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U.S. Mission to Vietnam

<p><span style="color: black;">U.S. Mission Vietnam's Public Diplomacy Section seeks proposals to implement workforce development and innovation programs through American Spaces. This program builds a pipeline of skilled, English-capable Vietnamese youth who support U.S. trade, investment, and innovation partnerships while expanding economic opportunity in Vietnam.</span></p> <p><span style="color: black;">The project targets university students, educators, and early-career professionals (ages 18–40) in Hanoi, Thai Nguyen, Ho Chi Minh City and An Giang. Activities strengthen English proficiency and technology skills in artificial intelligence, coding, cybersecurity, and entrepreneurship.</span></p> <p><span style="color: black;">This program showcases American excellence in science, technology, and innovation -demonstrating how U.S. technological leadership and educational institutions create opportunity and drive progress. By connecting participants to U.S. networks, the program expands opportunities for American businesses, strengthens commercial ties, and reinforce U.S. strategic cooperation in Vietnam. Success includes stronger public-private partnerships, expanded participation in U.S. exchanges, improved English proficiency, and greater recognition of U.S. technological leadership among Vietnamese audiences.</span></p>

Bureau of Land Management

The Headquarters Bureau of Land Management (BLM) offices have collaborated with Qualified Youth Corps, as authorized by the Public Lands Corps Act (PLC), to accomplish natural and cultural resource-focused projects for numerous years. This program"s projects provide opportunities to gain work experience in public lands and natural resources management. Through their BLM experience, youth gain an appreciation for public lands, learn about natural resource management careers, and become the next generation of public lands stewards. The BLM Youth Program helps the agency accomplish projects across all program areas in support of the BLM"s multiple-use mission. The BLM Youth Program partners with qualified youth corps through the Public Lands Corp (PLC) Program to engage individuals between the ages of 16 and 30 (inclusive) and veterans up to age 35 (inclusive), including tribal members. The PLC program mandates employing youth who are interested in working on natural and cultural resource projects that protect public lands.Projects available under the PLC Program are developed in collaboration with the State Youth Program Lead and District/Field Office project coordinators. The projects emphasize hands-on engagement in on-the-ground projects, skill development training, and mentorship opportunities for participants. These projects create jobs that strengthen America"s economy and foster relationships with youth corps organizations striving for balanced stewardship and use of public lands.Proposed projects within this funding opportunity notice will support the goals of the PLC Program and may also incorporate the goals of the Indian Youth Service Corps Program through outreach to Indian tribes and tribal-serving youth corps organizations. Projects will include the following:Enhancement of recreation opportunities through trail building, maintenance and restoration, and other improvements to visitor and recreation facilities (e.g. kiosks, campgrounds, signage etc.).Monitoring riparian area vegetation and hydrological functions, collecting soil and stream data as well as timber stand improvement projects for wildlife habitat and overall forest health.Habitat restoration and wildlife protection, including reduction of invasive species, tree planting, fence removal/installation, riparian area restoration, etc.Development and implementation of natural and cultural resource stewardship plans or educational materials for visitors.Studies such as resource inventories, historic or archival research, archaeological excavation or stabilization, oral histories, historic preservation, habitat surveys, etc.Preservation of cultural resources, including historic structures.Seed collection for restoration of lands affected by natural disastersReduction of wildfire risk to communities, watersheds, and other public land ecosystems.Production of materials and programs on natural, cultural, and/or paleontological resources, communication, education, and interpretation of natural and cultural resources.In-house projects, such as cartography, records management, realty or wildland fire support, must demonstrate a clear benefit to natural or cultural resources and include a field component of at least 120 hours.

Bureau of Land Management

The Headquarters Bureau of Land Management (BLM) offices have collaborated with Qualified Youth Corps, as authorized by the Public Lands Corps Act (PLC), to accomplish natural and cultural resource-focused projects for numerous years. This program"s projects provide opportunities to gain work experience in public lands and natural resources management. Through their BLM experience, youth gain an appreciation for public lands, learn about natural resource management careers, and become the next generation of public lands stewards. The BLM Youth Program helps the agency accomplish projects across all program areas in support of the BLM"s multiple-use mission. The BLM Youth Program partners with qualified youth corps through the Public Lands Corp (PLC) Program to engage individuals between the ages of 16 and 30 (inclusive) and veterans up to age 35 (inclusive), including tribal members. The PLC program mandates employing youth who are interested in working on natural and cultural resource projects that protect public lands.Projects available under the PLC Program are developed in collaboration with the State Youth Program Lead and District/Field Office project coordinators. The projects emphasize hands-on engagement in on-the-ground projects, skill development training, and mentorship opportunities for participants. These projects create jobs that strengthen America"s economy and foster relationships with youth corps organizations striving for balanced stewardship and use of public lands.Proposed projects within this funding opportunity notice will support the goals of the PLC Program and may also incorporate the goals of the Indian Youth Service Corps Program through outreach to Indian tribes and tribal-serving youth corps organizations. Projects will include the following:Enhancement of recreation opportunities through trail building, maintenance and restoration, and other improvements to visitor and recreation facilities (e.g. kiosks, campgrounds, signage etc.).Monitoring riparian area vegetation and hydrological functions, collecting soil and stream data as well as timber stand improvement projects for wildlife habitat and overall forest health.Habitat restoration and wildlife protection, including reduction of invasive species, tree planting, fence removal/installation, riparian area restoration, etc.Development and implementation of natural and cultural resource stewardship plans or educational materials for visitors.Studies such as resource inventories, historic or archival research, archaeological excavation or stabilization, oral histories, historic preservation, habitat surveys, etc.Preservation of cultural resources, including historic structures.Seed collection for restoration of lands affected by natural disastersReduction of wildfire risk to communities, watersheds, and other public land ecosystems.Production of materials and programs on natural, cultural, and/or paleontological resources, communication, education, and interpretation of natural and cultural resources.In-house projects, such as cartography, records management, realty or wildland fire support, must demonstrate a clear benefit to natural or cultural resources and include a field component of at least 120 hours.

Gap Foundation

Invests in youth empowerment and workforce readiness programs for underserved young adults.

National Park Service

The Architect/Engineer intern will be assisting the Project Manager for the park, working on on-going design and construction projects; performing building condition assessment field work, assisting in organizing electronic drawings and records and reviewing and/or preparing future project proposals. The Landscape Architect intern will work for both the park s Chief of Facilities and the Chief of Cultural Resources to develop a post hurricane Sandy Landscape Preservation Treatment Plan for Jacob Riis Park located along the Rockaway Peninsula on the Atlantic ocean. The landscape features and buildings were severely impacted by Hurricane Sandy and are vulnerable to climate change. The intern will prepare a condition assessment and master plan to guide future landscape management for the 220 acre Jacob Riis Park. The Camping Education intern will work with the Ecology Village program at Floyd Bennett Field in Brooklyn, NY to expand school and youth group camping and participate in leadership training sessions, facilitate park based resource stewardship activities that introduce youth to the natural and cultural resources of the park. The Web Developer intern will work with the Business Management office to develop a public website highlighting historical assets of the park, including a digital catalog documenting interior and exterior building conditions, etc. The Web intern will work with other divisions in the park to gather information, documents, utilize other data already existing to incorporate into the website. The Management Analyst intern will work with the Facility Management division documenting, analyzing and evaluating existing and proposed processes and procedures, gathering, reviewing and summarizing data from financial asset management systems and tracking and organizing records related to the Facility Management program. The Safety and Occupational Health Intern reports to the park Safety Officer. Responsibilities include conducting safety and health workplace inspections for facilities, buildings and processes to evaluate compliance with safety regulations. Performs risk assessments, documents and/or prepares reports, assists staff in preparing Job Hazard Analysis for specific job tasks and updates Hazardous Chemical Inventories. The Vegetation Management Interns will report to the Chief of Natural Resources and assist in removing invasive non-native plants and tending new plantings of native species on Staten Island and at Jamaica Bay in New York. Interns will assist with fieldwork to advance restoration progress while gaining experience and specialized knowledge in natural resources stewardship. In addition, all eight of the interns will be provided park based training ranging from endangered species monitoring, resource protection and safety based operational leadership training.

Administration for Children & Families - ACYF/FYSB

<p>The Administration for Children and Families, Administration on Children, Youth and Families, Family and Youth Services Bureau announces the availability of funds under the Sexual Risk Avoidance Education (SRAE) Program.&nbsp; The purpose of the SRAE Program is to fund projects to implement sexual risk avoidance education that teach participants how to voluntarily refrain from non-marital sexual activity.&nbsp; The services are targeted to participants that reside in areas with high rates of teen births and/or are at greatest risk of contracting sexually transmitted infections (STIs). The goals of SRAE are to empower participants to make healthy decisions, and provide tools and resources to prevent pregnancy, STIs, and youth engagement in other risky behaviors.&nbsp; Successful applicants are expected to submit program plans that agree to: 1) use medically accurate information referenced to peer-reviewed publications by education, scientific, governmental or health organizations; 2) implement sexual risk avoidance curricula and/or strategies with an evidence-based approach to integrate research findings with practical implementation that aligns with the needs and desired outcomes for the intended audience; and 3) teach the benefits associated with self-regulation, success sequencing for poverty prevention, healthy relationships, goal setting, and resisting sexual coercion, dating violence, and other youth risk behaviors such as underage drinking or illicit drug use without normalizing teen sexual activity.</p>

Administration for Children & Families - ACYF/FYSB

The Administration for Children and Families, Administration on Children, Youth and Families, Family and Youth Services Bureau announces the availability of funds under the Sexual Risk Avoidance Education (SRAE) Program. The purpose of the SRAE Program is to fund projects to implement sexual risk avoidance education that teach participants how to voluntarily refrain from non-marital sexual activity. The services are targeted to participants that reside in areas with high rates of teen births and/or are at greatest risk of contracting sexually transmitted infections (STIs). The goals of SRAE are to empower participants to make healthy decisions, and provide tools and resources to prevent pregnancy, STIs, and youth engagement in other risky behaviors. Successful applicants are expected to submit program plans that agree to: 1) use medically accurate information referenced to peer-reviewed publications by education, scientific, governmental or health organizations; 2) implement sexual risk avoidance curricula and/or strategies with an evidence-based approach to integrate research findings with practical implementation that aligns with the needs and desired outcomes for the intended audience; and 3) teach the benefits associated with self-regulation, success sequencing for poverty prevention, healthy relationships, goal setting, and resisting sexual coercion, dating violence, and other youth risk behaviors such as underage drinking or illicit drug use without normalizing teen sexual activity.

generationOn

Funds youth-led service projects and service-learning programs.

NIDA - National Institute on Drug Abuse

PROJECT SUMMARY Early initiation of cannabis use (<16 years of age) increases risk for cannabis use disorder (CUD), mental illness, cognitive impairment, later unemployment, and poor social relationships. Prevention of early initiation is critical for improving social and health outcomes. Precision prevention programs have reduced youth substance use, but no approaches have specifically targeted cannabis use. Furthermore, no studies have comprehensively considered risk factors for early cannabis initiation (genetic, social, behavioral, environmental, and cognitive) to enhance the prediction of early use and inform precision prevention approaches. Comprehensive multivariable prediction models for early cannabis initiation that include genetics and social/environmental factors are needed. Cannabis use is polygenic, influenced by multiple genetic variants with weak-to-moderate effects, and polygenicity makes it difficult to translate genetics for clinical application. One method for clinically applying genetics is through the development of polygenic risk scores (PRS) that are composite scores representative of overall genetic risk. Prior PRS have typically lacked portability to non-European populations; however, a state- of-the-art method has been developed to build PRS with significantly improved risk prediction (34% improvement) across ancestries. There is a need to apply this method to develop cross-ancestry PRS for cannabis use for inclusion of overall genetic risk in comprehensive prediction models. Furthermore, given the complex interplay between genetics and social/environmental factors, research is needed to understand gene by environment (GxE) interactions in which social/environmental factors synergistically impact the risk conferred by genetics. Research into GxE interactions is statistically and computationally challenging, and traditional single-variant and more recent polygenic approaches focus on lower order 2-way interactions. Our logic forest (LF) algorithm efficiently searches all possible interactions up to 8 variables without a priori specification. This study will apply these state-of-the-art computational methods to the Adolescent Brain Cognitive Development (ABCD) Study, which examines childhood risk factors and initiation of substance use from ages 9-10 years to early adulthood in a population demographically reflective of the U.S. Nearly all youth had not used cannabis at recruitment, enabling the prospective measurement of initiation and the development of prediction models integrating genetics with pre-substance use measurements of cognitive, social, and environmental factors. This research will 1) develop cross-ancestry PRS for inclusion in prediction models that comprehensively consider genetic, sociodemographic, behavioral, cognitive, and environmental factors, and 2) apply LF to gene-sets within known biological pathways across the whole genome to identify pathway-specific GxE interactions. Comprehensive models coupled with a more complete understanding of GxE factors influencing early cannabis initiation can identify 1) high risk youth populations for targeted prevention, 2) targetable factors present among high-risk clusters for tailored interventions, and 3) biological pathways for therapeutic development.

Georgia Council for the Arts

Georgia Council for the Arts Arts Education grants support in-school and community arts education programs, artist residencies, and initiatives that bring arts experiences to Georgia students and youth.

GOWANUS CANAL CONSERVANCY INC

Youth ages 14-24 will create an environmental impact through stewardship in the Gowanus neighborhood and by engaging community members. They will gain environmental career awareness, skills and motivation to pursue environmental careers.

GOWANUS CANAL CONSERVANCY INC

Youth ages 14-24 will create an environmental impact through stewardship in the Gowanus neighborhood and by engaging community members. They will gain environmental career awareness, skills and motivation to pursue environmental careers.

GOWANUS CANAL CONSERVANCY INC

Youth ages 14-24 will create an environmental impact through stewardship in the Gowanus neighborhood and by engaging community members. They will gain environmental career awareness, skills and motivation to pursue environmental careers.

GOWANUS CANAL CONSERVANCY INC

Youth ages 14-24 will create an environmental impact through stewardship in the Gowanus neighborhood and by engaging community members. They will gain environmental career awareness, skills and motivation to pursue environmental careers.

National Park Service

Support and stimulate work and training opportunities for ranger corps interns to work with the visiting public, educating them about the park in various formats. This would include traditional ranger programs, education programs with youth and school groups, and developing their public communication skills through media projects throughout Great Basin.

National Park Service

A. Project Goals The goal of this Task Agreement is to support the development of the Groundwork Network of 20 community-based organizations across the country, which engage communities in the reuse brownfield and other derelict lands for recreation, conservation, economic development, and other community benefits. B. Project Objectives a. To support Groundwork USA in the development of the Groundwork Network through training, information sharing, networking, and technical assistance with projects that reuse brownfields for parks, trails, conservation areas, and other community amenities. b. To build the capacity of the Groundwork Network to coordinate community engagement and youth programming, Green Teams and Youth Corps, in a diversity of locations, including state and National Parks and other public lands. Green Teams and Youth Corps learn green job skills through their service learning experiences.

Fish and Wildlife Service

The purpose of this federal assistance is to restore and manage native habitat on federal lands, adjacent non-federal lands and areas of interest in support of the USFWS youth program located throughout the states of Wisconsin, Michigan, Iowa, Illinois and Minnesota. To accomplish this goal, the recipient intends to provide youth crews to restore both native grassland, oak savannas, wetland, riparian, and forest habitat; in addition to other stewardship services such as invasive species removal, hazardous fuel reduction, fence line removal, tree cutting and or planting, habitat mapping and installation of parking lots and gates to provide for and direct public access. These actions will help conserve and protect native plants and animals for not only their benefit, but also for the public good derived from such conservation efforts. Through the activities provided through this Agreement, the Service will be better able to manage grassland, wetland, riparian, forest and oak savanna habitat. Many of these activities will be projects completed by working side-by-side with Service staff in the field.

National Park Service

United States Department of the Interior, National Park Service (NPS) Notice of Intent to Award. This is not a request for applications. This posting is to provide public notice of NPS' intention to fund the following project activities: Task Agreement P17AC01597 under master Cooperative Agreement P15AC00049 with KUPU, for the project titled, "Haleakala National Park Youth Conservation Programs."

Center for Medicare and Medicaid Services

<p>The Health Equity Data Access program (HEDAP) provides funding for six (6) “seats” in the <a href="https://www.resdac.org/cms-virtual-research-data-center-vrdc" target="_blank">CMS Virtual Research Data Center (VRDC).</a> The VRDC assists researchers in gaining access to CMS restricted data for minority health research. Seats, in this context are defined as an individual user with VRDC access. These researchers will conduct health services research on health care topics such as physical health, oral health, behavioral health, population health, and social determinants of health focusing on, but not limited to, racial and ethnic minority groups; people with disabilities; members of the lesbian, gay, bisexual, transgender, and queer (LGBTQ+) community; individuals with limited English proficiency; individuals residing in rural areas; and individuals (including children, youth, and families) adversely affected by persistent poverty or inequality. The HEDAP supports specific applied research projects that relate to creative and innovative methods utilizing CMS data to identify, document, assess, and evaluate health disparities among Medicare and Medicaid and CHIP enrollees.&nbsp;</p> <p>&nbsp;</p> <p>The project should enhance the capacity of the researcher to understand and utilize CMS data in future research projects. Additionally, HEDAP encourages cutting-edge proposals that explore intersectionality. “Intersectionality” <a href="https://www.cdc.gov/healthcommunication/HealthEquityGuidingPrinciples.pdf" target="_blank">means that people belong to more than one group and, therefore, may have overlapping health and social inequities, as well as overlapping strengths and assets</a>.&nbsp;</p> <p>&nbsp;</p> <p>Results of the HEDAP will provide CMS and its partners, (e.g. Quality Improvement Organizations, Hospital Engagement Networks, and other stakeholders) with actionable information on the subgroups of enrollees. This will aid the efforts of CMS and its agents to identify and eradicate health disparities in underserved populations.&nbsp;</p> <p>&nbsp;</p> <p>VRDC seat access will be funded for a period of 36 months each, based on the availability of funds.</p> <p>&nbsp;</p>

Hershey Foundation

Funds youth development, education, and community programs in the Hershey, PA area and cocoa-growing communities.

Honda Foundation

Funds youth development, STEM education, and environmental programs through employee-driven community grants.

Hong Kong Jockey Club Charities Trust

One of the world's top charity donors (500M+ USD/yr). Supports youth, elderly, sports, arts, and community programs in Hong Kong.

National Park Service

This announcement is to provide public notice of the National Park Services intention to fund the following project activities without full and open competition to the Hoonah Indian Association for the amount of 166,464 to cooperatively complete the project described below. STATUTORY AUTHORITY: National Historic Preservation Act 16 USC 470a, as amended (PL-89-665.) STATEMENT OF JOINT OBJECTIVES/PROJECT MANAGEMENT PLAN: The objectives of this project are to complete a house screen to be displayed on the outside front of the Tribal House; to preserve ethnographic resources associated with the Huna Tlingit; to ensure that traditional skills and knowledge are passed from elders to youth; to interpret the project to the public as well as Hoonah community members; to document this and previous Tribal House cultural projects; and to complete a strategic plan for adorning the interior of the Tribal House. The house screen is a vital cultural component of the Huna Tribal House. Traditional Tlingit houses included carved and painted exterior screens as a means of identifying the affiliation of the residents and capturing their history and ancestral knowledge. HIA is the sole entity with the cultural expertise, traditional craftsmen skills, and cultural authority to complete the screen. Second, the completion of the screen will provide an opportunity to gather, compile, and preserve relevant ethnographic information from published literature, oral history audio/video recordings, and ongoing elder interviews regarding the history and culture of the Huna Tlingit clans. This information will be used to design the screen and will be retained for future use by tribal members. The project will also provide a venue for skilled craftsmen to pass traditional skills associated with form line design, carving, weaving, and adzing to another generation. The Master and Assistant Carvers will instruct Hoonah City Schools (HCS) students, other community youth, and community members on a weekly basis. Importantly, the carving work site will serve as an informal classroom where craftsmen convey not only traditional skills, but also oral histories, life ways, and Tlingit laws and protocols. Traditionally, resource gathering activities in homeland were one means by which tribal elders transmitted traditional knowledge, cultural practices, and social mores to tribal youth. Unfortunately, an array of social and regulatory changes has drawn the Tlingit away from their traditional seasonal rounds in Glacier Bay, reducing opportunities for intergenerational learning. The Service and HIA believe that these ethnographic resources will be preserved by providing a venue that closely mirrors the traditional learning structure of the Tlingit whereby culture bearers convey traditional knowledge to youth in the course of everyday work. Last, the project will allow HIA to prepare an administrative history of this, and past efforts associated with cultural elements completed for the tribal house. An administrative history will serve as an important record of the project, including narrative documentation of the chronology of the projects, personnel involved, decisions rendered, etc. as well as an archival collection of photographs, recordings, etc. In addition, the project will assist HIA in identifying the types of utilitarian items necessary to furnish the interior of the Tribal House such that furnishing can be produced in future years. The partner, in cooperation with the National Park Service will: 1. Create a traditional form line design for the exterior front of the Huna Tribal House, transfer the design to cedar planks, and carve and paint the design. 2. Assign one HIA staff, the Master Carver, as the HIA Project Lead for the project to be responsible for all project activities and products including the house screen carving, travel logistics, purchases and budgeting, and general program oversight; and to liaison with the Service Project Manager. 3. Coordinate the project closely with the Service Project Manager and other Service staff responsible for tribal house design and construction to ensure that the house screen meets design needs and architectural standards. 4. Maintain a daily work log of carving and other associated activities. 5. Maintain a visitor log of local and other individuals who visit the carving project. 6. With the Service Project Manager, Service Interpretive staff, and Huna Heritage Foundation (HHF), collaboratively plan and implement a strategic planning. 7. Document project progress with still photographs and/or videography. Provide copies of photographs videos, other documentary material, with release forms from participants for use by the Service each week. 8. With the Service Project Manager and HHF, complete an administrative history of projects to date (FY 11-13) including written project documentation to include: a narrative documenting important dates and decisions; references for relevant literature, oral history, and photographs; guidelines for archiving project photographs and video footage; and narrative for each cultural element (interior house screen, exterior house screen, 4 house posts). 9. Provide a narrative trip report with photographs of museum/tribal house visits. NATIONAL PARK SERVICE INVOLVEMENT -Substantial Involvement :3. Assign the Service s Project Manager and the Park Management Assistant to research cultural themes, oral histories, traditional designs, etc. for incorporation into the house screen design, administrative history, and associated project documentation. The Service Project Manager will meet frequently with the Master Carver and Assistant Carvers t Lead to convey appropriate anthropological information for screen design and review house screen design. 4. Assign the Service Project Manager to facilitate meetings with clan elders to obtain cultural information for house screen design and capture oral histories associated with the final design. Record and transcribe/translate interviews with elders and/or meeting minutes of consultation meetings with elders and/or other tribal members. 5. Assess project progress and identify opportunities and/or challenges. 6. Assign the Service Project Manager to liaison between the HIA Master Carver and Service architectural staff and contractors to ensure that the final house screen design, dimensions and materials are compatible with the Huna Tribal House architectural design. 7. Assign the Service Project Manager and Park Interpretive staff to develop and/or assist in developing both on- and off-site educational and outreach opportunities related to the carving effort and the overall Huna Tribal House Project. SINGLE-SOURCE JUSTIFICATION: Department of the Interior Policy (505 DM 2) requires a written justification which explains why competition is not practicable for each single-source award . The National Park Service did not solicit full and open competition for this award based the following criteria: Unique Qualifications, The Hoonah Indian Associationis the only entity that can effectively execute this program as it is the tribal government for the Huna Tlingit who claim Glacier Bay National Park as homeland, is the only entity representing and employing individuals with the cultural expertise and cultural authority to complete the work, and has the administrative infrastructure to achieve program objectives. Technical contact information: Mary Beth Moss, mary_beth_moss@nps.gov,907-945-3230,National Park Service, Alaska Region. End of FOA

NIDA - National Institute on Drug Abuse

PROJECT SUMMARY/ABSTRACT This K01 proposal aims to elucidate mechanisms underlying effects of prenatal opioid exposure (PODE) on infant brain and behavioral development. PODE is related to behavioral and cognitive deficits that emerge during infancy and persist through adolescence, but the neural mechanisms contributing to these divergent trajectories are virtually unknown. The proposed research addresses this gap by identifying PODE effects on longitudinal brain growth and characterizing associations between brain structure-function coupling, environmental factors, and behavioral outcomes. This K01 application presents a program of research and training that will support the PI’s transition to an independent investigator with a focus on examining early origins of neurodevelopmental heterogeneity using a multidisciplinary approach. In addition to building on the PI’s prior training and experience, this training plan capitalizes on an exceptional mentorship team and translational research environment to foster the candidate’s expertise in: 1) cross-modal neuroimaging analysis for brain structure-function integration, 2) big data analysis using advanced statistical methods for longitudinal and multivariate modeling, 3) environmental impacts on brain development in the context of marginalized populations, and 4) interpretable machine learning approaches for generating predictive models of outcome. This project will capitalize on the largest cohorts of infants with PODE to date and investigate PODE effects on development of brain structure-function coupling across the first year (Specific Aim 1), dissect the moderating impact of environmental factors on brain growth (Specific Aim 2), and build interpretable machine learning models to predict 12-month cognitive and language outcomes (Specific Aim 3). The central hypothesis is that longitudinal development of higher-order cognitive networks (i.e., circuits that are enriched with opioid receptors) is impaired by PODE and shaped by environmental factors, such that the interaction between brain and environment is predictive of behavioral outcomes. This work will elucidate biological mechanisms underlying the impact of PODE on neurodevelopmental heterogeneity and improve early intervention strategies and personalized treatments. The proposed research will take place at Cedars-Sinai Medical Center under the mentorship of Drs. Wei Gao (cross-modal neuroimaging), John Gilmore (structural network analysis in pediatric populations), Rina Eiden (prenatal substance exposure and environmental adversity/resilience), Jason Moore (machine learning methodologies), Wesley Thompson (nonlinear trajectories), Vinicius Calsavara (multivariate statistical analysis), and Kimberly Gregory (marginalized populations). Together, the research and training experiences and the expertise developed through this K01 award will support the PI’s career development as an independent investigator and leading expert in the developmental etiology of prenatal substance exposure and neurodevelopmental disorders. Findings will support a future R01 extending this work to population-level datasets in youth with prenatal substance exposure to investigate mechanisms underlying neurobehavioral heterogeneity across the entire developmental period.