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Towards Multi-modal Biomarker and Personalized Medicine: Integrating Esophageal Biochemical, Structural, and Molecular Alterations in Pediatric Eosinophilic Esophagitis

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NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases

Project Summary: Eosinophilic esophagitis (EoE) is a chronic, allergen-mediated, clinicopathologic disease, and a leading cause of upper gastrointestinal morbidity among children in the United States. It is characterized by esophageal eosinophilic infiltration and progressive fibrotic remodeling leading to debilitating dysfunction, dysphagia, and esophageal food impactions. Advances in understanding EoE pathophysiology have led to the development of clinical, endoscopic, histological, and molecular indices. While these metrics have enhanced our ability to identify EoE, essential gaps remain. Specifically, their limited accuracy in classifying disease activity status, stratifying severity and risk of fibrotic complications, and informing personalized therapy continues to constrain progress in optimizing patient care. The increasing prevalence of pediatric EoE reiterates the urgency to address these translational gaps through innovative approaches. To this end, during his K23 award, the Principal Investigator (PI), an Early Stage Investigator, identified distinct biochemical and architectural features that distinguished non- EoE controls from EoE, and active EoE (aEoE) from inactive EoE (iEoE) by using Raman spectroscopy (RS), stimulated Raman spectroscopy (SRS), and second-harmonic generation (SHG) microscopy. In this proposal, he will leverage the emerging paradigm shift toward integrative, multimodal markers — an approach yet to be applied in EoE, and build on his previous work to develop more comprehensive metrics of disease processes. He has preliminarily demonstrated that (a) Raman-RNA (biochemical-molecular) biomarker signature [area under the curve (AUC) = 0.937] outperforms Raman alone (AUC = 0.875) and RNA alone (AUC = 0.875) in differentiating aEoE from iEoE, (b) epithelial biochemical and structural changes correlate with subepithelial ECM and LPF, and (c) baseline esophageal glycogen, protein, and lipid content can classify responders from non- responders to non-biologic EoE therapies such as proton-pump inhibitors and topical corticosteroids. Advancing these innovations further, he will develop Raman-RNA biomarker signatures that stratify aEoE and iEoE and compare their diagnostic performance against existing activity indices (Aim 1), identify Raman-SRS-SHG signatures for fibrotic transformation by investigating how the epithelial biochemical changes relate to and predict subepithelial ECM and LFP (Aim 2), and in a prospective cohort, evaluate if the baseline esophageal biochemical, clinical, endoscopic, and histologic features predict response to dupilumab (Aim 3). The investigative team's expertise, proven track record, exciting preliminary data, established protocols, state-of-the- art resources, institutional support, and a motivated patient population position this project for success within the funding period. This innovative and interdisciplinary research will address critical translational gaps in EoE and improve clinical outcomes for children with EoE. It will also catalyze new avenues of investigation and technological innovations, establishing the PI as an independent investigator at the intersection of pediatric gastroenterology and translational research.

Up to $669K
2031-02-28
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Tracing developmental signaling histories with imaging-based molecular recording

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NIGMS - National Institute of General Medical Sciences

Project Summary Signals that cells receive over time from a small set of pathways (e.g., BMP, Wnt, and TGFβ) shape their fate and phenotype during development, regeneration, and disease. Despite their central importance, signaling histories of individual cells are often inaccessible to direct observation, hindering quantitative analysis and obscuring their connection to eventual cell fate. This challenge is particularly pronounced in mammalian systems, where limited optical access and the constraints of size and timescale often render live imaging impractical. To address this issue, we have developed an approach to reconstruct the history of signaling activity in single cells based on endpoint fluorescence images. This is achieved by regulating CRISPR base editors to generate mutations in engineered target sites at rates proportional to the signal of interest. These mutations create a heritable record of signaling activity in the genome, which can be read out at a later time, together with the gene expression profile of the cells. Using this approach, we demonstrated that cells retain a memory of their past response level to BMP signaling for up to 18 days, providing a mechanism for long-term interactions between signals that can facilitate coordination of developmental processes over time. In this proposal, we will expand the scope and utility of our signal recording approach by extending its dynamic range to capture the broad spectrum of in vivo signal intensities and enabling simultaneous recording of the sequence and timing of two signaling pathways. We will also engineer mouse embryonic stem cells to record three key developmental pathways: BMP, Wnt, and Nodal. This will allow us to generate stem cell-derived embryo models and chimeric embryos to link cell fate and spatial organization at the onset of organogenesis with signaling activity at different time windows earlier in development. Additionally, we will investigate mechanisms that enable long-term changes in BMP responsiveness following an initial stimulation, without requiring differentiation. We will then test whether similar mechanisms exist in Wnt and Nodal pathways and assess their role in mediating long-term crosstalk between pathways. To achieve these goals, we will take an interdisciplinary approach combining gene editing, quantitative imaging, epigenomic assays, computational analysis, and generation of developmental models. The proposed goals build on my prior publications, recent preliminary data from our lab, and collaborations I have established since launching my lab. This research program will substantially advance the state of the art in molecular recording, transforming it into a technology that can be used in vivo, in mammalian systems to drive biological discovery. Our long term vision is to identify how signaling history controls cellular decision making during development, and how instructions that cells receive are coordinated over time to produce tissues with the correct number, types, and spatial arrangement of cells. Ultimately, this knowledge will inform strategies for tissue engineering, and open new avenues for understanding and treating diseases driven by dysregulated signaling.

Up to $433K
2031-02-28
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Tracking Residential Air Quality to Quit Smoking

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NCI - National Cancer Institute

The goal of TRAQ-to-Quit is to increase the potency and efficacy of behavioral interventions for smoking cessation treatment in low-income communities by leveraging state-of-the art Internet-of-Things (IoT) technology to merge three evidence-based approaches into a single comprehensive, multilevel intervention: i.) brief pediatrician advice and referral to cessation services; ii.) novel behavioral tele-counseling that guides smokers towards establishing a smokefree home (SFH) as an initial step toward cessation; and iii.) the deployment of an IoT system consisting of an indoor air quality (IAQ) smart home device that collects continual, objective measures of IAQ and integrates them into both smokers’ home environments and a tele-counselor participant dashboard that enables individualized, data-guided advice/problem solving. The proposed treatment model builds on several of our previous trials, most notably the Kids Safe and Smokefree (KiSS) trial, which demonstrated the efficacy of a multilevel behavioral intervention initiated by pediatricians in safety-net systems on the promotion of long-term bioverified abstinence, and Project Fresh Air (PFA), which demonstrated efficacy in reducing in-home smoking and children’s tobacco smoke exposure (TSE) using residential air monitors that continually assessed indoor air quality and immediately provided feedback upon detection of elevated air particulate levels. Given that most unregulated smoking occurs in smokers’ homes and evidence that SFH adoption relates to long-term abstinence, TRAQ to Quit aims to bolster the KiSS trial’s limited home-level intervention components with a PFA-inspired, potentially powerful IoT home monitoring system. We will enroll 272 parent/caregiver smokers referred from safety-net pediatric health systems serving low-income areas. A 2-group randomized control trial design will be conducted with measures collected at baseline, 8- (end of treatment), 12- and 24-weeks after the target quit date to compare: i.) KiSS Usual Care (KiSS-UC) to KiSS + the state-of-the art IoT system (KiSS+IoT). The feedback from the IoT system is expected to augment treatment effects on home-level determinants of smoking behavior change (i.e., knowledge/awareness of in-home exposure risk; motivation to protect children from exposure). Evidence suggests that among low-income smokers, such changes can improve SFH achievement, self-efficacy, home support for cessation, and the fostering of a supportive accountability dynamic, all of which are mediators of long-term abstinence in prior trials. More potent interventions are necessary to reduce tobacco-related morbidity and mortality in low-income communities. Our proposed strategy allows two public health priorities to be simultaneously addressed: i.) maximizing long-term smoking cessation success and ii.) reducing TSE for other household occupants, including children. If TRAQ-to-Quit is efficacious, it presents an innovative, potent and pragmatic pediatric system-initiated telehealth intervention model that could ultimately be disseminated via linkages between pediatric systems and large service providers (e.g. state quitlines).

Up to $650K
2031-05-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Transcriptional overload: unlocking a new anti-cancer paradigm by targeting DDX19A

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NCI - National Cancer Institute

PROJECT SUMMARY/ABSTRACT: A key problem in the treatment of cancer is targeting master transcription factors (TFs) that drive oncogenesis. Many malignancies are characterized by TFs that regulate aberrant epigenetic and gene expression programs. A phenomenon that has been observed in the regulation of malignant TFs is the necessity to restrain oncogenic TF activity in order to preserve cancer cell wellbeing. We have identified DDX19A as a top genomic dependency in Ewing sarcoma (ES), an aggressive bone malignancy driven by the fusion oncoprotein and potent TF EWSR1:FLI1 (EWS/FLI). Intriguingly, we have observed that loss of DDX19A leads to marked global upregulation of transcription, chromatin opening, and increase in enhancer binding by H3K27Ac in ES cells, suggesting that this RNA helicase is a crucial negative regulator of transcription in ES tumors. We have gone on, through chemical screening efforts, to develop seed compounds that selectively target DDX19A. The objective of this proposal is to examine the mechanism of action of DDX19A in ES, and to use medicinal chemistry optimization to develop small molecule probes with which to target this protein. Our central hypothesis is that DDX19A constrains transcription and epigenetic programs directed by EWS/FLI, and that the loss of DDX19A leads to toxicity from transcriptional overload subsequent cell death. Thus, we believe that DDX19A is a promising new target for therapeutic development. We will test this hypothesis in two parallel specific aims: 1) Interrogate how DDX19A regulates gene expression programs controlled by EWS/FLI, and 2) Develop potent and selective allosteric inhibitors of DDX19A. First, we will use state-of-the-art functional genomic, epigenomic, and proteomic approaches to examine how DDX19A activity is critical specifically in EWS/FLI-driven tumors. Next, we will rigorously interrogate how DDX19A regulates nascent transcription specific to ES. Next, we will use chemical biology methods to validate specific DDX19A engagement and functional modulation in ES cells. Through a hit-to-lead strategy, we will obtain inhibitors with optimized pharmacokinetic properties, which will serve as lead compounds for therapeutic discovery. We will test optimized compounds for efficacy using in vitro ES cell lines as well as in vivo in ES PDX models. Importantly, animal subjects are indispensable for establishing pre-clinical rationale for development of new targeted therapeutics. Specifically, animal subjects are the only available means to study in vivo pharmacokinetics, test dosing schedules/routes, examine pharmacodynamics (in tumor-bearing animals), and measure toxicities that may impact human patients. These studies are innovative as they combine extensive molecular biologic investigation with sophisticated chemistry approaches to target ES, an aggressive, difficult-to-treat malignancy. Our proposal is significant because it will expand our understanding of how cancer cells control oncogenic transcription in order to promote cell survival. Successful completion of these aims will provide proof-of-concept that de-repressing TF activity and initiating transcriptional overload is a viable strategy for treating TF-driven malignancies.

Up to $648K
2031-06-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Translational and cross-species studies of the impact of cannabis use and HIV on mitochondrial homeostasis in brain macrophages

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NIDA - National Institute on Drug Abuse

Summary/Abstract People with HIV (PWH) remain vulnerable to central nervous system complications (e.g., neurocognitive impairment) despite antiretroviral therapy (ART) that suppresses viral replication. While many etiologies of these complications exist, mitochondrial dysfunction and inflammation are consistently implicated yet seldom studied simultaneously. PWH also use cannabis more frequently than the general population and recent evidence by our group and others indicates that cannabis may protect PWH from mitochondrial damage by improving metabolic homeostasis and reducing inflammation through triggering receptor expressed on myeloid cells (TREM) 2. Moreover, this mechanism may be more important as PWH age, with the average age of PWH currently being >55. This proposed multidisciplinary, translational project will combine a clinical observational study with cellular and in vivo preclinical models to determine the effects of cannabis use on TREM2-mnediated changes in mitochondrial function in the brain in PWH. The preclinical models will include a) personalized ex vivo/in vitro modeling of mitochondrial toxicity in brain macrophages and neurons, and b) a mouse model for HIV-induced neurotoxicity (Eco-HIV) and age-related neuropathogenesis (TREM2*R47H). Using this multilevel approach, we will test the hypothesis that cannabis effects on TREM2-mediated changes in brain mitochondrial homeostasis vary based on patterns of use: moderate use will be associated with beneficial effects, due to the TREM2 promoting and anti-inflammatory properties of cannabis, but chronic daily use will have detrimental effects. In a cohort of aged (>50 years old) PWH across a range of cannabis use from naïve to daily users, we will measure in plasma and cerebrospinal fluid (CSF) a panel of biomarkers that reflect the mitochondrial homeostasis, TREM2 function, and inflammation. These readouts will be correlated with neurocognitive assessments and PET imaging for TSPO, a marker of neuroinflammation associated with mitochondrial function (Aim 1). We will model brain macrophages using personalized ex vivo cultures of monocyte derived microglia collected from Aim 1 study participants and culture these cells with neurons to identify mechanisms of mitochondrial dysfunction (Aim 2). Using a cross-species approach, we will investigate how different precise doses of cannabinoids interact with HIV and TREM2 variants to affect mitochondrial homeostasis in wild-type and TREM2*R47H mice infected with EcoHIV (Aim 3). This highly innovative, multidisciplinary research proposal is very likely to generate impactful translational knowledge regarding mechanisms of pathogenesis and guide future therapeutic interventions. With our combined clinical and pre-clinical expertise in HIV infection, substance abuse, imaging, and mitochondrial homeostasis, we are uniquely suited to perform the proposed research.

Up to $1.5M
2031-04-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Translational Gerontology and Geroscience Training Program

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NIA - National Institute on Aging

PROJECT SUMMARY The rapid aging of the global population presents a significant societal challenge, with an increasing number of older adults experiencing chronic diseases that compromise their health-span despite advances in medical technologies. This paradox results in substantial economic burdens due to lost productivity and healthcare expenditures. To address this, there is a critical need for strategies that enhance health-span, enabling older adults to maintain functional abilities, independence, and quality of life. The proposed Translational Gerontology and Geroscience (TG2) Training Program at the University of Alabama at Birmingham (UAB) aims to develop the next generation of interdisciplinary, aging-focused scientists. This program will support 5 predoctoral and 3 postdoctoral trainees; providing them with collaborative, interdisciplinary mentoring and comprehensive research training. The goal is to inspire and develop dedicated, motivated, and well-trained scientists capable of tackling society’s big challenges in the field of aging. TG2 will emphasize bidirectional training to create an interdisciplinary experience that addresses physical, mental, and social aspects of health necessary for healthy aging. The program will leverage an exceptionally rich institutional environment that offers a robust infrastructure in aging research, including NIA P30 awards for an Alzheimer’s Disease Research Center, Nathan Shock Center in the Basic Biology of Aging, and Resource Center for Minority Aging Research; as well as one of four McKnight Brain Institutes sites and a VA Geriatric Research, Education, and Clinical Center (GRECC). The program integrates 40+ faculty from five UAB Schools and Colleges (Medicine, Arts & Sciences, Nursing, Optometry, Health Professions) and includes established, independent investigators with strong mentoring history as well as rising stars in the aging field who will be part of our Mentoring on Mentoring Program. Together the trainee, mentor, and a Translational Mentoring Team will craft an individual development plan that includes coursework, laboratory and clinical research, professional development programs, workshops, presentations locally and at national meetings, and training in the responsible conduct of research. Overall, the program will build and develop a multidisciplinary cohort of scholars that will support, learn from, and challenge one another to think critically about how to address the complex challenges of aging and how to develop successful careers in gerontology and geroscience.

Up to $218K
2031-06-30
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

U.S. Embassy Bogota PAS Annual Program Statement

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U.S. Mission to Colombia

PAS Bogota invites proposals for programs that strengthen societal and cultural ties, shared values, and bilateral cooperation between the United States and Colombia in support of U.S. Embassy Strategic Goals. All programs must include a U.S. cultural or educational element or connection with American expert/s, organization/s, or institution/s in a specific field that will promote increased understanding of U.S. policy and perspectives, and build partnerships between our citizens. Examples of PAS Small Grants Program programs include, but are not limited to: Academic and professional lectures, seminars and speaker programs; Artistic and cultural workshops, joint performances, and exhibitions; Awareness-raising programs on the challenges persons with disabilities face accessing the democratic process, including the lack of reasonable accommodations and information to exercise their political rights. Cultural heritage conservation and preservation programs; Policy advocacy programs that promote and advance the human rights of historically underserved and marginalized groups such as Afro-Colombians, Indigenous, lesbian, gay, bisexual, transgender, queer, and intersex (LGBTQI+), persons with disabilities, and persons otherwise adversely affected by persistent inequality. Workshops to strengthen networks of U.S. government (USG) programs alumni, CSO/NGO networks, entrepreneurial networks, and/or educational groups. Priority Program Areas: The Embassy s Cultural and Educational Grants Program supports U.S. Mission Bogota s strategic objective of enhancing opportunities for citizen participation in support of peace through cultural and educational program and advances the diversity, equity, inclusion, and accessibility (DEIA) and climate and environment priorities. Diversity, Equity, Inclusion, and Accessibility (DEIA) Disability Rights: o Projects that advance the rights of persons with disabilities, build capacity of organizations that advocate for enforcement and effective implementation of disability-inclusive legislation and policies, and promote democracy and political participation of persons with disabilities, among others. o Projects focused on improving access to educational opportunities for persons with disabilities. LGBTQI+: o Policy advocacy programs that advance the rights of lesbian, gay, bisexual, transgender, queer, and intersex (LGBTQI+) persons, including efforts to safeguard LGBTQI+ youth from harmful practices (e.g., so called conversion therapy ). o Programs that improve the quality of investigative journalism and transparency, increase awareness of the impact of stereotypical and biased reporting on LGBTIQI+ persons and women, and help counter disinformation. Climate and Environment Environmentally-focused activities addressing the climate crisis, combating wildlife trafficking, fostering resilience, conserving nature, water security, and reducing harmful pollutants, including, but not limited to, awareness raising campaigns, leadership, or capacity-building training workshops for youth and underserved communities, a recycled art installation or competition, among others. In addition to the outlined priority program areas, the Public Affairs Section may give consideration to project proposals focusing on the following topics: Science, Technology, Engineering, Arts, and Mathematics (STEAM) Economic empowerment of women, girls, Afro-Colombians, Indigenous communities, the Venezuelan diaspora, LGBTQI+ persons, and other underserved populations. Any other initiatives supporting Colombia s transition to a sustainable and inclusive peace. Project proposals managed by teams of U.S. government (USG) program alumni or designed to strengthen the USG alumni network in Colombia are highly desirable and will be given priority.

$5K – $15K
rolling
other

Free to search & build · $99 one-time to unlock the application pack · No subscription

U.S. Embassy Jerusalem Public Diplomacy Annual Program Statement

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U.S. Mission to Israel

U.S. Embassy Jerusalem s Public Diplomacy Section (PDS) announces an open competition to implement projects that advance U.S. economic, commercial, and security interests in Israel. This Annual Program Statement (APS) outlines strategic goals, expected outcomes, target audiences, eligibility criteria, and application guidelines for cooperative agreements ranging from $25,000 to $250,000, with a project duration of up to 12 months. Project proposals must address at least one of the following goals: 1. Advance U.S. economic interests and technological leadership 2. Counter malign influence and promote free speech 3. Promote President Trump s 20-point Peace Plan 4. Advance U.S. interests through American arts and culture 5. Engage alumni networks to advance U.S. interests In addition to aligning with one of the strategic goals, applicants should clearly explain how they advance American leadership and excellence and how the projects deliver measurable results. This APS seeks to partner with eligible entities, including not-for-profit organizations, education institutions, or individuals to achieve these goals. Please read the entire APS package before submitting an application. Applications must be submitted by July 22, 2026, for projects beginning as early as September 1, 2026. For more information, contact TelAvivGrants@state.gov. Applications that do not meet the eligibility criteria and do not contain all of the required information will not be considered.

$25K – $250K
2026-07-22
other

Free to search & build · $99 one-time to unlock the application pack · No subscription

U.S. EMBASSY TO LIBYA PAS ANNUAL PROGRAM STATEMENT

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U.S. Mission to Tunisia

U.S. DEPARTMENT OF STATE U.S. EMBASSY TO LIBYA, PUBLIC AFFAIRS SECTION Notice of Funding Opportunity (NOFO) Funding Opportunity Title: U.S. Embassy to Libya PAS Annual Program Statement Funding Opportunity Number: PAS Tripoli FY2024 CFDA Number: 19.040 Public Diplomacy Programs Maximum for Each Award: $25,000 USD PROGRAM DESCRIPTION The U.S. Embassy Tripoli Public Affairs Section (PAS) is pleased to announce that funding is available through its Public Diplomacy Small Grants Program. This is an Annual Program Statement, outlining our funding priorities, the strategic themes we focus on, and the procedures for submitting requests for funding. Please carefully follow all instructions below. The objectives of the Public Diplomacy Grant Program are to build capacity and community, promote social good, and enhance mutual understanding between the people of Libya and the United States. The U.S. Embassy to Libya is seeking projects that: Capitalize on arts initiatives to increase unity, social cohesion, and reconciliation that deepen Libyan national identity and are consistent with U.S. values. Promote leadership, positive community engagement, volunteerism, entrepreneurship, and soft skills development among youth, women, and underserved communities. Increase Libyan youth capabilities to help them explore and develop technological solutions for social problems through Science, Technology, Engineering, Arts, and Math (STEAM) programs. Projects that address environmental challenges to mitigate the effects of climate change are highly encouraged. Note: Alumni of U.S. Government funded exchange programs are encouraged to apply. Initiatives that support diversity and inclusion of minority groups and link with U.S. universities or organizations are also welcome. Additional information on this link: https://ly.usembassy.gov/notice-of-funding-opportunity-nofo/

$500 – $25K
rolling
community development

Free to search & build · $99 one-time to unlock the application pack · No subscription

U.S. Mission in Morocco

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U.S. Mission to Morocco

The U.S. Mission in Morocco s Public Affairs Office (PAO) is pleased to announce that funding is available through the Public Diplomacy Grant Program for projects ranging in value from $5,000 to $25,000. Projects for lesser or greater values will be considered on a case-by-case basis. The objectives of the Public Diplomacy Grant Program are to promote positive relations between Morocco and the United States; reinforce shared values; and connect Morocco s emerging leaders to the American people through projects that: Strengthen understanding of U.S. values and institutions; highlight U.S. culture, including American Studies, English language teaching/learning, and study in the United States; and support diversity, acceptance of minority groups, and other areas of mutual interest. Help Moroccan youth explore and discover their potential through innovative science, technology, engineering, arts, and math (STEAM,) programs, as well as entrepreneurship programs. Encourage Moroccan youth to participate in civic life through social entrepreneurship, volunteerism, and community engagement. APPLICATION PROCESSApplication DeadlinesApplications will be reviewed three times during Fiscal Year 2020. The deadlines for application are:Round 1: November 30, 2019Round 2: March 31, 2020Round 3: June 30, 2020Proposal FormatTo apply, please complete these forms in English:The Project Narrative (DOC 47 KB)The Budget Proposal (XLSX 22 KB)SF424 (Application for Federal Assistance Must be signed) (PDF 265 KB)SF424A (Budget Information) (PDF 1 MB)SF424B (Assurances Must be signed) (PDF 70 KB)Submit all forms in electronic format to: Rabatgrants@state.gov

$5K – $25K
rolling
other

Free to search & build · $99 one-time to unlock the application pack · No subscription

U.S. Talent Program for the U.S. Embassy and Consulates in Canada

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U.S. Mission to Canada

The U.S. Department of State s Embassy Ottawa announces an open competition to implement a program to connect U.S. citizen talent, including subject matter experts, artists and cultural professionals, and current and former American athletes and coaches, with Canadian audiences and institutions on topics of strategic importance to the United States. Recipients should be prepared to identify and recruit U.S. citizen experts in the following strategic areas, in addition to arts, cultural, and sports experts that showcase American excellence: U.S. prosperity and economic security (e.g. supply chains; digital policy; trade; transboundary water issues, etc.). Defense (e.g. defense spending, procurement; NORAD modernization; Arctic domain awareness and deterrence, etc.). Border security (e.g. combatting illegal trafficking, smuggling, migration, etc.). Freedom of speech (e.g. exposing censorship, promoting transparency etc.). Artificial Intelligence (e.g. promoting American AI exports, building enabling infrastructure, countering foreign influence in emerging technologies, etc.).Programs will be conducted in-person and/or through virtual platforms. The proposal should outline how the grantee would address both options. In-person programs will generally range from two days to one week in length. Virtual programs will usually take place on a single specified date and time and may be part of a continuing series. U.S. talent will address topics identified by the U.S. Mission to Canada that will advance Administration and U.S. Mission to Canada strategic goals.

$100K – $200K
2026-07-31
other

Free to search & build · $99 one-time to unlock the application pack · No subscription

U.S. Talent Program for the U.S. Embassy and Consulates in Canada

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U.S. Mission to Canada

<p>The U.S. Department of State’s Embassy Ottawa announces an open competition to implement a program to connect U.S. citizen talent, including subject matter experts, artists and cultural professionals, and current and former American athletes and coaches, with Canadian audiences and institutions on topics of strategic importance to the United States. Recipients should be prepared to identify and recruit U.S. citizen experts in the following strategic areas, in addition to arts, cultural, and sports experts that showcase American excellence:</p><p>·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;U.S. prosperity and economic security (e.g. supply chains; digital policy; trade; transboundary water issues, etc.).</p><p>·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Defense (e.g. defense spending, procurement; NORAD modernization; Arctic domain awareness and deterrence, etc.).</p><p>·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Border security (e.g. combatting illegal trafficking, smuggling, migration, etc.).</p><p>·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Freedom of speech (e.g. exposing censorship, promoting transparency etc.).</p><p>·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Artificial Intelligence (e.g. promoting American AI exports, building enabling infrastructure, countering foreign influence in emerging technologies, etc.).</p><p>Programs will be conducted in-person and/or through virtual platforms. The proposal should outline how the grantee would address both options. In-person programs will generally range from two days to one week in length. Virtual programs will usually take place on a single specified date and time and may be part of a continuing series. U.S. talent will address topics identified by the U.S. Mission to Canada that will advance Administration and U.S. Mission to Canada strategic goals.</p><p><br></p>

$100K – $200K
2026-07-31
otherArts & Culture

Free to search & build · $99 one-time to unlock the application pack · No subscription

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