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27th and Cambridge Coalition

The 27th and Cambridge Coalition will organize a fun, free, community building event for National Night Out on Tuesday, Aug 6 from 5:00-8:00 pm in the Courtyard of Longfellow Apartments, 9413 - 27th Avenue Southwest. There will be food, games and art activities for all ages, face painting, and live music.

National Institutes of Health

This Notice of Funding Opportunity (NOFO) encourages applications for support of resources that will provide access to state-of-the-art equipment, technologies, research tools, materials, organisms, software, and/or services to a substantial regional (multi-state) or national user base. Only those resources with technical capabilities that fall within the NIGMS-supported program areas are eligible for awards. The resources should already be established or may be formed through consolidation of existing local or regional facilities. The intent is to provide resource access to investigators without regard to the specific biomedical focus of their research, while not duplicating or replacing resources supported by sources such as other NIH Institutes and Centers (ICs) or host institutions. The resource is expected to be maintained or upgraded to current best practices, make its capabilities and availability known to the biomedical research community through a robust web presence and outreach activities, and provide user training and support.

National Institutes of Health

This Notice of Funding Opportunity (NOFO) encourages applications for support of resources that will provide access to state-of-the-art equipment, technologies, research tools, materials, organisms, software, and/or services to a substantial regional (multi-state) or national user base. Only those resources with technical capabilities that fall within the NIGMS-supported program areas are eligible for awards. The resources should already be established or may be formed through consolidation of existing local or regional facilities. The intent is to provide resource access to investigators without regard to the specific biomedical focus of their research, while not duplicating or replacing resources supported by sources such as other NIH Institutes and Centers (ICs) or host institutions. The resource is expected to be maintained or upgraded to current best practices, make its capabilities and availability known to the biomedical research community through a robust web presence and outreach activities, and provide user training and support.

Seattle Chinatown International District Preservation and Development Authority

Building off the momentum of the 2024 Nihonmachi Alley Concept Plan, which was funded by DON, SCIDpda will collaborate with community partners including the Japantown planning group, Wing Luke Museum, and CID Business Improvement Area to continue revitalization efforts. This funding allows work to continue in Nihonmachi Alley in 2 areas which are accessible to the public: Placemaking and Design & Planning. Placemaking efforts focus on Chiyo’s Garden where we will install new art from Erin Shigaki and install a decorative railing inside the gate to improve the usability and safety of the garden. The design and planning portion will build on the 2024 Concept Plan to hire an architecture/design and engineering team to repave the alley for safety and plan for permanent decorative and public art features. The anticipated project completion date is November 30, 2026.

Friends of Japantown

Revitalize and beautify Japantown's Nihonmachi Alley with public art, lighting, and programming opportunities.

NCI - National Cancer Institute

Project Summary/Abstract Acute myeloid leukemia (AML), the most common type of adult acute leukemia, originates from somatic mutation(s) which results in impaired differentiation and aberrant proliferation of hematopoietic stem/progenitor cells. We recently identified recurrent mutations in the gene BRAF, which encodes an integral kinase in the RAS/MAPK/ERK signaling pathway, in AML patients. Divergent from other cancer subtypes, the majority of the BRAF mutations we identified were outside of the well-characterized V600 codon hotspot and therefore, noncanonical mutations. Moreover, the presence of a BRAF mutation correlated with dismal survival outcomes for these AML patients, regardless of therapeutic regimen, suggesting that BRAF mutations may drive therapeutic resistance to front-line AML therapies. This is in contrast with other RAS/MAPK pathway mutant AMLs, which typically respond to the front-line chemotherapy regimens. Our preliminary data in novel BRAF-mutant mouse models indeed confirms these findings from our BRAF-mutant AML clinical cohort. Therefore, our understanding of how BRAF and more broadly, the RAS/MAPK pathway, can contribute to AML pathogenesis and drive therapeutic resistance remains incomplete. In this proposal, state-of-the-art approaches and models will be applied to interrogate innovative concepts in novel, genetically engineered mouse models (GEMM) and patient derived xenografts (PDX). Specifically, we will delineate the contributions of BRAF mutations to leukemogenesis, disease phenotype, and therapeutic response through a combination of single cell multiomic analysis of primary AML samples and functional dissection of BRAF-mutant GEMMs and BRAF-mutant AML PDXs. We expect to elucidate aberrant BRAF-driven signaling pathways and how these mechanisms alter hematopoietic output and cellular response to therapeutic agents. To achieve this, we will discover and examine abnormal hematopoietic output, dysregulated transcriptional programs, and rewired signaling pathway that are specific to leukemic clones harboring BRAF mutations (Aim 1). Next, we will interrogate mechanisms in BRAF-mutant cells that lead to resistance to front-line AML therapies and assess potential efficacious therapies for BRAF-mutant AML (Aim 2). The use of genetically engineered mouse models provides critical isogenic systems to dissect the contribution and impact of BRAF mutations in AML development without the vast heterogeneity and complexity observed in AML patient samples. Moreover, therapeutic studies in BRAF-mutant PDX models in vivo allow for insight into systemic effects of therapies in a native context and uncover important contributions of the bone marrow niche to therapeutic response. In sum, the proposed work will dissect critical contributions of BRAF mutations, and more broadly aberrant functions of RAS/MAPK pathway proteins, to AML pathogenesis and response to therapy to inform and develop novel therapeutic strategies that will improve AML patient outcomes.

NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases

Project Summary The purpose of this ‘A1 Single-Year NIAMS/NCI R13 Research Conference Grant’ is to host the highest impact scientific and mentoring conference on “Bone: Musculoskeletal Tumor Perspectives’ that will bring together translational and clinical investigators from diverse specialties. Musculoskeletal Tumor Society (MSTS) is the primary host organization that will partner with OREF, ORS, AAOS, and JOR. Musculoskeletal Oncology is a distinct hybrid clinical and research field that requires the solution to 3 distinct problems: ‘Diagnosing’ and ‘Treating’ molecular oncogenesis of MSK tissues and ‘Reconstructing’ afflicted tissue structures to restore limb function. Due to underlying oncological pathophysiology and massive skeletal defects, traditional orthopaedic treatments using trauma or arthroplasty disciplines were associated with high rate of complications. Furthermore, no cross-disciplinary research and mentoring endeavors on bone tumors have not been offered. Many bone and osteoclast-associated molecules were discovered from bone diseases and tumors such as the giant cell tumor of bone. The last AAOS-initiated R13 Conference was in 2017. There is a serious issue of discontinuation of clinician scientists and basic scientists who conduct cross-disciplinary research on bone and reconstruction science from a perspective of musculoskeletal tumors. There is an urgent need to host a R13 conference to offer mentorship for emerging investigators and to develop new collaborations. Our innovative meeting format features sessions addressing challenging clinical problems with plenary overview talks by experts on state-of the art techniques (spatial biology, artificial intelligence, novel signaling & targeted therapies, novel skeletal stem cells, RNA/DNA therapeutics, 3D printed custom device, and mixed reality). We will invite junior surgeon-scientists to present their innovative solutions in mentoring sessions where a panel of established investigators will critique proposed strategies and Specific Aims in a live multi-disciplinary “study section”. ESI selection criteria are based on one-page Specific Aims that summarizes clinical barriers, hypothesis-/technology-driven scientific and clinical investigation plans, and specific needs for mentorship. A meet-the-mentors session will be set up to foster multi-disciplinary collaboration among mentors and emerging surgeon-scientists, engineers, and basic scientists. In order to facilitate networking and matching mentors- mentees, the meeting phone Apps and website will list mentors and participants with well-prepared research ideas (Specific Aims) and other scientific abstracts. Two Specific Aims are Aim 1. Innovative Mentorship for Emerging Clinicians and Scientists; and Aim 2. Dissemination of Cross-Disciplinary New Knowledge and Techniques for New Collaborations and Enhanced Patient Care. A stand-alone R13 conference could be ideal but too costly for meeting space rent, audio/visual services, and support for young investigators. The R13 Conference will be strategically held immediately prior to the 50th MSTS Annual Meeting for cost reduction and improved participation from clinicians, scientists, allied health care workers, and industry R&D staffs.

North Carolina Arts Council

North Carolina Arts Council provides grants to support arts and cultural programming, artist fellowships, arts education, and community-based arts projects across NC.

North Dakota Community Foundation

North Dakota Community Foundation ($100M in assets) supports nonprofits in ND through grants focused on education, community development, health, arts. Awards range from $1,000 to $25,000.

North Dakota Council on the Arts

Institutional Support Grants provide general operating support to North Dakota arts organizations, enabling them to sustain programming, build capacity, and serve their communities through arts and cultural activities.

North Dakota Council on the Arts

Special Project Grants fund specific arts activities and events in North Dakota, including performances, exhibitions, arts education programs, and community cultural initiatives that enhance public access to the arts.

North Texas Community Foundation

North Texas Community Foundation ($100M in assets) supports nonprofits in TX through grants focused on education, health, community development, arts. Awards range from $2,000 to $75,000.

Northern New York Community Foundation

Northern New York Community Foundation ($100M in assets) supports nonprofits in NY through grants focused on education, community development, health, arts. Awards range from $1,000 to $25,000.

NIDA - National Institute on Drug Abuse

This project will develop and apply a novel, data-driven modeling approach to guide HIV and hepatitis C virus (HCV) prevention resource allocation among people who use drugs (PWUD) in the United States. Despite advances in HIV prevention and treatment, including long-acting injectable ART, the United States continues to fail to meet the needs of PWUD, a population central to intersecting HIV, HCV, and overdose crises. A key reason is the absence of a rapid, scalable, and comprehensive way to capture and act on the preferences and behaviors of PWUD. Revolutionary advances in large language models (LLMs) now make it possible to create highfidelity “digital twins” — artificial-intelligence powered simulations of individuals that reflect their intervention preferences and even behaviors. Using a community-based participatory process, we will train an LLM on data from multiple PWUD cohorts to generate PWUD digital twins that simulate locally-specific intervention preferences. These digital twins will be integrated into an epidemic and economic model that simulates HIV and HCV transmission, overdose, and related complications, across numerous jurisdictions in the United States. The integrated modeling framework will be used to evaluate the impact and cost-effectiveness of different HIV/HCV prevention and treatment strategies, including responses to potential funding constraints. Epidemic model outputs will be shared through an interactive dashboard designed in consultation with public health departments. Ultimately, our project aims to improve intervention implementation and reduce HIV, HCV, and overdose. Our project includes the following activities: 1) Co-design, development, and validation of a PWUD-informed LLM. 2) Digital twin simulations within a HIV/HCV transmission and overdose model to inform resource allocation. 3) Dissemination and implementation of the epidemic and resource allocation dashboard to county health departments. The proposed research will enable rapid, data-driven evaluation of prevention strategies and resource allocation options. It aligns with the NIH Office of AIDS Research priority to reduce new HIV infections and address HIV coinfections.

National Park Service

Notice of intent to award, applications will not be accepted for this agreement. This task agreement is being awarded under CESU Master Cooperative Agreement P14AC0088. The primary objective of this project is to expand upon a previous passive acoustic effort in Florida Bay, applying state-of-the-art passive acoustic sensors to the detection of several soniferous fish and shrimp species and to develop techniques for passive acoustic data management and processing that is appropriate for use in remote monitoring. Additional objectives include evaluating the impact of recent ecological events and management actions by extracting ecologically significant information from remote locations within Everglades National Park. This project provides research and technical assistance to the National Park Service while students and faculty of Cornel.

National Foundation on the Arts and the Humanities

The Institute of Museum and Library Services (IMLS), as part of its continuing effort to reduce paperwork and respondent burden, conducts a pre-clearance consultation program to provide the general public and Federal agencies with an opportunity to comment on proposed and/or continuing collections of information in accordance with the Paperwork Reduction Act. This pre-clearance consultation program helps to ensure that requested data can be provided in the desired format, reporting burden (time and financial resources) is minimized, collection instruments are clearly understood, and the impact of collection requirements on respondents can be properly assessed. The purpose of this Notice is to solicit comments related to the Guidelines for IMLS Grants to States Five-Year Evaluation. A copy of the proposed information collection request can be obtained by contacting the individual listed below in the ADDRESSES section of this notice.

National Foundation on the Arts and the Humanities

The Institute of Museum and Library Services (IMLS), as part of its continuing effort to reduce paperwork and respondent burden, conducts a pre-clearance consultation program to provide the general public and Federal agencies with an opportunity to comment on proposed and/or continuing collections of information in accordance with the Paperwork Reduction Act. This pre-clearance consultation program helps to ensure that requested data can be provided in the desired format, reporting burden (time and financial resources) is minimized, collection instruments are clearly understood, and the impact of collection requirements on respondents can be properly assessed. The purpose of this Notice is to solicit comments related to the IMLS Grants to States Program "State Reporting System." A copy of the proposed information collection request can be obtained by contacting the individual listed below in the ADDRESSES section of this notice.

National Foundation on the Arts and the Humanities

The Institute of Museum and Library Services (IMLS), as part of its continuing effort to reduce paperwork and respondent burden, conducts a pre-clearance consultation program to provide the general public and Federal agencies with an opportunity to comment on proposed and/or continuing collections of information in accordance with the Paperwork Reduction Act. This pre-clearance consultation program helps to ensure that requested data can be provided in the desired format, reporting burden (time and financial resources) is minimized, collection instruments are clearly understood, and the impact of collection requirements on respondents can be properly assessed. The purpose of this Notice is to solicit comments concerning renewal of the three-year approval of the forms necessary to report on grant and cooperative agreement activities on an interim and final basis for all IMLS grant programs for 2026-2028 Grant Performance Report Forms. A copy of the proposed information collection request can be obtained by contacting the individual listed below in the ADDRESSES section of this Notice.

National Foundation on the Arts and the Humanities

The Institute of Museum and Library Services (IMLS), as part of its continuing effort to reduce paperwork and respondent burden, conducts a pre-clearance consultation program to provide the general public and federal agencies with an opportunity to comment on proposed and/or continuing collections of information in accordance with the Paperwork Reduction Act. This pre-clearance consultation program helps to ensure that requested data can be provided in the desired format, reporting burden (time and financial resources) is minimized, collection instruments are clearly understood, and the impact of collection requirements on respondents can be properly assessed. The purpose of this Notice is to solicit comments concerning the three-year approval of the forms necessary to submit an application to any IMLS grant program. A copy of the proposed information collection request can be obtained by contacting the individual listed below in the ADDRESSES section of this notice.

Arts Nova Scotia

Provides grants to artists and arts organizations in Nova Scotia for creation, professional development, and arts presentation.

NIEHS - National Institute of Environmental Health Sciences

PROJECT SUMMARY Electronic cigarette (e-cig) use during pregnancy has become a major health concern in recent years and is perpetuated by the perception that e-cigs are less harmful than traditional combustible cigarettes. Recent estimates show 7% of women use e-cigs in pregnancy, and 45% view them as less harmful and may help them quit or reduce combustible cigarettes in pregnancy. An extensive knowledge gap persists regarding their health impact when aerosolized, especially during pregnancy. Using our well-established pregnant rat model, we obtained preliminary data utilizing a state-of-the-art e-cig system with a commercial e-cig unit and atomizer that offered a translational inhalation delivery and generated vapor profiles directly comparable to human vaping. Our preliminary data demonstrated that a cardinal outcome of e-cig use was a significant fetal and neonatal growth deficit. Concomitant with growth restriction, our exciting preliminary data provides direct evidence that e-cig vaping significantly alters developmental brain hippocampal mTOR system. As a critical node, mTOR regulates essential brain metabolic activities, including protein synthesis and autophagy. Interestingly, our new preliminary data indicate that these mTORC1 and mTORC2 signaling adaptations were accompanied by altered fetal hippocampal dendritic morphology and hippocampal-dependent long term memory deficits. We subsequently generated critical preliminary data that demonstrated that optimizing mTORC1/C2 activity via in vivo administration of the 3rd gen mTORC1/C2 blocker (RapaLink-1) concomitant with e-cig aerosol exposure reversed specific e-cig-induced fetal developmental phenotypes. Thus, we hypothesize that the mTOR system plays a central role in e-cig induced alterations in fetal brain hippocampal adaptations. To test this hypothesis, we will (1) seek to answer fundamental questions about the impact of e-cig aerosol exposure on hippocampal mTORC1/C2 system using novel mechanistic in vivo studies, (2) assess the role of mTOR in e-cig-induced fetal brain hippocampal developmental adaptations using morphometric, stereological and behavioral approaches, and (3) identify e-cig-induced protein signal propagation pathways leading to activation of mTOR and signal propagation downstream of mTORC1/C2 utilizing mass spectrometry- based phosphoproteomics followed by stochastic optimization and reinforcement learning algorithms. We will then compare and interpret the signature pathways impacted by e-cig vaping with and without mTOR blocker using machine learning models. Upon successful completion of these aims, we will have comprehensively characterized the mTOR signaling cascade as it transduces cues from e-cig vaping into molecular action, enabling the identification of potential strategies to mitigate e-cig-induced neurodevelopmental deficits in the hippocampus. The proposed studies develop a strong etiological framework and directly address a “major research area” of developmental impacts under Theme One of NIEHS Strategic Plan 2018-2023, titled “Advancing Environmental Health Sciences”.

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY Influenza vaccines remain the most cost-effective tool for reducing infection and disease burden. However, despite decades of research and development, the protection they provide is often suboptimal. A key challenge is the wide variability in vaccine induced immune responses among individuals, which is poorly understood. Addressing this knowledge gap is crucial for improving vaccine efficacy and vaccination strategies. Predictive modeling, with its demonstrated success in advancing medical research and public health, holds significant promise in this regard. By harnessing predictive models, we can tailor vaccination strategies to individuals, optimizing protection and improving outcomes. Current predictive models, however, suffer from critical limitations. Most rely solely on static, pre- vaccination data and focus narrowly on antibody responses to a single vaccine component (in current vaccines, these are H3N2, H1N1 and one or two of the B lineages). Existing models do not account for the dynamic nature of the immune system or the role of heterologous, non-vaccine-specific antibody responses, reducing their accuracy and practical utility. These shortcomings hinder the development of more comprehensive, adaptable models for predicting vaccine efficacy across diverse populations and viral strains. This project aims to overcome these limitations by developing and validating advanced predictive models for influenza vaccine responses. Our approach integrates systematically collected, longitudinal data with state-of-the-art statistical and machine-learning methods. Specifically, we will: 1. Develop predictive models that incorporate long-term antibody response trajectories and heterolo- gous strain data to improve predictions for vaccine strain responses. 2. Expand the scope of these models to predict heterologous breadth and overall antibody responses, offering a more complete understanding of vaccine-elicited immunity. 3. Generate and analyze high-throughput antibody landscape data to further refine and enhance our predictive models. By combining these innovations, we aim to establish a new framework for individualized vaccine re- sponse prediction. This framework will significantly improve upon existing models, enabling tailored vac- cination strategies designed to optimize protection for each individual. Ultimately, this work will provide a robust scientific foundation for guiding future influenza vaccination efforts, contributing to better public health outcomes worldwide.

NHLBI - National Heart Lung and Blood Institute

PROJECT SUMMARY Our overall vision and long-term goal are to obtain a more complete understanding for how cellular signaling pathways, in particular G proteins and integrin receptors, control platelet adhesion and plug formation in hemostasis and thrombosis. Furthermore, we aim to elucidate aspects of the signaling machinery that function differentially in hemostasis versus thrombosis (both arterial and venous). The conceptual framework is that human thrombotic diseases result from an otherwise protective mechanism gone awry, and that disease-induced changes to platelet reactivity (priming) are a major contributor to thrombotic disease. A detailed understanding of platelet activation pathways is critical for the development of novel antithrombotic therapies, and for the identification of new biomarker assays for a prothrombotic state. Over the last two decades, my lab has utilized state-of-the-art in vitro and in vivo approaches to redefine our understanding of the molecular mechanisms regulating platelet reactivity in circulation and at sites of vascular injury. Key findings include the identification of tightly balanced G protein networks, an integrin activation complex that is unique to platelets, and injury-specific contributions of platelets to vascular integrity and thrombotic complications. The proposed work will focus on several areas within the general conceptual framework outlined above: (1) studies on G protein networks and integrin affinity regulation in platelets; (2) studies on the role of platelets in venous thrombosis pathogenesis and novel antithrombotic strategies; (3) development of novel assays to measure levels of primed platelets in different diseases; and (4) studies to better understand and correct defects in platelet count and function associated with inherited and acquired platelet disorders. Exciting preliminary findings include the identification of a novel G protein network in platelets, the establishment of new assays to monitor an elusive intermediate affinity conformation in platelet integrins, and a critical role for intermediate affinity integrins in thrombocytopenia and/or thrombosis associated with platelet disorders and cancer. In summary, the proposed studies will investigate significant knowledge gaps in basic platelet biology and provide a new understanding for how disease states like cancer affect platelet reactivity and platelet plug formation. Our studies have high translational relevance in the areas of antithrombotic therapy, biomarker development, and transfusion therapy.

NIMH - National Institute of Mental Health

Abstract Despite the effectiveness of antiretroviral therapies (ART) in reducing systemic HIV viral loads, central nervous system (CNS) dysfunction remains prevalent in 30-50% of people living with HIV (PWH). ART does not eliminate viral reservoirs in the CNS, leading to chronic neuroimmune dysfunction and conditions like HIV-associated neurocognitive disorder (HAND). Current preclinical research has primarily focused on models that simulate acute HIV infection, but there is a pressing need for models that accurately reflect CNS dysfunction in the context of chronic ART-suppressed infections. Recent advancements in immunodeficient mouse models with humanized immune systems have shown promise, allowing for natural HIV infection and crossing of the blood-brain barrier. These models have provided insights into HIV infection in the CNS and the role of human microglia cells. However, significant gaps remain, particularly in developing models that incorporate multiple human CNS cell types and accurately represent chronic infection dynamics. This proposal aims to develop preclinical NeuroHIV models that better mimic CNS-immune interactions in general and in particular during ART suppression. Specifically, our goal is to develop the next generation NeuroHIV model composed of autologous peripheral human immune cells, relevant human glial cell types, and an intact blood-brain barrier all in the context of ART-mediated HIV suppression.