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NIGMS - National Institute of General Medical Sciences

This proposal requests funding for a Liquid Chromatography-Mass Spectrometry (LCMS) system to support biomedical research and educational initiatives across East Tennessee State University's Academic Health Science Center. The instrument will primarily serve researchers and students in the Colleges of Medicine and Pharmacy, while remaining accessible to investigators from the Colleges of Public Health and Arts and Sciences. The acquisition of this LCMS system addresses a critical infrastructure gap that emerged in 2022 when the university's previous LCMS instrument became non-functional. From 2009-2022, LCMS capabilities at ETSU facilitated significant research productivity across multiple investigative teams, resulting in over 40 peer-reviewed publications. This research spans an array of biomedical applications including: pharmacokinetic studies of therapeutic drugs and substances of abuse; development of novel drug delivery systems; quantification of endogenous biomarkers in disease states; stability studies of compounded pharmaceuticals; analysis of environmental contaminants; and investigation of lipid mediators in cardiovascular disease. This productivity has been severely hampered by the lack of this essential analytical capability since 2022. Beyond supporting faculty research programs, this instrument will provide exceptional educational opportunities for a broad spectrum of students, including PharmD, MD, PhD, MS, and undergraduate trainees. Hands-on training with sophisticated LCMS technology will equip these learners with specialized analytical skills highly valued in both academic and industrial research settings. This training represents an uncommon opportunity, particularly for undergraduate science students, enhancing their competitiveness for advanced educational programs and future employment. The strategic placement of this instrument within our shared research infrastructure will maximize its impact, supporting ongoing NIH-funded investigations in areas including pharmacokinetics, drug metabolism, natural product chemistry, biomarker discovery, and neonatal abstinence syndrome research. Additionally, the instrument will enable new collaborative research directions that align with institutional priorities in addiction science, infectious disease, and rural health disparities. In summary, this LCMS system will rejuvenate research capabilities that previously flourished at ETSU, while simultaneously enriching the educational experience of our student population in the biomedical sciences.

NIDA - National Institute on Drug Abuse

Project Summary: The rising incidences of synthetic opioids misuse and emerging psychoactive substances pose significant challenges for public health and forensic toxicology. Conventional detection methods such as liquid chromatography-mass spectrometry (LC-MS) offer high sensitivity and specificity but are costly, require skilled operators, and are not feasible for rapid, point-of-care applications. To address these limitations, this project aims to develop a Surface-Enhanced Raman Spectroscopy (SERS)-based lateral flow assay for the rapid detection and quantification of existing and emerging illicit drugs in urine samples. This platform is designed to provide comparable analytical performance of LC-MS while reducing costs, increasing portability, and enabling drug testing in resource-limited settings such as rural health clinics, emergency departments and harm reduction centers. The proposed approach integrates three key innovations: (1) a SERS-active lateral flow cartridge that processes the urine sample – removing potential interferents while simultaneously separating drug mixtures and metabolites by Thin Layer Chromatography (TLC). Raman signals are enhanced via embedded nanoparticles in the TLC material for high-sensitivity detection. The SERS approach is a label-free technique that directly measures the unique vibrational modes of drug molecules, eliminating the need for biological elements like antibodies or aptamers. Unlike labeled methods, it has no strict shelf-life or storage requirements and can rapidly adapt to emerging drugs, for which specific biological recognition elements are unavailable; (2) a low-cost, Fourier Transform Raman (FT-Raman) instrument engineered for portability. The FT-Raman system offers several advantages over typical dispersive Raman systems: It provides higher spectral accuracy through interferometer-based calibration. Additionally, FT-Raman system uses a NIR excitation source to reduce fluorescence from biological samples. With fewer moving parts, the FT-Raman system offers more stability and requires less maintenance; (3) advanced chemometrics / machine learning algorithms for spectral analysis, enabling precise identification and quantification of drug compounds and their metabolites. Future phases will focus on prototype refinement and commercialization, targeting a per-test cost below $10 to enhance accessibility. Successful development of this technology has the potential to transform drug testing by enabling real-time, reliable, highly sensitive detection in decentralized settings, improving clinical decision- making and public health interventions.

Department of Health and Human Services

MATERNAL, INFANT AND EARLY CHILDHOOD HOMEVISITING GRANT PROGRAM - 11 SHS AUGUSTA ME 04333-0011 MARYANN HARAKALL 207-557-2470 © 207-287-4743 (F) MARYANN.HARAKALL@MAINE.GOV MATERNAL, INFANT AND EARLY CHILDHOOD HOME VISITING GRANT ANNOTATION: THIS PROJECT WILL PROVIDE THE PARENTS AS TEACHERS EVIDENCED-BASED PROGRAM TO ANY FAMILY IN MAINE WHO ACCEPTS THE SERVICES. THERE WILL BE ELEVEN LOCAL IMPLEMENTING AGENCIES STATEWIDE TO PROVIDE SERVICES TO FAMILIES AND TO CONNECT FAMILIES TO ADDITIONAL SERVICES WHEN NEEDED. THE OVERALL GOAL IS TO IMPROVE MATERNAL, INFANT, CHILD AND FAMILY PHYSICAL AND RELATIONAL HEALTH AND WELLBEING FOR FAMILIES IN MAINE. TO ACHIEVE THIS, MAINE’S MIECHV PROGRAM WILL CONTINUE TO RECRUIT FAMILIES TO PARTICIPATE, ACTIVELY ENGAGE IN CONTINUOUS QUALITY IMPROVEMENT PROJECTS AND IMPLEMENT HEALTH EQUITY ACTIVITIES. PROBLEM: MAINE IS A RURAL STATE AND ALL COMMUNITIES WITHIN THE STATE ARE AT RISK OF HAVING FAMILIES WHO ARE AT RISK FOR POOR MATERNAL AND CHILD HEALTH OUTCOMES. PURPOSE: MAINE’S MIECHV PROGRAM PROVIDES EFFECTIVE DELIVERY AND ONGOING IMPROVEMENT OF MAINE’S STATEWIDE HOME VISITING SERVICES WITH FIDELITY TO THE PARENTS AS TEACHERS (PAT) EVIDENCE-BASED MODEL, AS PART OF A COORDINATED STATEWIDE EARLY CHILDHOOD SYSTEM. THE GOAL OF THIS PROJECT IS TO IMPLEMENT A COMPREHENSIVE AND INCLUSIVE STATEWIDE SYSTEM TO IMPROVE THE PHYSICAL AND RELATIONAL HEALTH AND WELL-BEING OF MAINE’S MOST VULNERABLE CHILDREN AND FAMILIES. GOALS AND OBJECTIVES: GOAL 1. IMPROVE MATERNAL, INFANT, CHILD AND FAMILY PHYSICAL AND RELATIONAL HEALTH AND WELLBEING FOR PARTICIPATING FAMILIES. OBJECTIVE 1.A. ENGAGE ELIGIBLE FAMILIES WITH PAT EVIDENCE-BASED HOME VISITING SERVICES BY MAINTAINING MAINE FAMILIES ENROLLMENT LEVELS AS A PERCENTAGE OF POINT-IN-TIME CAPACITY. OBJECTIVE 1.B. RETAIN VULNERABLE FAMILIES WITH PAT BY MAINTAINING OR INCREASING RETENTION OF ELIGIBLE FAMILIES. OBJECTIVE 1.C. EXPLORE OPPORTUNITIES FOR PROGRAM PARTICIPANTS TO AUTHENTICALLY ENGAGE IN ADVISORY AND COLLABORATIVE ROLES TO CREATE MORE INCLUSIVE AND EQUITABLE SYSTEMS. GOAL 2. MAINTAIN AND CONTINUOUSLY IMPROVE STATEWIDE DELIVERY OF EVIDENCE-BASED PAT SERVICES BY MAINE FAMILIES WITH FIDELITY AND HIGH QUALITY. OBJECTIVE 2.A. SUPPORT CONTINUED FIDELITY AND QUALITY OF PAT DELIVERY BY MAINTAINING AND STRENGTHENING STATE-LEVEL SYSTEMS OF SUPPORTS FOR LIAS INCLUDING PERFORMANCE-BASED CONTRACTING, OVERSIGHT, TRAININGS, POLICIES, DATA SYSTEMS, TECHNICAL ASSISTANCE, CONTINUOUS QUALITY IMPROVEMENT (CQI) MONITORING, SUPPORTED THROUGH STATE-LEVEL CQI PROCESS. OBJECTIVE 2.B. SUPPORT LIA’S ABILITY TO MAINTAIN MAXIMUM STAFFING CAPACITY BY EXPLORING ADDITIONAL SYSTEM-WIDE STRATEGIES AND MONITORING THE IMPACT OF NEW HIRING QUALIFICATIONS FOR MAINE FAMILIES STAFF. GOAL 3. DEVELOP AND IMPROVE HEALTH EQUITY PRACTICES AROUND DIVERSITY, EQUITY, INCLUSION, AND ACCESSIBILITY. OBJECTIVE 3.A. MAINTAIN A STAFF DEMOGRAPHIC DATASET TO COMPARE WITH PARTICIPANT DEMOGRAPHIC DATA AND MONITOR FOR STAFF DIVERSIFICATION WITHIN THE SYSTEM. OBJECTIVE 3.B. MAINTAIN STATEWIDE DIVERSITY, EQUITY, INCLUSION AND ACCESSIBILITY WORKGROUP. OBJECTIVE 3.C. IDENTIFY FUNDING SUPPORT TO IDENTIFY HEALTH DISPARITIES IN MIECHV PERFORMANCE MEASURE DATA AND FAMILY ENGAGEMENT. APPROACH: PARENTS AS TEACHERS ALL MAINE COMMUNITIES WILL BE SERVED WITH THIS GRANT. THE PROPOSED CASELOAD FOR THE FY 2024 AWARD PERIOD, IS 1,202 FOR EACH YEAR OF THE PERFORMANCE PERIOD.

Department of Health and Human Services

MATERNAL, INFANT AND EARLY CHILDHOOD HOMEVISITING GRANT PROGRAM - ABSTRACT PROJECT TITLE: ALABAMA’S MATERNAL, INFANT, AND EARLY CHILDHOOD HOME VISITING (MIECHV) PROGRAM PURPOSE: THIS PROJECT SUPPORTS NATIONAL EFFORTS TO ENSURE HIGH-QUALITY, COMPREHENSIVE EARLY CHILDHOOD SUPPORT STATEWIDE FOR FAMILIES WITH CHILDREN FROM BIRTH TO KINDERGARTEN ENTRY. ALABAMA’S FIRST TEACHER HOME VISITING PROGRAM WILL IMPLEMENT THE PARENTS AS TEACHERS AND NURSE-FAMILY PARTNERSHIP MODELS THROUGH 14 LOCAL IMPLEMENTING AGENCIES (LIAS). MATCHING FEDERAL FUNDS WILL BE USED TO STRENGTHEN SERVICE DELIVERY. GOALS AND OBJECTIVES: GOAL 1: INCREASE ENROLLMENT IN MIECHV PROGRAMS TO EXPAND EFFECTIVE HOME VISITING. OBJECTIVE 1.1: MAINTAIN SERVICE PROVISION IN COUNTIES SERVED AS OF FY 2024. GOAL 2: IMPROVE MATERNAL AND NEWBORN HEALTH. OBJECTIVE 2.1: MAINTAIN OR IMPROVE FY2022 OUTCOMES IN MIECHV BENCHMARK 1 (HRSA-DEFINED). GOAL 3: PREVENT CHILD INJURIES, ABUSE, NEGLECT, AND REDUCE EMERGENCY VISITS. OBJECTIVE 3.1: MAINTAIN OR IMPROVE FY2022 OUTCOMES IN BENCHMARK 2. GOAL 4: ENHANCE SCHOOL READINESS AND ACHIEVEMENT. OBJECTIVE 4.1: MAINTAIN OR IMPROVE FY2022 OUTCOMES IN BENCHMARK 3. GOAL 5: REDUCE INTIMATE PARTNER VIOLENCE. OBJECTIVE 5.1: MAINTAIN OR IMPROVE FY2022 OUTCOMES IN BENCHMARK 4. GOAL 6: SUPPORT FAMILY ECONOMIC SELF-SUFFICIENCY. OBJECTIVE 6.1: MAINTAIN OR IMPROVE FY2022 OUTCOMES IN BENCHMARK 5. GOAL 7: IMPROVE COORDINATION AND REFERRALS TO COMMUNITY RESOURCES. OBJECTIVE 7.1: MAINTAIN OR IMPROVE FY2022 OUTCOMES IN BENCHMARK 6. GOAL 8: SUPPORT COMPREHENSIVE EVALUATION OF PROJECT OUTCOMES. OBJECTIVE 8.1: MONITOR SITE PERFORMANCE USING ALABAMA'S COMMON BENCHMARKS; PROVIDE TECHNICAL ASSISTANCE. OBJECTIVE 8.2: DEVELOP METHODS TO LINK FIRST TEACHER DATA WITH OTHER EARLY CHILDHOOD PROGRAMS TO EVALUATE SCHOOL READINESS. OBJECTIVE 8.3: INTEGRATE HOME VISITING DATA WITH K-12 DATA TO ASSESS EDUCATIONAL PERFORMANCE. GOAL 9: PROMOTE BEST PRACTICES AND IMPROVED SERVICE DELIVERY. OBJECTIVE 9.1: LIAS WILL ENGAGE IN CONTINUOUS QUALITY IMPROVEMENT (CQI) PROJECTS. APPROACH: THE PROGRAM WILL SERVE A PROPOSED CASELOAD OF 1,395 FAMILIES ANNUALLY, ACROSS 39 OF ALABAMA’S 67 COUNTIES, INCLUDING JEFFERSON, MONTGOMERY, MOBILE, AND SEVERAL RURAL COUNTIES. SERVICES ARE DELIVERED BY 14 LIAS RECEIVING FUNDS DURING THE PERFORMANCE PERIOD. ALABAMA’S FTHV PROGRAM DOES NOT PLAN TO EXPAND GEOGRAPHIC COVERAGE AT THIS TIME. INSTEAD, IT WILL USE FEDERAL MATCHING FUNDS TO INCREASE PER-FAMILY SUPPORT FOR THE PARENTS AS TEACHERS MODEL FROM $4,200 TO $5,000. THIS INCREASE WILL ALLOW FOR STRONGER SERVICE DELIVERY, ENHANCED STAFF SUPPORT, PROFESSIONAL DEVELOPMENT, AND IMPROVED OUTCOMES FOR FAMILIES. THE ADDITIONAL RESOURCES WILL HELP ENSURE PROGRAM SUSTAINABILITY AND FOSTER LONG-TERM IMPACT IN KEY EARLY CHILDHOOD INDICATORS.

Department of Health and Human Services

MATERNAL, INFANT AND EARLY CHILDHOOD HOMEVISITING GRANT PROGRAM - ABSTRACT PROJECT TITLE: MATERNAL, INFANT AND EARLY CHILDHOOD HOME VISITING PROGRAM NON-COMPETING CONTINUATION UPDATE, FISCAL YEAR 2025 RECIPIENT NAME: CALIFORNIA DEPARTMENT OF PUBLIC HEALTH (CDPH)/MATERNAL, CHILD AND ADOLESCENT HEALTH DIVISION (MCAH)/CALIFORNIA HOME VISITING PROGRAM (CHVP) ADDRESS: 1615 CAPITOL AVENUE, MS 8304, SACRAMENTO, CA 95899-7420 PROJECT DIRECTOR NAME: SUSAN ZIMNY PHONE NUMBER: 866-241-0395 EMAIL: SUSAN.ZIMNY@CDPH.CA.GOV WEBSITE: HTTPS://WWW.CDPH.CA.GOV/PROGRAMS/CFH/DMCAH/CHVP/PAGES/DEFAULT.ASPX GRANT PROGRAM FUNDS: $25,188,343 (BASE GRANT) + $3,798,942 (MATCHING GRANT) = $28,987,285 PURPOSE: CDPH/CHVP SUPPORTS FAMILIES IN UNDERSERVED COMMUNITIES THROUGH EARLY CHILDHOOD HOME VISITING. CDPH/CHVP SUPPORTS THE IMPLEMENTATION OF EVIDENCE-BASED HOME VISITING (EBHV) PROGRAMS IN 22 LHJS IN 21 URBAN AND RURAL CALIFORNIA COUNTIES, PAIRING NURSES OR FAMILY SUPPORT PROFESSIONALS WITH FAMILIES IN NEED. THE PROGRAMS PROVIDE SERVICES TO IMPROVE MATERNAL AND CHILD HEALTH, PROMOTE ATTACHMENT AND POSITIVE PARENTING PRACTICES, MONITOR AND SUPPORT HEALTHY CHILD DEVELOPMENT, IMPROVE SCHOOL READINESS, AND INCREASE RESILIENCE AND ECONOMIC SELF-SUFFICIENCY. GOALS: 1) PROVIDE LEADERSHIP AND STRUCTURE FOR IMPLEMENTATION OF CHVP TO SERVE FAMILIES, 2) INTEGRATE CHVP INTO STATEWIDE AND LOCAL EARLY CHILDHOOD SYSTEMS 3) COMPLY WITH MIECHV DATA COLLECTION AND REPORTING REQUIREMENTS TO MONITOR PROGRAM IMPLEMENTATION AND 4) IMPROVE MATERNAL MENTAL HEALTH AMONG HOME VISITING PARTICIPANTS AS A COMMUNITY HEALTH NEED. OBJECTIVES: 1.1) COORDINATE WITH THE EBHV MODELS TO ENSURE THAT FAMILIES RECEIVE TARGETED AND INTENSIVE HOME VISITING SERVICES 1.2) PROVIDE PROGRAMMATIC OVERSIGHT TO SUBRECIPIENTS TO ENSURE LOCAL HOME VISITING PROGRAMS MEET STATE AND FEDERAL REQUIREMENTS, SOW OBJECTIVES AND MODEL REQUIREMENTS 1.3) REVIEW AND REVISE AS NEEDED ALL MIECHV SUBRECIPIENT MONITORING TOOLS TO PROVIDE CLEAR, CONSISTENT AND RESPONSIVE GUIDANCE IN THE IMPLEMENTATION OF HOME VISITING SERVICES 1.4) IMPLEMENT CONTINUOUS QUALITY IMPROVEMENT PROJECTS TO SUPPORT A CULTURE OF GROWTH AND EXCELLENCE 1.5) PROVIDE TARGETED, RESPONSIVE TECHNICAL ASSISTANCE TO ALL LOCAL HEALTH JURISDICTIONS (LHJS) TO SUPPORT ONGOING GROWTH AND A ROBUST IMPLEMENTATION OF HOME VISITING SERVICES 1.6) ADDRESS THE TRAINING NEEDS OF LOCAL AND STATE-LEVEL STAFF; 1.7) ENSURE LHJS INCREASE THE PROPORTION OF HOME VISITS CONDUCTED IN-PERSON FROM 60% TO 80%; 1.8) COMPLY WITH ALL MIECHV REPORTING REQUIREMENTS TO ENSURE ALL HOME VISITING SERVICES ARE IMPLEMENTED AND OVERSEEN IN ACCORDANCE WITH FEDERAL GUIDANCE; 2.1) COLLABORATE WITH OTHER STATE DEPARTMENTS, LOCAL GOVERNMENT AGENCIES AND NON-PROFIT ORGANIZATIONS TO BUILD HOME VISITING CAPACITY AND COORDINATE SERVICES TO FAMILIES; 2.2) ENSURE EVERY LHJ IS EMBEDDED IN THEIR LOCAL EARLY CHILDHOOD SYSTEM AND SEEKS INPUT AND FEEDBACK ON PROGRAM PLANNING, IMPLEMENTATION, AND EVALUATION FROM COMMUNITY PARTNERS; 3.1) MONITOR AND SUBMIT ALL INFORMATION REQUIRED FOR MIECHV QUARTERLY AND ANNUAL PERFORMANCE REPORTING; AND 4.1) IMPLEMENT A PLAN TO REDUCE MENTAL HEALTH CONCERNS AND BUILD RESILIENCE FOR THE HOME VISITING FAMILIES SERVED. APPROACH: THE PROPOSED ANNUAL CASELOAD FOR FFYS 2025-2027 IS 1,609 FAMILIES. CHVP SERVES 22 LHJS IN 21 COUNTIES AS DETERMINED BY CALIFORNIA’S 2020 NEEDS ASSESSMENT. CHVP WILL USE ITS FEDERAL MATCHING FUNDS TO PROVIDE ADDITIONAL FUNDING TO LHJS THAT CAN BE USED FOR EXPANSION, PROGRAM IMPROVEMENT ACTIVITIES AND/OR SUSTAINING HOME VISITING PROGRAMS.

Department of Health and Human Services

MATERNAL, INFANT AND EARLY CHILDHOOD HOMEVISITING GRANT PROGRAM - ABSTRACT PROJECT TITLE: MATERNAL, INFANT AND EARLY CHILDHOOD HOME VISITING PROGRAM NOTICE OF FUNDING OPPORTUNITY, FISCAL YEAR 2024 RECIPIENT NAME: CALIFORNIA DEPARTMENT OF PUBLIC HEALTH (CDPH)/MATERNAL, CHILD AND ADOLESCENT HEALTH DIVISION (MCAH)/CALIFORNIA HOME VISITING PROGRAM (CHVP) ADDRESS: 1615 CAPITOL AVENUE, MS 8304, SACRAMENTO, CA 95899-7420 PROJECT DIRECTOR NAME: JANE TROGLIA PHONE NUMBER: 866-241-0395 EMAIL: JANE.TROGLIA@CDPH.CA.GOV WEBSITE: HTTPS://WWW.CDPH.CA.GOV/PROGRAMS/CFH/DMCAH/CHVP/PAGES/DEFAULT.ASPX GRANT PROGRAM FUNDS: $25,188,343 (BASE GRANT) + $725,893 (MATCHING GRANT) = $25,914,236 ANNOTATION: THE CHVP AIMS TO SUPPORT FAMILIES AND IMPROVE FAMILY RESILIENCE IN UNDERSERVED COMMUNITIES THROUGH HOME VISITING. CHVP SUPPORTS THE IMPLEMENTATION OF EVIDENCE-BASED HOME VISITING (EBHV) PROGRAMS IN 22 LIAS IN 21 URBAN AND RURAL CALIFORNIA COUNTIES, PAIRING NURSES OR FAMILY SUPPORT PROFESSIONALS WITH FAMILIES IN NEED. THE PROGRAMS PROVIDE SERVICES TO IMPROVE MATERNAL AND CHILD HEALTH, PROMOTE ATTACHMENT AND POSITIVE PARENTING PRACTICES, MONITOR AND SUPPORT HEALTHY CHILD DEVELOPMENT, IMPROVE SCHOOL READINESS AND INCREASE ECONOMIC SELF-SUFFICIENCY. PROBLEM: THE PROGRAM AIMS TO ADDRESS HEALTH INEQUITIES AND FAMILY CHALLENGES, INCLUDING DEVELOPMENTAL DISABILITIES, CHILD ABUSE/NEGLECT, SUBSTANCE USE DISORDER, AND HOUSING AND FINANCIAL INSTABILITY. PURPOSE: THE PURPOSE IS TO REDUCE DISPARITIES AND IMPROVE HEALTH AND SOCIAL OUTCOMES FOR FAMILIES FACING THE GREATEST INEQUITIES IN CALIFORNIA. GOALS: 1) PROVIDE LEADERSHIP AND STRUCTURE FOR EFFICIENT AND EQUITABLE ADMINISTRATION AND IMPLEMENTATION OF CHVP, 2) FOSTER MEANINGFUL PARTNERSHIP AND COLLABORATION TO INTEGRATE CHVP INTO THE STATEWIDE AND LOCAL EARLY CHILDHOOD SYSTEMS, 3) COMPLY WITH MIECHV DATA COLLECTION AND REPORTING REQUIREMENTS TO MONITOR PROGRAM IMPLEMENTATION AND 4) CENTER A RACIAL AND HEALTH EQUITY MINDSET AND INTEGRATE EQUITY-FOCUSED APPROACHES INTO ALL PROGRAM AND DATA ASPECTS OF CHVP. OBJECTIVES: 1.1) COORDINATE WITH THE EBHV MODELS TO ENSURE THAT FAMILIES RECEIVE TARGETED AND INTENSIVE HOME VISITING SERVICES; 1.2) PROVIDE PROGRAMMATIC OVERSIGHT TO SUBRECIPIENTS TO ENSURE LOCAL HOME VISITING PROGRAMS MEET STATE AND FEDERAL REQUIREMENTS, SOW OBJECTIVES AND MODEL REQUIREMENTS; 1.3) REVISE ALL MIECHV SUBRECIPIENT MONITORING TOOLS TO PROVIDE CLEAR, CONSISTENT AND RESPONSIVE GUIDANCE IN THE IMPLEMENTATION OF HOME VISITING SERVICES; 1.4) IMPLEMENT CONTINUOUS QUALITY IMPROVEMENT PROJECTS TO SUPPORT A CULTURE OF GROWTH AND EXCELLENCE; 1.5) PROVIDE TARGETED, RESPONSIVE TECHNICAL ASSISTANCE TO ALL LOCAL IMPLEMENTING AGENCIES (LIAS) TO SUPPORT ONGOING GROWTH AND A ROBUST IMPLEMENTATION OF HOME VISITING SERVICES; 1.6) CREATE A WORKFORCE TRAINING PLAN TO ADDRESS TRAINING NEEDS OF LOCAL AND STATE-LEVEL STAFF; 1.7) ENSURE LIAS INCREASE THE PROPORTION OF HOME VISITS CONDUCTED IN-PERSON VS. VIRTUALLY FROM 60% TO 80%; 1.8) COMPLY WITH ALL MIECHV REPORTING REQUIREMENTS TO ENSURE ALL HOME VISITING SERVICES ARE IMPLEMENTED AND OVERSEEN IN ACCORDANCE WITH FEDERAL GUIDANCE; 2.1) COLLABORATE WITH OTHER STATE DEPARTMENTS, LOCAL GOVERNMENT AGENCIES AND NON-PROFIT ORGANIZATIONS TO BUILD HOME VISITING CAPACITY AND COORDINATE SERVICES TO FAMILIES; 2.2) ENSURE EVERY LIA IS EMBEDDED IN THEIR LOCAL EARLY CHILDHOOD SYSTEM AND SEEKS INPUT AND FEEDBACK ON PROGRAM PLANNING, IMPLEMENTATION, AND EVALUATION FROM COMMUNITY PARTNERS; 3.1) MONITOR AND SUBMIT ALL INFORMATION REQUIRED FOR MIECHV QUARTERLY AND ANNUAL PERFORMANCE RE PORTING; AND 4.1) DEVELOP AND EXECUTE A HEALTH EQUITY PLAN DESIGNED TO INCREASE EQUITY THROUGHOUT THE CHVP PROGRAM AND ADDRESS SELECTED SOCIAL DETERMINANTS OF HEALTH. APPROACH: CHVP OFFERS THE HEALTHY FAMILIES AMERICA AND NURSE FAMILY PARTNERSHIP EBHV MODELS VIA ITS 22 LIAS IN 21 COUNTIES. CHVP WILL CONTINUE TO SERVE FAMILIES IN THE COUNTIES CURRENTLY SERVED BASED ON THE RESULTS OF THE 2020 NEEDS ASSESSMENT. THE PROPOSED CASELOAD FOR FFYS 2024-2026 IS 1,532 FAMILIES.

Department of Health and Human Services

MATERNAL, INFANT AND EARLY CHILDHOOD HOMEVISITING GRANT PROGRAM - ADDRESS 401 S CLINTON STREET, CHICAGO, IL 60607 PROJECT DIRECTOR LORI ORR PHONE 312-919-3426 E-MAIL LORI.A.ORR@ILLINOIS.GOV WEBSITE: WWW.IGROWILLINOIS.ORG FUNDS REQUESTED $13,126,310 PURPOSE THE PURPOSE OF IL MIECHV IS TO IMPROVE CHILD AND FAMILY OUTCOMES IN AT-RISK COMMUNITIES, WITH AN EMPHASIS ON SERVING FAMILIES EXPERIENCING HOMELESSNESS, PREGNANT AND PARENTING YOUTH IN CHILD WELFARE CARE, FAMILIES WITH SUBSTANCE USE ISSUES. IL MIECHV COMMUNITIES INCLUDE URBAN SITES WITH CONCENTRATED POVERTY, SUBURBS WITH FAST-GROWING POPULATIONS, AND RURAL COUNTIES WHERE ISOLATION AND LACK OF TRANSPORTATION EXACERBATE CONDITIONS FOR PRIORITY POPULATIONS. IL MIECHV SUPPORTS THREE EVIDENCE-BASED MODELS: HEALTHY FAMILIES AMERICA, PARENTS AS TEACHERS, AND FAMILY CONNECTS (AS A COORDINATED INTAKE STRATEGY IN SELECTED COMMUNITIES). IL MIECHV IMPLEMENTS EVIDENCE-BASED HV SERVICES AND STRENGTHENS CROSS-SYSTEMS PARTNERSHIPS TO SUPPORT COMPREHENSIVE, COORDINATED SERVICES FOR FAMILIES. MATCHING FUNDS ARE ANTICIPATED TO SUPPORT EXPANSION OF HOME VISITING SERVICES IN SELECTED COMMUNITIES IDENTIFIED IN ILLINOIS’ 2020 NEEDS ASSESSMENT, BECAUSE OF THE ILLINOIS COMPETITIVE HV NOFO WHICH WAS RELEASED IN APRIL 2025. IN ADDITION, COMMUNITY READINESS AND CAPACITY-BUILDING ACTIVITIES WILL CONTINUE IN SUBURBAN COOK COUNTY AND IN CENTRAL ILLINOIS. GOAL(S) AND OBJECTIVES GOAL 1 PROVIDE COMPREHENSIVE HOME VISITING SERVICES TO ELIGIBLE FAMILIES LIVING IN COMMUNITIES THAT FACE BARRIERS TO ACHIEVING POSITIVE MATERNAL AND CHILD HEALTH OUTCOMES.1.1 COORDINATED SYSTEM OF SUPPORTS;1.2 CAPACITY-BUILDING FOR AT-RISK COMMUNITIES. GOAL 2 STRENGTHEN PROGRAMS AND ACTIVITIES THAT ADDRESS PREVENTIVE AND PRIMARY CARE SERVICES FOR PREGNANT WOMEN, INFANTS AND CHILDREN UNDER TITLE V OF THE SOCIAL SECURITY ACT. 2.1 COLLABORATION AND ALIGNMENT WITH THE TITLE V PROGRAM;2.2 GROW & RETAIN THE HV WORKFORCE; 2.3 INCREASE FAMILY ENGAGEMENT - PROGRAM LEVEL;2.4 COMPREHENSIVE COST MODEL TOOL; 2.5 DATA TO IMPROVE FAMILY OUTCOMES AND SERVICES;2.6 FEEDBACK ON PRIORITIES AND STRATEGIES. GOAL 3 IMPROVE COORDINATION OF SERVICES WITHIN COMMUNITIES IDENTIFIED IN THE APPROVED STATEWIDE NEEDS ASSESSMENT AS AT RISK FOR POOR MATERNAL AND CHILD HEALTH OUTCOMES. 3.1 CI PROGRAMS WILL ANALYZE DATA TO IMPROVE COORDINATION AND FAMILY OUTCOMES; 3.2 REFINE ACTION PLAN FOR A STATEWIDE COORDINATED INTAKE SYSTEM FOR HV; 3.3 IMPROVE HOW PRIORITY POPULATIONS ARE SYSTEMATICALLY CONNECTED TO HV; 3.4 STRENGTHEN SYSTEMS CONNECTIONS BETWEEN HV AND SDOH. APPROACH MAJOR METHODS AND ACTIVITIES INCLUDE ONGOING PROFESSIONAL DEVELOPMENT, QUALITY ASSESSMENT, CQI AND MONITORING; CAPACITY-BUILDING; ALIGNMENT WITH TITLE V; SUPPORTING LOCAL IMPLEMENTING AGENCIES (LIAS) WITH FAMILY ENGAGEMENT; UTILIZING A COMPREHENSIVE COST MODEL FOR HIGH QUALITY HV SERVICES; BUILDING COMMUNITY READINESS IN NEW COMMUNITIES, AND COORDINATING REFERRALS BETWEEN HV AND CHILD WELFARE, FAMILY CASE MANAGEMENT, AND UNIVERSAL NEWBORN SUPPORTS. CASELOAD TOTAL PROPOSED CASELOAD OF MIECHV FAMILY SLOTS FOR EACH FFY: 829. MIECHV COMMUNITIES IL WILL CONTINUE TO SERVE THE FOLLOWING AT-RISK COUNTIES: COOK: DUPAGE; KANE; KANKAKEE, MACON, PEORIA, ST.CLAIR, STEPHENSON, VERMILION, AND WINNEBAGO COUNTIES. PENDING THE OUTCOME OF THE NOTICE OF FUNDING OPPORTUNITY, WE MAY EXPAND SERVICES IN ONE OR MORE COUNTIES IDENTIFIED IN ILLINOIS’ 2020 NEEDS ASSESSMENT.LIAS IL WILL CONTINUE TO CONTRACT WITH 18 LIAS THAT SERVE A TOTAL OF 10 COUNTIES. DEPENDING ON THE OUTCOME OF A PENDING NOTICE OF FUNDING OPPORTUNITY, ADDITIONAL LIAS MAY BE ADDED. MATCHING FUNDS IL MIECHV PLANS TO USE FEDERAL MATCHING FUNDS TO CONTINUE COMMUNITY READINESS AND CAPACITY BUILDING IN SOUTH SUBURBAN COOK COUNTY (CHICAGO AREA) AND IN CASS-MORGAN COUNTIES (IN CENTRAL ILLINOIS). DEPENDING ON THE OUTCOME OF A PENDING NOTICE OF FUNDING OPPORTUNITY, WE MAY ADD SERVICES IN ONE OR MORE COUNTIES IDENTIFIED IN THE 2020 NEEDS ASSESSMENT.THE SOURCE OF NON-FEDERAL FUNDS IS STATE GENERAL REVENUE FUNDING.

Department of Health and Human Services

MATERNAL, INFANT AND EARLY CHILDHOOD HOMEVISITING GRANT PROGRAM - ADDRESS: 401 S. CLINTON STREET, CHICAGO, ILLINOIS 60607 PROJECT DIRECTOR: LORI ORR PHONE: (312) 919-3426 E-MAIL: LORI.A.ORR@ILLINOIS.GOV WEBSITE: WWW.IGROWILLINOIS.ORG FUNDS REQUESTED: $ 11,942,559 ANNOTATION: ILLINOIS MIECHV (IL) AIMS TO IMPROVE CHILD AND FAMILY OUTCOMES BY IMPLEMENTING EVIDENCE-BASED HOME VISITING (HV) MODELS IN AT-RISK COMMUNITIES, AND BY STRENGTHENING CROSS-SYSTEMS PARTNERSHIPS TO SUPPORT COMPREHENSIVE, COORDINATED SERVICES. IL COMMUNITIES INCLUDE URBAN SITES WITH CONCENTRATED POVERTY, SUBURBS WITH FAST-GROWING MIGRANT POPULATIONS, AND RURAL COUNTIES WHERE ISOLATION AND LACK OF TRANSPORTATION EXACERBATE CONDITIONS FOR PRIORITY POPULATIONS. KEY ACTIVITIES INCLUDE ONGOING PROFESSIONAL DEVELOPMENT, QUALITY ASSESSMENT, CQI AND MONITORING; CAPACITY-BUILDING; ALIGNMENT WITH TITLE V; SUPPORTING LOCAL IMPLEMENTING AGENCIES (LIAS) WITH FAMILY ENGAGEMENT; DEVELOPING AND UTILIZING A COMPREHENSIVE COST MODEL FOR HIGH QUALITY HV SERVICES; AND COORDINATING REFERRALS BETWEEN HV AND CHILD WELFARE, FAMILY CASE MANAGEMENT, AND UNIVERSAL NEWBORN SUPPORTS. PROBLEM: ILLINOIS MATERNAL AND CHILD OUTCOMES ARE CONCERNING. FOR EXAMPLE, THE LATEST MATERNAL MORTALITY REPORT SHOWS THAT BLACK WOMEN ARE TWICE AS LIKELY AS WHITE WOMEN TO DIE FROM A PREGNANCY-RELATED CONDITION, AND 91% OF ALL PREGNANCY-RELATED DEATHS ARE PREVENTABLE. AND EACH YEAR, MORE THAN 35,000 CHILDREN ARE IMPACTED BY SUBSTANTIATED REPORTS OF CHILD ABUSE OR NEGLECT. IN 2022-23, 81% OF IL MIECHV FAMILIES EARNED LOW INCOMES, 24% HAD LOW STUDENT ACHIEVEMENT, 15% HAD A CHILD WITH DEVELOPMENTAL ISSUES, 15% HAD TOBACCO USE IN THE HOME, 14% HAD CHILD WELFARE INVOLVEMENT, AND 6% HAD SUBSTANCE USE CONCERNS. PURPOSE: THE PURPOSE OF IL MIECHV IS TO IMPROVE CHILD AND FAMILY OUTCOMES IN AT-RISK COMMUNITIES, BY IMPLEMENTING EVIDENCE-BASED HV SERVICES AND BY STRENGTHENING CROSS-SYSTEMS PARTNERSHIPS TO SUPPORT COMPREHENSIVE, COORDINATED SERVICES FOR FAMILIES. GOAL(S) AND OBJECTIVES: GOAL 1: IDENTIFY AND PROVIDE COMPREHENSIVE HV SERVICES TO ELIGIBLE FAMILIES LIVING IN COMMUNITIES THAT FACE BARRIERS TO ACHIEVING POSITIVE MCH OUTCOMES. 1.1 COORDINATED SYSTEM OF SUPPORTS;1.2 CAPACITY-BUILDING RESOURCES FOR AT-RISK COMMUNITIES. GOAL 2: STRENGTHEN AND IMPROVE PROGRAMS AND ACTIVITIES THAT ADDRESS TITLE V PREVENTIVE AND PRIMARY CARE SERVICES FOR PREGNANT PEOPLE, INFANTS AND CHILDREN.2.1 COLLABORATION AND ALIGNMENT WITH THE TITLE V PROGRAM; 2.2 GROW & RETAIN THE HV WORKFORCE; 2.3 INCREASE FAMILY ENGAGEMENT - PROGRAM LEVEL.;2.4 COMPREHENSIVE COST MODEL TOOL; 2.5 DATA TO IMPROVE FAMILY OUTCOMES AND SERVICES; 2.6 FEEDBACK ON PRIORITIES AND STRATEGIES. GOAL 3: IMPROVE COORDINATION OF SERVICES WITHIN ‘AT-RISK COMMUNITIES’ IDENTIFIED IN THE APPROVED NEEDS ASSESSMENT. 3.1 CI PROGRAMS WILL ANALYZE DATA TO IMPROVE COORDINATION AND FAMILY OUTCOMES; 3.2 IMPLEMENT ACTION PLAN FOR CREATING A STATEWIDE COORDINATED INTAKE SYSTEM FOR HV; 3.3 IMPROVE HOW PRIORITY POPULATIONS ARE SYSTEMATICALLY CONNECTED TO HV; 3.4 STRENGTHEN SYSTEMS CONNECTIONS BETWEEN HV AND SDOH. APPROACH: EVIDENCE-BASED MODELS: IL SUPPORTS THREE EVIDENCE-BASED MODELS: HEALTHY FAMILIES AMERICA, PARENTS AS TEACHERS, AND FAMILY CONNECTS - USED AS A COORDINATED INTAKE STRATEGY IN SELECTED COMMUNITIES. COMMUNITIES: IL WILL CONTINUE TO SERVE THE FOLLOWING AT-RISK COMMUNITIES: CICERO; CHICAGO SOUTHSIDE CLUSTER; CHICAGO WEST SIDE; EAST ST LOUIS; ELGIN; ROCKFORD; AND STEPHENSON, PEORIA, KANKAKEE, MACON, AND VERMILION COUNTIES. DEPENDING ON THE RESULTS OF A PENDING NOTICE OF FUNDING OPPORTUNITY, WE MAY ADD ONE OR MORE OF THE FOLLOWING AT-RISK COUNTIES: CASS; COLES; DOUGLAS; DUPAGE; LAKE; MORGAN; MOULTRIE; ROCK ISLAND. TARGET POPULATIONS INCLUDE FAMILIES EXPERIENCING HOMELESSNESS, PREGNANT AND PARENTING YOUTH IN CHILD WELFARE CARE, DUAL LANGUAGE LEARNERS, AND FAMILIES WITH SUBSTANCE USE ISSUES. TOTAL PROPOSED CASELOAD OF MIECHV FAMILY SLOTS FOR EACH FFY: 836.

Department of Health and Human Services

MATERNAL, INFANT AND EARLY CHILDHOOD HOMEVISITING GRANT PROGRAM - ARKANSAS’S MATERNAL, INFANT AND EARLY CHILDHOOD HOME VISITING (MIECHV) PROGRAM I. PROJECT ABSTRACT ADDRESS: ARKANSAS DEPARTMENT OF HEALTH, 4815 W MARKHAM ST, SLOT 16, LITTLE ROCK, AR 72205 PROJECT DIRECTOR: MICHAEL CONYERS, 501-661-2086, MICHAEL.CONYERS@ARKANSAS.GOV ARKANSAS DEPARTMENT OF HEALTH (ADH) WEBSITE: WWW.HEALTHY.ARKANSAS.GOV GRANT PROGRAM FUNDS REQUESTED: $9,455,628.00 PURPOSE: THE PURPOSE OF THE ARKANSAS MIECHV PROGRAM IS TO IMPROVE OUTCOMES FOR AT-RISK CHILDREN AND FAMILIES. RESEARCH SHOWS THAT HOME VISITING (HV) PROGRAMS ARE EFFECTIVE IN ADDRESSING THE HEALTH AND WELL-BEING NEEDS OF AT-RISK FAMILIES, PARTICULARLY IN RURAL AREAS. HOME VISITING SERVICES ARE SUPPORTED BY ONGOING TRAINING, REFLECTIVE SUPERVISION, DATA COLLECTION AND REVIEW, COORDINATED INTAKE, PROGRAM EVALUATION, CONTINUOUS QUALITY IMPROVEMENT (CQI), AND SUBRECIPIENT MONITORING. GOALS AND OBJECTIVES: GOAL: MAINTAIN FUNDING FOR EXISTING LOCAL IMPLEMENTING AGENCIES AND HOME VISITING MODELS. BY SEPTEMBER 2027, THE PROGRAM WILL: • INCREASE THE QUARTERLY ACTIVE ENROLLMENT FOR EACH MODEL TO 85% OF MAXIMUM SERVICE CAPACITY, • STRENGTHEN ARKANSAS'S NETWORK OF HV PROGRAMS AND THEIR INTEGRATION INTO EARLY CHILDHOOD PROGRAMS BY 20% AND, • MAINTAIN EXISTING COLLABORATIVE PARTNERSHIPS WITH STAKEHOLDERS AND BUILD ONE NEW COLLABORATIVE PARTNERSHIP. GOAL: PREPARE THE HV WORKFORCE BY DEVELOPING AND DELIVERING TRAINING TO HV STAFF. BY SEPTEMBER 2027, THE PROGRAM WILL: • DEVELOP TWO NEW ONLINE TRAININGS AND UPDATE ONE EXISTING ONLINE TRAINING BASED ON NEEDS ASSESSMENTS, CORE COMPETENCIES, AND EVALUATION DATA, • DEVELOP TWO NEW INSTRUCTOR-LED TRAININGS AND UPDATE TWO EXISTING TRAININGS BASED ON NEEDS ASSESSMENTS, CORE COMPETENCIES, AND EVALUATION DATA AND, • DELIVER AT LEAST 24 INSTRUCTOR-LED TRAININGS TO HOME VISITORS, SUPERVISORS, AND COORDINATORS. GOAL: CONTRIBUTE TO THE HV KNOWLEDGE BASE THROUGH COORDINATED INTAKE, CQI INITIATIVES, AND EVALUATION ACTIVITIES. BY SEPTEMBER 2027, THE PROGRAM WILL: • USE BENCHMARKS AND OTHER DATA TO SUPPORT CQI PROJECTS AT THE STATE AND LOCAL LEVELS, • DISSEMINATE FINDINGS IN PEER-REVIEWED PUBLICATIONS AND CONFERENCES AS FEASIBLE, • PARTICIPATE IN AN ADVISORY CAPACITY IN NATIONAL HV ASSOCIATIONS AND COUNCILS AND, • CONDUCT RIGOROUS RESEARCH OF THE STATE'S PROMISING APPROACH, FOLLOWING BABY BACK HOME. APPROACH: HOME VISITING SERVICES ARE PROVIDED BY 29 LOCAL IMPLEMENTING AGENCIES (LIAS) THROUGH FOUR EVIDENCE-BASED MODELS AND ONE PROMISING APPROACH: HEALTHY FAMILIES AMERICA (HFA), HOME INSTRUCTION FOR PARENTS OF PRESCHOOL YOUNGSTERS (HIPPY), NURSE-FAMILY PARTNERSHIP (NFP), PARENTS AS TEACHERS (PAT), AND PROMISING APPROACH-FOLLOWING BABY BACK HOME (FBBH). ARKANSAS MIECHV SERVES THE FOLLOWING COUNTIES: ARKANSAS, ASHLEY, BAXTER, BENTON, BOONE, BRADLEY, CALHOUN, CARROLL, CLARK, CLEBURNE, CLEVELAND, COLUMBIA, CONWAY, CRAIGHEAD, CRITTENDEN, CROSS, DALLAS, FAULKNER, FULTON, GARLAND, GRANT, HEMPSTEAD, HOT SPRING, HOWARD, INDEPENDENCE, IZARD, JACKSON, JEFFERSON, LAWRENCE, LEE, LINCOLN, LONOKE, MADISON, MARION, MILLER, MISSISSIPPI, MONROE, MONTGOMERY, NEVADA, NEWTON, OUACHITA, PHILLIPS, PIKE, POINSETT, POLK, PRAIRIE, PULASKI, RANDOLPH, SAINT FRANCIS, SALINE, SCOTT, SEARCY, SEBASTIAN, SHARP, STONE, UNION, VAN BUREN, WASHINGTON, AND WHITE. PROPOSED CASELOAD OF FAMILY SLOTS: OCTOBER 2025 - SEPTEMBER 2026: 1,395 OCTOBER 2026 - SEPTEMBER 2027: 1,403 NON-FEDERAL MATCHING FUNDS FOR ARKANSAS' MIECHV PROJECT WILL BE USED TO SUPPORT SERVICE DELIVERY THOUGH THE HIPPY, PAT AND HFA EVIDENCE-BASED HOME VISITING MODELS BY FUNDING 22.75 EXISTING HOME VISITING FTE'S THAT WOULD OTHERWISE BE CUT FROM THE FORMULA BUDGET AND TO SUPPLEMENT TRAVEL, QUALITY MONITORING, AND DATA COLLECTIONS COSTS. MATCH FUNDS ARE STATE GENERAL FUNDS LEGISLATIVELY APPROPRIATED TO SUPPORT HOME VISITING SERVICE DELIVERY UNDER A STATE GRANT AWARDED TO ARKANSAS CHILDREN'S HOSPITAL BY THE ARKANSAS DEPARTMENT OF EDUCATION ABC PROFESSIONAL SERVICES GRANT.

Department of Health and Human Services

MATERNAL, INFANT AND EARLY CHILDHOOD HOMEVISITING GRANT PROGRAM - I. PROJECT ABSTRACT PROJECT TITLE: COLORADO- HRSA FY 2025 MIECHV PROGRAM: BASE AND MATCHING GRANT AWARDS APPLICANT NAME: COLORADO DEPARTMENT OF EARLY CHILDHOOD PROJECT DIRECTOR: BRITTANY MARTENS, MIECHV PROGRAM MANAGER ADDRESS: COLORADO DEPARTMENT OF EARLY CHILDHOOD 710 S. ASH ST (BUILDING C), DENVER, CO 80220 P| (303) 653-3109 F (303)-866-4453, BRITTANY.MARTENS@STATE.CO.US; HTTPS://CDEC.COLORADO.GOV ANNOTATION: COLORADO MIECHV WILL IMPLEMENT THREE EVIDENCE-BASED HOME VISITING MODELS ACROSS ALL 64 COUNTIES IN COLORADO TO IMPROVE PARENT AND FAMILY OUTCOMES, INCLUDING DECREASES IN PRETERM BIRTH RATES AND CHILD MALTREATMENT INVESTIGATED CASES, INCREASES IN BREASTFEEDING AND PRIMARY CAREGIVER EDUCATION ATTAINMENT, AND IMPROVEMENTS IN OTHER CRUCIAL INDICATORS (AS SET BY HRSA’S MIECHV BENCHMARKS). CO MIECHV WILL CONTINUE TO BUILD STATEWIDE COLLABORATION AND SYSTEMS OF SUPPORT AND REFERRAL NETWORKS FOR HOME-VISITING PROFESSIONALS THROUGH ENHANCED OPPORTUNITIES AT ORIENTATION TRAINING. COLORADO WILL WORK TO EXPAND ACCESS TO ALL 64 COUNTIES THROUGH THE APPROVED UPDATED NEEDS ASSESSMENT AND IMPROVED CENTRALIZED INTAKE SYSTEMS; THIS WORK IS FULLY SUPPORTED THROUGH BOTH BASE AWARD AND MATCHING FUNDS. PROBLEM: COLORADO WILL CONTINUE TO RECRUIT AT-RISK FAMILIES, INCLUDING FAMILIES EXPERIENCING LOW INCOMES, LIVING IN POVERTY, LOW EDUCATIONAL ATTAINMENT, FAMILIES IMPACTED BY DOMESTIC VIOLENCE, FAMILIES AFFECTED BY SUBSTANCE ABUSE, AND FAMILIES FACING STRESSORS THAT PUT THEM AT RISK FOR PREMATURE BIRTH, LOW-BIRTH-WEIGHT INFANTS, INFANT MORTALITY, POOR HEALTH, OR MALTREATMENT. PURPOSE: ENHANCE PARENT AND FAMILY OUTCOMES THROUGH EVIDENCE-BASED HOME VISITING ACROSS 64 COUNTIES, TARGETING PRETERM BIRTH REDUCTION, BREASTFEEDING PROMOTION, CAREGIVER EDUCATION IMPROVEMENT, AND STRENGTHENING SUPPORT NETWORKS FOR PROFESSIONALS WHILE EXPANDING SERVICE ACCESS. GOALS AND OBJECTIVES: SMARTIE GOAL 1: IN EVERY MONTH OF THE PERIOD OF PERFORMANCE (SEPTEMBER 30, 2025 – SEPTEMBER 29, 2027), PROVIDE EVIDENCE-BASED HOME VISITING SERVICES IN 22 COLORADO COUNTIES SERVING A CASELOAD OF 1,461 FAMILIES. ? SMARTIE OBJECTIVE: EVERY MONTH OF THE PERFORMANCE PERIOD, PROVIDE EVIDENCE-BASED HOME VISITING SERVICES IN 22 CO COUNTIES SERVING A CASELOAD OF 1,461 FAMILIES. SMARTIE GOAL 2: PROVIDE ADDITIONAL SUPPORT TO HOME VISITORS TO IMPROVE WORKFORCE DEVELOPMENT, RETENTION, AND SATISFACTION OF HOME-VISITING PROFESSIONALS AND LEADERS DURING THE PERFORMANCE PERIOD (SEPTEMBER 30, 2025- SEPTEMBER 29, 2027). ? SMARTIE OBJECTIVE: ENHANCE TRAINING FOR HOME VISITOR PROFESSIONALS THROUGH EIGHT ORIENTATIONS FOCUSED ON STAFF WELL-BEING AND SAFETY THROUGH COLLABORATION WITH INTERNAL AND EXTERNAL PARTNERS BETWEEN SEPTEMBER 30, 2025, AND SEPTEMBER 29, 2027. SMARTIE GOAL 3: IMPROVE FAMILY ENGAGEMENT IN HOME VISITING SERVICES AND ASSESS THE EXPANSION OF SERVICES INTO NEW HIGH-RISK COUNTIES THROUGH AN UPDATED NEEDS ASSESSMENT. ? SMARTIE OBJECTIVE: INCREASE AVERAGE MONTHLY CASELOADS TO 80% BETWEEN SEPTEMBER 30, 2025, AND SEPTEMBER 29, 2027, ACROSS URBAN, RURAL, AND FRONTIER COUNTIES. APPROACH: COLORADO WILL USE EVIDENCE-BASED MODELS HIPPY, NFP, AND PAT, WITH STATE AND LOCAL AGENCIES TO SERVE HIGH-RISK COMMUNITIES IDENTIFIED IN THE 2020 MIECHV NEEDS ASSESSMENT. THE TARGETED COUNTIES INCLUDE ADAMS, ALAMOSA, ARCHULETA, BACA, BENT, BOULDER, CHAFFEE, CHEYENNE, CLEAR CREEK, CONEJOS, COSTILLA, CROWLEY, CUSTER, DELTA, DENVER, DOLORES, DOUGLAS, EAGLE, EL PASO, FREMONT, GARFIELD, GILPIN, GRAND, GUNNISON, HUERFANO, JACKSON, JEFFERSON, KIOWA, LA PLATA, LAKE, LARIMER, LAS ANIMAS, LINCOLN, LOGAN, MESA, MINERAL, MOFFAT, MONTEZUMA, MONTROSE, OTERO, OURAY, PARK, PHILLIPS, PITKIN, PROWERS, PUEBLO, RIO GRANDE, ROUTT, SAGUACHE, SAN JUAN, SAN MIGUEL, SEDGWICK, SUMMIT, TELLER, WASHINGTON, AND WELD. COLORADO AIMS TO SERVE 1,461 FAMILIES IN THE FIRST YEAR AND 1,499 IN THE SECOND YEAR.

Department of Health and Human Services

MATERNAL, INFANT AND EARLY CHILDHOOD HOMEVISITING GRANT PROGRAM - PROJECT ABSTRACT PROJECT TITLE: WEST VIRGINIA HOME VISITATION PROGRAM (WVHVP) APPLICANT NAME: WEST VIRGINIA DEPARTMENT OF HEALTH (WVDH) ADDRESS: 350 CAPITOL STREET, ROOM 427, CHARLESTON, WEST VIRGINIA 25301 PROJECT DIRECTOR: JACKIE NEWSON CONTACT PHONE #S: VOICE: (304) 414-0648 FAX: (304) 558-4984 E-MAIL ADDRESS: JACKIE.J.NEWSON@WV.GOV ANNOTATION: THE WVHVP WILL CONTINUE TO IMPLEMENT A WELL-COORDINATED PROGRAM THROUGH EVIDENCE-BASED HOME VISITING SERVICES, STATEWIDE DATA COLLECTION, PROFESSIONAL DEVELOPMENT, CONTINUOUS QUALITY IMPROVEMENT (CQI), HEALTH EQUITY PLANNING, AND A HELP ME GROW (HMG) COORDINATED INTAKE SYSTEM (CIS) THAT WILL INCLUDE A PROMISING PRACTICE MODEL, RIGHT FROM THE START PROGRAM (RFTS). PROBLEM: WEST VIRGINIA IS RURAL WITH HIGH POVERTY RATES AND MULTIPLE RISK FACTORS FOR FAMILIES INCLUDING SUBSTANCE USE, CHILDREN’S ENTRY INTO THE CHILD WELFARE SYSTEM AND FIRST-TIME MOMS IMPACTING MANY FAMILIES SERVED. PURPOSE: THE WVHVP IS THE LEAD PROGRAM TO COORDINATE VOLUNTARY HOME VISITING SERVICES WITH LOCAL IMPLEMENTING AGENCIES (LIAS). THE INTENT IS TO IMPROVE OUTCOMES FOR FAMILIES SERVED. GOALS AND OBJECTIVES: BASED UPON 2023 BASELINE PERCENTAGES, COLLECTIVE EFFORTS BETWEEN STATE AND LOCAL STAKEHOLDERS WILL ENSURE IDENTIFIED OBJECTIVES AND GOALS REFLECT IMPROVEMENTS: 1) REDUCE DISPARITIES BY 10% IN THE HEALTH AND WELL-BEING OF FAMILIES UTILIZING EVIDENCE-BASED PRACTICES IN FAMILIES SERVED THROUGH SEPTEMBER 2026; 2) ENSURE IMPLEMENTATION OF HOME VISITING SERVICES THROUGH THE HMG CIS TO PROVIDE POSITIVE OUTCOMES WITH HARDER-TO-ENGAGE FAMILIES THROUGH SEPTEMBER 2026; 3) INCREASE THE NUMBER OF PRIORITY POPULATION FAMILIES SERVED THROUGH FAMILY-CENTERED APPROACHES IN THE TARGETED HIGHEST AT-RISK COUNTIES BY 10% BY SEPTEMBER 2026; 4) INCREASE HOME VISITOR PROFESSIONAL DEVELOPMENT, OUTREACH AND SERVICES TO FAMILIES IMPACTED BY SUBSTANCE USE, CHILD WELFARE ENTRY OR FIRST-TIME MOMS BY 10% BY SEPTEMBER 2026; AND 5) PARTICIPATE IN A RIGOROUS EVALUATION OF RFTS AS A PROMISING PRACTICE MODEL. METHODOLOGY: THE WVHVP INTENDS TO SERVE AN AVERAGE OF 1,875 FAMILIES PER YEAR WITH EFFORTS TOWARDS TARGETED INTENSIVE HOME VISITING SERVICES. WVHVP WILL PROVIDE A SOLID FRAMEWORK THROUGH USE OF IMPROVED REFERRAL PROCESSES, HEALTH EQUITY PLANNING, CQI SPECIALISTS, SOCIAL DETERMINANTS OF HEALTH SCREENING, LINKAGES BETWEEN MEDICAL HOME, AND THE HMG CIS. WVHVP WILL UTILIZE A PARENT ADVISORY GROUP AND COMMUNITY PARTNERS TO ADDRESS NEEDS IN HIGHEST RISK POCKETS OF COUNTIES SERVED. A TRANSITION TO A REGIONAL APPROACH WITH SUBRECIPIENT GRANTEES WILL STREAMLINE MONITORING AND FISCAL APPROACHES. THE USE OF HMG WILL ASSIST WITH WAITING LISTS AND AREAS WITH LIMITED HOME VISITING SERVICES. EVIDENCE-BASED MODELS TO BE USED ARE PARENTS AS TEACHERS (PAT), HEALTHY FAMILIES AMERICA (HFA), EARLY HEAD START HOME BASED OPTION (EHS), NURSE FAMILY PARTNERSHIP (NFP), AND THE MATERNAL INFANT HEALTH OUTREACH WORKER PROGRAM (MIHOW). A RIGOROUS EVALUATION OF RFTS WILL BE A PRIORITY FOCUS AND ASSIST WITH LINKING THROUGH MEDICAID FUNDING. A CONTINUUM OF CARE WILL INCLUDE COORDINATED EFFORTS BETWEEN EARLY INTERVENTION, PART C, AND CHILDREN WITH SPECIAL HEALTH CARE NEEDS.

Department of Health and Human Services

MATERNAL, INFANT AND EARLY CHILDHOOD HOMEVISITING GRANT PROGRAM - PROJECT ABSTRACT SUMMARY ADDRESS: 450 W. STATE STREET - 4TH FLOOR, BOISE, ID 83702-6056 PROJECT DIRECTOR: TARYN YATES PHONE: (208) 334-4961 EMAIL ADDRESS: TARYN.YATES@DHW.IDAHO.GOV WEBSITE: HTTPS://HEALTHANDWELFARE.IDAHO.GOV/SERVICES-PROGRAMS/CHILDREN-FAMILIES/ABOUT-HOME-VISITING FUNDS REQUESTED: $3,956,227 ANNOTATION: THE IDAHO MIECHV PROGRAM SERVES 27 OF 44 COUNTIES IN THE STATE WITH PLANS TO EXPAND TO 41 BY SEPTEMBER 2025. SERVICES ARE IMPLEMENTED THROUGH EACH OF THE SEVEN PUBLIC HEALTH DISTRICTS ACROSS THE STATE AND WILL SOON BE ACCOMPANIED BY TWO ADDITIONAL PROGRAMS, INCLUDING A TRIBAL PROGRAM, TO MEET THE GROWING NEED IN THE STATE. THE IDAHO MIECHV PROGRAM AIMS TO OFFER HIGH QUALITY SERVICES TO AS MANY FAMILIES AS POSSIBLE WHILE MAINTAINING A STABLE AND SKILLED WORKFORCE. WITH LIMITED SERVICES AVAILABLE TO YOUNG FAMILIES, HOME VISITING IS A CRITICAL SERVICE TO MEET THE NEEDS OF IDAHO’S FAMILIES. PROBLEM: IDAHO IS A RURAL AND HISTORICALLY UNDERSERVED AREA. THERE IS A LACK OF ADEQUATE HEALTHCARE, MENTAL HEALTHCARE, AND EARLY CHILDHOOD SERVICES IN MOST REGIONS OF THE STATE. HOME VISITING MEETS FAMILIES WHERE THEY ARE AND SERVES NOT ONLY AS A DIRECT SUPPORT, BUT AS A CONNECTION TO THE RESOURCES THAT DO EXIST IN THEIR COMMUNITIES. PURPOSE: HOME VISITING PROGRAMS AIM TO SUPPORT FAMILIES IN AT-RISK COMMUNITIES, ADVANCE HEALTH EQUITY BY LEVERAGING INDIVIDUAL FAMILY STRENGTHS, IDENTIFY AND ADDRESS THE SOCIAL DETERMINANTS OF HEALTH, AND ENSURE CHILDREN AND FAMILIES HAVE EQUAL OPPORTUNITY TO REACH THEIR FULLEST POTENTIAL. GOALS AND OBJECTIVES: IDAHO MIECHV AIMS TO IMPLEMENT VOLUNTARY, EVIDENCE-BASED HOME VISITING PROGRAMS THAT SERVE FAMILIES IN AT-RISK COMMUNITIES TO IMPROVE OUTCOMES, ENSURE HIGH-QUALITY HOME VISITING SERVICES, AND COLLABORATE WITH STATE AND LOCAL PARTNERS TO COORDINATE EARLY CHILDHOOD SYSTEMS AND HIGH-QUALITY SERVICES. IDAHO MIECHV WILL ACCOMPLISH THIS BY: 1) DEMONSTRATING OUTCOMES THROUGH PROGRAM EVALUATION AND BENCHMARK REPORTING 2) OFFERING REFLECTIVE CONSULTATION AND TRAINING OPPORTUNITIES TO HOME VISITORS THAT ARE ALIGNED AND COORDINATED WITH THE COMPETENCIES OF INFANT MENTAL HEALTH 3) DEVELOPING AND SUPPORTING CQI PROJECTS 4) BUILDING A COLLABORATIVE OF HOME VISITING PROGRAMS STATEWIDE 5) IMPLEMENTING A SUSTAINABLE MEDICAID BILLING PROCESS APPROACH: IDAHO MIECHV HAS ESTABLISHED CONTRACTS WITH LIAS TO DELIVER EBHV SERVICES IN AT-RISK COMMUNITIES USING THE NURSE-FAMILY PARTNERSHIP (NFP) AND PARENTS AS TEACHERS (PAT) MODELS. THE AT-RISK COMMUNITIES IN IDAHO FUNDED BY IDAHO MIECHV INCLUDE THE FOLLOWING: ADA, ADAMS, BANNOCK, BEAR LAKE, BENEWAH, BINGHAM, BOISE, BONNER, BONNEVILLE, BOUNDARY, CANYON, CARIBOU, CASSIA, CLARK, CLEARWATER, CUSTER, ELMORE, FRANKLIN, FREMONT, GEM, GOODING, IDAHO, JEFFERSON, JEROME, KOOTENAI, LATAH, LEMHI, LEWIS, LINCOLN, MADISON, MINIDOKA, NEZ PERCE, ONEIDA, OWYHEE, PAYETTE, POWER, SHOSHONE, TETON, TWIN FALLS, VALLEY, WASHINGTON, AND COUNTIES, AS WELL AS THE COUNTIES THAT ENCOMPASS THE COEUR D’ ALENE, NEZ PERCE, AND SHOSHONE-BANNOCK TRIBAL RESERVATIONS. THE 2024 NEEDS ASSESSMENT AMENDMENT IDENTIFIED ALL 44 IDAHO COUNTIES AS COMMUNITIES IN NEED OF SERVICES. OF THOSE 44 COUNTIES, A TOTAL OF 41 WILL BE SERVED WITH MIECHV FUNDS. THE TOTAL PROPOSED CASELOAD OF FAMILY SLOTS IS 528 FOR FY2024 AND FY2025. KEY ACTIVITIES TO ENSURE APPROPRIATE NETWORKING AND SUPPORT INCLUDE: REGULARLY COORDINATING AND CONVENING WITH STATE AND COMMUNITY PARTNERS TO GUIDE PLANNING AND IMPLEMENTATION; EVALUATION OF PROGRAM ACTIVITIES, OUTCOMES, AND IMPLEMENTATION; AND SUBRECIPIENT MONITORING VIA CHECK-IN CALLS, REPORTS, DATA ANALYSIS, AND BIENNIAL SITE VISITS.

Department of Health and Human Services

MATERNAL, INFANT AND EARLY CHILDHOOD HOMEVISITING GRANT PROGRAM - PURPOSE: ARIZONA AIMS TO IMPLEMENT VOLUNTARY EVIDENCE-BASED AND EVIDENCE-INFORMED HOME VISITING PROGRAMS, DELIVERED BY TRAINED EDUCATORS, IN COMMUNITIES IDENTIFIED IN THE NEEDS ASSESSMENT, TO IMPROVE MATERNAL AND CHILD HEALTH OUTCOMES FOR FAMILIES. HOME VISITING PROGRAM CONTRACTS WITH STATE AGENCIES, COUNTY HEALTH DEPARTMENTS, TRIBAL NATIONS AND NON-PROFIT ORGANIZATIONS TO IMPLEMENT THE FOLLOWING MODELS: FAMILY SPIRIT, HEALTHY FAMILIES, PARENTS AS TEACHERS, NURSE FAMILY PARTNERSHIP, SAFECARE AUGMENTED, MATERNAL AND EARLY CHILDHOOD SUSTAINED HOME-VISITING AND HEALTH START. GOALS AND OBJECTIVES: A) SUPPORT VOLUNTARY EVIDENCE-BASED AND PROMISING APPROACH HOME VISITING PROGRAMS THAT ARE ACCESSIBLE TO ELIGIBLE FAMILIES RESULTING IN POSITIVE OUTCOMES IN AT LEAST 4 OF THE 6 BENCHMARK AREAS BY IMPLEMENTING HOME VISITING SERVICES IN AT-RISK COMMUNITIES WITH AN OVERALL CASELOAD CAPACITY OF 2,385 AND EVALUATE THE PROMISING APPROACH THROUGH AN INSTITUTE OF HIGHER EDUCATION. B) IMPROVE COORDINATION AND INFORMATION PERTAINING TO THE ARIZONA HOME VISITING SYSTEM TO MAXIMIZE FUNDING, SUPPORT, SERVICES AND RESOURCES FOR HOME VISITORS, SUPERVISORS AND ELIGIBLE FAMILIES BY CONVENING THE STRONG FAMILIES AZ HOME VISITING ALLIANCE; USING TECHNOLOGY TO PROVIDE INFORMATION AND TRAINING TO HOME VISITORS, SUPERVISORS AND FAMILIES; COORDINATE EARLY CHILDHOOD EFFORTS AND OUTCOMES; MAINTAIN THE STATEWIDE DATA MANAGEMENT SYSTEM; AND STRENGTHEN COMMUNITY CAPACITY TO IMPROVE HEALTH OUTCOMES. C) ENSURE PROGRAM IMPLEMENTATION OVERSIGHT TO MEET THE GRANT GOALS, OBJECTIVES, BUDGET AND ACTIVITIES BY MAXIMIZING HUMAN AND FINANCIAL RESOURCES; UTILIZE TOOLS TO APPROPRIATELY AND ACCURATELY TRACK ACTIVITIES AND TIMELINES; PARTICIPATE IN MEETINGS, CONFERENCES AND SEEK TECHNICAL ASSISTANCE TO MEET THE GRANT REQUIREMENTS AND IMPROVE THE HEALTH AND WELLBEING OF ARIZONA’S FAMILIES. APPROACH: TO ACHIEVE THE GOALS OF THIS GRANT, ARIZONA WILL: IMPLEMENT VOLUNTARY EVIDENCE-BASED HOME VISITING PROGRAMS AND A PROMISING APPROACH MODEL IN AT-RISK COMMUNITIES WITH EFFECTIVE OVERSIGHT AND GUIDANCE; COLLECT, COMPILE AND REPORT DATA TO ENSURE THE FIDELITY OF THE MODEL BEING USED AND PROGRESS TOWARD BENCHMARKS; AND COORDINATE SERVICES ACROSS THE EARLY CHILDHOOD SYSTEM. DURING THIS PROJECT PERIOD THE HEALTH START PROGRAM WILL BE GOING THROUGH THE REQUEST FOR GRANT APPLICATION PROCESS THROUGH THE ARIZONA PROCUREMENT SYSTEM. ALL SERVICE AREAS ARE IDENTIFIED IN THE 2020 MIECHV NEEDS ASSESSMENT. MIECHV FUNDS ARE USED TO SUPPORT PROGRAMS IN 37 URBAN, 29 RURAL, 4 FRONTIER AND 5 TRIBAL COMMUNITIES IN 25 LOCAL IMPLEMENTING AGENCIES. ARIZONA’S CURRENT CASELOAD CAPACITY IS 2,385 FAMILY SLOTS. ARIZONA PROPOSES A CASELOAD CAPACITY OF 1,571 FROM SEPTEMBER 30, 2025-SEPTEMBER 29, 2027 FOR EVIDENCE-BASED HOME VISITING MODELS. CURRENTLY, WE ARE SERVING 814 FAMILY SLOTS WITH OUR PROMISING APPROACH PROGRAM, HEALTH START. THE MATCHING FUNDS WILL BE UTILIZED TO EXTEND SERVICES DURING THE PROJECT PERIOD AND SUPPORT THE OUTREACH AND REFERRAL PROGRAM, FAMILY CONNECTS. FIRST THING FIRST IS A STATE FUNDED AGENCY DEDICATED TO EARLY CHILDHOOD PROGRAMS AND SERVICES THAT ADDRESS THE DEVELOPMENT, EDUCATION AND HEALTH NEEDS OF CHILDREN BIRTH TO AGE FIVE. FIRST THINGS FIRST WILL PROVIDE THE NON-FEDERAL CONTRIBUTION AND MEETS THE MATCHING REQUIREMENTS TO IMPROVE OUTCOMES FOR INDIVIDUAL FAMILIES AND CORE COMPONENTS OF THE MIECHV PROGRAM.

Rural Business-Cooperative Service

The U.S. Department of Agriculture (USDA), Rural Development (RD) Rural Business Cooperative Service (RBCS or Agency), requests applications for the Meat and Poultry Processing Expansion Program - Phase 4 (the Program or MPPEP-4) - Fortifying the American Beef Industry. MPPEP-4 is authorized under Section 1001(b)(4) of the American Rescue Plan Act of 2021 (ARPA), which provides funding to make loans and grants and provide other assistance to maintain and improve food and agricultural supply chain resiliency. Pursuant to this authority, USDA is making competitive grant funding available to Very Small Processors and Small Processors, and to Intermediate Processors to maximize the value and utilization of their existing capacity, with a focus on promoting local supply chains. Grant funding in the amount of $60 million is available under this Program. Funding will be divided equally into two separate competitions: one for Very Small Processors and Small Processors, and one for Intermediate Processors. Each competition will have its own ranking and award process. Cost share is required. Applicants will be required to identify sources and amounts that will make up the required cost share in the application and will need to verify cost share funding prior to final award approval. Two types of applications for each of the funding competitions will be accepted:1. Processing Expansion Projects. Awards will range from $50,000 to $2 million to support a range of activities to increase and diversify processing capacity of American Meat and Poultry, including Equipment-only purchases over $250,000, and necessary improvements, upgrades, renovations or retrofits to an existing Facility needed to install the Equipment. A match requirement of 50 percent of the Project Cost is required for Processing Expansion Projects. 2. Simplified Equipment-Only Projects. Awards will range from $10,000 to $250,000 for projects that only request the cost of Equipment and do not include renovation, labor, installation, or certification costs. A match requirement of 25 percent of the Project Cost is required for Simplified Equipment-Only Projects.Eligible applicants for MPPEP-4 include entities that are currently engaged in the Primary Processing of cattle for commercial markets or toll process and have been in business for at least one year. Eligible applicants include For Profit Organizations, Nonprofit Organizations, Producer-owned cooperatives, Tribes, and Tribal Entities. Privately-owned entities must be Independently Owned and Operated, and all applicants must be Domestically Owned. Additionally, an applicant s Facility must be physically located and operating in a State. Eligible applicants must be currently operating under a FSIS grant of inspection, grant of inspection under a Cooperative Interstate Shipment Program, or a State Meat and Poultry inspection program with standards at least equal to Federal inspection.Ineligible applicants include entities that have an active Federal Award through MPPEP Phase 1, MPPEP Phase 2, MPPEP Phase 3, USDA Agricultural Marketing Service (AMS) Local Meat Capacity Grants program, or USDA AMS Meat and Poultry Inspection Readiness Grant program. An active award means that the Period of Performance has not ended.Applicants must meet the definition of a Very Small Processor, a Small Processor, or an Intermediate Processor. Applicants that are nationally dominant in beef, pork, chicken, or turkey processing are ineligible; for the purpose of this NOFO, nationally dominant is characterized as holding a market share greater than or equal to the entity that holds the fourth largest share of the market for beef, pork, chicken, or turkey processing.

Rural Business-Cooperative Service

<p>The U.S. Department of Agriculture (USDA), Rural Development (RD) Rural Business‐Cooperative Service (RBCS or Agency), requests applications for the Meat and Poultry Processing Expansion Program - Phase 4 (the Program or MPPEP-4) - Fortifying the American Beef Industry. MPPEP-4 is authorized under Section 1001(b)(4) of the American Rescue Plan Act of 2021 (ARPA), which provides funding to make “loans and grants and provide other assistance to maintain and improve food and agricultural supply chain resiliency.” Pursuant to this authority, USDA is making competitive grant funding available to Very Small Processors and Small Processors, and to Intermediate Processors to maximize the value and utilization of their existing capacity, with a focus on promoting local supply chains.&nbsp;&nbsp;&nbsp;</p><p><br></p><p>Grant funding in the amount of $60 million is available under this Program. Funding will be divided equally into two separate competitions: one for Very Small Processors and Small Processors, and one for Intermediate Processors. Each competition will have its own ranking and award process.&nbsp;Cost share is required. Applicants will be required to identify sources and amounts that will make up the required cost share in the application and will need to verify cost share funding prior to final award approval. Two types of applications for each of the funding competitions will be accepted:</p><p><br></p><p>1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<em>Processing Expansion Projects.</em> Awards will range from $50,000 to $2 million to support a range of activities to increase and diversify processing capacity of American Meat and Poultry, including Equipment-only purchases over $250,000, and necessary improvements, upgrades, renovations or retrofits to an existing Facility needed to install the Equipment.&nbsp;A match requirement of 50 percent of the Project Cost is required for <em>Processing Expansion Projects.</em>&nbsp;</p><p>2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<em>Simplified Equipment-Only Projects. </em>Awards will range from $10,000 to $250,000<em> </em>for projects that only request the cost of Equipment and do not include renovation, labor, installation, or certification costs.&nbsp;&nbsp;A match requirement of 25 percent of the Project Cost is required for <em>Simplified Equipment-Only Projects.</em></p><p><br></p><p>Eligible applicants for MPPEP-4 include entities that are currently engaged in the Primary Processing of cattle for commercial markets or toll process and have been in business for at least one year.&nbsp;Eligible applicants include For‐Profit Organizations, Nonprofit Organizations, Producer-owned cooperatives, Tribes, and Tribal Entities.&nbsp;Privately-owned entities must be Independently Owned and Operated, and all applicants must be Domestically Owned. Additionally, an applicant’s Facility must be physically located and operating in a State.&nbsp;Eligible applicants must be currently operating under a FSIS grant of inspection, grant of inspection under a Cooperative Interstate Shipment Program, or a State Meat and Poultry inspection program with standards at least equal to Federal inspection.</p><p><br></p><p>Ineligible applicants include entities that have an active Federal Award through MPPEP Phase 1, MPPEP Phase 2, MPPEP Phase 3, USDA Agricultural Marketing Service (AMS) Local Meat Capacity Grants program, or USDA AMS Meat and Poultry Inspection Readiness Grant program. An active award means that the Period of Performance has not ended.</p><p><br></p><p>Applicants must meet the definition of a Very Small Processor, a Small Processor, or an Intermediate Processor. Applicants that are nationally dominant in beef, pork, chicken, or turkey processing are ineligible; for the purpose of this NOFO, nationally dominant is characterized as holding a market share greater than or equal to the entity that holds the fourth largest share of the market for beef, pork, chicken, or turkey processing.</p>

NIGMS - National Institute of General Medical Sciences

Project summary This proposal seeks to develop a therapeutic strategy for cancer treatment by simultaneously inhibiting cyclin- dependent kinases (CDKs) 2, 4, and 6. These kinases regulate cell cycle progression, and their dysregulation drives tumor growth and resistance to therapy. CDK4/6 inhibitors are FDA-approved for metastatic breast cancer and prolong progression-free survival; however, about 20% of patients fail to respond to these agents from the outset, and virtually all patients eventually develop resistance. A key mechanism of resistance is compensatory activation of CDK2, which bypasses CDK4/6 inhibition. Conversely, selective CDK2 inhibition alone is insufficient because CDK4/6 can substitute for CDK2 function. Simultaneous inhibition of CDK2 and CDK4/6 therefore represents a rational approach to overcome resistance and extend therapeutic benefit across cancers. Novel thiazolyl-pyrimidine compounds have been discovered and patented that selectively inhibit CDK2/4/6 while sparing essential kinases such as CDK1, CDK7, and CDK9. Unlike current CDK4/6 inhibitors, which leave CDK2 activity intact, this new class directly targets the cooperative functions of CDK2/4/6. Preliminary studies demonstrate that these compounds suppress proliferation of breast cancer and leukemia cells, indicating proof- of-concept activity. Their selectivity profile also suggests reduced toxicity compared to earlier multi-CDK inhibitors. Our central hypothesis is that the thiazolyl-pyrimidine scaffold provides a structural framework that enables selective targeting of CDK2/4/6, and that its rational multiparameter optimization leads to development candidates capable of overcoming resistance to existing CDK4/6- or CDK2-selective inhibitors and expand the therapeutic reach of CDK inhibition to cancers driven by CDK2. To test this hypothesis, aim 1 will define mechanisms of action through kinase profiling, cell viability and apoptosis assays, and resistance modeling in breast and ovarian cancer. Aim 2 will focus on medicinal chemistry to identify analogs with improved potency, selectivity, and drug-likeness and safety. Compounds will undergo in vitro biochemical characterization, cellular efficacy testing, and absorption, distribution, metabolism, and toxicity evaluations. Beyond direct therapeutic impact, this work addresses a significant gap in cancer pharmacology by providing chemical probes to interrogate CDK2/4/6 biology and mechanisms of resistance. Equally important, the research will enhance the research capacity of Idaho State University, the only provider of graduate education in pharmaceutical sciences in the state, where opportunities for biomedical research are limited. The SuRE-First (R16) program will strengthen this under-resourced environment by supporting the development of next-generation CDK inhibitors while directly involving students in experimental design, laboratory assays, and data analysis. Participation in these studies will provide first-generation and rural students with hands-on training, mentorship, and dissemination opportunities at conferences, preparing them for advanced careers in biomedical science.

MI Dept of Agriculture & Rural Development

Grants for specialty crops, food safety, and rural economic development.

Michigan Department of Agriculture and Rural Development

MDARD provides grants to farmers, agribusinesses, food banks, and rural organizations for agricultural development, local food systems, food safety, and rural community economic development across Michigan.

NCI - National Cancer Institute

Title: Microfluidic Isolation and Deep Learning-based Profiling of Subtypes of Circulating Tumor Cells during Epithelial Mesenchymal Transition Project Summary/Abstract Circulating tumor cells (CTCs) are highly heterogeneous and contain many cellular subpopulations. It is known that specific CTC subpopulations, rather than the whole, are responsible for cancer metastases. Recently, epithelial mesenchymal transition (EMT) of adherent epithelial cells to a migratory mesenchymal state has been implicated in tumor metastasis. CTCs isolated from cancer patients exhibit dynamic changes in epithelial and mesenchymal composition, and serial CTC monitoring in those patients suggested an association of EMT in CTCs. Emerging microfluidic technologies have shown great promise for the complete capture of the CTCs population with high yield and enhanced purity. However, most existing devices simply isolate all CTCs in blood without resolving them into distinct subpopulations: isolation of CTC populations with specific EMT markers remains a significant challenge. Consequently, epithelial-mesenchymal plasticity of CTCs during cancer progression is largely unknown, preventing researchers from acquiring true insights into the metastatic potential of CTCs. In the R15 project, we propose to develop the HU microchip platform for isolation and profiling of CTCs in pre-clinical settings, with the focus on detecting and understanding features associated with CTC subtypes during the course (or intermediate states) of EMT. To do so, we will isolate CTCs and explore deep learningbased profiling platforms using both micro and nanometer-scale features found from microscope images obtained from our HU microfluidic devices. This is expected to achieve super-high accuracy for profiling CTC subtypes with varied cell plasticity (i.e., more “epithelial” or more “mesenchymal” type). Building on the success of this project, we expect to develop an integrated system comprising 1) a user-friendly HU microchip for highly efficient isolation of CTCs from blood samples, and 2) an AI-based image analysis platform that can identify CTC subtypes for monitoring cancer progression and support cancer diagnosis and treatment. CTCs with defined EMT stages generated from the NSG mouse model will used to provide critical ground-truth information for validation of the proposed AI model, which cannot be accomplished using other alterative models. This project is strongly integrated with an educational plan to expose undergraduates to advanced experiments in the areas of biomedical engineering and cancer research. It is our belief that involving all students in cutting-edge research will have a significant positive impact on attracting and retaining students in science and healthcare fields. In this grant, we will provide research opportunities for 6 undergraduate students and 1 graduate to learn advanced knowledge on cancer biology, obtain hands-on experience in microfabrication and biological assays. Texas Tech University (TTU) is located in Lubbock, a rural area in northwestern Texas and TTU has been classified as "Tier 1" status in 2016. Due to historical and geographical reasons, life sciences research is not a strength for TTU, and TTU is not a recipient of major NIH grants. This R15 grant will strengthen our research and training at TTU and help us to reach our goal to be one of the best bioengineering programs in Texas.

Minnesota Department of Agriculture

The MDA provides grants to farmers, food system organizations, and rural communities for sustainable agriculture, local food systems, beginning farmer support, agricultural marketing, and rural economic development across Minnesota.

Montana Department of Commerce

The Big Sky Economic Development Trust Fund provides grants and loans to Montana communities for infrastructure and economic development projects that create or retain jobs, with priority given to projects in rural and distressed areas.

NCI - National Cancer Institute

PROJECT SUMMARY/ABSTRACT The long-term objective of this K99/R00 application is to develop Dr. Kelsey Day’s ability to become a leader in community-based physical activity research and cancer prevention, particularly through the development of sustainable, multilevel, and participatory solutions. In the K99 phase of the project, Dr. Day will receive support in meeting four training objectives that will facilitate her transition to an independent investigator and expand her knowledge in key content areas that are highly relevant to her long-term career goals. First, she will expand her knowledge of text message and mHealth intervention approaches to increasing physical activity. Second, she will learn how to analyze objective device-measured physical activity data. Third, she will gain theoretical and practical knowledge of community based participatory research methodology. Finally, Dr. Day will obtain advanced training in qualitative research methods. In the K99 phase, Dr. Day will also initiate the research aims of a multilevel, faith-based project focused on physical activity. In Aim 1, she will use a participatory design process to convene focus groups of rural church members to adapt a rural physical activity text message intervention with spiritual content and tailored physical activity feedback. Concurrently, in Aim 2, she will conduct workshops with leaders from rural churches who are paired with a leader from their local Parks and Recreation departments to: 1) establish partnerships; 2) use a participatory approach to adapt evidence-based intervention strategies to increase physical activity; 3) determine barriers and facilitators to the selected strategies within the church/Parks partnership. In Aim 3 (R00 phase), Dr. Day will deliver the multilevel intervention (individual text message intervention, plus church/Parks strategies) to a pilot group of rural churches to evaluate feasibility indicators, including: limited efficacy (changes in Fitbit-measured physical activity among rural churchgoers); acceptability; implementation; and demand. The proposed research seeks to address critical rural health disparities and to promote rural cancer prevention by increasing physical activity opportunities and capacity through a sustainable, multilevel approach. The project is consistent with the NCI’s mission of conducting cancer research that helps individuals across the country live longer and healthier lives, as well as the NCI’s strategic focus on rural cancer disparities. Dr. Day proposes to pursue these training objectives and begin the proposed research aims with the support of the University of Virginia Comprehensive Cancer Center and the Department of Public Health Sciences in the University of Virginia School of Medicine. This environment offers an optimal setting, including research support and resources, to assist her in reaching her training and research objectives.

National Association of Development Organizations

Rural transportation planning and infrastructure development

NC Department of Agriculture and Consumer Services

The NC Department of Agriculture provides grants to farmers, agribusinesses, food banks, and rural organizations for agricultural development, food system infrastructure, farmland preservation, and rural community support.