance the purposes of this program. In addition, the Department may retain up to $1,500,000, and may transfer portions of those funds to the Administrators of the Federal Highway Administration, the Federal Transit Administration, the Federal Railroad Administration, and the Maritime Administration, to fund the award and oversight of grants made under this program. Award Ceiling: $300,000,000 per project. Award Floor: $20,000,000 per project. The Department may waive the $20,000,000 minimum grant size for the purpose of funding significant projects in smaller cities, regions, or States. CFDA Number(s): 20.932 Cost Sharing or Matching Requirement: The Federal share of the costs for which an expenditure is made under this program may be up to 100 percent, however, the Department will give priority to projects that require a contribution of Federal funds in order to complete an overall financing package. Eligible Applicants The funds provided under this program will be awarded to State or local governments or transit agencies on a competitive basis. Recipients of Recovery Act funds and their first tier sub-awardees will be required to have a DUNS number (www.dnb.com) and a current registration in the Central Contractor Registration (www.ccr.gov). Recipients of Recovery Act funds must have systems and internal controls that allow them to separately track and report Recovery Act funds even if the funds are being used to fund an existing project/activity. Additional Information on Eligibility: The Department is in the process of developing criteria and requirements for this program. Additional information will be available when the Department publishes a full announcement. Agency Name Office of the Assistant Secretary for Transportation Policy, Office of the Secretary, U.S. Department of Transportation. Description The Office of the Secretary, through the Office of the Assistant Secretary for Transportation Policy (OST-P), announces a Request for Applications under a competitive discretionary grant program that provides capital investments for surface transportation infrastructure. The program is funded by the American Recovery and Reinvestment Act of 2009, Pub. L. 111-5,123 Stat.115 (Feb.17, 2009) ( Recovery Act ). Under this program, $1,500,000,000 is available through September 30, 2011, for the Department to make grants on a competitive basis for projects that will have a significant impact on the Nation, a metropolitan area, or a region. Projects eligible for funding provided under this program include, but are not limited to, highway or bridge projects eligible under title 23, United States Code, including interstate rehabilitation, improvements to the rural collector road system, the reconstruction of overpasses and interchanges, bridge replacements, seismic retrofit projects for bridges, and road realignments; public transportation projects eligible under chapter 53 of title 49, United States Code, including investments in projects participating in the New Starts or Small Starts programs that will expedite the completion of those projects and their entry into revenue service; passenger and freight rail transportation projects; and port infrastructure investments, including projects that connect ports to other modes of transportation and improve the efficiency of freight movement. The Department may also use an amount not to exceed $200,000,000 for the purpose of paying the subsidy and administrative costs of projects eligible for federal credit assistance under chapter 6 of title 23, United States Code, if the Department finds that such use of the funds would advance the purposes of this program. In distributing funds available under this program, the Department must take measures to ensure an equitable geographic distribution of funds and an appropriate balance in addressing the needs of urban and rural communities. Grants provided under this program shall generally be not less than $20,000,000 and not greater than $300,000,000; however, the Department may waive the $20,000,000 minimum grant size for the purpose of funding significant projects in smaller cities, regions, or States. Not more than 20 percent of the funds made available under this program will be awarded to projects in a single State. The Federal share of the costs for which an expenditure is made under this program may be up to 100 percent, however, the Department will give priority to projects that require a contribution of Federal funds in order to complete an overall financing package, and to projects that are expected to be completed by February 17, 2012. Projects conducted using funds provided under this program must comply with the requirements of subchapter IV of chapter 31 of title 40, United States Code. Recipients will be required to comply with all of the applicable reporting requirements under the Recovery Act. The Department is in the process of developing criteria and requirements for this program. Additional information about criteria and requirements will be available when the Department publishes a full announcement. Link to Full Announcement The Department is in the process of developing criteria and requirements for this program. The criteria and requirements will be included in the full announcement. The full announcement will be available on the Department s TIGER Grants website at http://www.dot.gov/recovery/ost/. Additional Department information related to the Recovery Act is available at http://www.dot.gov/recovery/. If you have difficulty accessing the full announcement electronically, please contact: Jim Mowery at james.mowery@dot.gov [_____] Synopsis Modification History There are currently no modifications for this opportunity.

National Park Service

This announcement is to provide public notice of the National Park Services intention to fund the following project activities without full and open competition to Go North! Adventure Learning for the amount of $30,000 to cooperatively complete the project described below. STATUTORY AUTHORITY: National Historic Preservation Act 16 U.S.C.470. STATEMENT OF JOINT OBJECTIVES/PROJECT MANAGEMENT PLAN: Through this project, Traditional Beringian Sports and Games, the NPS and the Shared Beringian Heritage Program (SBHP) will support an adventure learning program designed to promote, preserve and encourage Beringia s rich tradition of sports and games. This project fits with the goals of the SBHP, as well as with the overall goals of the National Park Service. In conjunction with our partner GoNorth! Adventure Learning, the NPS will join forces with the Administration of Chukotka (the SBHP s counterpart across the Bering Strait) in an effort to protect and promote Beringia s traditional sports and games. Through the encouragement of adventure learning programming and website support, SBHP s contribution will augment funding from the Chukotka Administration. (For detailed information on the level of financial and logistical support provided by the Chukotka Administration, please see the attached original proposal.) With the support of the SBHP this programming will provide a unique opportunity for the people of Beringia, and around the world, to explore the region through the prism of traditional games and sports in a new and growing medium: adventure learning. Traditional sports and games are expressions indigenous cultures and ways of life, and are a vital part of human heritage. They advance cultural diversity and protect cultural identity at the local, national and international level. They can form the backbone of a community (UNESCO, 2012). They can also link communities and regions through participation in regional, national, and international events celebrating the importance of sports and games, especially within the communities of Beringa. Beringian Traditional Sports and Games will: Transmit knowledge, enhance understanding and disseminate and share information on the heritage of traditional sports and games Improve the role and opportunity for traditional sports and games activities in the formal education process and in the promotion of cultural heritage in both Alaska and Russia. Strengthen cooperation and exchanges between the United States and Russia Based on the concepts and methods of adventure learning, GoNorth provides learners of all ages across the US and worldwide with transformational learning experiences. These are experiences that advance healthy active living and build literacy in order to ensure sustainable development while enhancing cultural collaboration. A. The partner, in cooperation with the National Park Service will: Go North! Adventure Learning agrees to: 1. Work directly with the Administration of the Chukotka Autonomous Okrug and native organizations on the Russian side to successfully conduct the activities outlined under this project. 2. Go North will work directly with the Shared Beringian Heritage Program to incorporate the goals and results into the greater context of the Beringia Program to show the importance of traditional sports and games in rural and urban communities within Chukotka. 3. Go North will support and encourage the participation of community members from rural Alaska and rural Chukotka in the Beringia Games; this work will be accomplished with the input of the Shared Beringian Heritage Program. 4. Project partner and Go Mille Porsild will work with three designated entities of the Government of Chukotka: The Department for Natural Resources and Agriculture, Department for Education and Culture and Department for Sports and Tourism. Collaborating with these entities is an essential part of this project, and facilitates greater communication between the Shared Beringian Heritage Program and the Administration of Chukotka on an important element of our shared culture: traditional sports and games. 5. Go North will promote the Racing Beringia and Beringia Games curriculum in schools , but the primary vehicle for distribution will be the existing users of the Go North website PolarHusky.com . This adventure learning website has an audience in the millions. It is seen in 6000+ schools in 38 countries across the 50 US states and around the world. 6. Go North will continue to maintain and promote their website through mechanisms like the SBHP website and Facebook page. 7. Go North will share results and solicit feedback on project results and will develop project materials with input from the Shared Beringian Heritage Program. B. NATIONAL PARK SERVICE INVOLVEMENT -Substantial Involvement : The National Park Service agrees to: 1. Cooperate and collaborate with Go North Adventure Learning by linking this project to the Beringia Program s network of contacts in Alaska and Russia (especially in native communities). The Beringia Program s contacts differ from those already established by the cooperator due to their status and access. The SBHP will assist the cooperator in deepening the relationships between the various entities. 2. Use the network of contacts, the Beringia program s website, and the program Facebook page to share information from the final and interim reports with the public, as well as targeted audiences through the development of distribution plan for project materials and results. 3. Work cooperatively with Go North on developing formal relationships with entities in Chukotka, whether government or non-profit. The National Park Service will assist with the exchange of information and the process of writing international agreements. The NPS s Shared Beringian Heritage Program has experience in writing successful agreements with Russian organizations, and can also advise the cooperators on cultural matters. 4. The Beringia Program will act as a liaison when needed to facilitate exchanges, enhance communication, provide translation services, and provide logistical support. 5. The NPS SBHP will also support GoNorth by presenting information about the project to other interested parties, as well as sharing the goals of the project with others in the NPS/SBHP network, thereby facilitating collaboration and cooperation between past and current partners. 6. Assign Elizabeth Shea, Program Specialist for the Shared Beringian Heritage Program, National Park Service, as the Agreements Technical Representative (ATR) for the administration of this Cooperative Agreement; and as Liaison between the NPS and for the implementation of the program(s) identified within this agreement. 7. Provide $30,000 during FY 2013 to GoNorth Adventure to carry out the work stated in the preceding objectives. (See attached Detailed budget ). SINGLE-SOURCE JUSTIFICATION: Department of the Interior Policy (505 DM 2) requires a written justification which explains why competition is not practicable for each single-source award . The National Park Service did not solicit full and open competition for this award based the following criteria: Unique Qualifications. The field research that the cooperator specializes in is an essential component of the project. The partner has the necessary background in adventure learning, working with youth, dog-mushing, project management, and cultural exchanges. Technical contact information: Elizabeth Shea, Elizabeth_shea@nps.gov, 907-644-3606. National Park Service, Alaska Region, End of FOA

NCATS - National Center for Advancing Translational Sciences

PROJECT SUMMARY The mission of the UC Davis Clinical and Translational Science Center (CTSC) is to advance clinical and translational science (CTS) by coalescing the expertise within our premier, comprehensive university and core collaborators to improve human health. We have been the home for CTS researchers at UC Davis for nearly 20 years and have exceeded the essential characteristics of successful CTSA Hubs, both locally and nationally. For the proposed grant period, the UC Davis CTSC will integrate the broad knowledge and expertise of our public, land-grant, research-intensive academic institution and the geographic reach of our university to generate broad knowledge translation. Our CTSC will build transformative teams to uniquely tackle CTS barriers by coalescing the expansive expertise in six UC Davis schools and four colleges, our leading healthcare system at UC Davis Health, rural cooperative extension sites across the state, and community partners representing our broad catchment areas. The Specific Aims of our proposal are: Aim 1: Synergize our existing CTSC systems and infrastructure with new multi-sector leadership, empowered team and staff management, and team science- focused evaluation (A: Overview and B: Strategic Management); Aim 2: Proactively coordinate staff and trainee as well as core collaborators with our services, pilot awards, and data science approaches to support the day-to-day and future work of transformative CTS teams (C1: Workforce, C2: Engagement, D1: Resources, D2: CTS Pilots, D3: Data Science); Aim 3: Implement new projects and teams that address CTS gaps, in both community and clinical settings, and with a focus on dissemination of successful processes and findings back into our Center’s unified suite of assets and to the broader CTS field (E: CTS Research). To achieve these Aims, we strategically developed structures and activities to facilitate CTS within and across every Element of the application and have: 1) elevated all core collaborator audiences to the leadership board, including academic, healthcare system, rural cooperative extension partners, and community members representatives (B: Strategic Management); 2) rooted our training in transdisciplinary and team-centered knowledge creation and standardized our broad array of programs with foundational skill development (C1: Workforce); 3) re-focused our engagement activities on co-creation of scientific questions and long-term partnerships across the spectrum of research processes (C2: Engagement); 4) linked cross-cutting offerings and developed new communication strategies to ensure researchers gain access more efficiently and holistically across disciplines, while maintaining rigor, reproducibility, and high ethical standards (D1: Resources); 5) redesigned the CTSC pilot awards to support these alignments across research teams and collaborator audiences (D2: CTS Pilots); and 6) emphasized continuous iteration and improvement of core CTSC resources, innovation within implementation and data science methodologies, and upfront multi-sector collaborator engagement to speed up impact into real- world settings (D3: Data Science).

NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases

PROJECT SUMMARY/ABSTRACT Youth-onset type 2 diabetes (YO-T2D) is increasingly prevalent in parallel with the obesity epidemic, yet effective treatment and prevention strategies are limited. The physiologic increase in insulin resistance occurring during puberty, in combination with obesity-related insulin resistance, enhances the risk of T2D. Yet, it remains unclear why some youth progress through puberty with intact β-cell function, while others do not, despite similar phenotypic and metabolic characteristics. More information is needed regarding the unique events during puberty to better understand 1) the basic pathophysiology of glucose control, insulin sensitivity, β-cell function, and T2D risk in youth, 2) differences among girls and boys, populations at highest risk, and urban and rural geographies, and 3) the potential contribution of other risk factors including psychological, behavioral, and social and external contexts. Importantly, this research needs to address the timeline of pathophysiology and progression from normoglycemia or prediabetes to YO-T2D. The DISCOVERY of Risk Factors for Type 2 Diabetes in Youth (DISCOVERY) study provides a unique opportunity to characterize the risk progression profile and mechanisms underlying the development of YO-T2D, and evaluate the effects of modifiable and non-modifiable risk factors. Ultimately, the results of this study will establish a basic pathophysiology to inform future studies aimed at achieving target glycemia, improving insulin sensitivity, preserving β-cell function, and/or preventing YO-T2D. To address this goal, DISCOVERY will recruit, enroll, and follow a nationally-representative cohort of 3,600 at-risk obese youth in early puberty; extensively phenotype them as they transition through puberty; and characterize the course of decline and dysfunction in pathophysiological indicators that lead to YO-T2D. The expected duration of the DISCOVERY is 5 years, including planning, recruitment, follow-up, analysis, and reporting. In addition, DISCOVERY will store longitudinal biospecimens and genetic material with the intention of acquiring additional ancillary funding to pursue analysis of emerging indicators. Texas Children's Hospital, Baylor College of Medicine has experience in multicenter and diabetes-related investigations and will contribute to DISCOVERY through the recruitment of approximately 240 at-risk youth, implementation of the IRB-approved consensus protocol, participation on DISCOVERY committees, and collaboration on the analyses and dissemination of the findings from DISCOVERY.

NIGMS - National Institute of General Medical Sciences

Healthcare challenges of the 21st century in the U.S. require well-trained physician-scientists to bridge the gap between groundbreaking biomedical research and community-engaged research to transform healthcare and improve health outcomes for all. The University of Louisville (UofL) Medical Scientist Training Program (MSTP) prepares physician-scientists to lead biomedical and community-engaged research that addresses the root causes of disease and improves health outcomes across health-challenged populations. With MSTP support, we will expand our program from 5 to 6 annual trainees, enhance our competency-guided curriculum, and strengthen the integration of clinical, translational, and community-partnered research. UofL is one of 102 U.S. institutions with both Carnegie R1 and Community Engaged classifications, offering exceptional infrastructure for training in both basic science and community-engaged (CE) clinical research. Our objectives are to: 1: Expand the program from five to six annual matriculants and focus on recruiting trainees passionate about community- engaged health research. 2: Implement a competency-guided curriculum ensuring mastery of ten core competencies required in physician-scientists, including the conduct of rigorous research leveraging foundational knowledge, patient care, communication skills, grantsmanship, leadership, and drive to provide CE healthcare. 3: Enhance mentoring through faculty training via the Center for the Improvement of Mentored Experiences in Research (CIMER) training framework, augmented with peer mentoring, MSTP specific case-based scenarios, and self-assessments supporting students and building a mentoring environment safe for all students. 4: Support transitions across training stages with structured resources, including a clinical re-immersion course, longitudinal clinical experiences during research years, and opportunities in clinical trials and translational research. 5: Leverage alumni for mentorship and networking through retreats, newsletters, and program evaluations. 6: Foster innovation through entrepreneurial opportunities through partnerships with existing UofL centers of excellence in bio-innovation and translational research. 7: Enhance residency competitiveness by promoting early research involvement, strong publication records, CE clinical research experience, and participation in physician-scientist events. 8: Mitigate attrition by prioritizing student wellness and promoting a safe and supportive training environment. Over the past five years, graduates have published an average of 8 papers (3.6 first author), secured competitive fellowships (e.g., NIH F30, Fulbright), and matched into top-tier residency programs. Our programmatic curriculum includes longitudinal CE training, specialized distinction tracks in public/global health, education, business/leadership, medicine/social impact, as well as biodesign/innovation. By embedding CE and clinical research competencies across all training phases, our MSTP develops leaders who bridge science and medicine to transform healthcare in Kentucky, the Appalachian region, the rural heartland, and beyond.

USDA Rural Development

Grants and low-interest loans for essential community facilities in rural areas including healthcare, education, public safety, and community support services.

USDA Rural Development

USDA provides grants for essential community facilities in rural areas including healthcare, public safety, and educational facilities.

U.S. Department of Agriculture

USDA Rural Development programs with tribal set-asides for community facilities, housing, business development, and water/waste infrastructure in tribal areas.

NIH

Background: How can we apply the community health worker (CHW) model to help both care partners and Veterans with serious illness in rural areas? Little is known about this approach. We will test a VA-supported intervention successfully piloted in the Durham VA and surrounding rural communities in 2021. VA’s Office of Rural Health, Caregiver Support Program and National Social Work Office are aware and support this work. Significance: Clinically, this work will help improve care for rural Veterans with serious illness by supporting care partners in their caregiving role in the community thus bolstering the care of Veterans receiving primary support from care partners in rural areas. A strength of our intervention is that it adapts and extends a successful model of individualized support commonly used outside of the VA. This approach maximizes the potential for sustainability, broad dissemination, and care delivery impact across the VA. This work will be generalizable. Strategically, this SDR proposal responds to the National Academies report recommending all health systems, including VA, develop processes to routinely identify, assess, and support needs of care partners. Our project meets rural health access, long-term care/aging, engagement science, and caregiving HSR priorities for investigator-initiated research focused on rural populations. Additionally, our proposed efforts fit squarely with the VA’s Rural Health State of the Art conclusion that we must expand VA partnerships in the community and help Veterans and their families understand their options for care and support in the community and at the VA. Innovation & Impact: This project is innovative because of its focus on social and practical needs of care partners, advances the science of community engagement in VA care and support, and situates a care partner- focused community health worker model squarely in the VA system for the first time. The entire project is guided by a Community Advisory Board (CAB) composed of social service, serious illness care, and rural care experts plus Veterans and care partners with lived experience. Specific Aims: Aim 1. Determine CHW effectiveness in reducing care partner burden, increasing Veterans' well-being, and increasing care partner-Veteran satisfaction with VA care in the intervention group compared with the usual care (CSP) group: We will apply our feasible CHW intervention to a larger sample, randomized control trial. (Hl) Care partners randomized to the intervention group will have lower mean Zarit-12 scores at 6 months compared to the control group. (H2) Care partners and Veterans randomized to the intervention group will have higher mean 1-item CAHPS Global Satisfaction scores at 6 months compared to the control group. (H3) Veterans randomized to the intervention group will have higher mean Warwick Edinburgh Mental Well- Being scores at 6 months compared to the control group. Aim 2: Following intervention, explore Veterans' and care partners' experience of care and support using subgroup semi-structured interviews in the intervention group. We then facilitate CAB Delphi Method sessions (including study Veterans, CHWs, and care partners) exploring Aims 1/2 data using equity-focused intervention mapping for wider implementation. Aim 3: Conduct budget impact analysis from the VA perspective to evaluate cost-drivers and assess feasibility to inform adaptation and implementation of the intervention within Durham VA Health Care System. Methodology: Two-arm randomized control trial using validated measures. We follow this using qualitative exploration with participants plus a Delphi method exploring implementation with the community advisory board and participants. We end with a unique business impact analysis of the intervention. Next Steps/Implementation: We are supported/advised by VA’s Office of Rural Health and Caregiver Support Program in Durham, NC with additional advisement from National Social Work Office, Chaplaincy, Palliative Care, county Veteran Services and Area Agencies on Aging (see LOS). If successful, this intervention can be added to the options available from CSP to support rural care partners and their seriously ill Veterans.

Utah Governor's Office of Economic Opportunity (GOED)

Utah's CDBG program provides grants to non-entitlement communities for infrastructure, public facilities, housing rehabilitation, and economic development projects that benefit low- and moderate-income residents in rural and small-town Utah.

Utah Governor's Office of Economic Opportunity

Provides Economic Development Tax Increment Financing (EDTIF), Industrial Assistance Fund, and rural economic development grants.

Utah Governor's Office of Economic Opportunity (GOED)

The Rural Economic Development Incentive provides post-performance tax credits and grants to businesses creating jobs in rural Utah counties, stimulating economic growth and diversification in underserved communities.

USDA Rural Development

Grants to agricultural producers for planning and working capital to develop value-added products from raw agricultural commodities.

NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases

PROJECT SUMMARY / ABSTRACT Colonoscopy reduces the risk of colorectal cancer (CRC) mortality through the detection and removal of pre- cancerous polyps (adenomas), but the magnitude of risk reduction depends upon the quality of the colonoscopy. Most colonoscopy quality improvement (QI) initiatives have focused on higher-volume gastroenterologists. In rural and peri-urban communities in the United States, most colonoscopies are performed by lower-volume colonoscopists, who are mostly surgeons, and CRC outcomes are worse compared to urban areas. These lower- volume colonoscopists have marked variability in quality and many fail to adhere to best practices or meet national benchmarks. Higher adenoma detection rate (ADR) is the quality metric most associated with reduced CRC mortality. However, ADR is less accurate at lower colonoscopy volumes, suggesting that ADR alone cannot reliably differentiate quality or provide meaningful information to improve quality in lower-volume colonoscopists. Thus, alternative methods to measure and improve quality in lower-volume colonoscopists are needed. Video evaluation of procedures such as colonoscopy is a valuable tool for assessing and improving technical skills in multiple specialties. In prior work, we found that higher-volume gastroenterologists’ colonoscopy skill, assessed by expert evaluation of video-recorded colonoscopies using a validated technical skill scoring rubric, is highly correlated with quality metrics requires fewer colonoscopies for accurate assessment, and correlates with ADR. Further, we showed that delivery of focused feedback based on technical skill scores improves colonoscopy quality. While expert video evaluation of colonoscopies is an effective tool to measure and improve quality in lower-volume colonoscopists, it is not feasible on a larger scale given the time and cost of manual video review. We therefore developed and validated an AI-based tool that identifies key steps in colonoscopy videos, for rapid expert review and scoring. This study focuses on the implementation and evaluation of an AI-augmented intervention to improve colonoscopy quality of lower-volume colonoscopists in rural and peri-urban areas to ultimately reduce CRC mortality. The intervention, the “Colonoscopy Quality Improvement Bundle” (ColonQI Bundle), combines (1) AI-augmented expert assessment and scoring of technical skills; (2) AI-augmented automated calculation of quality metrics (e.g., ADR, withdrawal time), and (3) Targeted feedback of specific technical skill deficits based on the scores (audit-feedback, structured video-based didactics, coaching, mentoring). Lower-volume colonoscopists, with a focus on surgeons will be recruited to: (1) Assess the needs and preferences of, and select strategies for implementation of the ColonQI Bundle using an implementation science framework; (2) Implement the ColonQI Bundle, using tailored implementation strategies tailored to the needs and preferences of lower-volume colonoscopists; and (3) Assess the effectiveness of the ColonQI Bundle to improve colonoscopy quality and technical skills among lower-volume colonoscopists.

National Park Service

This announcement is to provide public notice of the National Park Services intention to fund the following project activities without full and open competition to Seward Association of the Advancement of Marine Science dba the Alaska SeaLife Center (ASLC)for a cooperative agreement in the amount of $42,997 to cooperatively complete the project described below. STATUTORY AUTHORITY: 16 USC 1g, Agreements for the Transfer of Appropriated Funds to Carry Out NPS Programs. STATEMENT OF JOINT OBJECTIVES/PROJECT MANAGEMENT PLAN: OVERVIEW The unique nature of Alaska, with its many rural and remote villages, provides the challenge of getting quality marine science education to students in schools which are usually multi-grade facilities with minimal staff support. Staff members of both Kenai Fjords National Park and the Alaska SeaLife Center have been successfully taking science to these students for the past ten years. In a state with such an abundance of science, natural resources, and students longing to understand them the OASLC Village Outreach Program is a natural fit. With a track record of success and a recent increase in teacher participation and frequency of outreach trips, this program has the potential for continued growth and even greater success as schools are looking for unique, cost-effective, and inquiry-based learning experiences for their students. STATEMENT OF JOINT OBJECTIVES/PROJECT MANAGEMENT PLAN Village outreach trips are conducted jointly by the ASLC and NPS staff. Villages are chosen in collaboration. Content for lessons are contributed by both ASLC and NPS staff and lessons are designed by the ASLC. Staff from both ASLC and NPS travel to the villages and both present lessons and programs related to marine and park resources. NPS staff will give a presentation on jobs and careers opportunities in the NPS. Objectives 1. To share the scientific research and information available at both the Alaska SeaLife Center and Kenai Fjords National Park with teachers and students across Alaska in an effort to create a climate of ocean stewardship through understanding of the natural resources and unique features of our local oceans, seas and coastal communities. 2. To inspire continued education in STEM-related content through exposure to science, technology, and careers related to stewardship of Alaska s oceans and their resources. 3. To provide quality education content on marine research and glaciers from the ASLC and the NPS-KEFJ, who are uniquely qualified on these subjects, to all students in Alaska. 4. Four week-long outreach trips between August 2014 and June 2015: Northwest Arctic Borough School District sites in consultation with NPS office in Kotzebue (2 educators). Goals include 1-4 schools and <750 students. Nome and Bering Strait School District sites, in consultation with the Nome office (2 educators). Goals include 1-4 schools and <500 students. Chatham School District or other area of priority to the Glacier Bay office (1 educator). Goals include 1-3 sites and <120 students. Priority communities in the Lake &amp; Peninsula School District, in consultation with the Katmai and Lake Clark offices (1 educator). Goals include 1-3 sites and <120 students. 5. Two week-long outreach trips to the schools in Port Graham and Nanwalek between August 2014 and June 2015. During the first visit, ASLC educators will begin a dialogue with the students and will work with teachers to establish a long-term project for the school year. Between visits, ASLC educators will stay in touch with classes to continue the dialogue and to use the resources of the aquarium to highlight certain lessons (e.g., mammals swimming in their tanks to discuss different methods of locomotion.) 6. Assessment results that will inform future outreach goals and methods. RECIPIENT INVOLVEMENT The Alaska SeaLife Center will work with NPS to identify villages and schools to visit. The ASLC take the lead on developing marine science lessons focused at appropriate grade levels. Examples of lessons adaptations of marine birds and mammals, comparative anatomy of marine invertebrates, comparative anatomy of vertebrates, and investigative science using the scientific method focused on walruses. The ASLC will also take the lead on delivering lessons in each of the identified villages. The ASLC shall establish long term contact with schools in Port Graham and Nanwalek in order to develop a long term school project and to deliver lessons throughout the school year from their facilities and resources in Seward using distance learning technology. Finally the ASLC will be responsible for conducting evaluations of the village outreach lessons from teachers and students in order to inform future outreach goals and lessons. 3. Collaboratively choose schools and villages for outreach trips with NPS staff. 4. Provide content and develop lessons focused on marine science for K-12 students. 5. Provide staff to travel to villages and deliver lessons. 6. Establish a long term project with students in Port Graham and Nanwalek, maintain contact throughout the school year, and between visits deliver lessons focused on resources present at the ASLC using distance learning technology. 7. Conduct evaluations with teachers and students to inform future outreach goals and lessons. NATIONAL PARK SERVICE INVOLVEMENT Substantial involvement on the part of the National Park Service is anticipated for the successful completion of the objectives to be funded by this award. In particular, the National Park Service will be responsible for the following: 1. Collaboratively choose schools and villages for outreach trips with ASLC staff. 2. Provide content and develop programs focused on park natural and cultural resources for K-12 students. 3. Provide staff to travel to Port Graham, Nanwalek and when possible other villages to deliver lessons and programs (NPS Travel is not part of the cost proposed and will be processed outside this agreement). 4. Develop and present program to inform students and village youth about jobs and career opportunities in the National Park Service. SINGLE-SOURCE JUSTIFICATION: Department of the Interior Policy (505 DM 2) requires a written justification which explains why competition is not practicable for each single-source award . The National Park Service did not solicit full and open competition for this award based the following criteria: (4) Unique Qualifications The applicant is uniquely qualified to perform the activity based upon a variety of demonstrable factors such as location, property ownership, voluntary support capacity, cost-sharing ability if applicable, technical expertise, or other such unique qualifications;The focus of the village outreach program is on ocean science and issues with a strong emphasis on engaging rural schools in Alaska. The Alaska SeaLife Center is a leader in both conducting marine science in the state of Alaska and educating rural pre-K-12 grade students on the results. They are the only educational institution (non-profit, for profit or government) within the state that has a state wide reach to rural pre-K-12 grade schools. This is particularly important for schools not located near the Gulf of Alaska. Since its inception in 1998 the Alaska SeaLife Center has been sharing scientific knowledge to promote understanding and stewardship of Alaska's marine ecosystems through educational programs to all ages. Throughout that time the ASLC has engaged in village outreach efforts like the project described in this task agreement. They have demonstrated both a commitment and excellence in conducting educational outreach to rural schools. The ASLC has demonstrated knowledge and skills that put them in a position of leadership in informal education. Each of the ASLC educational staff are certified informal science educators. In addition, the ASLC provides training to staff at other institutions, for example the Anchorage Museum, on informal education. The ASLC also conducts teacher workshops and training for individuals wishing to become Certified Interpretive Guides through the National Association of Interpreters (NAI). The ASLC has also received three Pinnacle Awards in 2008, 2011 and 2013, along with two honorable mentions in 2009 and 2010. Pinnacle Awards are presented by the Center for Interactive Learning and Collaboration (CILC) to institutions providing content for distance learning and informal education programs. Awardees are selected based on teacher evaluations. There are only four entities in the state of Alaska providing marine science outreach to grade school children: The Sitka Sound Science Center, The Prince William Sound Science Center, the Kachemak Bay Research Reserve, and the Alaska SeaLife Center. The first three are limited in scope and mission to their local areas, and all are on the Gulf of Alaska, in the southern part of the state. The villages in this project are spread out throughout the state. The ASLC is the only institution with both the experience and scope to reach all the villages in this project.Technical contact information: Benjamin Pister, benjamin_pister@nps.gov, 907-422-0501, National Park Service, Alaska Region, End of FOA