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Substance Abuse and Mental Health Services Adminis

The purpose of this program is to support a comprehensive, public health, and evidence-based approach for colleges and universities that: improves access to behavioral health services for all college students, including those at risk for suicide, depression, serious mental illness, and substance use disorders that can lead to school failure; prevents and reduces suicide, mental health and substance use disorders; promotes student help-seeking behaviors and reduces stigma; improves the identification and treatment of at-risk college students.Note: At least six awards will be made to junior/community colleges pending adequate application volume.

National Institutes of Health

In 1999, at the direction of Congress, the National Institute on Aging (NIA), in conjunction with the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH), and the National Institute of Nursing Research (NINR) embarked on the Alzheimer's Disease (AD) Prevention Initiative. An important part of the AD Prevention Initiative is to quicken the pace for translating basic science findings into clinical trials to evaluate treatment and prevention strategies. This Funding Opportunity Announcement (FOA) focuses on AD drug discovery while companion FOAs are targeted to AD drug development and AD pilot clinical trials. In this FOA, participating institutes invite qualified researchers to submit research grant applications directed toward the discovery, development, and preclinical testing in cellular, tissue, and animal models of novel compounds for the prevention and treatment of the cognitive impairment and behavioral symptoms associated with Alzheimer's disease (AD). Applications submitted to the NIH will be assigned and reviewed according to the usual NIH peer review procedures. Meritorious applications will be funded by the assigned NIH Institutes or co-funded by the assigned NIH Institute and the Institute for the Study of Aging (ISOA). NIA has set-aside $3.0 Million total costs in FY 2006 for applications sent in response to this PA. -This FOA will use the NIH Exploratory/Developmental Grant (R21) award mechanism. -The R21 is intended to encourage exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. -All investigator-initiated exploratory/developmental grant applications described in this announcement will be assigned to participating ICs according to standard PHS referral guidelines and specific program interests. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -Project Period and Award Levels: The applicant may request a project period of up to two years with a combined budget for direct costs of up to $275,000 for the two-year period. -Eligible organizations: For-profit organizations; Non-profit organizations; Public or private institutions, such as universities, colleges, hospitals, and laboratories; Eligible agencies of the Federal government; Units of State government; Units of local government; Domestic Institutions; and Foreign Institutions. -Eligible Project Directors/Principal Investigators (PD/PIs): Any individual with the skills, knowledge and resources necessary to carry out the proposed research, is invited to work with his/her institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. -An R21 is not renewable. -Applicants may submit more than one application, provided they are scientifically distinct.

Substance Abuse and Mental Health Services Adminis

Grants to Expand Substance Use Disorder Treatment Capacity in Adult and Family Treatment Drug Courts

Substance Abuse and Mental Health Services Adminis

The purpose of this program is to expand substance use disorder (SUD) treatment and recovery support services in existing drug courts. Grant recipients will be required to implement a coordinated, multisystem approach that combines the legal authority of treatment drug courts with evidence-based SUD treatment services.IMPORTANT NOTE: SAMHSA will accept and review only the first 50 complete, successfully submitted, and high-quality applications received via eRA. Once this threshold is met, the submission portal will close, and no further applications will be considered.

NHLBI - National Heart Lung and Blood Institute

Project Summary Sudden, life-threatening cardiac events can be terrifying experiences that can trigger the onset of posttraumatic stress disorder (PTSD). PTSD symptoms are common after cardiac events, with over 1 in 5 patients receiving implantable cardioverter defibrillators (ICDs) for prevention of life-threatening arrhythmias and sudden cardiac arrest exhibiting elevated PTSD symptoms. Cardiac disease-induced PTSD symptoms are associated not only with worse mental health but a worse clinical prognosis, including poorer quality of life (QoL), greater disability, and greater risk of event recurrence and/or all-cause mortality. Further, cardiac-focused anxiety sensitivity—a unique aspect of cardiac disease-induced PTSD—is linked to worse health, medical reassurance seeking, and greater healthcare utilization. However, evidence-based interventions for these cardiac-induced psychological presentations are lacking. This R34 proposal will draw from existing, evidence-based psychotherapies to develop a streamlined intervention that addresses cardiac trauma-related fear and cardiac-focused anxiety sensitivity— two key manifestations of PTSD after cardiac events that relate to adverse outcomes and are direct targets of gold standard, exposure-based interventions for PTSD and panic disorder. Trauma-focused exposure reduces trauma-related fear and interoceptive exposure reduces anxiety sensitivity, but neither intervention has been tested in patients with cardiac trauma. After initial intervention development (Stage Ia), a pilot randomized controlled trial (RCT) will be conducted (Stage Ib), in which patients with ICDs (N=70) from the UCLA Cardiac Arrhythmia Center will be randomized to 1) the trauma and anxiety sensitivity exposure-based treatment, called Cardiac Fears Treatment (CFT), or 2) standard supportive therapy (treatment as usual [TAU]). Participants will be assessed at pre-treatment, several periods throughout treatment, post-treatment, and a 6-month follow-up. In Aim 1, we will develop the CFT intervention using an iterative approach, guided by prior research and qualitative interviews with key stakeholders (e.g., cardiology experts), and pilot testing in a small (N=8) open trial of patients with ICDs will yield initial feasibility and acceptability data. Subsequent aims will analyze data from the pilot RCT, generating additional feasibility and acceptability data, along with preliminary efficacy information. In Aim 2, we will compare CFT to TAU on psychological responses (self-report and behavioral task measures of cardiac trauma-related fear and cardiac-focused anxiety sensitivity). Aim 3 will compare CFT to TAU on health- related outcomes (health-related QoL and healthcare utilization). Finally, in Aim 4, we will explore whether key psychological processes targeted in the intervention (cardiac trauma-related fear and cardiac-focused anxiety sensitivity) mediate change in health-related outcomes. By targeting key psychological processes associated with adverse outcomes after a cardiac trauma, this mechanism-focused study has the potential to improve the emotional and physical health of cardiac patients and will generate critical feasibility, acceptability, and preliminary efficacy data needed to inform a grant proposal to test a refined version of CFT in a larger RCT.

The Headstrong Project

Grants for barrier-free mental health treatment for post-9/11 veterans with PTSD and related conditions.

National Institutes of Health

<p>Forty to sixty percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to support 11 unique clinical trials to test novel interventions for the management of co-occurring chronic pain and OUD at the patient-level. The current NOFO will develop strategies to address barriers to the sustainable and effective delivery of integrated OUD/pain care at the health systems level. IMPOWR identified patient interventions that were effective and ready to implement. The current NOFO will address how health systems could be improved to facilitate the use of effective integrative interventions, including the involvement and roles of peer specialists, clinicians, health system leaders and other key decision makers.&nbsp;Also, this NOFO will characterize where such care can be optimally and efficiently delivered. Studies will identify collaborative care models, implementation strategies, and other innovative health system approaches to meaningfully integrate CP and OUD service provision in health settings. These studies will address complex factors that influence the ability to scale and sustain effective collaborative and integrated care for pain and OUD.&nbsp;</p><p><br></p><p>The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of chronic pain management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO.</p>

National Institutes of Health

Forty to sixty percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to support 11 unique clinical trials to test novel interventions for the management of co-occurring chronic pain and OUD at the patient-level. The current NOFO will develop strategies to address barriers to the sustainable and effective delivery of integrated OUD/pain care at the health systems level. IMPOWR identified patient interventions that were effective and ready to implement. The current NOFO will address how health systems could be improved to facilitate the use of effective integrative interventions, including the involvement and roles of peer specialists, clinicians, health system leaders and other key decision makers. Also, this NOFO will characterize where such care can be optimally and efficiently delivered. Studies will identify collaborative care models, implementation strategies, and other innovative health system approaches to meaningfully integrate CP and OUD service provision in health settings. These studies will address complex factors that influence the ability to scale and sustain effective collaborative and integrated care for pain and OUD. The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the RM1 activity code. Investigators with expertise and insights into this area of chronic pain management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO.

National Institutes of Health

40-75% percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to test novel interventions for the management of co-occurring CP and OUD at the patient level. This initiative will test different implementation strategies and other approaches to address scalability and sustainability of evidence based practices for CP and OUD from a health system perspective. Studies will engage key decision leaders in health systems including but not limited to: peer specialists, clinicians, health system leaders, and payers. Studies will execute a single hybrid II/III implementation-effectiveness trial to focus on collaborative care models and implementation strategies to meaningfully integrate CP and OUD service provision in diverse health settings. These studies will address complex factors that influence the ability to scale and sustain effective and integrated care for CP and OUD. The BEACON Center will provide: (1) network coordination support, (2) capacity building at the intersection of CP, OUD, and implementation science, (3) annual surveys/qualitative activities to understand different barriers and attitudes impacting access and sustained use to integrated CP and OUD service delivery, (4) develop important resources for key stakeholder audiences that can inform/improve sustainability and scalability of evidence-based practices.The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U2C activity code. Investigators with expertise and insights into this area of CP management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO. Grant authorities that allow NIDA to forecast this opportunity are as follows: 42 U.S.C. 241 and 284.

National Institutes of Health

<p>40-75% percent of individuals with opioid use disorder (OUD) have co-occurring chronic pain (CP), which impacts their ability to fully engage in treatment. Effective management of both conditions is hindered by siloed medical disciplines and health systems. HEAL Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR) was funded in FY21 to test novel interventions for the management of co-occurring CP and OUD at the patient level. This initiative will test different implementation strategies and other approaches to address scalability and sustainability of evidence based practices for CP and OUD from a health system perspective. Studies will engage key decision leaders in health systems including but not limited to: peer specialists, clinicians, health system leaders, and payers. Studies will execute a single hybrid II/III implementation-effectiveness trial to focus on collaborative care models and implementation strategies to meaningfully integrate CP and OUD service provision in diverse health settings. These studies will address complex factors that influence the ability to scale and sustain effective and integrated care for CP and OUD. The BEACON Center will provide: (1) network coordination support, (2) capacity building at the intersection of CP, OUD, and implementation science, (3) annual surveys/qualitative activities to understand different barriers and attitudes impacting access and sustained use to integrated CP and OUD service delivery, (4) develop important resources for key stakeholder audiences that can inform/improve sustainability and scalability of evidence-based practices.</p><p>The National Institute on Drug Abuse (NIDA) in partnership with National Institute on Alcohol and Alcoholism (NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Mental Health (NIMH), and National Center for Complementary and Integrative Health (NCCIH), and National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the effective management of OUD and CP. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U2C activity code. Investigators with expertise and insights into this area of CP management and OUD/opioid misuse are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in community-based participatory research approaches, implementation science, and other strategies to amplify scalability and sustainability will be encouraged and, these investigators should also begin considering applying for this NOFO. Grant authorities that allow NIDA to forecast this opportunity are as follows: 42 U.S.C. § 241 and § 284.</p>

Heal The Hood Committee

The Marvin Thomas Memorial Fund requests Neighborhood Matching Funds to host five community events from November 2024 to October 2025, promoting engagement among underrepresented groups, non-native English speakers, and communities of color in King County, specifically Southeast Seattle residents who have some of the highest poverty rates and the largest percentage of low-income residents in Seattle. These free, inclusive events will strengthen community connections, raise awareness of health disparities, and celebrate local culture. Events include a basketball tournament, a community BBQ, a back-to-school supply giveaway, a cancer awareness event honoring local heroes, and a senior storytelling and basket giveaway. All events will be held in Seattle encouraging relationship building and physical, mental, and social well-being.

Health Canada

Grants for community-based mental health promotion, substance use prevention, and harm reduction programs across Canada.

NIDA - National Institute on Drug Abuse

PROJECT SUMMARY Alcohol, tobacco, and other drug use (ATOD), sexual health risks, and postpartum depression (PPD) are common and significant interrelated factors that are associated with poor health consequences for pregnant women and their infants, especially among rural, under-resourced communities. Thus, there is an urgent need to simultaneously address these health risks together during this vulnerable time. While pregnancy has been recognized as a window of opportunity in which to intervene, there are no empirically supported interventions tailored to specifically address these growing public health concerns together in rural women during pregnancy and postpartum. The objective of this R01 study is to fill this critical gap by building upon our promising R21/R01 findings by (1) partnering with a community advisory board to adapt and optimize the existing Health Check-up for Expectant Moms (HCEM) web-delivered Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) program to include the interconnected risks of tobacco use and postpartum depression (PPD) among rural pregnant women (herein referred to as HCEM+), and (2) testing the efficacy of the HCEM+ in reducing ADOT, STI, and PPD risk more than a time and information matched control condition in rural pregnant women seeking prenatal care. This research addresses cross-cutting priorities in line with NIDA’s Strategic Plan to advance science on drug use: (1) prioritizing research to combat stigma and improve engagement in treatment, (2) developing and enhancing culturally responsive and tailored interventions, and (3) delivering care for substance use and co-occurring health conditions such as STIs and mental illness. We propose a two-group, randomized controlled trial in which a sample of 250 high-risk rural pregnant women attending prenatal care will be assigned to either (a) a web-delivered, two-session SBIRT/P plus two booster sessions consistent with motivational interviewing and informed by the Information-Motivation-Behavior (IMB) model, the HCEM+, or (b) a web-delivered control condition. Web-delivered follow-up assessments will occur at 8 and 24 weeks antenatally, and at 6 weeks postpartum, extending outcomes to the postpartum period. Specific Aim 1 is to test the hypothesis that HCEM+, compared to an attention, time and information matched control condition, will reduce unprotected sexual occasions and ADOT use among at-risk pregnant women during pregnancy at 2 and 6-months follow-up, and will increase treatment engagement. Specific Aim 2 is to test the hypothesis that HCEM+, compared to control, will reduce STIs and ADOT use at 6 weeks postpartum and will result in better birth outcomes and reduced rates of PPD. An economic evaluation of the costs of the HCEM+ will occur to guide future implementation and dissemination. Results of this program of research are expected to inform the development of a practical, cost-effective, high-reaching web-delivered SBIRT/P program tailored to reach high-risk rural and under-resourced women with extended impact to the postpartum period.

National Institutes of Health

-Purpose. The purpose of this Funding Opportunity Announcement (FOA) is to invite grant applications for biological, behavioral, social, addictive, and mental health research related to the health of lesbian, gay, bisexual, transgender, intersex, and other diverse populations. Proposed research should be appropriate for the missions of one or more of the participating Institutes. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Research applications that better fit under other award mechanisms, including the NIH Small Research Grant (R03) (see http://grants.nih.gov/grants/guide/pa-files/PA-06-180.html ), the NIH Academic Research Enhancement Award (R15) (see http://grants.nih.gov/grants/guide/pa-files/PA-06-042.html ), and the NIH Exploratory/Developmental Research Grant (R21) (see http://grants.nih.gov/grants/guide/pa-files/PA-06-181.html) are encouraged to be submitted under those other mechanisms. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

State Treasurer's Office

Eligibility -Must be a health facility as defined in the Authority's Act (Section 15432(d) of the California Government Code) -Must be a non-profit 501(c)(3) corporation and qualify as a small or rural health facility or public health facility (e.g., district hospital) as defined in the Authority's Act (Section 15432(e) of the California Government Code)  -Small facilities must have annual gross revenues of $30 million or less (no revenue limit for rural facilities or district hospitals) -Must be licensed by the State of California, typically through the Department of Health Care Services, Public Health, or Social Services -Must have been in existence for at least three years, providing the same types of services -Must demonstrate evidence of discal soundness and the ability to meet the terms of the proposed loan -Facility must be certified, organized, maintained and operated for the diagnosis, care, prevention, and treatment of human illness, or physical, mental, or developmental disability, including convalescence and rehabilitation and including during care during and after pregnancy Use of Funds Funds may be used for: -Purchase, construction, renovation, or remodeling of real property -Purchase equipment and furnishings -Perform feasibility studies, site tests, and surveys associated with real property -Pay permit fees, architectural fees, and pre-construction costs -Refinancing existing debt Loan Terms -Minimum loan amount of $25,000 -Maximum loan amount of $1.5 million ($1 million for refinancing existing debt) -Interest rate of 3% (4% for refinancing existing debt) -Maximum loan maturity depends on use of funds.  Between 5 years for equipment and furnishings and 20 years for the purchase, construction and renovation of real property (15 years for refinancing existing debt) -Gross revenue pledge, as well as a lien on the equipment or property, is required -Maximum loan-to-value ratio of 95% -Borrowers must contribute a minimum of 5% (in the form of cash or documented project expenditures) toward project costs -Proforma debt service coverage of at least 1.0x Fees -$50 non-refundable application fee -Initial fee of 1.25% of the loan amount payable at closing -No ongoing program fees Required Documentation -Three most recent fiscal years of audited financial statements -Proof of adequate property and business insurance  

State Treasurer's Office

Eligibility -Must be a health facility as defined in the Authority's Act (Section 15432(d) of the California Government Code) -Must be a non-profit 501(c)(3) corporation and qualify as a small or rural health facility or public health facility (e.g., district hospital) as defined in the Authority's Act (Section 15432(e) of the California Government Code)  -Small facilities must have annual gross revenues of $30 million or less (no revenue limit for rural facilities or district hospitals) -Must be licensed by the State of California, typically through the Department of Health Care Services, Public Health, or Social Services -Must have been in existence for at least three years, providing the same types of services -Must demonstrate evidence of discal soundness and the ability to meet the terms of the proposed loan -Facility must be certified, organized, maintained and operated for the diagnosis, care, prevention, and treatment of human illness, or physical, mental, or developmental disability, including convalescence and rehabilitation and including during care during and after pregnancy Use of Funds Funds may be used for: -Purchase, construction, renovation, or remodeling of real property -Purchase equipment and furnishings -Perform feasibility studies, site tests, and surveys associated with real property -Pay permit fees, architectural fees, and pre-construction costs -Refinancing existing debt Loan Terms -Minimum loan amount of $25,000 -Maximum loan amount of $1.5 million ($1 million for refinancing existing debt) -Interest rate of 3% (4% for refinancing existing debt) -Maximum loan maturity depends on use of funds.  Between 5 years for equipment and furnishings and 20 years for the purchase, construction and renovation of real property (15 years for refinancing existing debt) -Gross revenue pledge, as well as a lien on the equipment or property, is required -Maximum loan-to-value ratio of 95% -Borrowers must contribute a minimum of 5% (in the form of cash or documented project expenditures) toward project costs -Proforma debt service coverage of at least 1.0x Fees -$50 non-refundable application fee -Initial fee of 1.25% of the loan amount payable at closing -No ongoing program fees Required Documentation -Three most recent fiscal years of audited financial statements -Proof of adequate property and business insurance  

FIC - John E. Fogarty International Center for Advanced Study in the Health Sciences

Healthy Choices is a four-session behavior change communication intervention that was developmentally tailored for emerging adults to address self-management of health behaviors and HIV with evidence of positive effect on stigma and depression, built on Motivational Enhancement Therapy, integrating Motivational Interviewing with brief cognitive-behavioral strategies. Healthy Choices can be delivered in community settings by trained community health workers. When delivered with fidelity and in adequate dose, Healthy Choices results in reductions in alcohol use, HIV stigma, viral loads, and depression over follow-up compared to standard care. In the Dominican Republic, stigmas harm young people with HIV (YPWH). The Dominican Republic is a low- to middle- income country in the Latin America and Caribbean region, is 1 of 5 countries that accounts for over 95% of Caribbean HIV infections and has a culture that perpetuates stigmatizing attitudes and behaviors toward YPWH. To our knowledge, there are no Spanish-language interventions that concurrently address mental health, viral suppression, and stigma, tailored for young adults who are in a developmental period marked by exploration and a need for autonomy in health decision making. Considering the need for stigma reduction among YPWH to improve rates of viral suppression, reduce poor mental health, and encourage healthy coping by reducing problem alcohol use, we propose to adapt Healthy Choices for Spanish with local contexts plus co-create implementation strategies with community advising for future scale up. We will pilot test the adapted intervention and proposed intervention strategies, using a community-led implementation approach for feasibility, acceptability, and to assess for a signal of potential effectiveness on continuum of care outcomes including antiretroviral adherence and viral load. Considering the importance of context and the community-orientation of this study, we will apply the Exploration, Preparation, Implementation, Sustainment (EPIS) implementation science model, focusing on the Exploration and Preparation phases. We will engage community-based organizations (CBO) and a clinic in the Dominican Republic that work extensively with YPWH. Our investigator team has a long history of successful collaboration with impact on public health policy in the Latin American and Caribbean region. We propose three aims: (1) Elucidate barriers and implementation strategies for the Healthy Choices intervention; (2) Adapt and culturally translate the intervention for local contexts, and (3) Pilot test Healthy Choices with implementation strategies for feasibility and acceptability. If successful, we will have preliminary data for a full-scale hybrid type 1 effectiveness implementation randomized controlled trial of the intervention for underserved Spanish-speaking YPWH in the Dominican Republic with potential relevance to Spanish-speaking groups in the United States.

Health and Human Services Department

Thanks to President Trump's leadership, since 2017, the country has made significant progress in addressing mental health and substance use. However, President Trump and HHS Secretary Kennedy realize that the Department and country have more work to do. To facilitate this effort, HHS invites public comment in response to this RFI on the research, development, programs, and policies that have been most successful in improving availability of and access to effective prevention, treatment, and recovery interventions for addiction, mental illness, and co-occurring substance use and mental disorders. The purpose of this RFI is to identify research, programs, and policies that have been successful and recommend novel policy ideas and gaps in research that could be addressed and implemented to further the Great American Recovery using existing funding.

National Institutes of Health

-Purpose. This purpose of this Funding Opportunity Announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop and commercialize technologies for high throughput data acquisition and analysis that could aid the research fields of basic behavioral science, neuroscience or neuroAIDS relevant to the missions of the National Institute of Mental Health (NIMH) and National Institute of Neurological Disorders and Stroke (NINDS). -Mechanism of Support. This FOA will utilize the SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-08-002, that solicits applications under the Small Business Technology Transfer (STTR) (R41/R42) grant mechanisms. -Funds Available and Anticipated Number of Awards. For this FOA, budgets up to $300,000 total costs per year and time periods up to 2 years for Phase I may be requested. Budgets up to $500,000 total costs per year and up to 3 years may be requested for Phase II. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

National Institutes of Health

-Purpose. This purpose of this Funding Opportunity Announcement (FOA) solicits Small Business Technology Transfer Program (STTR) grant applications from small business concerns (SBCs) that propose to develop and commercialize technologies for high throughput data acquisition and analysis that could aid the research fields of basic behavioral science, neuroscience or neuroAIDS, relevant to the missions of the National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS). -Mechanism of Support. This FOA will utilize the STTR (R41/R42) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with a FOA of identical scientific scope, PA-08-001, that solicits applications under the Small Business Innovation Research (SBIR) (R43/R44) grant mechanisms. -Funds Available and Anticipated Number of Awards. For this FOA, budgets up to $300,000 total costs per year and time periods up to 2 years for Phase I may be requested. Budgets up to $500,000 total costs per year and up to 3 years may be requested for Phase II. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

NIMH - National Institute of Mental Health

PROJECT SUMMARY / ABSTRACT Monitoring neuronal activity modulation is pivotal for elucidating brain functionality and addressing neurological disorders. Despite the advancements brought by green fluorescent calcium indicators like GCaMP and neuromodulator sensors, a considerable gap persists in the development of red fluorescent sensors that match the properties of their green counterparts. This gap, characterized by limitations in dynamic range, photostability, and kinetics, restricts a more comprehensive exploration of neuronal interactions, especially in multiplexed, dual-imaging imaging scenarios. Additionally, the iterative engineering approach for new sensor development is notoriously slow and labor-intensive. Our central goal is to leverage our sensor screening platform, Opto-MASS, as well as our recent successes in using machine learning to expedite the optimization of fluorescent sensors. This project aims to engineer red fluorescent calcium and neuromodulator sensors that match the kinetics and dynamic range of green sensors and further enhance their properties. Our objectives include the rigorous benchmarking of these sensors against the best-in-class for properties such as dynamic range, kinetics, and photostability, followed by comprehensive in vivo validation across multiple laboratories and application scenarios using fiber photometry and two and 3-photon imaging. Our project is innovative because it utilizes a high-throughput screening assay capable of evaluating over 10,000 sensor variants from library collections in under an hour, a significant advancement over current methods. Coupled with pioneering machine learning models that identify key residues affecting sensor performance, we will significantly accelerate fluorescent sensor development, particularly for red calcium and GPCR-based sensors. Importantly, we aim to achieve these goals while reducing time and resource commitments. Our project directly addresses critical needs outlined in this FOA, including a broader range of reliable sensors in neuroscience research that facilitate nuanced, multidimensional studies of brain activity. By developing sensors with improved dynamic ranges, kinetics, and photostability, we aim to overcome existing barriers to multiplexed imaging of neuronal dynamics in vivo. Ultimately, the successful completion of this project would not only fill a vital gap in neuroscientific research tools but also align with the NIH BRAIN Initiative's objectives to advance neurotechnology and set new standards for molecular tool development and in vivo validation in neuroscience.

NIMH - National Institute of Mental Health

Project Summary Region-specific brain organoids derived from human induced pluripotent stem cells (hiPSCs) provide a tractable platform to study disease mechanisms in a human cellular context. Moreover, organoids have the capacity to generate a diversity of cell types that can be maintained in culture long-term and assembled in vitro to form physiologically relevant connections. However, despite this exciting potential, the high variability of organoid differentiation across and within hiPSC lines have halted their broad utility and significantly hindered biological and technical interrogations of human neural development reproducibly and at scale. To address these challenges, this MPI group has established the Brain Organoid Hub at Emory University. A primary goal for the hub, and for this proposal, is to understand the underlying biology of progenitor cells that contribute to variability in 3D neural cultures. Additionally, we hope to develop metrics of hiPSC biology (molecular and/or morphological) that accurately predict the likelihood of successful organoid differentiation, as well as attributes of young organoids that correlate with robust molecular and functional maturation at later stages of culture. Towards this goal, we have designed three specific aims to test the hypothesis that progenitor cell states contain information about future differentiation potential. First, we will use molecular profiling of hiPSCs prior to their 3D formation to ask whether cell state heterogeneity and/or specific gene programs correlate with successful cortical organoid differentiation. Second, we will use machine learning-based approaches to ask whether morphological features of hiPSC growth dynamics are correlated with organoid success. Finally, we will address questions of organoid maturation, and ask whether molecular readouts of young organoids can predict successful functional maturation in late-stage organoid cultures. Altogether, these complimentary aims will not only (1) help reveal fundamental principles that contribute to variation in neurodevelopmental patterning, and (2) provide new assays for improving brain organoid reproducibility while avoiding costly and uninformative differentiations, but also 3) uncover novel biological insights into the genetic programs underlying neural cell specification and maturation. This knowledge could circumvent wasteful studies and instead lead to inclusion of additional biological replicates (hiPSC lines) in experiments. Importantly, our questions are deliberately crafted to align with the core objectives of the Brain Organoid Hub, to ensure reproducibility, efficient resource management, accessibility, and effective dissemination in the field of brain organoid cultures.

National Institutes of Health

-Purpose. This funding opportunity announcement (FOA) issued by the National Institute of Mental Health and National Institute on Drug Abuse invites grant applications from applicant organizations to advance scientific research and intervention regarding HIV treatment adherence. -Mechanism of Support. This FOA will utilize the NIH Small Research Grant (R03) mechanism and runs in parallel with FOAs of similar scientific scope, PA-07-338, which solicits applications under the Research Project Grant (R01) mechanism; PA-07-340, which solicits applications under the Exploratory/Developmental (R21) mechanism; and PAR-07-341, which solicits applications under the Exploratory Grants for Mental Health Interventions and Services (R34) mechanism. Please note that the participating organizations vary across this set of FOAs. -The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology.

National Institutes of Health

-Purpose. This funding opportunity announcement (FOA) issued by the National Institute of Mental Health, National Institute on Drug Abuse, and National Institute of Nursing Research invites grant applications from applicant organizations to advance scientific research and intervention regarding HIV treatment adherence. -Mechanism of Support. This FOA will utilize the NIH Exploratory/Developmental (R21) grant mechanism and runs in parallel with FOAs of similar scientific scope, PA-07-338, which solicits applications under the Research Project Grant (R01) mechanism; PA-07-339, which solicits applications under the under the Small Research Grant (R03) mechanism; and PAR-07-341, which solicits applications under the Exploratory Grants for Mental Health Interventions and Services (R34) mechanism. Please note that the participating organizations vary across this set of FOAs. -The R21 grant mechanism is intended to encourage exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.