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Nano-Biosensing

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U.S. National Science Foundation

The Nano-Biosensing program is part of the Engineering Biology and Health cluster, which includes also 1) Cellular and Biochemical Engineering; 2) Engineering of Biomedical Systems; 3) Biophotonics; and 4) Disability and Rehabilitation Engineering. The Nano-Biosensing program supports fundamental engineering research on devices and methods for measurement and quantification of biological analytes. Proposals that incorporate emerging nanotechnology methods are especially encouraged. Areas of interest include: Multi-purpose sensor platforms that exceed the performance of current state-of-the-art devices. Novel transduction principles, mechanisms and sensor designs suitable for measurement in practical matrix and sample-preparation-free approaches. These include error-free detection of pathogens and toxins in food matrices, waterborne pathogens, parasites, toxins, biomarkers in body fluids, and others that improve human condition. Nano-biosensors that enable measurement of biomolecular interactions in their native states, transmembrane transport, intracellular transport and reactions, and other biological phenomena. Studies that examine intracellular measurements must include discussion on the significance of the measurement. Proposals should clearly identify the proposed problem to be solved, describe why the proposed approach is superior to current available methods, and articulate the benefit of solving the identified problem for the society at large. Sensor designs that yield reliable measurements are encouraged. While sensitivity is important, it cannot be at the expense of reproducibility. Every application must include research strategies for addressing reproducibility of measurement and sensor response, as well as approaches that reduce errors. The program does not support applications with incremental improvements of existing approaches and technologies. Projects that do not include experimental characterization of sensor responses to biological analytes are discouraged, and may be returned without a review. Studies on surface functionalization and immobilization of bio-recognition molecules, and/or orientation of them are not encouraged. Research that is focused on new recognition chemistry is also discouraged. The novelty or potentially transformative nature of the research must be included in the Project Summary. The last line in Project Summary must include three key phrasesthat describe: (1) sensor transduction principles, (2) type of biological analytes, (3) potential application areas. Innovative ideas outside of the above specific interest areas may be considered. However, prior to submission, it is recommended that the PI contact the Program Director to avoid the proposal being returned without review. NOTE: Projects related to water quality may be jointly supported with the Environmental Engineering program (CBET 1440). Photonic nanosensors with medical applications and/or imaging should be submitted to Biophotonics (CBET 7236). The Nano-Biosensing program does not support imaging applications. The duration of unsolicited awards is generally one to three years. The typical award size for the program is approximately $100,000 per year. Proposals requesting a substantially higher amount than this, without prior consultation with the Program Director, may be returned without review. INFORMATION COMMON TO MOST CBET PROGRAMS Proposals should address the novelty and/orpotentially transformative natureof the proposed work compared to previous work in the field. Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact on society and/or industry of success in the research. The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. Faculty Early Career Development(CAREER)program proposals are strongly encouraged. Award duration is five years. The submission deadline for Engineering CAREER proposals is in July every year. Please see the CAREER URLherefor more information. Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the Program Director before submission of the proposal. Grants forRapid Response Research(RAPID)andEArly-concept Grants for Exploratory Research(EAGER)are also considered when appropriate. Please note that proposals of these types must be discussed with the program director before submission. Further details are available in theProposal and Award Policies and Procedures Guide(PAPPG)download foundhere.Grant Opportunities for Academic Liaison with Industry (GOALI)proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that GOALI proposals must be submitted during the annual unsolicited proposal window for each program. More information on GOALI can be foundhere. COMPLIANCE: Proposals which are not compliant with theProposal and Award Policies and Procedures Guide (PAPPG)will be returned without review.

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sciencetechnology

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NASA RESEARCH ANNOUNCEMENT - 2013 COMPETITIVE PROGRAM FOR SCIENCE MUSEUMS PLANETARIUMS AND NASA VISITOR CENTERS PLUS OTHER OPPORTUNITIES CP4SMP+

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NASA Headquarters

Awards will be made as grants, cooperative agreements, and inter- or intra-agency transfers depending on the nature of the proposing organization and/or project requirements. The period of performance for an award may be one to five years. Note that it is NASA policy that all investigations involving non-U.S. organizations will be conducted on the basis of no exchange of funds. An optional pre-proposal teleconference will be held on Feb 20, 2013 from 1:00 p.m. Eastern Time to 3:00 p.m. Eastern Time. Prospective proposers are requested to submit any questions in writing to CP4SMP@jpl.nasa.gov no later than 4 business days before the teleconference so that NASA will be able to cover as much information as possible at the teleconference. NASA plans to post written questions and answers and teleconference charts to the NSPIRES website. An opportunity to ask questions and solicit clarification will be provided in the teleconference. To dial into the teleconference, call 1-888-469-1385. The participant passcode is CP4SMP. For relay services for the hearing impaired, call 711 at least 30 minutes before the call is to begin. Only non-profits that are legally recognized by a federal, state or local authority, including all types of NASA Visitor Centers (e.g., private, state or federal entities) located in the United States or its Territories that provide science, technology, engineering and mathematics (STEM) education programming (such as but not limited to exhibits) are eligible to apply for this NASA Research Announcement (NRA). An eligible institution does not need to have the words museum, visitor center, science, or planetarium in its legal name. No later than the due date for proposals, proposers to this NRA are required to have: 1) a Data Universal Numbering System (DUNS) number, 2) a valid registration with the System for Award Management (SAM) [formerly known as the Central Contractor Registry (CCR)], 3) a valid Commercial And Government Entity (CAGE) Code, 4) a valid registration with NASA Solicitation and Proposal Integrated Review and Evaluation System (NSPIRES) (this also applies to any entities proposed for subawards or subcontracts.) Consult Section VII. Eligibility Requirements of this NRA for the complete detailed explanations and caveats related to institutional and all other eligibility criteria. Principal Investigator Requirement: Principal Investigators (PIs) must be the President, Vice President, Chief Executive Officer, Chief Financial Officer, Chairman of the Board, or similarly ranked executive (e.g., Planetarium Director, Director of Sponsored Research) from an eligible institution. Limit on Number of Proposals per Organization: Eligible organizations shall submit only ONE (1) proposal per DUNS number. If an eligible organization submits more than one proposal using the same DUNS number, then none of the proposals will be evaluated. The NASA Office of Education, in cooperation with NASA Headquarters' Offices of Communications and Chief Technologist, Mission Directorates (i.e., Aeronautics Research, Human Exploration and Operations, and Science), and Mission Support Directorate solicits proposals to support NASA-inspired space, science, technology, engineering, or mathematics (S-STEM) informal education projects, including exhibits and partnerships with K-12 schools or districts, to support inquiry-based education. This NRA or solicitation seeks projects featuring NASA-themed content in space exploration, aeronautics, space science, Earth science, or microgravity, or a combination of these topics (See Section III of this document) to support NASA education outcomes. Leadership of the proposed projects must reside at informal education institutions (IEI); partnership relationships are highly encouraged (See Appendix C for partnership discussion). Proposed projects should address NASA's most current Strategic Plan and propose efforts that are well-aligned with NASA and do not duplicate other federal investments. Proposals also should address substantiated (e.g., through an existing needs assessment or other evidence) national, regional or local educational needs or challenges and offer solutions with potential for significant impact. Examples of eligible projects include but are not limited to: exhibits (permanent, traveling, or virtual); STEM programming serving educators, students, youth, parents, and the general public; STEM programming for informal education providers and staff professional development (e.g., youth groups, out-of-school-time programs, youth group leaders, workshop or activity leaders, curriculum developers, docent managers, exhibit designers, library professionals, community education leaders, education and public outreach (EPO) professionals); informal learning research in STEM, informal education programs, data usage and analysis; curriculum support for informal science education, technology development, performing arts, or activities that are culturally focused on targeted populations, such as women and minorities. Grantee institutions have the responsibility for budgeting and documenting compliance with Code of Federal Regulations, 14 CFR 1230, commonly referred to as "the Common Rule for the Protection of Human Subjects." Research to develop NASA-themed exhibits, programs, curriculum products, etc., may involve full human subjects review through an Institutional Review Board or IRB or it may be exempt. An IRB also certifies when research is exempt. Every institution that intends to submit a proposal to this NRA, including the proposed prime award or any partner whether an informal education institution, other non-profit institutions, state and local Government agencies, and other organizations that will serve as subawardees or contractors, must be registered in NSPIRES. Electronic submission of proposals is required by the due date and must be submitted by an authorized official of the proposing organization. Such registration must identify the authorized organizational representative(s) who will submit the electronic proposal. All principal investigators and other participants (e.g. co-investigators) must be registered in NSPIRES regardless of submission system. Potential proposers and proposing organizations are urged to access the system(s) well in advance of the proposal due date(s) of interest to familiarize themselves with its structure and enter the requested information. Electronic proposals may be submitted via the NASA proposal data system NSPIRES or via Grants.gov. Organizations that intend to submit proposals via Grants.gov must be registered 1-- with Grants.gov and 2--with NSPIRES. Additional programmatic information for this NRA may develop before the proposal due date. If so, such information will be added as a Frequently Asked Question or FAQ or formal amendment to this NRA and posted on http://nspires.nasaprs.com . It is the proposer's responsibility to regularly check NSPIRES for updates to this NRA. When the CP4SMP+ portal page on NSPIRES is updated a notice will be added to the NASA Education Express weekly news service. To subscribe to NASA Express, go to http://www.nasa.gov/education/express .

$100K – $1.3M
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other

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National Center for Quantitative Biology of Complex Systems

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NIGMS - National Institute of General Medical Sciences

PROJECT SUMMARY: Propelled by considerable federal and private investment over the last twenty years, state-of-the-art mass spectrometry systems have become powerful fixtures in the fabric of biomedical research across the country. Researchers submit samples, typically to a core facility but also to expert collaborators, to interrogate the proteome with speed, depth, and precision. Lipidomics and metabolomics are on a similar trajectory. The investment in fundamental technology development by the NIH and other agencies has thus paid off in the revelation of otherwise unseen biology. Another result of these advances, however, is the increasingly widespread appreciation for the value of multi-omic data uniquely capable of revealing the critical interplay between proteins, modified proteins, lipids, and metabolites. It is this orchestra of key biological effector molecules – not any one player, and not simply genes – that regulates complex organisms. That said, the technology paradigm remains single-ome analysis; global quantification methodologies are not routine, even for most expert laboratories. Attaining and understanding multi-omic data in effect requires researchers or laboratories to triple their expertise to piece together the protocols of three different disciplines. Indeed, the proteome alone harbors tremendous complexity that is inaccessible to conventional widely employed methods. Pervasive access to comprehensive technologies would greatly accelerate our understanding of the networks that regulate the health and disease of complex organisms. These technologies are essential for furthering human health – for example by advancing the mechanistic understanding of aging to laying the foundation for personalized cancer treatment. The National Center for Quantitative Biology of Complex Systems (NCQBCS) expedites this transformation in quantitative biology. For nearly a decade, the NCQBCS has developed and delivered next-generation technologies for rapid, accessible biomolecular characterization and measurement. These technologies have led to remarkable biological discoveries and considerable economic growth through patents, technology licensure, and commercialization. The Center is now poised to optimize these technologies for broad dissemination to experts and non-experts alike, lowering the barrier to improved biomolecular characterization, to accessible multi-plexed quantification of proteins and lipids, and to fully integrated multi-omic workflows. For biomedical researchers, success in these goals will open new avenues of inquiry across health and disease contexts and sample types and scales.

Up to $3.7M
2030-06-30
health research

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NATIONAL LAB OPPORTUNITY

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NASA Headquarters

OPPORTUNITY FOR THE USE OF THE INTERNATIONAL SPACE STATION BY DOMESTIC ENTITIES OTHER THAN U.S. FEDERAL GOVERNMENT AGENCIES 1.0 INTRODUCTION AND BACKGROUND The National Aeronautics and Space Administration (NASA) is operating a share of the United States accommodations on the International Space Station (ISS) as a national laboratory in accordance with Section 507 of the NASA Authorization Act of 2005 (P.L. 109-155) and to seek to increase the utilization of the ISS by other federal entities and the private sector. To facilitate and increase such utilization of the ISS, NASA is providing access to the ISS for the conduct of basic and applied research, technology development and industrial processing (collectively, R&D) to U.S. federal, state and local government entities, and to U.S. private entities (including, but not limited to, commercial firms, non-profit entities, and academic institutions) as part of the national laboratory. In preparation for the ISS post-assembly phase and during the post-assembly complete phase, NASA is seeking proposals from domestic entities other than U.S. federal government agencies for the conduct of R&D activities on the ISS as a national laboratory. NASA anticipates using its authority to enter into Space Act Agreements to support national laboratory activities, including providing necessary access to NASA facilities, personnel and technical information, however, there will be no provision of funds in connection with this opportunity. Respondents will be responsible for financing their own activities. Participation in this National Lab Opportunity will be contingent upon selection by NASA and negotiation of an appropriate Agreement between NASA and the proposer. Proposed activities should involve R&D, including, but not limited to, life sciences, sensors, communication equipment, engineering testbeds, spacecraft design and testing, or education and should demonstrate potential benefit to the public, such as development of future products and services contributing to U.S. industrial capacity and economic growth or improving STEM education. This opportunity is not exclusive; NASA, at its discretion, may negotiate with other parties for access to ISS under this opportunity. Response Date: This announcement is open through December 31, 2014. NASA will engage in ongoing review of proposals as received prior to the Response Date of December 31, 2014. NASA reserves the right to amend or withdraw this Announcement at any time prior to the Response Date. NASA will not issue paper copies of this Announcement. NASA reserves the right to select for Space Act Agreement negotiations all, some, or none of the proposals submitted in response to this Announcement. NASA provides no funding for reimbursement of proposal development costs. Material submitted in response to this Announcement will not be returned. It is the policy of NASA to safeguard all proposals as confidential and privileged information, as provided by law. NASA will not, without permission of the proposers, use the proposal contents for other than evaluation purposes. It is not NASA's intent to publicly disclose proprietary information obtained during this solicitation. To the full extent that it is protected pursuant to the Freedom of Information Act and other laws and regulations, information identified by a respondent as "Proprietary or Confidential" will be kept confidential. NASA may use contractor support personnel to assist in providing expertise regarding proposals. Any support contractor involved in the evaluation process shall be free of conflicts of interest, will be bound by appropriate non-disclosure agreements to protect proprietary and competition sensitive information. By submitting a proposal under this Announcement, the proposer is deemed to have consented to release of data in its proposal to NASA contractors supporting evaluation of proposals. 2.0 GENERAL INFORMATION Agency Name: NASA (National Aeronautics and Space Administration) Opportunity Title: Opportunity for the use of the International Space Station by Domestic Entities Other than U.S. Federal Government Agencies Response Date: Electronic Proposals must be received by December 31, 2014 at 4:30 P.M. EST via email to jason.c.crusan@nasa.gov. Proposals may be submitted at any time before the response date. Points of Contact: If you have any questions concerning this opportunity please contact: Marybeth Edeen Manager, ISS National Lab Office Telephone: 281-483-9122 Fax: 281-244-8292 Email: marybeth.a.edeen@nasa.gov Jason Crusan SOMD Agreement Manager 202-358-0635 202-358-3530 jason.crusan@nasa.gov Instrument Type(s): It is anticipated that awards under this Opportunity will be in the form of Space Act Agreements, executed under the authority of 42 U.S.C. 2473(c)(5). Selection Recommendation Committee: Government personnel from NASA, other Federal agencies, and NASA contractors may participate in the evaluation of proposals. All contractor personnel participating in the evaluation will be bound by conflict of interest provisions and appropriate non-disclosure requirements to protect proprietary information. Selection Notification Date: Selection for negotiations is anticipated to be within 60 days of receiving a proposal. Submission Instructions: All Proposals under this Announcement must be emailed to jason.c.crusan@nasa.gov. Paper submissions will not be reviewed. Proposals may be submitted at any time before the Response Date. You are encouraged to submit as early as practicable prior to the Response Date. Proposals received by the Government after the Response Date will not be accepted. If a proposer is concerned about information security during transmission NASA has the ability to accept secure transmission. Contact the Point of Contact for secure transmission requirements. Files can be submitted in MS Word, PDF, or RTF. 3.0 ELIGIBILITY INFORMATION All categories of domestic entities other than U.S. federal government agencies are eligible to submit proposals in response to this Announcement. NASA will not consider proposals which do not include a domestic entity as the lead proposer. 4.0 PROPOSAL EVALUATION AND SELECTION 4.1 Evaluation and Selection Process All proposals will be initially screened to determine their compliance to the eligibility (section 3.0) and proposal instructions (section 5.0) of this Announcement. Proposals that do not comply may be declared noncompliant and rejected without further review. A submission compliance checklist is provided in section 5.0. This checklist provides proposers a list of the items that NASA will check for compliance before releasing a proposal for evaluation. Proposals deemed in compliance with this Announcement will be assessed against the evaluation criteria outlined in Section 4.2 by the Selection Recommendation Committee. Proposed collaborators should be aware that during the evaluation and selection process, NASA may request clarification of a specific point or points in a proposal. Such a request and the proposed collaborator's response shall be in writing. NASA reserves the right to suggest collaboration between proposers where it will enhance the effort, in which case proposers will be given the opportunity to accept or decline participation with other proposers prior to selection. The Selection Recommendation Committee members will conduct independent assessments of the proposals according to evaluation criteria outlined in Section 4.2. 4.2 Evaluation Criteria The evaluation factors below are of equal weighting during evaluation. Factor 1: Approach to Proposed Effort: The overall merit, rationale, feasibility, and suitability of the proposed effort or concept and its relevance to R&D that access to the ISS provides. Highest priority will be placed on an approach or concept that will create substantial increases in the current state-of-the-art. Describe how the proposer proposes to receive resulting data and/or samples from orbit. Factor 2: Level of Benefit to the Public: The proposed effort or concept's anticipated benefit to the public, in terms such as development of future products and services, and contribution to U.S. industrial capacity and/or economic growth. Factor 3: Level of Financial Commitment and Business Plan: The description of the level of financial commitments supporting the proposed efforts, including any third party financing required. Include a brief business plan for the proposed efforts or describe how the proposed efforts contribute to existing business plans. Identify the non-U.S. Government market potential for the R&D efforts. The proposed space activity is essential to product research, development, or processing, and is targeted to an addressable market. A roadmap exists; it includes the essential activities to bring the product to market beyond the development space activities. In addition, describe all cargo to be transported between Earth and the ISS that your proposed efforts require and how your business plan addresses meeting those requirements including any sample return and disposition of the on-orbit equipment/payloads. In addition, NASA reserves the right to assess information outside the proposal as it relates to the factors listed above. 4.3 Selection Factors As described in Section 4.1, the results of the proposal evaluations based on the criteria above and the subsequent Selection Recommendation Committee deliberations will be considered in the selection process. The Selection Recommendation Committee may take into account a variety of programmatic factors in deciding whether or not to select any proposals, including, but not limited to, available on-orbit resources, and compatibility to the ISS. The Selection Authority shall be the Associate Administrator for Space Operations. The Selection Authority will make the final selection of those approved for this opportunity after the completion of negotiations, depending on the outcome of the negotiations. 4.4 Selection Notification NASA will notify all proposed collaborators of the results of the evaluation and selection process. Selection does not guarantee a launch opportunity. Selection does guarantee NASA will provide the on orbit resources and trained crew to perform the experiment once it is on board. After the completion of the evaluation and selection process, NASA will begin negotiations with the selected proposer(s). The purpose of the negotiations is to define the terms and conditions of the Agreement supporting the participation of the proposers and to align the selected proposals with the anticipated on-orbit resource availability. All work will commence after the parties execute the Space Act Agreement. 5.0 PROPOSAL INSTRUCTIONS Proposals must comply with the following requirements. Page Limitations Proposal Section - Total Pages Proposal Cover Page - 1 Proposal Title Page - 1 Points of Contact - 1 Proposal Abstract - 750 words Proposal Detail - 10 Appendix Resumes - No Page Limit Additional Documentation - No Page Limit Pages in excess of the page limitations for each section will not be evaluated. A page is defined as one (1) sheet 8 x 11 inches using a minimum of 12-point font size for text and 8-point for graphs. There is no limit on appendix documentation. The intent is to allow proposals to include current documentation in its current format without having to alter any documents. The proposal must include the following sections, in this order: Proposal Cover Page: Solicited Proposal Application - Title of Announcement and Proposal Contact Information. An optional graphic image may be included. Proposal Title Page, with Notice of Restriction on Use and Disclosure of Proposal Information, if any. Points of Contact: List contact information for all Points of Contact including a Technical Point of Contact. Provide: a. Name b. Title c. Address d. Phone and Fax e. Email Proposal Abstract: Executive summary describing the prominent and distinguishing features of the proposal. Proposal Detail: The proposal shall contain sufficient information to enable reviewers to make informed judgments to assess the three criteria of the proposed effort. Proposal Appendix: * Resumes o Resumes may be included for key personnel. In general, resumes should be limited to no more than 1-2 pages each. * Additional documentation Include any documentation in the appendix that validates or supports the proposal Compliance checklist and required documents o The proposer is a domestic entity other than U.S. federal government agency o Proposal includes demonstration of the overall merit, rationale, feasibility, and suitability that access to the ISS provides o Proposal includes a description of the level of benefit to the public o Proposal includes a description of the level of financial commitment and business plan o Proposal includes a schedule for remaining development required before flight o Proposal includes a management/ project plan for remaining development o Proposal includes funding commitment letters demonstrating sufficient financial support for remaining development or financial milestones required to complete development

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