Search Grants — Free, No Account Required

NIGMS - National Institute of General Medical Sciences

PROJECT DESCRIPTION Trace metal micronutrients, such as copper, iron, and zinc are vital to a host of biological processes, but their dyshomeostasis is associated with a number of disease states. The context in which a metal resides within a biological environment significantly influences its activity and function. Recent years have seen a rise in tools for monitoring metal ions and have illuminated the diversity in metal speciation in biology, but many of these tools are focused on probing metals in the intracellular space. The state-of-the-art methods for assessing metal status in extracellular fluids such as blood plasma focus either on absolute quantitation or evaluate a limited number of metal-containing species. While these methods have offered important insight into extreme cases of metal deficiency or overload, subtle imbalances are more challenging to diagnose and understand with the available methods. The objective of this research program is to expand and elucidate the metal speciation of the extracellular space, with an immediate focus on blood-based fluids due to their clinical importance in biomarker assessment. In previous work, we developed new bioluminescence-based probes and enrichment methods for mass spectrometry-based proteomics for identifying reactive copper pools and potential binding partners in serum. Additionally, we identified new interactions between transition metals and peptide hormones that influence their cellular behavior, quantitation in diagnostic assays, and interaction with other proteins in serum. In this proposal proposal, we seek to further develop the extracellular metal biochemical profile in the following ways. First, we seek to expand the toolbox for assessing extracellular metal interactions. Optical sensing approaches include the use of native albumin as a bioluminescence enzyme to pair with metal-responsive substrates and the development peptide-based detection platforms with metal-responsive cell surface interactions or internalization. Second, we will progress our metal-affinity enrichment strategies via on-resin digestion methods to gain new insight on metal chelate-interaction sites, with additional approaches that include incorporating pre-enrichment steps to identify metal-binding species in plasma subproteomes. Finally, we seek to expand the understanding of metal-mediated molecular interactions in blood plasma by developing and applying strategies to identify and investigate metal-mediated peptide/protein interactions these may influence hormone bioavailability and function. Objectives in this area include size-based fractionation methods develoepd and optimized with fluorescently-labeled peptide analogues, and catch-and-release peptide affinity strategies for identifying protein binding partners. The tools developed in this proposal will be applied to samples from collaborators, biorepositories, and mouse models to generate metal-centric biomarker profiles in metabolic disorders. The insights and technologies that emerge from this proposal will directly impact nutritional treatments, therapeutic peptide development, and biomarker discovery for metal status.

Allied Arts Foundation

Allied Arts Foundation, (AAF), will present 6 free and open-to-the-public outdoor performances by multicultural emerging and up-and-coming local artists during July and August 2022 at the Volunteer Park Amphitheater located at 1247 15th Ave E. This is a rare opportunity to present a series of free public performances by piggy-backing onto an existing production. We are partnering with Volunteer Park Trust, which is producing their Summer Series at the Amphitheater, and will sponsor New Voices at the Volunteer Park Amphitheater. Funds from this Small Sparks will help pay the artist fees for six opening acts ($500 x 6) who will present shorts sets, each performing as opening acts for bigger name bands. This series will help AAF promote opportunities for artists, give back to the people of Seattle, and fulfill our mission to the support the arts. 18,000 people are expected to attend. This project will be completed by September 30, 2022.

New York Community Trust

New York Community Trust ($3.0B in assets) supports nonprofits in NY through grants focused on education, health, arts, environment, community development. Awards range from $5,000 to $300,000.

New York State Council on the Arts

New York State Council on the Arts provides grants to support arts and cultural programming, artist fellowships, arts education, and community-based arts projects across NY.

New York State Council on the Arts

NYSCA General Support provides multi-year operating support for established New York arts organizations, enabling long-term planning and programmatic stability.

New York State Council on the Arts

NYSCA's Regrants Program supports arts organizations and individual artists in New York through a network of 47+ local arts agencies that distribute funding at the community level.

Newfoundland & Labrador Arts Council

Provides grants to artists and arts organizations in Newfoundland and Labrador for creation, production, and professional development.

NIGMS - National Institute of General Medical Sciences

ABSTRACT The goal of this project is to enable scientific discovery and advances in biomedical research through the development of cutting-edge software tools that provide integrated visualizations and analyses of molecular structures and related biological information. Our tools can be applied to diverse types of biomolecular data, including atomic-resolution coordinates, 3D cryo-EM and cryo-ET density maps, and protein and nucleic acid sequences, annotations, and networks. During the next five years we will continue our emphasis on the unmet software needs for basic and applied biomedical research using highly trained and talented staff, with excellent interdisciplinary knowledge and specialized, state-of-the-art expertise in software engineering, computer graphics, and data analysis. Our primary focus will be on the interactive visualization and analysis of structures of molecules, molecular assemblies, and sequence-structure relationships. These areas are critical for addressing important and highly relevant biomedical problems such as identifying the molecular bases of disease, identifying targets for drug development, designing drugs, and engineering proteins with new functions. The tools we develop and disseminate will enable scientists to understand, analyze, and illustrate to others the important principles of molecular structure, function, and interactions. Our tools such as ChimeraX are widely recognized as works of the highest quality, and are available for free on our website as executable applications and in source-code form through our GitHub repository. We fully support and maintain these tools, and provide detailed documentation and tutorials. Our technological developments are disseminated widely via scientific publications, lectures, software distribution, and web-accessible videos.

NEI - National Eye Institute

Project Summary The molecular mechanisms controlling the growth of axonal projections in the central nervous system (CNS) are still poorly understood. Similarly, the molecular basis of the failure of axon regeneration in the CNS are still elusive, and no regenerative therapies exist to date that could help patients with axonal injuries. Retinal ganglion cells (RGCs) are prototypical CNS projection neurons that do not spontaneously regenerate axons disrupted in optic neuropathies caused by trauma, ischemia, or glaucoma, resulting in irreversible loss of vision. Our goal is to investigate the molecular mechanisms through which the Nfe2l3 protein, whose neuroprotective functions we recently identified, regulates the regeneration process of the damaged optic nerve axons, and to test their potential for restoring simple visual functions after optic nerve injury. We will utilize established animal models and state-of-the-art technologies for investigating through which molecular mechanism the Nfe2l3 protein activates the retinal ganglion cells’ intrinsic capacity for regenerating long-distance axons through the optic nerve. We will also determine which retinal ganglion cells respond to the Nfe2l3 protein by regenerating injured axons. We expect that these studies will lead to the development of a novel approach for restoring simple visual functions after optic nerve injury, with the potential to treat different types of optic neuropathies.

National Institutes of Health

The overall goal of this program is to accelerate scientific discovery, improve research efficiency, and enhance the translation of research findings into improved health outcomes. Centers funded under this program will also foster multidisciplinary collaboration, support workforce development across career stages, and promote training in emerging areas such as data science, artificial intelligence, and implementation research. The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) requests applications for the NIAMS P30 Centers Program to support integrated research Centers within its mission areas of skin biology and diseases; bone, muscle, and orthopaedic research; and rheumatic diseases. The NIAMS P30 Centers Program supports Centers that provide coordinated research infrastructure, shared resources, and methodological expertise to advance basic, translational, and clinical research. These Centers are expected to integrate state-of-the-art research resources with capabilities that support clinical and translational research, including the development, testing, and dissemination of novel analytical methods, study designs, outcome measures, and data-driven approaches. The overall goal of this program is to accelerate scientific discovery, improve research efficiency, and enhance the translation of research findings into improved health outcomes. Centers funded under this program will also foster multidisciplinary collaboration, support workforce development across career stages, and promote training in emerging areas such as data science, artificial intelligence, and implementation research.

FIC - John E. Fogarty International Center for Advanced Study in the Health Sciences

Women comprise about 50% of the 36.7 million people living with HIV worldwide and in many sub-Saharan African countries including Nigeria, ~2 out of 3 HIV infected adults are women. Even more worrisome is the observation that overwhelming number of new infections in Nigeria occur among young women of childbearing age, and as such, one-third of all global cases of mother-to-child transmission of HIV occurs in the country. Not only is the burden of HIV higher in women, the impact of its scourge is far more reaching. HIV is the leading cause of morbidity and mortality among women of reproductive age in Nigeria. HIV complicates every aspect of health across a woman’s lifespan, including reproductive health where it impacts partner sero-sorting and sexual habits, fertility desires and contraceptive choices, pregnancy and delivery, menopause and aging. Tackling the myriads of health challenges confronting women living with HIV is a necessary step to achieving the WHO global strategy for women’s, children’s and adolescent health. It will require nurturing a critical mass of local health scientists and equipping them with the skills to conduct valid research that addresses the local health needs of women living with HIV. To address these needs, we established the Emory-Nigeria HIV Research Training Program (EN-RTP). The EN-RTP leverages the research education infrastructure at Emory University and the partnering Nigerian institutions (Nigerian Institute of Medical Research (NIMR); University of Lagos (UNILAG); and AIDS Prevention Initiative Nigeria (APIN)) to provide state-of-the-art in-country research training with focus on methodologies, rigorous mentorship, and grant management capacity building. The EN-RTP training is focused on three main domains of HIV/women’s health research: a) HIV prevention and reproductive health; b) Challenges in HIV therapeutics unique to women living with HIV (WLWH); and c) Complications of chronic HIV infection relevant to WLWH. Preceptors are selected based on their expertise in these areas and their international research education and mentoring experience. We can report that the EN- RTP is now an established program with a cohesive administrative structure and program plan that includes both didactic and mentored research components implemented by a multidisciplinary team of in-country faculty and US-based investigators who have a wide range of mentoring experiences. The short- and medium-term accomplishments include high scholar productivity (over $3M in grant funding, including 3 NIH K 43 awards and more than 150 peer-reviewed publications by trainees), fostering robust scientific networking opportunities, developing emerging in-country scientific leaders, and nurturing the next generation of HIV research mentors. The EN-RTP has demonstrated a potential to be truly transformative in promoting mentored research training and the growth of the HIV biomedical research workforce. Committed to the primary goal of capacity building in HIV research, we look forward with enthusiasm the next cycle – particularly the opportunity to pilot new initiatives and best practices arising from our evaluation processes to enhance program outcomes.

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

Women comprise about 50% of the 36.7 million people living with HIV worldwide and in many sub-Saharan African countries including Nigeria, ~2 out of 3 HIV infected adults are women. Even more worrisome is the observation that overwhelming number of new infections in Nigeria occur among young women of childbearing age, and as such, one-third of all global cases of mother-to-child transmission of HIV occurs in the country. Not only is the burden of HIV higher in women, the impact of its scourge is far more reaching. HIV is the leading cause of morbidity and mortality among women of reproductive age in Nigeria. HIV complicates every aspect of health across a woman’s lifespan, including reproductive health where it impacts partner sero-sorting and sexual habits, fertility desires and contraceptive choices, pregnancy and delivery, menopause and aging. Tackling the myriads of health challenges confronting women living with HIV is a necessary step to achieving the WHO global strategy for women’s, children’s and adolescent health. It will require nurturing a critical mass of local health scientists and equipping them with the skills to conduct valid research that addresses the local health needs of women living with HIV. To address these needs, we established the Emory-Nigeria HIV Research Training Program (EN-RTP). The EN-RTP leverages the research education infrastructure at Emory University and the partnering Nigerian institutions (Nigerian Institute of Medical Research (NIMR); University of Lagos (UNILAG); and AIDS Prevention Initiative Nigeria (APIN)) to provide state-of-the-art in-country research training with focus on methodologies, rigorous mentorship, and grant management capacity building. The EN-RTP training is focused on three main domains of HIV/women’s health research: a) HIV prevention and reproductive health; b) Challenges in HIV therapeutics unique to women living with HIV (WLWH); and c) Complications of chronic HIV infection relevant to WLWH. Preceptors are selected based on their expertise in these areas and their international research education and mentoring experience. We can report that the EN- RTP is now an established program with a cohesive administrative structure and program plan that includes both didactic and mentored research components implemented by a multidisciplinary team of in-country faculty and US-based investigators who have a wide range of mentoring experiences. The short- and medium-term accomplishments include high scholar productivity (over $3M in grant funding, including 3 NIH K 43 awards and more than 150 peer-reviewed publications by trainees), fostering robust scientific networking opportunities, developing emerging in-country scientific leaders, and nurturing the next generation of HIV research mentors. The EN-RTP has demonstrated a potential to be truly transformative in promoting mentored research training and the growth of the HIV biomedical research workforce. Committed to the primary goal of capacity building in HIV research, we look forward with enthusiasm the next cycle – particularly the opportunity to pilot new initiatives and best practices arising from our evaluation processes to enhance program outcomes.

27th and Cambridge Coalition

The 27th and Cambridge Coalition will organize a fun, free, community building event for National Night Out on Tuesday, Aug 6 from 5:00-8:00 pm in the Courtyard of Longfellow Apartments, 9413 - 27th Avenue Southwest. There will be food, games and art activities for all ages, face painting, and live music.

National Institutes of Health

This Notice of Funding Opportunity (NOFO) encourages applications for support of resources that will provide access to state-of-the-art equipment, technologies, research tools, materials, organisms, software, and/or services to a substantial regional (multi-state) or national user base. Only those resources with technical capabilities that fall within the NIGMS-supported program areas are eligible for awards. The resources should already be established or may be formed through consolidation of existing local or regional facilities. The intent is to provide resource access to investigators without regard to the specific biomedical focus of their research, while not duplicating or replacing resources supported by sources such as other NIH Institutes and Centers (ICs) or host institutions. The resource is expected to be maintained or upgraded to current best practices, make its capabilities and availability known to the biomedical research community through a robust web presence and outreach activities, and provide user training and support.

National Institutes of Health

This Notice of Funding Opportunity (NOFO) encourages applications for support of resources that will provide access to state-of-the-art equipment, technologies, research tools, materials, organisms, software, and/or services to a substantial regional (multi-state) or national user base. Only those resources with technical capabilities that fall within the NIGMS-supported program areas are eligible for awards. The resources should already be established or may be formed through consolidation of existing local or regional facilities. The intent is to provide resource access to investigators without regard to the specific biomedical focus of their research, while not duplicating or replacing resources supported by sources such as other NIH Institutes and Centers (ICs) or host institutions. The resource is expected to be maintained or upgraded to current best practices, make its capabilities and availability known to the biomedical research community through a robust web presence and outreach activities, and provide user training and support.

Seattle Chinatown International District Preservation and Development Authority

Building off the momentum of the 2024 Nihonmachi Alley Concept Plan, which was funded by DON, SCIDpda will collaborate with community partners including the Japantown planning group, Wing Luke Museum, and CID Business Improvement Area to continue revitalization efforts. This funding allows work to continue in Nihonmachi Alley in 2 areas which are accessible to the public: Placemaking and Design & Planning. Placemaking efforts focus on Chiyo’s Garden where we will install new art from Erin Shigaki and install a decorative railing inside the gate to improve the usability and safety of the garden. The design and planning portion will build on the 2024 Concept Plan to hire an architecture/design and engineering team to repave the alley for safety and plan for permanent decorative and public art features. The anticipated project completion date is November 30, 2026.

Friends of Japantown

Revitalize and beautify Japantown's Nihonmachi Alley with public art, lighting, and programming opportunities.

NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases

Project Summary The purpose of this ‘A1 Single-Year NIAMS/NCI R13 Research Conference Grant’ is to host the highest impact scientific and mentoring conference on “Bone: Musculoskeletal Tumor Perspectives’ that will bring together translational and clinical investigators from diverse specialties. Musculoskeletal Tumor Society (MSTS) is the primary host organization that will partner with OREF, ORS, AAOS, and JOR. Musculoskeletal Oncology is a distinct hybrid clinical and research field that requires the solution to 3 distinct problems: ‘Diagnosing’ and ‘Treating’ molecular oncogenesis of MSK tissues and ‘Reconstructing’ afflicted tissue structures to restore limb function. Due to underlying oncological pathophysiology and massive skeletal defects, traditional orthopaedic treatments using trauma or arthroplasty disciplines were associated with high rate of complications. Furthermore, no cross-disciplinary research and mentoring endeavors on bone tumors have not been offered. Many bone and osteoclast-associated molecules were discovered from bone diseases and tumors such as the giant cell tumor of bone. The last AAOS-initiated R13 Conference was in 2017. There is a serious issue of discontinuation of clinician scientists and basic scientists who conduct cross-disciplinary research on bone and reconstruction science from a perspective of musculoskeletal tumors. There is an urgent need to host a R13 conference to offer mentorship for emerging investigators and to develop new collaborations. Our innovative meeting format features sessions addressing challenging clinical problems with plenary overview talks by experts on state-of the art techniques (spatial biology, artificial intelligence, novel signaling & targeted therapies, novel skeletal stem cells, RNA/DNA therapeutics, 3D printed custom device, and mixed reality). We will invite junior surgeon-scientists to present their innovative solutions in mentoring sessions where a panel of established investigators will critique proposed strategies and Specific Aims in a live multi-disciplinary “study section”. ESI selection criteria are based on one-page Specific Aims that summarizes clinical barriers, hypothesis-/technology-driven scientific and clinical investigation plans, and specific needs for mentorship. A meet-the-mentors session will be set up to foster multi-disciplinary collaboration among mentors and emerging surgeon-scientists, engineers, and basic scientists. In order to facilitate networking and matching mentors- mentees, the meeting phone Apps and website will list mentors and participants with well-prepared research ideas (Specific Aims) and other scientific abstracts. Two Specific Aims are Aim 1. Innovative Mentorship for Emerging Clinicians and Scientists; and Aim 2. Dissemination of Cross-Disciplinary New Knowledge and Techniques for New Collaborations and Enhanced Patient Care. A stand-alone R13 conference could be ideal but too costly for meeting space rent, audio/visual services, and support for young investigators. The R13 Conference will be strategically held immediately prior to the 50th MSTS Annual Meeting for cost reduction and improved participation from clinicians, scientists, allied health care workers, and industry R&D staffs.

North Carolina Arts Council

North Carolina Arts Council provides grants to support arts and cultural programming, artist fellowships, arts education, and community-based arts projects across NC.

North Dakota Community Foundation

North Dakota Community Foundation ($100M in assets) supports nonprofits in ND through grants focused on education, community development, health, arts. Awards range from $1,000 to $25,000.

North Dakota Council on the Arts

Institutional Support Grants provide general operating support to North Dakota arts organizations, enabling them to sustain programming, build capacity, and serve their communities through arts and cultural activities.

North Dakota Council on the Arts

Special Project Grants fund specific arts activities and events in North Dakota, including performances, exhibitions, arts education programs, and community cultural initiatives that enhance public access to the arts.

North Texas Community Foundation

North Texas Community Foundation ($100M in assets) supports nonprofits in TX through grants focused on education, health, community development, arts. Awards range from $2,000 to $75,000.

Northern Mariana Islands Council on the Arts

Arts and cultural grants for organizations in Northern Mariana Islands, supported by NEA federal funding.