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National Institutes of Health

Purpose. The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system. This FOA is released in affiliation with the Neuroscience Blueprint, with Institutes and Centers participating independently, and with participation by Institutes that are not part of the Neuroscience Blueprint. Institutes that are not part of the Blueprint are also participating. Optimal use of informatics tools (e.g., tools for analyzing data, etc.) and resources (e.g., databases, data sets, etc.) depend upon explicit understandings of concepts related to the data upon which they compute. This is typically accomplished by a tool or resource adopting a formal controlled vocabulary and ontology. For the purpose of this Funding Opportunity Announcement (FOA), an ontology is defined as a controlled vocabulary that describes objects and the relationships between those objects in a formal way. Generally, an ontology has a grammar that allows the terms of the vocabulary to express something meaningful to the biomedical researcher. In an effort to advance the use of powerful informatics approaches in biomedical research, this FOA solicits Research Project Grant (R01) applications from institutions/ organizations that propose to develop an ontology that will make it possible for software to understand how two or more existing data sets relate to each other. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. However, it is anticipated that most of the awards will be for limited amounts ($100,000 to $200,000 direct costs per year) and for short periods of time (2-3 years). It is not likely that these R01s will be renewed. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); Non-domestic (non-U.S.) Entity (Foreign Organization). Eligible Project Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of Applications. Applicants may submit more than one application, provided each application is scientifically distinct. Renewals and Resubmissions. Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement). Number of PDs/PIs. More than one PD/PI, or multiple PDs/PIs, may be designated on the application. Application Materials. See Section IV.1 for application materials. General Information. For general information on SF424 (R and R) Application and Electronic Submission, see these Web sites: SF424 (R and R) Application and Electronic Submission Information: http://grants.nih.gov/grants/funding/424/index.htm General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ Hearing Impaired. Telecommunications for the hearing impaired is available at: TTY 301-451-0088. Technical Assistance Workshop. A technical assistance workshop is planned on October 18 to answer questions about this FOA. Participants can attend the meeting in person at the Natcher Auditorium on the NIH Campus or can participate via a videocast. Registration for the meeting and additional information can be found at http://www.nbirn.net . Special Submission/Receipt Date(s): January 18, 2008, September 18, 2008, January 21, 2009, and September 21, 2009 Special Review convened by CSR

DC Department of Small & Local Business Development

Provides grants, technical assistance, and certification programs for small businesses in Washington DC, with focus on Certified Business Enterprises.

Denver Economic Development & Opportunity

Programs supporting small business growth, workforce development, and neighborhood economic vitality in Denver. Includes microloan programs and technical assistance grants.

Dept of the Army -- Materiel Command

The purpose of this Broad Agency Announcement (BAA) under Federal Acquisition Regulation (FAR) Part 35 and Funding Opportunity Announcement (FOA) under 2 Code of Federal Regulations (CFR) 200.204 (henceforth referred to as BAA ) is to solicit research proposals for submission to the U.S. Army Combat Capabilities Development Command (DEVCOM) Analysis Center (DAC) for funding consideration. The DAC is the Army's foundation for data-driven analytical decisions across the lifecycle to ensure overmatch for a lethal Army. DAC s mission is to: Inform Army modernization and readiness decisions with objective Analysis enabled through Tool development and Data curation. DAC partners across the national security enterprise to deliver fundamentally advantageous change that is rooted in the creation and exploitation of scientific knowledge. DAC accomplishes this mission by funding the areas of applied research (budget activity 6.2), as defined by 32 CFR 22.105, advanced technology development (budget activity 6.3), and advanced component development and prototypes (budget activity 6.4). Whitepapers for initial concept reviews and full proposals are sought from institutions of higher education, nonprofit organizations, state and local governments, foreign organizations, foreign public entities, and for-profit organizations (i.e. large and small businesses) for scientific research that supports the DAC mission. The DAC BAA generally conforms to the portfolio structured around research area based mission execution. Whitepapers and full proposals are expected to be for cutting-edge innovative research that could produce discoveries with a significant impact to enable new and improved Army technologies and related operational capabilities and related technologies. In an effort to provide DAC's research topics and related information in an easy to digest format, DAC has published the following public website listing all current DAC research topics: https://www.army.mil/article/261533, hereafter referenced as the DAC BAA topics website. DAC focuses on executing in-house research programs but supplements our efforts with support from the broader technology base and Academia. DAC funds a modest amount of extramural research in certain specific areas, and those areas are described on the DAC BAA topics website. Changes to these topics will be made using this website on an as needed basis. A change to the DAC BAA topics website is not an amendment to this BAA and will not be posted on https://www.grants.gov/ and https://sam.gov/. A change to this document, the BAA itself, is an amendment and will be posted on https://www.grants.gov/ and https://sam.gov/. DAC will maintain a daily static snapshot of the DAC BAA topics website to ensure submissions are aligned with listed research topics on the day of submission. Interested parties are encouraged to continually browse the DAC BAA topics website for white paper and proposal topics that DAC desires to explore. These specific research topics should be viewed as suggestive, rather than limiting. DAC is always interested in considering other innovative research concepts of relevance to the Army if those concepts align with DAC's mission. Please see Section II, Detailed Information about the Funding Opportunity, for more information on the DAC research topics advertised through this BAA. Interested parties should also review https://www.grants.gov/ and https://sam.gov/ to obtain the latest version of the BAA for whitepaper and proposal submission requirements.

U.S. National Science Foundation

The Disability and Rehabilitation Engineering program is part of the Engineering Biology and Health cluster, which also includes: 1) the Biophotonics program; 2) the Biosensing program; 3) the Cellular and Biochemical Engineering program; and 4) the Engineering of Biomedical Systems program. The Disability and Rehabilitation Engineering program supports fundamental engineering research that will improve the quality of life of persons with disabilities through the development of new theories, methodologies, technologies, or devices. Disabilities could be developmental, cognitive, hearing, mobility, visual, selfcare, independent living, or other. Proposed projects must advance knowledge regarding a specific human disability or pathological motion or understanding of injury mechanisms. Research may be supported that is directed toward the characterization, restoration, rehabilitation, and/or substitution of human functional ability or cognition, or to the interaction between persons with disabilities and their environment. Areas of particular interest are neuroengineering, rehabilitation robotics, brain-inspired assistive or rehabilitative systems, theoretical or computational methods, and novel models of functional recovery including the development and application of artificial physiological systems. Emphasis is placed on significant advancement of fundamental engineering knowledge that facilitates transformative outcomes. The DARE Program encourages high-risk/high-reward proposals that surpass incremental technological improvements. The DARE Program also encourages participatory design and the inclusion of trainees with disabilities as part of the proposed research or broader impacts. Innovative proposals outside of the above specific interest areas may be considered. However, prior to submission, it is recommended that the PI contact the Program Director to avoid the possibility of the proposal being returned without review. NSF does not support clinical trials; however, feasibility studies involving human volunteers may be supported if appropriate to the project objectives. The development and application of artificial physiological systems that do not model functional recovery and instead improve fundamental understanding of physiological and pathophysiological processes would be appropriate for EBMS. Furthermore, the DARE program does not support proposals having as their central theme commercialization of a product. Small businesses seeking early stage R&amp;D funding for product development are encouraged to contact the NSF SBIR/STTR program in the America's Seed Fund within the Directorate for Technology, Innovation and Partnerships (TIP). INFORMATION COMMON TO MOST CBET PROGRAMS Proposals should address the novelty and/or <a href="http://www.nsf.gov/about/transformative_research/faq.jsp">potentially transformative nature</a> of the proposed work compared to previous work in the field. Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact of success in the research on society and/or industry. The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. The duration of unsolicited proposal awards in CBET is generally up to three years. Single-investigator award budgets typically include support for one graduate student (or equivalent) and up to one month of principal investigator time per year (awards for multiple investigator projects are typically larger). Proposal budgets that are much larger than typical should be discussed with the Program Director prior to submission. Proposers can view budget amounts and other information from recent awards made by this program via the "What Has Been Funded (Recent Awards Made Through This Program, with Abstracts)" link towards the bottom of this page. Faculty Early Career Development (CAREER) program proposals are strongly encouraged. Award duration is five years. The submission deadline for Engineering CAREER proposals is in July every year. Learn more in the <a href="https://www.nsf.gov/career">CAREER program description</a>. Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the program director before submission of the proposal. Grants for Facilitation Awards For Scientists And Engineers With Disabilities (FASED), EArly-concept Grants for Exploratory Research (EAGER), and Rapid Response Research (RAPID) are also considered when appropriate. Please note that proposals of these types must be discussed with the program director before submission. Grant Opportunities for Academic Liaison with Industry (GOALI) proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that FASED, EAGER, RAPID, and GOALI proposals can be submitted anytime during the year. Details about FASED, EAGER, RAPID, and GOALI are available in the Proposal &amp; Award Policies &amp; Procedures Guide (PAPPG), Part 1, Chapter II, Section E: Types of Proposals. Compliance: Proposals that are not compliant with the <a href="https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg">Proposal &amp; Award Policies &amp; Procedures Guide (PAPPG)</a> will be returned without review.

U.S. National Science Foundation

The Disability and Rehabilitation Engineering program is part of the Engineering Biology and Health cluster, which also includes: 1) the Biophotonics program; 2) the Biosensing program; 3) the Cellular and Biochemical Engineering program; and 4) the Engineering of Biomedical Systems program. The Disability and Rehabilitation Engineering program supports fundamental engineering research that will improve the quality of life of persons with disabilities through the development of new theories, methodologies, technologies, or devices. Disabilities could be developmental, cognitive, hearing, mobility, visual, selfcare, independent living, or other. Proposed projects must advance knowledge regarding a specific human disability or pathological motion or understanding of injury mechanisms. Research may be supported that is directed toward the characterization, restoration, rehabilitation, and/or substitution of human functional ability or cognition, or to the interaction between persons with disabilities and their environment. Areas of particular interest are neuroengineering, rehabilitation robotics, brain-inspired assistive or rehabilitative systems, theoretical or computational methods, and novel models of functional recovery including the development and application of artificial physiological systems. Emphasis is placed on significant advancement of fundamental engineering knowledge that facilitates transformative outcomes. The DARE Program encourages high-risk/high-reward proposals that surpass incremental technological improvements. The DARE Program also encourages participatory design and the inclusion of trainees with disabilities as part of the proposed research or broader impacts. Innovative proposals outside of the above specific interest areas may be considered. However, prior to submission, it is recommended that the PI contact the Program Director to avoid the possibility of the proposal being returned without review. NSF does not support clinical trials; however, feasibility studies involving human volunteers may be supported if appropriate to the project objectives. The development and application of artificial physiological systems that do not model functional recovery and instead improve fundamental understanding of physiological and pathophysiological processes would be appropriate for EBMS. Furthermore, the DARE program does not support proposals having as their central theme commercialization of a product. Small businesses seeking early stage R&amp;D funding for product development are encouraged to contact the NSF SBIR/STTR program in the America's Seed Fund within the Directorate for Technology, Innovation and Partnerships (TIP). INFORMATION COMMON TO MOST CBET PROGRAMS Proposals should address the novelty and/or potentially transformative nature of the proposed work compared to previous work in the field. Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact of success in the research on society and/or industry. The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. The duration of unsolicited proposal awards in CBET is generally up to three years. Single-investigator award budgets typically include support for one graduate student (or equivalent) and up to one month of principal investigator time per year (awards for multiple investigator projects are typically larger). Proposal budgets that are much larger than typical should be discussed with the Program Director prior to submission. Proposers can view budget amounts and other information from recent awards made by this program via the "What Has Been Funded (Recent Awards Made Through This Program, with Abstracts)" link towards the bottom of this page. Faculty Early Career Development (CAREER) program proposals are strongly encouraged. Award duration is five years. The submission deadline for Engineering CAREER proposals is in July every year. Learn more in the CAREER program description. Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the program director before submission of the proposal. Grants for Facilitation Awards For Scientists And Engineers With Disabilities (FASED), EArly-concept Grants for Exploratory Research (EAGER), and Rapid Response Research (RAPID) are also considered when appropriate. Please note that proposals of these types must be discussed with the program director before submission. Grant Opportunities for Academic Liaison with Industry (GOALI) proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that FASED, EAGER, RAPID, and GOALI proposals can be submitted anytime during the year. Details about FASED, EAGER, RAPID, and GOALI are available in the Proposal &amp; Award Policies &amp; Procedures Guide (PAPPG), Part 1, Chapter II, Section E: Types of Proposals. Compliance: Proposals that are not compliant with the Proposal &amp; Award Policies &amp; Procedures Guide (PAPPG) will be returned without review.

National Institutes of Health

Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute of Mental Health (NIMH), National Institutes of Health (NIH), invites investigator-initiated research grant applications for studies focused on the early identification and treatment of mental disorders in children and adolescents. Specific examples include studies focused on: the validation of early diagnosis of mental disorders in youth, especially in young children; the development of new interventions to treat mental disorders and prevent the exacerbation of associated functional impairment; the efficacy and safety of new and existing treatments; the identification and evaluation of predictors of treatment response and underlying mechanisms of action for new and existing treatments; the long-term effectiveness and impact of early intervention on later course; and the factors that promote or impede access to services and impact the effectiveness of services for these patients in community and practice settings. Assessment methods may include behavioral, neuropsychological, neuroimaging, and other physiological measures or markers. Intervention strategies to be studied may include pharmacological, psychosocial, and rehabilitative interventions, separately or in combination. Mechanism of Support. This FOA will use the NIH Research Project Grant (R01) award mechanism. Applications of related or identical scientific scope are also solicited under the NIH Small Research Grant (R03), the NIH Exploratory/Developmental Grant (R21), and the NIMH Clinical Exploratory Research Grant (R34), responding to FOAs PA-06-180, PA-06-181, and PAR-06-248, respectively. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations.

European Bank for Reconstruction and Development

Provides advice and financing to small businesses in EBRD countries of operations. Includes business advisory services, credit lines, and market linkage support.

NINDS - National Institute of Neurological Disorders and Stroke

Surgery and acute post-operative pain are major contributors to persistent pain, chronic pain, and opioid dependence. Currently, there are no products on the market in the United States that can be used to monitor surgical nociception. Existing products use indicators that are susceptible to intraoperative influences such as blood loss, anesthetic drugs and antihypertensives. This leaves anesthesiologists to guess whether or not the analgesic therapies they are providing will be effective at managing intra-operative nociception and subsequent post-operative pain. A significant fraction of surgeries also rely on regional anesthesia techniques, and, these techniques are not foolproof, and may fail during surgery, leading to potentially uncontrolled postoperative pain that is apparent only when the patient recovers consciousness after surgery in intense pain. As it stands, anesthesiologists have no way to directly assess the ongoing efficacy of their regional blocks, leading to unreliable nociception and pain management. Therefore, improved methods to monitor surgical nociception are clearly needed. The original grant proposed to develop new technology that makes it possible for the first time to use event-related potentials (ERPs) to actively assess pain and analgesia during general and regional anesthesia. ERPs are generated by painful stimuli and can be measured at the scalp by averaging waveforms from repeated stimuli generated by a variety of methods including electrical stimulation. ERPs are challenging if not impossible to use for anesthesia monitoring because they are very small, between ~1 to 10 microvolts, and are overshadowed by background electroencephalogram oscillations that are 10- to 100-fold larger in amplitude during general anesthesia or sedation. Recently, we developed a novel technology for processing ERPs that increases their precision ~150-fold even in the presence of orders-of-magnitude larger background oscillations. Building on our original grant’s achievement, we need to fill gaps in business expertise within the current small business leadership by hiring an experienced entrepreneur to attract private funding through private investment and partnership with industry

NCATS - National Center for Advancing Translational Sciences

ABSTRACT Monoclonal antibodies (mAbs) provide unchallenged specificity compared to small molecules, representing a growing market of 220+ billion dollars. Due to their structural complexity and poor stability, however, they remain difficult to formulate at high concentrations, making intravenous (IV) delivery of mAbs the “gold standard”. IV injections present major drawbacks, such as patient discomfort, long injection times, and high medical costs associated with in-hospital administration. Subcutaneous (SC) delivery is a convenient route of administration for large molecules, as it allows for rapid injections (seconds), requires minimal skills (self-injection), and allows for systemic delivery. It remains an open challenge to reformulate mAbs to a SC form. Most mAbs require large dosages to be effective (>300 mg), and SC administration volumes are constrained to only 1-2 ml, hundreds of times smaller than typical IV formulations. SC injections using microgels offer a promising method for encapsulating and delivering protein-based drugs. The composition, size, and mechanical properties of microgels can be widely tuned to facilitate their injection through needles for subcutaneous delivery. Alginate- based MP are becoming increasingly popular due to their rheological properties and high biocompatibility. Additionally, the anionic nature of alginate enables electrostatic entrapment of cationic proteins independently of the hydrogel porosity, making it a candidate for hydrogel-based antibody formulations. However, current manufacturing technologies are limited to low cargo loading for antibodies, or use of oils and solvents that can cause significant drawbacks including hypertonicity of the formulation and increased injection site pain. Through the support of this Small Business Innovation Research (SBIR) Phase II project, we aim at improving clinical care of millions of patients by reformulating IV-delivered mAbs to a SC form. We plan to leverage Acoustophoretic Printing (AP) to generate alginate microgels to stabilize highly concentrated mAbs formulation. This platform technology enables microparticle generation under modest shear forces without the need for a hydrophobic carrier fluid, thereby protecting the valuable cargo and minimizing contamination. The technology features: high bio-compatibility with no oil or surfactant required, making this technology particularly suitable for large proteins; high concentrations of cargo (>300mg/ml); low particle size variation (coefficient of variation of <5%) reducing costly sieving steps, consistency in cargo encapsulation and delivery - hence significantly improving Good Manufacturing Practices - even at extreme loading. In our prior work, we demonstrated the viability of this approach by (1) Manufacturing mAbs loaded microgels for SC delivery and characterize them in-vitro, including encapsulation efficiency, release profile, and injectability and by (2) demonstrating its in-vivo safety, bioavailability, and bioactivity of the microgel-based formulations in murine models. In this Phase II, we plan to build upon these achievements by working towards a pre-clinical formulation with scaled-up manufacturing capabilities and a customer-driven product development.

NIMHD - National Institute on Minority Health and Health Disparities

Modified Project Summary/Abstract Section Diagnostic errors impact 12 million Americans annually, contributing to nearly 40,000 deaths and costing the healthcare system over $100 billion yearly. Low-resource environments, including rural and inner-city communities in the US, encounter distinct challenges that adversely affect diagnostic accuracy and timeliness. These challenges include suboptimal healthcare infrastructure, physician shortages, and limited access to specialized care. These factors contribute to a high incidence of diagnostic errors in rural communities, leading to delayed diagnoses and misdiagnoses, suboptimal clinical outcomes, and increased healthcare expenditures. Artificial-intelligence tools are promising, but are untrusted, opaque (“black boxes”) and will require perpetual human-clinician oversight to avoid harm. Recognizing these issues, CollectiveGood’s overall objective is to deliver a mobile peer-consult platform that learns who the most suitable clinician reviewers are for any given case, weights their opinions intelligently, and explains the final consensus—thereby providing specialist-level diagnostic accuracy at generalist cost. Multiple studies across a range of domains show that aggregating independent clinical opinions significantly outperforms individual expert assessments—reducing error rates on the order of 33%. However, current medical crowdsourcing approaches are static, neglecting varying clinician competencies and lacking methods to optimize cost-efficiency over time. Addressing this, our platform will reduce diagnostic errors and enhance treatment outcomes by dynamically assessing clinician expertise profiles, selecting reviewers based on these profiles and case characteristics, and intelligently aggregating opinions with calibrated uncertainty estimates, thus maximizing diagnostic accuracy and minimizing resource use. In Phase I, we will enhance an already-deployed mobile peer-consult application with an attention network-powered collective-intelligence engine to develop a self-improving system that learns to predict the optimal number and composition of clinical opinions needed for different case types while continuously improving with each diagnostic decision. Specifically, we aim to 1) Create and validate a 15-minute onboarding process that assigns every new clinician a reliable “skill profile”; 2) Build a real-time “consensus engine” that converts many peer opinions into one high-quality answer; and 3) Evaluate the feasibility, acceptability, and user experience of the enhanced application in clinical settings. Completion of these aims will yield (1) a validated onboarding module, (2) a low-latency attention-based consensus engine, and (3) real-world feasibility data—all embedded in a HIPAA-compliant mobile app already in use. These assets position our university–small-business team for a multicenter Phase II trial and rapid SaaS scale-up, advancing diagnostic safety for America’s most low-resource communities.

National Aeronautics and Space Administration

Awards will be made as cooperative agreements to accredited Minority Serving Institutions (MSIs) partnered with non-profit organizations in the United States that are eligible to apply for this NASA Research Announcement (NRA). The period of performance for an award is up to 2 years. Prospective proposers are requested to submit any questions in writing to NASAMUSIC@nasaprs.com no later than 10 business days before the proposal due date so that NASA will have sufficient time to respond. Proposers to this NRA are required to have the following, no later than the due date: 1) a Data Universal Numbering System (DUNS) number, 2) a valid registration with the System for Award Management (SAM) [formerly known as the Central Contractor Registry (CCR)], 3) a valid Commercial And Government Entity (CAGE) Code, 4) a valid registration with NASA Solicitation and Proposal Integrated Review and Evaluation System (NSPIRES) (this also applies to any entities proposed for sub-awards or subcontracts.) Consult Appendix H Section H.3.1 for more eligibility information. Consult Appendix H Section 2.2 regarding teaming requirements and partnership guidelines. The goal of NASA MUSIC is: to provide strategic effort that will leverage research and contract relationships of MSIs and NASA through relationships developed by non-profit organizations that may include collaboration of subject matter experts and access to NASA research facilities; An effort to improve STEM education and research at MSIs; A funded activity that seeks to build institutional capacity of MSIs; An activity to support long-term sustainability of STEM research at MSIs. MUSIC seeks to address the agency goals and objectives through: Increasing the institutional awareness of NASA competitive resources that can build the capacity of MSIs to offer and conduct STEM undergraduate and graduate research with a focus on NASA opportunities. Assembling MSIs and their stakeholders with common interests, and challenges then provide common tools for MSIs to increase efficiency and optimize resources including opportunities to develop formal and informal partnerships. Connecting MSI administrators and university STEM leaders to cutting-edge initiatives at NASA that can increase interest in securing research and contracting opportunities while supporting NASA s policy to achieve an Agency-wide goal of providing one percent of total contract value of prime and subcontracting awards to MSIs. https://www.hq.nasa.gov/office/procurement/regs/1826.htm To achieve these goals, MUSIC seeks to increase university program capacity about practical uses of research to drive institution sustainability through the following targets: Advance the understanding of MSIs on how to effectively develop institutional administrative support by competing at the university level for funding opportunities, which will result in successful application to, and management of these funding opportunities (including those at NASA). Extend MSI s capabilities by: A. Leveraging the MSIs research capabilities with NASA research to develop Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) projects that develop and demonstrate innovative technologies that fulfill NASA needs and have significant potential for successful commercialization. B. Increasing the preparation of undergraduate and graduate science, technology, engineering, and mathematics faculty with opportunities to participate with NASA researchers and missions through grants and contracts. To achieve these goals and objectives, NASA solicits proposals from MSIs to implement the NASA MUSIC; to engage MSIs in authentic STEM experiences related to NASA missions; and to inspire and captivate learners utilizing NASA s unique assets to develop a keen interest in STEM. Every institution that intends to submit a proposal to this NRA, including the proposed prime award or any partner whether an education institution, other non-profit institutions, and other organizations that will serve as sub-awardees or contractors, must be registered in NSPIRES. Electronic submission of proposals is required by the due date and must be submitted by an authorized official of the proposing organization. Such registration must identify the authorized organizational representative(s) who will submit the electronic proposal. All principal investigators and other participants (e.g. co-investigators) must be registered in NSPIRES regardless of submission system. Potential proposers and proposing organizations are urged to access the system(s) well in advance of the proposal due date(s) of interest to familiarize themselves with its structure and enter the requested information. Electronic proposals may be submitted via the NASA proposal data system NSPIRES or via Grants.gov. Organizations that intend to submit proposals via Grants.gov must be registered 1) with Grants.gov and 2) with NSPIRES. Additional programmatic information for this NRA may develop before the proposal due date. If so, such information will be added as a Frequently Asked Question (FAQ) or formal amendment to this NRA and posted on http://nspires.nasaprs.com. It is the proposer s responsibility to regularly check NSPIRES for updates to this NRA.

National Institutes of Health

Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), solicits grant applications from institutions/organizations that propose epidemiological and behavioral research to improve oral health or increase the understanding of the determinants of oral health. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations.

Multiple - Small Manufacturing Business Expan Prog

Establishment of a loan program for small Oregon manufacturing businesses.

FedEx

Supports small business development, disaster relief, and community resilience through grants and in-kind shipping.

Friends of Alki Beach

Friends of Alki Beach is seeking funding for Phase One of the Alki Avenue Revitalization Project, focused on improving pedestrian safety and supporting small business recovery along the critical "Restaurant Row" corridor on Alki Avenue between 55th to 62nd Streets. This area supports some of Seattle’s highest traffic in the summer. But in the winter with dark neglected park areas and no summer tourists, area restaurants suffer extremely low traffic. As the City repairs long-neglected light posts in this busy but struggling district, this project proposes adding custom-designed flags to enhance visibility, signal positive change, and break the cycle of neglect—addressing the "broken-window syndrome”. These colorful, well-placed flags serve as affordable, high-impact wayfinding tools that make the corridor more inviting, walkable, and vibrant. The project directly aligns with city goals to foster safe, pedestrian-friendly streets and sustain local small businesses.

Florida Department of Economic Opportunity (DEO)

Florida Department of Economic Opportunity (DEO) offers grants, incentives, and financial assistance for small businesses, startups, and economic development projects in FL.

National Institute of Food and Agriculture

The goal of the FADI-EDEN program, under assistance listing 10.304, is to support CES s ability to maximize the resilience of the U.S. food and agriculture sector to biosecurity risks, weather events and disasters, cyber threats, and other shocks through the Extension Disaster Education Network (EDEN). EDEN is a national, collaborative network of CES professionals who are dedicated to improved all-hazards management of domestic disasters. EDEN supports all-hazards capacity-building efforts for peer CES professionals so that they are prepared for and skilled in directly providing education and technical assistance to farmers, youth and families, small businesses, and communities. The FADI-EDEN program provides coordination support and administrative leadership to EDEN so that it can achieve its mission.

National Institutes of Health

Forecast to Publish a Notice of Funding Opportunity for Small Business Transition Grant For Early Career Scientists (R41/R42 Clinical Trial Not Allowed)

National Institutes of Health

Purpose. Genetic and genomic studies have identified genes and gene variants that potentially modulate the fundamental biological mechanisms underpinning addictive processes. Discovery of these genes/variants, while extremely valuable, is only a first step in understanding molecular mechanisms of addiction. This Funding Opportunity Announcement encourages basic functional genomic research in two areas: 1. functional validation to determine which candidate genes/variants have an authentic role in addictive processes, and 2. detailed elucidation of the molecular pathways and processes modulated by candidate genes/variants, particularly for those genes with an unanticipated role in addiction. Mechanism of Support. This FOA will utilize the R01 grant mechanism and runs in parallel with an FOA of identical scientific scope, PA-07-167 that solicits applications under the R21 and an FOA of identical scientific scope, PA-07-168 that solicits applications under R03 mechanisms. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization, and Eligible agencies of the Federal government; Faith-based or community based organizations.

National Institutes of Health

Purpose. Genetic and genomic studies have identified genes and gene variants that potentially modulate the fundamental biological mechanisms underpinning addictive processes. Discovery of these genes/variants, while extremely valuable, is only a first step in understanding molecular mechanisms of addiction. This Funding Opportunity Announcement encourages basic functional genomic research in two areas: 1. functional validation to determine which candidate genes/variants have an authentic role in addictive processes, and 2. detailed elucidation of the molecular pathways and processes modulated by candidate genes/variants, particularly for those genes with an unanticipated role in addiction. Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism and runs in parallel with a FOA of identical scientific scope, PA-07-166 that solicits applications under the RO1 and PA-07-168 that solicits applications under the R03 mechanisms. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications Budget and Project Period: The total project period for an application submitted in response to this funding opportunity may not exceed two years. Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year. The R21 is not renewable. Eligible Organizations: Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Non-domestic (non-U.S.) Entity; Small Business; For-Profit Organization (Other than Small Business); State Government; Regional Organization; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations.

National Institute of Standards and Technology

The National Institute of Standards and Technology (NIST) invites small businesses to submit Phase I research applications under this Federal Funding Opportunity (FFO). Firms with strong research capabilities in any of the areas listed in Section 9 of the Full Announcement/FFO document are encouraged to participate. Applications not addressing one of the Subtopics in Section 9 are not responsive to this FFO.NIST offers two types of Subtopics in Section 9 of this FFO: standard research R and tech transfer TT Subtopics. Both R and TT subtopics are intended to cultivate private sector innovation and foster and encourage participation by minority and disadvantaged persons in technological innovation.

Office of Naval Research

ONR, ONRG, and MCWL are interested in receiving proposals for Long-Range S&amp;T Projects that offer potential for advancement and improvement of Navy and Marine Corps operations. Readers should note that this is an announcement to declare ONR, ONRG and MCWL s broad role in competitive funding of meritorious research across a spectrum of science and engineering disciplines.All responsible sources from academia, industry and the research community worldwide may submit proposals under this BAA. All businesses, both small and large, are encouraged to submit proposals and compete for funding consideration.

Georgetown Merchants Association

The Georgetown Carnival is a free, one-day, arts & music-focused street fair centered in Georgetown’s historic business district. The 2025 Carnival will take place on June 14, 12-10 pm, on Airport Way S between 12th Ave S & Corson Ave. The Carnival is a celebration of the neighborhood and its unique place as an artistic and small business haven surrounded by large-scale industry. It brings visibility to the neighborhood artists and businesses, and gives our small residential community a day of fun focused on our special neighborhood. With a residential population of only 1700, Georgetown’s small businesses rely on customers from other parts of Seattle to remain viable. Events like Carnival are vital in increasing the visibility of our local artists and businesses, and create a lasting economic impact by introducing new people to the neighborhood and encouraging them to return. In 2023, we welcomed over 5,000 people to the Carnival, many of whom were first time visitors to Georgetown.