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Testing the Effectiveness of a Remote Intervention to Reduce Infection Risk in Rural Areas of the United States

NIDA - National Institute on Drug Abuse

open
OpenLast verified: 2026-07-14

About This Grant

PROJECT SUMMARY Partly due to inaccurate beliefs about substance use disorder and inadequate public policies, the substance use epidemic has increased associated risks of infection with the Human Immunodeficiency Virus (HIV) and viral hepatitis (e.g., Hepatitis C Virus [HCV]) in rural regions of the United States. Identifying efficacious programs that are effective and scalable remains imperative. The proposed project, submitted in response to RFA-DA-25024, High Priority HIV and Substance Use Research, will examine the effectiveness of a virtual social intervention to increase HIV/HCV testing and prevention in rural areas of the US. The intervention convenes people with recent substance use and members of the community at large via Zoom to increase social integration, decrease negative beliefs, and improve pro-health norms in all involved. In addition to increasing social capital, the intervention provides remote access to testing and Naloxone (Narcan) and adapts to participants’ needs by promoting individual goal achievement within a group format and through an ad-hoc social platform. The research plan is supported by meticulously collected preliminary data establishing a large effect of the intervention on HIV testing, HCV testing, HIV prevention, and social integration as a composite primary outcome. The approach is also supported by impressive AI (Artificial Intelligence) data on the feasibility of developing an AI Co-Pilot to scale up this intervention by training and providing realtime assistance to community facilitators at a low cost. This five-year project will begin by preparing the infrastructure to conduct an implementation Cluster-Randomized Controlled Trial (C-RCT), including convening our Community Advisory Board (CAB) to cover at-risk rural counties and fine-tuning the AI Co-Pilot (Aim 1). We will enroll 700 participants from high-risk rural locations in the US, half using substances and the other half from the community at large, randomizing them to the AI-assisted intervention or a virtual supportgroup attention control, both with booster sessions (Aim 2). Over the next 6 months, we will measure the outcome of the intervention on a composite index of HIV and HCV testing, HIV prevention, and social integration, as well as each of those outcomes and mental health, substance use treatment seeking, substance use behaviors, and idiosyncratic goal achievement as supplementary outcomes. We will assess theoretical processes that mediate the intervention effects based on measures of norms, social support, goal session and implementation, and testing- and Narcan-kit requests. The project, which will document implementation outcomes, will be conducted by an interdisciplinary team with expertise in psychology, medicine, communication, public health, implementation science, computer science, and biostatistics, from the University of Pennsylvania and the University of North Carolina.

Grant Summary

Testing the Effectiveness of a Remote Intervention to Reduce Infection Risk in Rural Areas of the United States is a NIDA - National Institute on Drug Abuse grant providing up to $886K for university, nonprofit, healthcare org. Applications are due 2031-05-31 (open). Check eligibility and apply with FindGrants.

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Focus Areas

health research

Eligibility

universitynonprofithealthcare org

How to Apply

Funding Range

Up to $886K

Deadline

2031-05-31

Complexity
High
  1. 1Confirm your organization is eligible for Testing the Effectiveness of a Remote Intervention to Reduce Infection Risk in Rural Areas of the United States from NIDA - National Institute on Drug Abuse, checking organization type, location, and any population or project requirements.
  2. 2Gather the required documents and information, including your organization details, project plan, and budget figures.
  3. 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
  4. 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDA - National Institute on Drug Abuse before the deadline.
This record is a past award, contract, or funder profile — useful for research, but not an open grant application. Check the original source for current opportunities from this funder.

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Testing the Effectiveness of a Remote Intervention to Reduce Infection Risk in Rural Areas of the United States: Frequently Asked Questions

Who is eligible for the Testing the Effectiveness of a Remote Intervention to Reduce Infection Risk in Rural Areas of the United States?

Testing the Effectiveness of a Remote Intervention to Reduce Infection Risk in Rural Areas of the United States is offered by NIDA - National Institute on Drug Abuse and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.

How much funding does the Testing the Effectiveness of a Remote Intervention to Reduce Infection Risk in Rural Areas of the United States provide?

Testing the Effectiveness of a Remote Intervention to Reduce Infection Risk in Rural Areas of the United States provides up to $886K per award from NIDA - National Institute on Drug Abuse. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.

When is the Testing the Effectiveness of a Remote Intervention to Reduce Infection Risk in Rural Areas of the United States deadline?

Applications for Testing the Effectiveness of a Remote Intervention to Reduce Infection Risk in Rural Areas of the United States are due 2031-05-31 (open). Because deadlines can change, verify the date with the funder, NIDA - National Institute on Drug Abuse, and give yourself enough time to prepare a complete, competitive application before the close date.

How do you apply for the Testing the Effectiveness of a Remote Intervention to Reduce Infection Risk in Rural Areas of the United States?

To apply for Testing the Effectiveness of a Remote Intervention to Reduce Infection Risk in Rural Areas of the United States, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDA - National Institute on Drug Abuse.