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National Endowment for the Arts

See the application guidelines and instructions at arts.gov for more information.

National Endowment for the Arts

See the application guidelines and instructions at arts.gov for more information.

National Endowment for the Arts

See the application guidelines and instructions at arts.gov for more information.

National Endowment for the Arts

See the application guidelines and instructions at arts.gov for more information.

National Endowment for the Arts

See the application guidelines and instructions at arts.gov for more information.

National Endowment for the Arts

See the application guidelines and instructions at arts.gov for more information.

National Endowment for the Arts

See the application guidelines and instructions at arts.gov for more information.

National Endowment for the Arts

See the application guidelines and instructions at arts.gov for more information.

National Endowment for the Arts

Project-based grants supporting public engagement with, and access to, the arts including visual arts, music, dance, theater, literature, design, and media arts.

National Endowment for the Arts

Grants for creative placemaking projects that integrate arts and culture into community revitalization, improving livability, economic development, and social outcomes.

National Endowment for the Arts

Our Town is the NEA's creative placemaking grant program, funding partnerships between arts organizations and local governments to transform communities.

Nebraska Arts Council

Basic Support Grants provide general operating support to established Nebraska arts organizations, enabling them to sustain core programming, build organizational capacity, and expand community access to arts and cultural experiences.

Nebraska Arts Council

Mini Grants provide small, flexible funding to Nebraska organizations and schools for arts programming, artist residencies, community performances, and cultural events that increase access to the arts in underserved areas.

Call of Compassion NW

Call of Compassion NW will teach up to 20 youth-led teams of five people how to create temporary art pieces using chalk. The workshop will be on Saturday, August 26, 9am-12pm, at Blaine Memorial United Methodist Church in the parking lot (3001 24th Ave S). The day of art creation will happen on neighborhood business district sidewalks by September 15. A community celebration for the teams will be held in October.

NHLBI - National Heart Lung and Blood Institute

PROJECT SUMMARY Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide and a major driver of healthcare costs, yet few new therapies have emerged in recent decades. Repurposing existing drugs offers a faster, lower-cost path to treatment; repurposed agents succeed at three times the rate of de novo drugs. Further, drug candidates are twice as likely to be approved when supported by genetic evidence. However, the path to repurposing is often serendipitous rather than systematic. Systematic approaches that utilize genetic and multiple omics data to identify and validate drug repurposing candidates for COPD have not been applied. This project combines network-based computational methods with real-world clinical data to accelerate COPD drug repurposing. In Aim 1, we will build an updated COPD “disease module” by integrating the latest genome- wide association studies and multi-omics data into the human protein interactome. Using a proximity-based framework and hypothesis testing, we will identify drugs whose targets lie closest to COPD-related networks and prioritize those expressed in lung tissue and relevant immune cells. In Aim 2, we will perform comparative effectiveness studies in the Merative Marketscan dataset (>100 million covered lives) to test whether candidate drugs are associated with reduced COPD exacerbations compared to matched referent therapies using state- of- the-art methods for confounding control and causal inference. The expected outcomes include: (1) an updated COPD network module and publicly available web platform for continued repurposing efforts; (2) identification of promising drug candidates with biological plausibility; and (3) prioritization of agents for early-phase clinical trials. This project is innovative in systematically uniting genetics, omics, and network science with pharmacoepidemiology, and significant in contributing to a low-cost, scalable pipeline for drug repurposing in COPD. The work will generate critical preliminary data for subsequent R01 and clinical trial proposals, with the goal of expanding effective treatment options for millions of patients with COPD.

NIDA - National Institute on Drug Abuse

Project Summary Human immunodeficiency virus (HIV) infection frequently co-occurs with cocaine use disorder (CUD). Despite high rates of psychostimulant use among people living with HIV (PLWH), and the worsening of HIV outcomes by chronic drug exposure - including increased risk for neurocognitive impairment -, targeted therapeutic strategies to reduce drug use in PLWH are lacking. CUD is characterized by difficulty in terminating drug use and high propensity to relapse after even protracted abstinence. This can be modeled in rodents through extinction learning (persistent drug seeking) and reinstatement (relapse to use) models. Extinction and reinstatement are mediated in part by projections to the nucleus accumbens shell (NAcS) from the infralimbic subregion of the medial prefrontal cortex (IL). HIV infection and chronic drug exposure have independent and interactive effects on the brain and behavior, including regulation of reward seeking. Our previous and preliminary findings identify impaired extinction learning in multiple mouse models of HIV infection (humanized mouse model with HIV-1 infection and wild-type mice with EcoHIV infection). We further observe increased cocaine-primed reinstatement in the EcoHIV model. These behavioral changes are accompanied by dysregulation of the IL and NAc. Thus, this proposal will apply in vivo electrophysiology, tract tracing, and circuit-specific chemogenetics to test the overarching hypothesis that EcoHIV infection impacts activity in glutamatergic projections from the IL to the NAcS and that modulation of these projections is sufficient to suppress drug seeking in animals with EcoHIV infection. We propose that alterations in these circuits resulting from infection impair cognitive control of behavior which promotes the maintenance of and susceptibility to relapse to cocaine seeking. Aim 1 will determine the effects of EcoHIV and/or ART on IL encoding of cocaine reward and seeking behavior using in vivo electrophysiology to track neuronal activity across behavior. This Aim will further assess interactive effects of EcoHIV and/or ART exposure with a history of cocaine administration on later neurocognitive performance. Aim 2 will investigate the ability of modulation of ILNAcS circuit activity to suppress cocaine reinstatement in EcoHIV-infected mice. This will be accomplished using chemogenetic modulation of the IL and of IL projections to the NAcS and through local administration of an mGluR2/3 agonist to the NAc. Aim 3 will test the effects of EcoHIV and/or ART on cocaine-associated alterations in activity within IL to NAc circuitry. This will be accomplished using multiplexed tract tracing and immunofluorescent labeling. This Aim will further identify EcoHIV and ART effects on glutamate receptor expression within the prefrontal cortex and NAC using western blot. Together, the results of these experiments will inform the mechanisms by which EcoHIV alters cocaine seeking and taking behavior and expand our understanding of the circuit-level consequences of EcoHIV infection which may support next- generation CUD and HAND therapeutic development for PLWH.

NINDS - National Institute of Neurological Disorders and Stroke

Abstract Support is requested for a Keystone Symposia conference entitled Neurodevelopmental Disorders: Mechanisms and Therapeutics, organized by Drs. Tomasz Nowakowski, Xin Jin, Stephan Sanders and Zhaolan (Joe) Zhou, with scientific programming input from Keystone Symposia. The meeting will take place January 19-22, 2027 at Beaver Run Conference Center, Breckenridge, CO. Neurodevelopmental disorders (NDDs), including autism, intellectual disability, and epilepsy, arise from disruptions during brain development and pose major challenges to public health. Although advances in genetics have identified hundreds of causal genetic risk factors, identifying convergent mechanisms underlying their pathobiology remains a challenge, which hinders the development of personalized therapies. This meeting addresses the critical gap between emerging insights into causal factors, neurodevelopment, and therapeutic innovation by uniting experts across basic and translational neuroscience. The proposed conference will foster new collaborations between investigators in genetics, functional genomics, developmental neurobiology, and industry. Specific aims include showcasing breakthroughs in single-cell genomics, genome perturbation technologies, gene-environment interactions, and novel therapeutic strategies such as gene replacement therapies and antisense oligonucleotides (ASOs). The program is designed to challenge prevailing hypotheses towards understanding NDDs by taking a holistic perspective on molecular, cellular, and circuit level mechanisms underlying brain development and their vulnerabilities to genetic and environmental risk factors for NDDs. By integrating state-of-the-art technologies into biologically driven sessions, the conference will emphasize translational pathways from discovery of causal risk factors to clinical impact. Attendees will gain exposure to innovative methodologies, mechanistic frameworks, and considerations for clinical trials, thereby advancing the field toward tangible treatments. Unlike existing meetings that focus separately on neurodevelopment, stem cell models or therapeutic pipelines, this conference uniquely fuses mechanistic understanding of genetic and environmental causes with translational application. Interactive sessions, panel discussions, and strong industry participation make this a pivotal forum for scientists seeking to shape the next generation of neurodevelopmental disorder research.

NIAAA - National Institute on Alcohol Abuse and Alcoholism

PROJECT SUMMARY/ABSTRACT It has been fifty years since the identification of fetal alcohol spectrum disorders (FASD), and yet there remain virtually no studies of brain morphology and function in middle aged and older adults with FASD. Profound and detrimental impacts of prenatal alcohol exposure (PAE) on brain development have been consistently observed in children and adolescents. These impacts include smaller total brain volume and smaller volumes of frontal and medial temporal areas; less fractional anisotropy; attenuated default mode resting state network deactivation and altered structural and functional connectivity; abnormalities in shape and size of the corpus callosum; and smaller cerebellum and basal ganglia. Cross-sectional analysis of the relation between age and volume of these structures suggests that adolescents and young adults with FASD have atypical brain maturation patterns indicative of both disrupted developmental processes and accelerated aging. While this suggestion is supported by several multi-site longitudinal analyses conducted by the Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD) as well as a variety of other smaller cross-sectional and longitudinal studies in younger cohorts, to date there remain no longitudinal studies examining brain maturation in middle-aged and older adults with FASD. While emerging research suggests that, at midlife, the brain impacts of PAE observed in younger ages do indeed extend into middle-age and beyond, longitudinal studies in this area are essential to understand the trajectory of brain maturation as individuals with FASD age. To address this critical evidence gap, this project will conduct ground-breaking longitudinal and cross-sectional research focusing on age-related brain changes in 60 adults with FASD and 30 healthy comparison (HC) adults aged 30-65y at baseline. All participants will complete an evidence-based cognitive test battery to assess function in multiple cognitive domains. Longitudinal evaluation will use anatomical, diffusion, and resting state functional neuroimaging techniques, and cross- sectional methods will examine white matter hyperintensities, cerebral blood flow, and task inhibition. Imaging studies will employ state-of-the-art techniques specifically developed to evaluate the brain longitudinally. Our group has already completed 90 baseline scans (59 with FASD, 31 HC) using these parameters at the University of Washington as part of a previous R01 project (R01 AA026994). We will collect 21 additional baseline scans during Y1 (12 with FASD, 9 HC) and follow up scans in Y1-Y5 for a final sample of 90 individuals with two neuroimaging sessions averaging five years apart. This project stands to 1) provide critical information about the impact of PAE on the brain in middle and older adulthood, 2) establish a biological basis for neurobehavioral deficits, and 3) identify novel biological targets for treatment of adults with FASD.

NINDS - National Institute of Neurological Disorders and Stroke

There have been great advances in microscopic and non-invasive optical neuroimaging technologies, which allow neuroscientists to visualize molecular, cellular and systems-level brain physiology and functions. For the last five years, these technological efforts have been greatly facilitated by the BRAIN Initiative, which also supports the pipeline to commercialization. However, this fast growth has widened the gap between the developers and the neuroscience community in need. This is because to properly use these novel tools, it is important to understand the underlying physical principles and have the practical skills in data collection and analysis. Furthermore, each technique comes with its limitations, and understanding these limitations is critical for avoiding unconscious bias. Thus, although instrumentation may be available, the researchers are often not fully utilizing these tools due to the lack of proper training. To this end, we propose a two-week Summer School program in Neurovascular Imaging Across Scales in Animals and Humans run by the Boston University (BU) Neurophotonics Center. This program will offer hands- on, practical training in a number of optical imaging technologies applicable to in vivo studies in awake behaving animals. In addition, we include a macroscopic, non-invasive optical imaging modality applicable to humans. These technologies will be taught and exemplified in the context of specific neuroscience questions developed by trainees. These questions will be centered on neurovascular brain physiology in heath and disease addressing the mission of NINDS. The program will target graduate students and postdoctoral fellows in the beginning of their research projects who started using one of these imaging technologies and want to acquire practical “know-how” skills and gain exposure to other imaging technologies applicable to neurovascular studies. Our primary goal is to create an innovative educational program using neurophotonics as an enabler to understand neurovascular brain function in health and disease. This program will also contribute to broad dissemination of neurophotonics technologies, increase visibility of these tools within the neuroscience community, and promote the emerging interdisciplinary field of neurophotonics and the deliverables of the BRAIN Initiative. The program alumni will fill an acute nation-wide need for neuroscience investigators skilled in state- of-the-art neurophotonics technologies. In addition, we expect the key aspects of our innovative training approach to be translated to other interdisciplinary graduate and postgraduate education programs at BU and beyond. Our best practices and measured impacts of experiential learning will be disseminated to peer institutions and to graduate education stakeholders. Our primary goal is to create an innovative educational program using neurophotonics as an enabler to understand neurovascular brain function in health and disease. This program will also contribute to broad dissemination of neurophotonics technologies, increase visibility of these tools within the neuroscience community, and promote the emerging interdisciplinary field of neurophotonics and the deliverables of the BRAIN Initiative. The program alumni will fill an acute nation-wide need for neuroscience investigators skilled in state- of-the-art neurophotonics technologies. In addition, we expect the key aspects of our innovative training approach to be translated to other interdisciplinary graduate and postgraduate education programs at BU and beyond. Our best practices and measured impacts of experiential learning will be disseminated to peer institutions and to graduate education stakeholders.

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY/ABSTRACT Kaposi’s Sarcoma (KS), driven by Kaposi’s Sarcoma-associated Herpesvirus (KSHV), remains a leading AIDS- associated malignancy and a growing concern among immunocompromised populations, including people living with HIV (PLWH) and solid organ transplant recipients. Despite effective antiretroviral therapy (ART), KS can still emerge in individuals with suppressed HIV viral loads and preserved CD4+ T cell counts, underscoring an unmet critical need for immune interventions beyond ART and T cell-mediated control. One promising strategy involves harnessing antibodies capable of recruiting effector cells to eliminate infected cells. Results from preclinical vaccine studies and clinical trials indicate that Fc-mediated effector function of antibodies significantly contribute to overall antibody efficacy in treatment and prevention of numerous carcinogenic viral infections. However, there remains a gap in our knowledge regarding the role of antibodies with Fc-mediated effector functions in controlling KSHV in immunocompromised population. This proposal will leverage the rhesus macaque rhadinovirus (RRV)/rhesus macaque (RM) model, which closely mimics KSHV infection, to investigate the capacity of antibodies with Fc-mediated functions to recruit effector cells and suppress RRV reactivation following SIV co- infection. Specifically, we will compare antibody responses during primary RRV infection and following RRV reactivation due to SIV co-infection; assess whether RRV reactivation drives B cell maturation capacity of producing Fc-functional antibodies; and evaluate the efficacy of these antibodies in immunocompromised animals to prevent RRV reactivation. Our central hypothesis is that KSHV-specific antibodies with Fc-mediated functions are critical for controlling KSHV infection, and their presence during immune suppression will prevent KSHV reactivation and KS development. Preliminary data supports this hypothesis, demonstrating that plasma from RRV-infected RMs contains antibodies both recognize infected cells and exhibit Fc-mediated effector functions. The scientific premise in this K01 is that characterizing RRV-specific antibodies capable of recruiting NK cells and monocytes will inform future KSHV immunotherapies for PLWH. At the completion of the proposed research, my expected outcomes are two-fold: 1) scientific achievements: understanding of KSHV-specific humoral responses in presence of HIV co-infection in NHP model; and 2) career development: to gain knowledge and skills for leading a preclinical and translational research program using NHP models to develop and test vaccines and immunoprophylaxis strategies in the field of AIDS-associated malignancies.

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY A critical hurdle to further improving the quality of life for people living with HIV (PLWH) is the need to resolve the residual immune activation and inflammation that persists even in those taking effective antiretroviral therapy (ART), which suppresses HIV replication. This unresolved and persistent immune activation is associated with increased type-I interferon (IFN-I) signaling, and increased incidence of comorbidities. Encouragingly, reports demonstrate that blocking IFN-I signaling in animal models of HIV infection can reduce HIV reservoirs and restore T cell immune function. We hypothesize that blocking IFN-I would likewise augment engineered T cell-based therapies against HIV, such as chimeric antigen receptor (CAR) T cells. Our prior work has demonstrated that when engineered to express both the 4-1BB and CD28 costimulatory domains and protected from HIV infection, HIV-specific CD4 ectodomain CAR T cells can reduce acute viremia, prevent CD4+ T cell loss, and reduce viral burden in the tissues of HIV-infected humanized mice. However, the reduction of plasma viral loads was ultimately transient, suggesting that the potency of HIV-specific CAR T cells should be further optimized for clinical translation. Our preliminary data highlights interferon-beta (IFNb) as a key immunosuppressive IFN-I negatively regulating CAR T cell proliferation, and we demonstrate that neutralizing IFNb in vivo enhanced the engraftment and persistence of HIV-specific CAR T cells adoptively transferred into HIV-infected ART- suppressed humanized mice. This proposal will interrogate whether IFNb neutralization augments CAR T cell therapy through 1) identifying the mechanism(s) by which chronic IFNb exposure mediates HIV-specific CAR T cell dysfunction, and 2) determining the effect of neutralizing IFNb on CAR T cell function and persistence in HIV infection in vivo. The proposed aims seek to develop the neutralization of IFNb as a novel immunotherapy approach to maximize the potency of HIV-specific CAR T cells aimed at achieving a functional HIV cure.

Nevada Arts Council

Community Arts Development grants fund projects that bring arts programming to underserved Nevada communities, including rural areas and tribal communities, promoting cultural expression and community engagement through the arts.

Nevada Arts Council

The Nevada Arts Council provides operating support and project grants to nonprofit arts organizations and educational institutions, strengthening arts infrastructure and expanding public access to arts and cultural programming across Nevada.

Nevada Community Foundation

Nevada Community Foundation ($100M in assets) supports nonprofits in NV through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.