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NIA - National Institute on Aging

PROJECT SUMMARY: OVERALL The Columbia University (CU) – Weill Cornell Medicine (WCM) Center for AIDS Research (CFAR) is a partnership between two large New York City (NYC) academic institutions, each with an expanding investment in HIV research and connected by the NewYork-Presbyterian hospital system, which spans four NYC counties designated as priority high-burden jurisdictions by the US Ending the HIV Epidemic (EHE) initiative. The overall specific aims of the CU-WCM CFAR are to (1) catalyze innovative, interdisciplinary, inter-institutional HIV research that addresses key HIV research priorities for ending the epidemic in NYC and beyond; (2) engage and support career development of HIV researchers, including early-career investigators (ECIs) and investigators new to HIV; and (3) advance community-engaged participatory research that promotes health for all people. The CU-WCM CFAR will accomplish these goals by establishing, engaging, and working through six Cores: The Administrative Core will provide leadership and management; implement strategic planning; and stimulate communication, collaboration, and capacity building. The Developmental Core will provide grant funding awards; mentoring and career development for new investigators; and provide resources, training, and feedback for mentors to improve their skills. The Structural Immunology Core will provide state-of-the-art imaging and immunological technologies; molecular structure determination; and bioinformatics to understand antibody-virus co-evolution, and structural modeling. The Virology Core will provide specialized assays to measure virus replication, infectivity, and cell susceptibility to infection; comprehensive reservoir characterization; and training in these methodologies. The Clinical Research Core will provide consultative support across the course of a study ranging from study design and biostatistical planning to participant recruitment, and data analysis. The Behavioral, Implementation and Community Sciences Core will support investigators engaged in behavioral, implementation, health services, and community science research and catalyze bi-directional collaborations with communities. We also will establish a Scientific Working Group – Integrating Systems of Care to End the HIV Epidemic – that will bring together a group of dynamic multi-sector collaborators to develop a robust research agenda that addresses fragmentation of care for HIV, mental health, and substance use care co-morbidities. The CU-WCM CFAR will add value to our institutions’ existing strong research portfolios through scientific leadership and strategic planning that builds synergistic new collaborations, enhances community engagement on HIV research and health, and supports innovation and research productivity as well as the next generation of leading HIV researchers.

NIAID - National Institute of Allergy and Infectious Diseases

PROJECT SUMMARY With the most people ever in history currently living with HIV, stopping the HIV epidemic remains imperative. Combination antiretroviral therapy (ART) limits viral replication, but is not curative. Thus, there is an urgent need to design a functional cure via elimination of the viral reservoir. We recently found that the combination of antiretroviral therapy, broadly neutralizing antibodies, and CCR5 blockade were able to completely clear establishment of infection in newborn macaques when delivered by day three post-infection. However, it remains unclear how far post-infection this treatment window extends in newborns and if this treatment is also effective in adults. In specific aim 1, we will systematically identify the window of opportunity for this novel triple therapy treatment to clear the latent reservoir by delaying treatment multiple days. In specific aim 2, we will determine if this remarkable clearance of reservoir establishment via triple therapy is also effective in adults infected via sexual transmission. Because all three components of this triple therapy are currently being tested individually in humans, successful completion of the aims here will set the stage for clinical trials to for HIV cure.

NCI - National Cancer Institute

Project Abstract Many solid cancers are inoperable due to either tumor size or because the tumor is attached to, or near, major blood vessels, vital organs or other critical tissues. Focal ablation modalities utilizing a variety of energy forms to destroy/debulk tumor tissues are frequently used in the management of inoperable solid cancers. More than 45,000 tumor ablation procedures are performed each year. Three thermal ablation techniques, radiofrequency ablation (RFA), cryoablation (CA) and microwave ablation (MWA), account for more than 80% of all procedures, but residual tumor deposits often lead to recurrence rates that are 2 to 10 times higher than recurrence rates following surgical resection. As a result, patients with inoperable tumors have worse survival outcomes compared to patients with resectable tumors. Integrated Nanosecond Pulse Irreversible Electroporation (INSPIRE) is a novel, minimally invasive solid tumor ablation modality. This thermally-regulated approach uses ultrashort alternating polarity electrical pulses to destabilize tumor cell membranes while preserving the integrity of nearby vital structures. A key advantage of INSPIRE, which forms the crux of this proposal is the flexibility in energy delivery and numerous parameters combinations that allows us to modulate cell death mechanisms to favor immunogenic pathways, and subsequent antitumor immune responses. Induction of robust antitumor immunity following focal ablation is crucial for eliminating residual tumor cells and preventing local or distant recurrence which can be enhanced with secondary immunotherapy agents such as checkpoint inhibitors. Based on our preliminary studies, we hypothesize that there is a ‘best’ or most immunogenic INSPIRE protocol which maximizes the resultant antitumor immune. We further hypothesize that an adjunctive immunotherapy can boost the INSPIRE-induced antitumor response, thus enhancing both local and systemic tumor control. These hypotheses will be tested in an aggressive, transplantable murine melanoma model before translation into comparative oncology trials in pet dogs with spontaneous melanomas via three aims: Aim 1: Develop and validate INSPIRE protocols to maximize tumor-specific immunity; Aim 2: Evaluate the timing of adjunctive immunotherapy relative to INSPIRE; Aim 3: Validation of Combinatorial INSPIRE in a Spontaneous Large Animal Model of Disease. These aims will determine the treatment parameters which maximize immune stimulation via INSPIRE, improve systemic anti- tumor immune responses via optimized adjunctive immunotherapy regimens, and demonstrate clinical superiority of this combined approach in a relevant large animal model. Our long term goal is to develop a novel, minimally invasive focal treatment paradigm that is capable of preventing recurrences and eliminating metastatic deposits. Successful completion of the proposed project will support further translation of INSPIRE plus adjunctive immunotherapy into human trials while providing a state-of-the-art treatment for thousands of companion animals per year.

U.S. National Science Foundation

TheCombustion and Fire Systemsprogram is part of the Transport Phenomena cluster, which also includes 1) theFluid Dynamicsprogram; 2) theParticulate and Multiphase Processesprogram; and 3) theThermal Transport Processesprogram. The goal of theCombustion and Fire Systemsprogram is to<span>create new knowledge to support advances in clean energy, climate change mitigation, a cleaner environment and public safety.</span> The program endeavors to createfundamental scientific knowledge that is needed for safe, clean and useful combustion applications and for mitigating the effects of fire.The program aims to identify and understand the controlling basic principles and to use that knowledge to create predictive capabilities for designing and optimizing practical combustion devices and understanding fire. Important outcomesfor this program include: <ul type="disc"> <li>broad-based tools &mdash; experimental, theoretical, andcomputational &mdash; that can be applied to a variety of problems in combustion technologies and fire;</li> <li>science and technology for clean and efficient generation of power;</li> <li>discoveries that enable clean environments (for example, by reduction in combustion-generated pollutants); and</li> <li>enhanced public safety and climate change mitigation through research on wildland and building fire growth, inhibition, and suppression.</li> </ul> Research areas of interest for this program include: <ul type="disc"> <li>Basic combustion science: Combustion of gas, liquid, and solid fuels over abroad range of temperatures, pressures, and compositions; combustion at supercritical conditions; advanced propulsion concepts; flame synthesis ofmaterials; integration of fuel design and combustion; control of reaction pathways; development of chemical kinetics models, analytical and numerical predictive methods, and advanced diagnostic tools.</li> <li>Combustionscience related to clean energy: Increasing efficiency and reducing pollution; production and use of renewable and/or carbon-free fuels; biomass pyrolysis, gasification, and oxidation; technologies such as oxy-fuel combustion and chemical looping combustion for carbon capture.</li> <li>Fireprevention: Improved understanding of building and wildland fires to prevent their spread, inhibit their growth, and suppress them; prediction and mitigation of fires in the wildland-urban interface.</li> <li>Turbulence-chemistry interactions:Fundamental understanding of turbulent flow interactions with finite-rate chemical kinetic pathways at high Reynolds and Karlovitz number conditions, including but not limited to: (1) fundamental experiments to generate physico-chemical data to reduce theuncertainty of combustion chemistry and turbulent combustion models; (2)spatially/temporally well-resolved, multi-scale/multi-physics computations;novel approaches of developing embedded multi-scale direct numericalsimulation (DNS) of complex geometries and data-assimilations forincorporating measured data from the state-of-art in situ diagnostic approaches; (3) other innovative approaches on development and validation of predictive computational methods. NOTE: This is an NSF-AFOSR (Air Force Office of Scientific Research) joint funding area. Proposals will be jointly reviewed by NSF and AFOSR using the NSF merit reviewprocess.Actual funding format and agency split for an award(depending on availabilityof funds) will be determined after the proposal selection process. The AFOSR program that participates in this initiative is the program on Energy, Combustion, and Nonequilibrium Thermodynamics.</li> </ul> Innovative proposals outside of these specific interest areas may be considered.However, prior to submission, it is recommended that the Principal Investigator contact the program director to avoid the possibility of the proposal being returned without review. <div> <div id="_com_1"> INFORMATION COMMON TO MOST CBET PROGRAMS </div> </div> Proposals should address the novelty and/or<a href="http://www.nsf.gov/about/transformative_research/faq.jsp">potentially transformative nature</a>of the proposed work compared to previous work in the field.Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact on society and/or industry of success in the research.The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. The duration of unsolicited proposal awards in CBET is generally up to three years. Single-investigator award budgets typically include support for one graduate student (or equivalent) and up to one month of PI time per year(awards for multiple investigator projects are typically larger). Proposal budgets that are much larger than typical should be discussed with the program director prior to submission. Proposers can view budget amounts and other information from recent awards made by this program via the &ldquo;What Has Been Funded (Recent Awards Made Through This Program, with Abstracts)&rdquo; link towards the bottom of this page. Faculty Early Career Development(CAREER)program proposals are strongly encouraged.Award duration is five years.The submission deadline for Engineering CAREER proposals is in July every year. Learn more in the<a href="https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=503214">CAREER program description</a>. Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the program director before submission of the proposal. Grants forRapid Response Research(RAPID)andEArly-concept Grants for Exploratory Research(EAGER)are also considered when appropriate.Please note that proposals of these types must be discussed with the program director before submission.Grant Opportunities for Academic Liaison with Industry (GOALI)proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that RAPID, EAGER, and GOALI proposals can be submitted anytime during the year. Details about RAPID, EAGER, and GOALI are available in the Proposal &amp; Award Policies &amp; Procedures Guide (PAPPG), Part 1, Chapter II, Section E: Types of Proposals. Compliance: Proposals that are not compliant with the<a href="https://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg">Proposal &amp; Award Policies &amp; Procedures Guide (PAPPG)</a>will be returned without review.

U.S. National Science Foundation

TheCombustion and Fire Systemsprogram is part of the Transport Phenomena cluster, which also includes 1) theFluid Dynamicsprogram; 2) theParticulate and Multiphase Processesprogram; and 3) theThermal Transport Processesprogram. The goal of theCombustion and Fire Systemsprogram is tocreate new knowledge to support advances in clean energy, climate change mitigation, a cleaner environment and public safety. The program endeavors to createfundamental scientific knowledge that is needed for safe, clean and useful combustion applications and for mitigating the effects of fire.The program aims to identify and understand the controlling basic principles and to use that knowledge to create predictive capabilities for designing and optimizing practical combustion devices and understanding fire. Important outcomesfor this program include: broad-based tools experimental, theoretical, andcomputational that can be applied to a variety of problems in combustion technologies and fire; science and technology for clean and efficient generation of power; discoveries that enable clean environments (for example, by reduction in combustion-generated pollutants); and enhanced public safety and climate change mitigation through research on wildland and building fire growth, inhibition, and suppression. Research areas of interest for this program include: Basic combustion science: Combustion of gas, liquid, and solid fuels over abroad range of temperatures, pressures, and compositions; combustion at supercritical conditions; advanced propulsion concepts; flame synthesis ofmaterials; integration of fuel design and combustion; control of reaction pathways; development of chemical kinetics models, analytical and numerical predictive methods, and advanced diagnostic tools. Combustionscience related to clean energy: Increasing efficiency and reducing pollution; production and use of renewable and/or carbon-free fuels; biomass pyrolysis, gasification, and oxidation; technologies such as oxy-fuel combustion and chemical looping combustion for carbon capture. Fireprevention: Improved understanding of building and wildland fires to prevent their spread, inhibit their growth, and suppress them; prediction and mitigation of fires in the wildland-urban interface. Turbulence-chemistry interactions:Fundamental understanding of turbulent flow interactions with finite-rate chemical kinetic pathways at high Reynolds and Karlovitz number conditions, including but not limited to: (1) fundamental experiments to generate physico-chemical data to reduce theuncertainty of combustion chemistry and turbulent combustion models; (2)spatially/temporally well-resolved, multi-scale/multi-physics computations;novel approaches of developing embedded multi-scale direct numericalsimulation (DNS) of complex geometries and data-assimilations forincorporating measured data from the state-of-art in situ diagnostic approaches; (3) other innovative approaches on development and validation of predictive computational methods. NOTE: This is an NSF-AFOSR (Air Force Office of Scientific Research) joint funding area. Proposals will be jointly reviewed by NSF and AFOSR using the NSF merit reviewprocess.Actual funding format and agency split for an award(depending on availabilityof funds) will be determined after the proposal selection process. The AFOSR program that participates in this initiative is the program on Energy, Combustion, and Nonequilibrium Thermodynamics. Innovative proposals outside of these specific interest areas may be considered.However, prior to submission, it is recommended that the Principal Investigator contact the program director to avoid the possibility of the proposal being returned without review. INFORMATION COMMON TO MOST CBET PROGRAMS Proposals should address the novelty and/orpotentially transformative natureof the proposed work compared to previous work in the field.Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact on society and/or industry of success in the research.The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. The duration of unsolicited proposal awards in CBET is generally up to three years. Single-investigator award budgets typically include support for one graduate student (or equivalent) and up to one month of PI time per year(awards for multiple investigator projects are typically larger). Proposal budgets that are much larger than typical should be discussed with the program director prior to submission. Proposers can view budget amounts and other information from recent awards made by this program via the What Has Been Funded (Recent Awards Made Through This Program, with Abstracts) link towards the bottom of this page. Faculty Early Career Development(CAREER)program proposals are strongly encouraged.Award duration is five years.The submission deadline for Engineering CAREER proposals is in July every year. Learn more in theCAREER program description. Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the program director before submission of the proposal. Grants forRapid Response Research(RAPID)andEArly-concept Grants for Exploratory Research(EAGER)are also considered when appropriate.Please note that proposals of these types must be discussed with the program director before submission.Grant Opportunities for Academic Liaison with Industry (GOALI)proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that RAPID, EAGER, and GOALI proposals can be submitted anytime during the year. Details about RAPID, EAGER, and GOALI are available in the Proposal &amp; Award Policies &amp; Procedures Guide (PAPPG), Part 1, Chapter II, Section E: Types of Proposals. Compliance: Proposals that are not compliant with theProposal &amp; Award Policies &amp; Procedures Guide (PAPPG)will be returned without review.

Seattle Repertory Theater

Seattle Rep will produce a Community Sing-Along at one performance during the run of the musical Come From Away. The Community Sing-Along will be free to the public and led by volunteers who will take free musical theater workshops in advance of the event to learn the music and lead the audience in song. Up to 669 people will be able to enjoy a free performance of this world-renowned musical and feel closer to the art onstage by singing together with professional actors and community members. The free event will be held on December 31, 2025, at 12Pm in Seattle Rep’s Bagley Wright Theater located at 155 Mercer St, Seattle WA 98109.

National Endowment for the Humanities

COMMEMORATING AMERICA?S 250 [CIVIC SPIRIT?S COMMEMORATING AMERICA?S 250 PROGRAM WILL HONOR THE NATION?S SEMIQUINCENTENNIAL BY ENGAGING EDUCATORS AND THE PUBLIC IN CIVIC REFLECTION AND HISTORICAL LEARNING. THROUGH A YEAR-LONG WE THE EDUCATORS SERIES, MIDDLE AND HIGH SCHOOL TEACHERS IN FAITH-BASED SCHOOLS WILL EXPLORE FOUNDING TEXTS, PIVOTAL MOMENTS, AND CIVIC VIRTUES WHILE GAINING TOOLS TO FOSTER THOUGHTFUL CLASSROOM DIALOGUE. COMPLEMENTING THIS, THE WE THE PEOPLE SERIES WILL BRING SCHOLARS AND CITIZENS TOGETHER FOR LECTURES, TEXT-BASED DISCUSSIONS, AND CIVIL DISCOURSE ON AMERICAN PRINCIPLES AND DEMOCRATIC DEBATES. TOPICS WILL INCLUDE THE DECLARATION OF INDEPENDENCE, THE CONSTITUTION, CIVIC IDENTITY, FAITH AND DEMOCRACY, AND THE ROLE OF THE ARTS IN CIVIC CULTURE. THESE PROGRAMS WILL CREATE LASTING RESOURCES, STRENGTHEN CIVIC EDUCATION, AND MODEL PLURALISTIC DIALOGUE, ENSURING THE 250TH ANNIVERSARY SERVES AS A CATALYST FOR ENDURING CIVIC ENGAGEMENT.]

Lesley University College of Art and Design (LUCAD), Community Design Studio

Common Exchange Newspaper

Lesley University College of Art and Design (LUCAD), Community Design Studio

Common Exchange Newspaper

Communities Foundation of Texas

Communities Foundation of Texas ($2.2B in assets) supports nonprofits in TX through grants focused on education, community development, arts, health. Awards range from $5,000 to $250,000.

SouthEast Effective Development

Columbia City Gallery (CCG) requests funding to establish a community advisory task force to help realign our practices with the changing needs of Southeast Seattle. Our goal is to expand pathways for participation for BIPOC Southeast Seattle artists and organizations, and to ensure that our exhibitions and membership reflect the SE Seattle community. To better understand community needs, we will engage with five BIPOC artists and local arts advocates. They will review the Gallery's operating model, which as a cooperative requires member artists to pay monthly dues and work gallery shifts, and identify ways to shift towards a more equitable model. We will develop plants to reduce barriers to participation for underserved artists and better reflect the diversity of 98118. The group will meet twice/month for 3 months. We also plan to work with an EDI consultant to ensure the process is structured in an equity-centric way.

International Capoeira Angola Foundation - Seattle

Over the next 12 months the International Capoeira Angola Foundation will host a series of monthly events to showcase cultural arts from the African Diaspora. The location is the Union Cultural Center, 803 S. King St. The community will be brought together to share, learn, and participate in the vibrant cultures found in the region. The program will begin in January of 2020 and will conclude in December.

Beacon Arts

We seek funds to help pay rental of El Centro de la Raza's Centilia Room and Plaza for use at 4 Beacon Arts Street Fairs June 8, July 13, August 10 & Sept 14th 2024. We have had multiple requests for community dances. Centilia will be used to launch that project at the Street Fairs. Local professional dance teachers and facilitators will lead 4 sessions per day of interactive dance instruction in multiple disciplines and cultural traditions. Centilia first available June 8th. This adds dance to our inclusive, accessible neighborhood celebrations of community interests, accomplishments and local color. Each month features, art market, Garden Share, entertainment and information about projects in our community. Garden Share will be on Maestas Plaza and give away seeds and plants for food sustainability and beautification. BA has Street permits, provide liability insurance, funds and equipment. We partner with many local organizations to entertain and enlighten our neighbors.

Martial Arts in the Public Interest (Quantum Martial Arts)

The Quantum Community Empowerment and Self-Defense Day 2018 will include three 90-minute classes on Saturday, June 9, 2018, between 9am and 3pm at Quantum Martial Arts' studio at 1800 S. Jackson St. Free and open to the public, the classes will address the different self-defense needs of the general public, LGBT community, and female-identifying persons. The goal is to serve at least 80 individuals.

Community Foundation for a Greater Richmond

Community Foundation for a Greater Richmond ($1.0B in assets) supports nonprofits in VA through grants focused on education, community development, health, arts. Awards range from $5,000 to $200,000.

Community Foundation for Greater Atlanta

Community Foundation for Greater Atlanta ($1.4B in assets) supports nonprofits in GA through grants focused on education, community development, health, arts. Awards range from $2,500 to $200,000.

Community Foundation for Muskegon County

Community Foundation for Muskegon County ($200M in assets) supports nonprofits in MI through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

Community Foundation for Southeast Michigan

Community Foundation for Southeast Michigan ($1.0B in assets) supports nonprofits in MI through grants focused on education, arts, environment, health, community development. Awards range from $5,000 to $250,000.

Community Foundation for Southeast Michigan

The Community Foundation for Southeast Michigan funds nonprofits serving the seven-county region for arts and culture, education, environment, health, human services, and civic affairs, with emphasis on equity and opportunity.

Community Foundation of Acadiana

Community Foundation of Acadiana ($200M in assets) supports nonprofits in LA through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

Community Foundation of Broward

Community Foundation of Broward ($300M in assets) supports nonprofits in FL through grants focused on education, health, arts, community development. Awards range from $2,000 to $100,000.

Community Foundation of Broward

Community Foundation of Broward ($300M in assets) supports nonprofits in FL through grants focused on education, community development, health, arts. Awards range from $2,000 to $100,000.

Community Foundation of Central Illinois

Community Foundation of Central Illinois ($100M in assets) supports nonprofits in IL through grants focused on education, community development, health, arts. Awards range from $1,000 to $50,000.

Community Foundation of Collier County

Community Foundation of Collier County ($200M in assets) supports nonprofits in FL through grants focused on education, health, community development, arts. Awards range from $1,000 to $75,000.