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Waisman Center Intellectual and Developmental Disabilities Research Center

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NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

We seek continued support of the Waisman Center Intellectual and Developmental Disabilities Research Center, a comprehensive interdisciplinary program focused on IDD spanning the biological, behavioral, and biomedical sciences. The Waisman IDDRC brings together 61 PIs from 24 academic departments from the UW-Madison’s Schools of Medicine and Public Health, Veterinary Medicine, Agriculture and Life Sciences, Letters and Science, Education, Engineering, Social Work, and Human Ecology. This application requests support for an Administrative Core (Core A), providing scientific leadership, program and faculty development, facilitation of interdisciplinary collaboration, oversight of training programs, biostatistical and bioinformatics expertise; and dissemination of knowledges and best practices; and three innovative scientific core services: Clinical Translational (Core B), providing services, resources, and training in the recruitment of human participants, clinical research coordination/navigation, clinical assessment, behavioral methods development, and production of clinical grade biotherapeutics for use in clinical trials; Brain Imaging (Core C), providing access to state-of- the-art neuroimaging instrumentation for both human and animal studies (3T MRI, PET, and microPET scanners for human, non-human primate, and rodent scanning, an fNIRS, and an EEG recording system), as well as expertise and tools for image acquisition and analysis; and IDD Models (Core D), providing resources, expertise, and technical services in cellular and molecular neuroscience, the generation and manipulation of human pluripotent stem cell (hPSC) lines from humans with IDD conditions, as well as the generation and behavioral phenotyping of mutant or genetically engineered strains of mice and rats as models of IDD conditions. In addition, we request support for a Research Project that addresses a fundamental question on the emergence of ADHD symptoms in children with ASD, using a multidisciplinary approach that combines the power of neurobehavioral, brain imaging, statistical genomics, and machine learning analyses. We propose to provide core support to 59 research projects headed by 42 PIs addressing three broad themes relevant to IDD: 1) neurodevelopment and mechanisms, 2) disorders of the nervous system, and 3) assessments and interventions. Collectively the core services and the research project of the Waisman Center IDDRC will stimulate new interdisciplinary IDD research and enhance existing IDD investigations, with a sharp focus on discovery, prevention, and treatment for IDD conditions, and improvement of the quality of life of individuals with IDD and their families.

Up to $1.2M
2027-05-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

WASHINGTON CROSSING FKA WASHINGTON ARTS COLLECTIVE (SITE 2)

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WAC, L.P.

NEW CONSTRUCTION

Up to $2.1M
Rolling
artsinfrastructure

Free to search & build · $99 one-time to unlock the application pack · No subscription

Whole Body Redox Maps for Metastatic Cancer Therapy

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NCI - National Cancer Institute

Project Summary Antioxidants have been widely believed to offer protection against cancer. However, landmark studies involving 35,000 men revealed the opposite: antioxidants such as vitamin E daily supplements, significantly increased, not decreased, the risk of developing prostate cancer (PC). At the Trotman Lab, we pioneered oxidative cell death therapy of PC: by giving the pro-oxidant menadione to mice with natively growing lethal PC we discovered that it affords a potent and durable therapeutic response. This is in contrast to castration therapy in RapidCaP and in men, which invariably is followed by relapse of disease. Menadione, a precursor of dietary vitamin K, selectively kills prostate cancer cells through triaptosis while sparing healthy tissues. At the same time standard of care (SOC) therapy interventions against PC such as radio- and radioligand therapy or chemotherapy are known to exert oxidative stress. However, we still lack cell level organ maps that inform us about (1) native redox states of tissues, (2) redox states of tumors and their metastases, and (3) if and how these redox states are changed by therapy. To satisfy this need, we here propose to expand on the rigorous approach, developed by the Lyons lab, of using the natural protein degradation based sensing of redox stress for in vivo visualization. The strategy uses ROS-dependent degradation of a red channel protein that reports the redox stress, while a green channel reporter serves as internal reference. With these reporters, we will generate two complementary native and immune competent animal models that reveal whole body redox maps of prostate cancer: OxiGEM will harbor the redox reporter in the germline in the Rosa26 locus so that organs reveal cell based redox states as red to green channel ratios (Aim 1). RoxyCaP will be based on RapidCaP, where virus based somatic gene transfer changes a single normal prostate cell into a tumor initiator but now it will also contain the redox reporter. This will allow us to reveal the cell level redox state of tumors during indolence and contrast it with escape and metastatic spread of the cancer. To visualize these models, we use 3 complementary state-of-the art whole organ imaging techniques that also ensure compatibility with molecular and -omics analyses of the results. Collectively, our models will yield a fundamental understanding of whether or not metastatic tumor progression and its therapy are dictated by redox states.

Up to $794K
2031-07-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Wide-Bore 3T MRI System for Advancing Multidisciplinary Research

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OD - NIH Office of the Director

Project Summary/Abstract This application requests support for the acquisition of a United Imaging uMR Ultra 3T MRI scanner to be installed at the Imaging Research Center (IRC) at the University of California, Davis. The new system is urgently needed to address the severe overutilization of the IRC’s existing 3T scanner, which serves as the primary human imaging platform for a broad community of NIH-funded investigators. Current demand exceeds capacity, with wait times frequently surpassing three weeks, jeopardizing the feasibility and integrity of longitudinal, time- sensitive, and protocol-driven studies. The proposed Ultra 3T MRI system will alleviate this capacity bottleneck and expand access to cutting-edge neuroimaging and body imaging capabilities. The Ultra offers a 70 cm wide bore for improved participant comfort, state-of-the-art gradient performance (100 mT/m, 346 T/m/s), a 192-channel RF system, and an AI-powered reconstruction platform that enables accelerated, motion-robust, and high-resolution imaging. These features will support advanced functional, structural, diffusion, and perfusion imaging techniques, as well as emerging multi-nuclear and quantitative protocols. This shared instrument will support a diverse range of research projects spanning neuroscience, musculoskeletal imaging, kidney disease, metabolism, and pediatric studies. It will enable high-throughput, reproducible imaging in both single-site and multi-site settings, accelerating progress toward the health-related goals of more than 30 NIH-funded projects. UC Davis has demonstrated long-standing commitment to imaging research through sustained investment in infrastructure, faculty, and interdisciplinary collaboration. The IRC is staffed with experienced technical and administrative personnel and is fully equipped to support the operation of this new system. The Ultra 3T MRI will be managed as a shared resource with rigorous scheduling and oversight to ensure equitable access for all users. In summary, acquisition of the United Imaging Ultra 3T MRI scanner will resolve a critical capacity limitation, foster methodological innovation, and strengthen UC Davis’s leadership in translational and collaborative imaging science.

Up to $2M
2027-06-14
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

Winter Conference to Advance New Approach Methodologies (NAMs) in Chemosensory Science

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NIDCD - National Institute on Deafness and Other Communication Disorders

Conference Title: WINTER CONFERENCE TO ADVANCE NEW APPROACH METHODOLOGIES (NAMS) IN CHEMOSENSORY SCIENCE Chemosensory and interoception research still relies on animal models, despite the national momentum to reduce, refine, and replace in vivo testing. To accelerate the adoption of non-animal alternatives, we will convene an inaugural four-day conference (Jan 12-17, 2027, Monell Chemical Senses Center, Philadelphia, PA) that integrates lectures, interactive workshops, and networking sessions focused on in vitro, ex vivo, and in silico NAMs relevant to taste, smell, and interoception. This meeting, to be held annually (2027 to 2031), will bring together ~100 academic investigators, industry scientists, regulators, and trainees, including at least 30 early-career scholars, to create a cross-sector forum for exchanging best practices and catalyzing collaborations. Program elements include: 1. Plenary Sessions highlighting breakthroughs in organoid models (e.g., oral, nasal, gut), high- throughput receptor assays, and AI-enabled chemosensory prediction tools. 2. Hands-on NAM Workshops led by Monell and external experts, covering receptor-based assays and organoid model development, transitional models aimed at reducing animals in research (e.g., ex vivo, in ovo), direct human measures (e.g., behavioral, EEG and fMRI) and machine learning pipelines for data integration and modelling. 3. Regulatory & Ethics Panels featuring scientists on validation standards and pathways for scientific and regulatory acceptance. 4. Trainee Lightning Talks & Mentoring to foster presentation skills and career development. 5. Industry Roundtable with chemosensory scientists, food, fragrance, and biotech companies to identify appropriate NAM uses, translational gaps, and commercialization opportunities. By the conference’s end, participants will: (i) understand the state of the art in NAMs and their potential application for chemosensory and interoception research, (ii) acquire practical skills to incorporate NAMs into grant proposals and product development and testing pipelines, and (iii) contribute to a consensus white paper outlining research priorities, prime applications and validation needs. All slide decks and workshop protocols will be posted on an open-access website; abstracts will also be publicly available. Evaluation surveys will track knowledge gains and subsequent adoption of NAM. This information will be leveraged to invite early NAMs adopters to participate in the Winter Conference in years 2-5. R13 support will offset meeting logistics, trainee travel awards, captioning for accessibility, and post-meeting dissemination, ensuring broad reach and sustained impact across academia, industry, and federal agencies.

Up to $60K
2027-05-31
health research

Free to search & build · $99 one-time to unlock the application pack · No subscription

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