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NIGMS - National Institute of General Medical Sciences

PROJECT SUMMARY/ABSTRACT Clemson University’s rapid growth in externally funded research has propelled it to R1 status, reflecting its expanding impact in advanced scientific inquiry. Five of Clemson’s nine academic colleges are STEM-fo- cused, encompassing over 30 academic units. In the last decade, Clemson’s NIH-funded portfolio has grown from $5.5 million in 2014 to $26 million in 2024, currently spanning 85 awards across 57 investigators. This growth is fueled by the university’s strategic investments in research infrastructure, equipment, and facilities. These actions foster a resource-rich environment capable of attracting and retaining top research talent. Three major NIH Centers of Biomedical Research Excellence (COBRE) underscore Clemson’s priorities: the Eukaryotic Pathogens Innovation Center (EPIC), the South Carolina COBRE for Translational Research Improving Muscu- loskeletal Health (SC-TRIMH), and the Clemson University Center for Human Genetics. To further strengthen Clemson’s research capabilities, we seek to acquire a Refeyn mass photometer, a transformative technology that enables single-particle mass measurements. Unlike bulk methods such as dynamic light scattering (DLS), mass photometry quantifies molecular mass, providing an unparalleled view of heterogeneity, oligomerization states, and binding interactions at the single-molecule level. This technology is valuable across disciplines and research foci on campus, from probing protein-ligand and protein-protein inter- actions that occur in eukaryotic pathogens (EPIC) to evaluating biomolecular assembly and integrity in mus- culoskeletal research (SC-TRIMH). Investigators in human genetics can rapidly assess protein-DNA/RNA interactions and more complex heterogenous multi protein-protein-DNA/RNA complexes. The Refeyn mass photometer offers remarkable advantages: (1) Minimal sample requirement—only a few microliters of material are needed; (2) Low per-sample cost, approximately $2, making it accessible to both established laboratories and student trainees; (3) Ease of operation, a simple pipetting step onto a glass slide significantly reduces technical barriers; and (4) Broad applicability, it excels in characterizing oligomeric states, monitoring antibody binding, and confirming molecular compositions in diverse sample types. By installing this mass photometer at Clemson, we will foster interdisciplinary collaboration, enrich hands- on learning opportunities, and expand the capabilities of ongoing NIH-funded projects. Moreover, this cutting- edge instrument will position Clemson researchers at the forefront of next-generation single-particle analytics, supporting a range of studies—from early discovery to late-stage translational research. Although it also inte- grates seamlessly into cryo-EM workflows, the mass photometer’s utility extends well beyond structural biology. Ultimately, this S10 instrumentation request will allow Clemson to elevate its research enterprise, amplify productivity, accelerate innovation, and strengthen the university as a leader in biomedical and research.

NIGMS - National Institute of General Medical Sciences

Modified Project Summary/Abstract Section This proposal requests funding for a Wyatt DAWN 8 Multi-Angle Light Scattering (MALS) system coupled with Size Exclusion Chromatography (SEC), referred to as SEC-MALS. The SEC-MALS system enables the measurements of molar mass, hydrodynamic radius, aggregation state, and sample heterogeneity of biomolecules and nanoparticles. The SEC-MALS system will support research with a biomedical focus in multiple departments, including Chemistry, Biology, Pharmacy, and the School of Medicine. In addition to supporting research, the instrument will enhance undergraduate training in biochemistry, organic, and polymer chemistry labs, aiding student training for careers in medicine and human related health fields. The long-term goal of this proposal is to build research and educational capacity at UT Tyler by enabling in-house access to advanced characterization tools. The SEC-MALS will eliminate reliance on external facilities, accelerate research, and improve hands-on student learning in STEM and biomedical fields. Plans are in place to extend access to researchers at nearby institutions, maximizing the instrument’s regional impact across East Texas.

NIGMS - National Institute of General Medical Sciences

Project Summary/Abstract The overarching goal of this proposal is to explore novel aspects of the actin cytoskeleton organization and function in health and disease. The remarkable functional versatility of the actin cytoskeleton stems from its ability to assemble into a variety of diverse structures – branched networks/meshes and aligned bundles. This architectural complexity is orchestrated by actin-binding proteins, whose activity is delicately regulated in response to internal and external signals. Human plastins are versatile actin-binding proteins that organize actin filaments into higher-order assemblies: bundles and networks. Plastins are involved in cytokinesis, migration, and stabilization of membrane protrusions, but also in the pathogenesis of the following diseases: carcinogenesis, neurodegeneration, and hereditary and infectious diseases. Despite the importance and long- lasting interest of the research community in these proteins, understanding of their interaction with actin and their regulation is superficial. Our first research direction is to contribute to human health and well-being by advancing the understanding of the actin cytoskeleton organization by actin-bundling proteins plastins and their contribution to pathologies (e.g., congenital diseases and metastatic cancers) at the molecular and cellular levels. Playing numerous vital roles in human defense mechanisms, the actin cytoskeleton is a common target for numerous bacterial pathogens, which developed various elegant and sophisticated ways to disrupt and usurp it by producing actin-targeting effectors. By hijacking the actin cytoskeleton, pathogenic toxins disturb cell morphology, cell motility, phagocytosis, epithelial permeability, and antigen presentation. Being constantly adjusted to the host cytoskeleton by co-evolution, they recognize weaknesses in the host defense and represent powerful tools that foster the understanding of the cytoskeleton on molecular and cellular levels. The urge for a thorough understanding of bacterial pathogenicity is further necessitated by the dissemination of multidrug- resistant pathogens that undermine the efficiency of antibiotics. The second research direction of this proposal is to decipher the in-depth molecular and cellular mechanisms of bacterial effectors targeting the actin cytoskeleton to i) enable alternative ways of targeting pathogens and ii) get a deeper understanding of the actin cytoskeleton per se. The current proposal is directly relevant to the NIH mission as it focuses on three families of bacterial effectors, all produced by human pathogens: Vibrio cholerae and Vibrio parahaemolyticus VopF/VopL (1) and VopM/VopV (2), and Legionella pneumophila MavH, RavH, and VipA (3). Furthermore, the proposal is of interest for a general understanding of human physiology as each of the above toxins reveals novel properties of the actin cytoskeleton. Finally, the understanding of the molecular and cellular mechanisms governing the function of actin-bundling proteins plastins contributes to explaining the pathology of plastin-related human diseases.

OD - NIH Office of the Director

Acute radiation syndrome (ARS) is a multi-organ failure (MOF) syndrome, resulting from accidental exposure to irradiation and/or nuclear terrorism. Acute and delayed effects of acute radiation exposure (DEARE) can also be seen in the clinic after radiotherapy. While there are FDA-approved drugs for mitigating hematopoietic ARS (H-ARS), there are no treatment for repairing irradiated intestines, primary cause of death and a critical component of gastrointestinal ARS (GI-ARS). A common feature of radiation injury is damage to the microvascular capillary endothelial cells (ECs) that are not only organotypically programmed to modulate metabolism but also provide tissue-specific angiocrine growth factors that orchestrate intestinal repair and regeneration post-radiation. Indeed, intestinal-specific microvascular ECs (InSECs), defined by the expression of transcription factor NKX2-3, establish instructive vascular niches that are essential for maintenance, repair and regeneration of intestinal stem cells (ISC) of irradiated intestines. We show that InSECs choreograph the polarization of the monocytes into reparative IL1beta macrophages that could play a key role in resolving radiation injury. The objective of this proposal is to leverage reproducible in vitro extra-corporeal perfusable vascularized intestinal organoids models to test approaches to restore normal homeostatic functions of InSEC. Thus, we hypothesize that radiation impairs NKX2-3+ InSEC-derived instructive signals and retards recruitment and programming of intestinotropic macrophages that convey reparative signals for intestinal repair. Restoration of NKX2-3 transcriptional signatures in InSECs would reconstitute angiocrine and intestinotropic macrophage functions, essential for resolution and recovery after radiation injury. Delivery of pro-reparative factors such as amphiregulins and epiregulins supplied by macrophages and InSECs could mitigate radiation-inflicted intestinal injury. These hypotheses will be tested through executing the following specific aims: Aim 1: Develop and characterize GI-ARS injury models in human Gut-On-VascularNet organoid extracorporeal platform. Aim 2: To characterize the “instructive” angiocrine signaling pathways of InSEC on pro-regenerative monocytic polarization that mitigate radiation injury to HIOs. Aim 3: To screen for intestinotrophic radiation MCMs to mitigate GI-ARS by using the Gut-On-VascularNet platform. To this end, Rafii and Guha groups plan to capitalize on an engineered scalable near-physiological and reproducible extra- corporeal human Gut-on-VascularNet platform to study radiation injury in GI-ARS. Leveraging this platform, also allows for examining the role of radiation in perfusable microfluidic devices harboring NKX2-3+ InSECs vascularized intestinal organoids to screen for angiocrine factors and reparative macrophages to mitigate GI- ARS. The human Gut-On-VascularNet platform would bridge the gap between animal models and humans for the approval of radiation countermeasures for mitigation of GI-ARS under the FDA “animal rule” guidance.

NINDS - National Institute of Neurological Disorders and Stroke

Spinal cord injury (SCI) affects over 300,000 patients in the US, often leading to severe complications. For example, more than 80% of these patients experience urinary dysfunctions, significantly diminishing their quality of life and sense of dignity. No effective treatment exists for these patients, as SCI frequently results in significant and permanent loss of neurons essential for normal functions. Progenitor cell transplantation is currently the most prevalent approach for replacing lost neurons following SCI. While progenitor cell transplantation has advanced to clinical trials, it presents several risks, including immunoreactions, uncertainty regarding the timeframe for transplantation following injury, and ethical considerations. Tumorigenesis is also a major concern with transplantation of cells derived from induced pluripotent stem cells. As an alternative, this project focuses on adult neurogenesis from resident glial cells in the adult spinal cord. This strategy not only generates neurons immune-compatible with the host but also ameliorates the pathological lesion microenvironment. Excitingly, our preliminary results demonstrate that adult neurogenesis promotes bladder function recovery following contusive SCI. Given that clinically relevant contusion SCI often leads to significant neuronal loss, generating a large number of new neurons may be particularly beneficial. Through recent in vivo screens, we identified a combination of transcription factors capable of rapidly inducing substantial neurogenesis from resident glial cells in the adult spinal cord. In this collaborative project, we will first systematically investigate the molecular and cellular mechanisms underlying induced adult neurogenesis after contusive SCI. Next, we will examine the maturation and synaptic integration of these newly generated neurons. Finally, we will assess their role in restoring bladder function post-SCI. Utilizing state-of-the-art technologies, this study has the potential to introduce a paradigm-shifting therapeutic strategy for treating autonomic dysfunction in SCI patients.

U.S. National Science Foundation

The NSF ADVANCE program contributes to the National Science Foundation's goal of a more diverse and capable science and engineering workforce.1 In this solicitation, the NSF ADVANCE program seeks to build on prior NSF ADVANCE work and other research and literature concerning gender, racial, and ethnic equity. The NSF ADVANCE program goal is to broaden the implementation of evidence-based systemic change strategies that promote equity for STEM2 faculty in academic workplaces and the academic profession. The NSF ADVANCE program provides grants to enhance the systemic factors that support equity and inclusion and to mitigate the systemic factors that create inequities in the academic profession and workplaces. Systemic (or organizational) inequities may exist in areas such as policy and practice as well as in organizational culture and climate. For example, practices in academic departments that result in the inequitable allocation of service or teaching assignments may impede research productivity, delay advancement, and create a culture of differential treatment and rewards. Similarly, policies and procedures that do not mitigate implicit bias in hiring, tenure, and promotion decisions could lead to women and racial and ethnic minorities being evaluated less favorably, perpetuating historical under-participation in STEM academic careers and contributing to an academic climate that is not inclusive. All NSF ADVANCE proposals are expected to use intersectional approaches in the design of systemic change strategies in recognition that gender, race and ethnicity do not exist in isolation from each other and from other categories of social identity. The solicitation includes four funding tracks: Institutional Transformation (IT), Adaptation, Partnership, and Catalyst, in support of the NSF ADVANCE program goal to broaden the implementation of systemic strategies that promote equity for STEM faculty in academic workplaces and the academic profession. The Institutional Transformation (IT) track is designed to support the development, implementation, and evaluation of innovative systemic change strategies that promote gender equity for STEM faculty within an institution of higher education. The Adaptation track is designed to support the work to adapt, implement, and evaluate evidence-based systemic change strategies that have been shown to promote gender equity for STEM faculty in academic workplaces and the academic profession. Adaptation projects can either: 1) support the adaptation of evidence-based systemic change strategies to promote equity for STEM faculty within an institution of higher education; or 2) facilitate national or regional STEM disciplinary transformation by adapting evidence-based systemic change strategies to non-profit, non-academic organizations. The Partnership track is designed to support the work to facilitate the broader adaptation of gender equity and systemic change strategies. Partnership projects are expected to result in national or regional transformation in STEM academic workplaces and the academic profession and demonstrate significant reach. Partnership projects can focus on the transformation of institutions and organizations and/or the transformation within one or more STEM disciplines. The Catalyst track is designed to broaden the types of IHEs that are able to undertake data collection and institutional self-assessment work to identify systemic gender inequities impacting their STEM faculty so that these can be addressed by the institution. Please note that NSF ADVANCE does not provide fellowships, research, or travel grants to individual students, postdoctoral researchers, or faculty to pursue STEM degrees or research. Undergraduate STEM opportunities can be found at stemundergrads.science.gov and graduate STEM opportunities at stemgradstudents.science.gov. [1]Building the Future Investing in Innovation and Discovery: NSF Strategic Plan 2018-2022. https://www.nsf.gov/pubs/2018/nsf18045/nsf18045.pdf. [2] All the STEM fields supported by NSF are supported by the ADVANCE program including the learning, social, behavioral, and economic sciences. ADVANCE does not support the clinical science fields.

NIBIB - National Institute of Biomedical Imaging and Bioengineering

Project Summary The Digital Health Research and AI Training Program at the University of North Texas (UNT) provides a hands-on summer research experience for high school science teachers in the Dallas-Fort Worth (DFW) region. This initiative immerses educators in digital health, AI-driven healthcare solutions, and wearable health technologies, equipping them with the skills to integrate real-world digital health applications into STEM curricula. Under the guidance of faculty mentors from engineering, health sciences, and education, participating teachers conduct research in active digital health and AI labs, gaining direct exposure to cutting-edge work in embedded systems, biosensors, medical imaging, and AI-powered diagnostics. The program places ten high school teachers in research laboratories, where they engage in structured study design, bio-signal data collection, and machine learning analysis of physiological signals such as ECG, PPG, and motion data. Educators also participate in targeted workshops designed to provide foundational knowledge in AI, digital health research, and embedded systems, ensuring they have the necessary prerequisites to apply these concepts in their teaching. Through hands-on training, teachers develop wearable health devices, implement real-time bio-signal processing, and explore AI-driven digital health applications, culminating in collaborative research studies with university faculty. Using a Community of Practice model, teachers work alongside faculty and peers to develop STEM lesson plans, curriculum maps, and instructional materials aligned with Next Generation Science Standards (NGSS) and Texas Essential Knowledge and Skills (TEKS). This program directly addresses the lack of hands-on AI and digital health research training opportunities for high school educators in the DFW region, bridging the gap between academic research and STEM education. By integrating biosensors, real-time signal processing, and embedded AI concepts into classroom instruction, educators empower students to engage with real-world biomedical challenges and explore careers in digital health, healthcare AI, and digital health technologies. The program includes a comprehensive evaluation plan assessing curriculum improvement, classroom implementation, and student engagement in biomedical AI topics. Teachers participate in pre- and post-program assessments, classroom observation studies, and long-term tracking of student learning outcomes. The initiative also incorporates structured dissemination opportunities, enabling educators to present their research experiences and curriculum materials at regional STEM education conferences, school district professional development workshops, and AI in healthcare summits. This initiative enhances teacher expertise in digital health and AI, expands the STEM workforce pipeline, and fosters student interest in healthcare innovation by providing a sustainable professional development model. Through collaborations with local research institutions, industry partners, and K-12 networks, the program ensures a lasting impact on high school STEM education in the DFW region.

U.S. National Science Foundation

The Advancing Informal STEM Learning (AISL) Program is committed to funding research and practice, with continued focus on investigating a range of informal STEM learning (ISL) experiences and environments that make lifelong learning a reality. This program seeks proposals that center engagement, broadening participation, and belonging, and further the well-being of individuals and communities who have been and continue to be excluded, underserved, or underrepresented in STEM along several dimensions. The current solicitation encourages proposals from institutions and organizations that serve public audiences, and specifically focus on public engagement with and understanding of STEM, including community STEM; public participation in scientific research (PPSR); science communication; intergenerational STEM engagement; and STEM media. Projects funded by AISL should contribute to research and practice that further illuminates informal STEM learning s role in engagement, broadening participation, and belonging in STEM; personal and educational success in STEM; advancing public engagement in scientific discovery; fostering interest in STEM careers; creating and enhancing the theoretical and empirical foundations for effective informal STEM learning; improving community vibrancy; and/or enhancing science communication and the public s engagement in and understanding of STEM and STEM processes. The AISL Program funds five types of projects: (1) Synthesis; (2) Conference; (3) Partnership Development and Planning; (4) Integrating Research and Practice; and (5) Research in Support of Wide-reaching Public Engagement with STEM. NOTES: Activities primarily focused on formal educational systems or outcomes are outside the scope of work supported by this program. AISL does not fund formal elementary, middle, or high school, or undergraduate or graduate education, whether in-person or online. Similarly, AISL does not fund formal workforce training (e.g., professional certifications and degree-earning programs) that is not aimed directly at informal STEM learning professionals. While the language in the Broadening Participation in STEM section draws attention to the diversity of institutions of higher education (IHEs), the AISL program encourages submissions from the full spectrum of diverse talent that society has to offer to include those from Non-profit, Non-academic Organizations, and Tribal Nations as core to the program s Broadening Participation and overall efforts to engage the diverse talent from communities and advance informal STEM education. Non-profit, Non-academic Organizations are directly associated with educational or research activities but do not grant degrees. They include but are not limited to independent museums, observatories, research laboratories, professional societies, and similar organizations located in the U.S. The term Tribal Nation means an American Indian or Alaska Native tribe, band, nation, pueblo, village, or community that the Secretary of the Interior acknowledges as a federally recognized tribe pursuant to the Federally Recognized Indian Tribe List Act of 1994, 25 U.S.C. 5130-5131.

NIA - National Institute on Aging

Project Summary/Abstract The world's population is aging rapidly, and by 2050, the population over 60 years will exceed 2 billion people or 25% of the total global population. Tissue repair is critical for the survival of all organisms. Aging causes a gradual decline in tissue integrity, partly due to a decline in stem cell function, a major hallmark of aging. Due to its accessibility and temporal predictability, cutaneous wound healing provides a valuable model framework to characterize the effects of aging on tissue injury1. Aging disrupts the precisely coordinated immune cell response that orchestrates the three phases of cutaneous wound healing. However, it is unknown whether this disruption is initiated by the aging of the tissue itself or the aging of the immune system. Recently, a breakthrough study showed that the aging immune system or “immunosenescence” precedes and drives organ aging2. Thus, an inference from this concept is that the mechanism by which aging impairs wound healing is largely dependent on how aging impairs the immune system. Our long-term goal is to identify how aging impairs immune cell function and show that we can restore youthful wound healing by reversing immune aging. Hematopoietic stem cells (HSCs) are remarkable cells in our bone marrow that make at least one trillion new blood cells daily. We have shown that HSCs produce all of our circulating immune cells and regulate their gene expression by “epigenetic reprogramming”. We will use sophisticated “single-cell epigenomics,” some of which were developed in our laboratories, to characterize how aging affects the gene expression of individual immune cells and how that expression is regulated by epigenetic modifications. We have three Aims: Aim 1: Determine if aging impairs wound healing by an HSC-Autonomous mechanism. Aim 2: Identify the aging-specific- HSC oxidant stress that drives immune aging and impairs wound healing. Aim 3: Identify the master epigenetic enzyme(s) in aged HSCs that epigenetically reprogram the gene expression of wound macrophages and their cross-talk with fibroblasts and keratinocytes. Once we identify the “master epigenetic enzyme” affected by aging in HSCs that reprograms the gene expression of immune cells, we will reverse the effects of aging on the master epigenetic enzyme to restore youthful wound healing. The fact that the effects are “epigenetic” implies that the effects of aging, at least on the immune system, are reversible and, by proof of principle, would open the door to new molecular therapies to reverse the effects of aging.

U.S. Mission to Indonesia

Executive Summary The U.S. Department of State s Embassy Jakarta announces an open competition to implement the AI Pathways to the Future program, a comprehensive initiative designed to strengthen U.S.-Indonesia partnerships in artificial intelligence education, research, and innovation. Promoting AI innovation and security is a top priority of the United States government, including in its foreign policy. By deepening U.S. - Indonesia bilateral educational cooperation in the field of AI, Indonesia s future AI innovators will build critical relationships with American technology, standards, and thought, thus strengthening pathways to long term collaborations and AI-ready workforces to boost unparalleled economic growth. The program consists of two interconnected components: Component 1: AI Pathways Workshop (Fall 2026) A multi-day workshop bringing together representatives from 2-3 U.S. higher education institutions (HEIs) with AI research hubs, 3-4 Indonesian universities exploring AI research partnerships, 1-2 U.S. technology companies, and AI-focused alumni of U.S. government exchange programs and U.S. universities. The workshop will engage Indonesian college students and faculty in discussions about AI innovation career pathways, and institutional development. Component 2: Five-Month AI Innovation Mentorship Challenge Following the workshop, U.S. professors will launch mentoring relationships with Indonesian professors and high-performing students who will compete to build AI-powered solutions addressing pressing Jakarta infrastructure challenges such as waste management, flooding, traffic congestion, or urban planning. The challenge culminates in project presentations to an expert panel, with the winning solution receiving a certificate and being promoted through social media and press engagement. Target Audiences: - Indonesian university students interested in AI and technology careers - Indonesian university faculty and administrators developing AI programs - Indonesian education and AI policymakers - STEM-focused high school students - Alumni of U.S. Government exchange programs with AI expertise Expected Outcomes: - Strengthened partnerships between U.S. and Indonesian higher education institutions in AI research. - Increased Indonesian student interest in U.S. graduate programs in AI and related fields. - Development of practical AI solutions to Indonesian infrastructure challenges. - Enhanced understanding of U.S. opportunities in AI higher education and employment. - Exploration of scholarship opportunities and potential Jakarta-based innovation hub development. - EducationUSA advisers will participate throughout the program, providing information on pathways to U.S. study for students interested in graduate programs, conducting workshops, and offering one-to-one advising for program participants.

NIAID - National Institute of Allergy and Infectious Diseases

ABSTRACT The mucus layer of the digestive system plays a key role in innate immunity, protecting intestinal epithelium from commensal bacteria, pathogens, and toxins. Goblet cells (GCs), secretory cells residing in the intestinal epithelium, are essential for mucin secretion to form this protective mucus layer and maintain its integrity. Ulcerative colitis (UC) is strongly correlated with a compromised colonic mucus layer and a decrease in the number and function of GCs, eventually resulting in inflammatory flare-ups. Unfortunately, current UC treatments display only limited eƯicacy and high recurrence rates, and mostly target the inflammatory process, without inducing mucosal regeneration. In this proposal, we aim to leverage the powerful regenerative potential of the patient’s own cells by activating colon-resident intestinal stem cells (ISCs) to diƯerentiate into GCs. We hypothesize this will augment mucus secretion and rebuild the broken mucosal barrier, eventually preventing pathogen invasion and the consequent inflammatory cascade. Accordingly, the first aim of our study will include artificial intelligence (AI)-guided identification of small molecules that boost GC diƯerentiation. We plan to build on our expertise in ISC diƯerentiation, combined with leveraging existing large biological datasets, including multi-omics datasets and chemical libraries to identify compounds that stimulate GC diƯerentiation. Our second aim is evaluation of AI-identified compounds in UC murine colon organoids (colonoids), and in colonoids derived from UC patients’ biopsies for identification of the most potent GC inducers in this clinically relevant in-vitro model. Our third aim will be dedicated to assessing the therapeutic impact of the top GC boosting molecules in an acute UC murine model. Our proposed strategy to harness the innate stemness of colonic ISCs is envisioned to result in renewal of the colonic GC pool, enhancement of GC-induced mucus secretion and restoration of the mucus barrier function and its key role in innate immunity. We believe the potent stem-cell boosting molecules identified in this study may eventually be developed into a novel treatment modality to replenish the mucus layer and significantly ameliorate inflammatory flares and related symptoms in UC patients.

Akamai Foundation

Supports STEM education and environmental sustainability through technology partnerships.

U.S. National Science Foundation

The Alliances for Graduate Education and the Professoriate (AGEP) program aims to develop the human capital and administrative and academic infrastructure that will enable the placement of underrepresented minorities (URMs; African-Americans, Alaska Natives, Native Americans, Hispanic Americans, and Native Pacific Islanders) in faculty positions at American universities, colleges and community colleges. Please note that AGEP welcomes participation by URM students with disabilities. From its inception in 1998 as the Minority Graduate Education (MGE) program, it has grown from 8 participating universities to 108 institutions, including about 80% of the top producers of African American and Hispanic PhDs. AGEP institutions have been successful at increasing the numbers of URMs enrolled in and graduated from their STEM graduate programs. The educational research portfolio contributes to the body of literature of successful practices in student recruitment, retention, persistence, and attainment of STEM undergraduate and graduate degrees, especially for populations underrepresented in STEM disciplines: African-Americans, Alaskan Natives, Native Americans, Hispanic Americans, and Native Pacific Islanders. AGEP welcomes the participation of URM persons with disabilities.AGEP alliances further the graduate education of underrepresented STEM students through the doctorate level, preparing them for fulfilling opportunities and productive careers as STEM faculty and research professionals. AGEP also supports the transformation of institutional culture to attract and retain STEM doctoral students into the professorate.

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

ABSTRACT The multinucleated syncytiotrophoblast (STB) is a tissue-sized single cell that separates the maternal and fetal vasculature during pregnancy. The STB wraps around the villous trees of the placenta lobules, encasing them in a cell with billions of nuclei in a common cytoplasm. This giant single cell facilitates the exchange of nutrients, is essential for fetal immunoprotection, is the primary producer of pregnancy hormones, and performs critical metabolic roles. Further, the STB must simultaneously respond to gradients in oxygen, nutrients, maternal hormones, and pathogens that fluctuate in space and time. How does a single cell support these diverse homeostatic tasks and simultaneously respond to local stresses? We hypothesize that the multinucleate organization is fundamental to supporting the many demands of production, metabolism, and stress response required of a single STB cell. Recent work and our preliminary data show that individual nuclei within the STB indeed have distinct transcriptional programs despite all sharing the same cell cytoplasm. This indicates that STB nuclei are heterogeneous in activity and function. Notably, GO terms for each of the STB nuclear clusters show mutually exclusive expression of homeostatic STB functions or stress response genes. Therefore, nuclear individuality could both facilitate the myriad of STB functions and the insulation of the stress response by spatially clustering in different regions depending on local functions or conditions. Major gaps in knowledge include how different nuclear identities are spatially patterned in the tissue, how nuclear identities arise mechanistically, and the functional consequences of nuclear heterogeneity within the STB cell. Spatial organization of the STB is disrupted in multiple forms of preeclampsia, a pregnancy disease that stems from improper placentation in the first trimester or maternal inflammation. We predict that the systemic stress seen in preeclampsia perturbs the functional balance and spatial organization of homeostatic and stress response pathways in STB nuclei. The proposed experiments will analyze heterogeneous gene expression in healthy and preeclamptic placentas with the following aims: Aim 1: Dissect the spatial patterns of RNA expression and localization in the STB cell and Aim 2: Identify the function and mechanism of heterogeneous nuclear gene expression in the STB. We will apply state-of-the-art spatial transcriptomics on placentas from healthy and preeclamptic pregnancies to analyze gene expression patterning in different locations of the STB. Using super-resolution, live-cell imaging, and genetic manipulations of placenta organoids, we will determine the mechanisms generating specialized nuclear transcription and the functional consequences of heterogeneous nuclear gene expression. This work will establish a functional atlas of STB nuclear identity patterning in health and preeclampsia and act as a guide to discover molecular drivers of pregnancy disease.

U.S. Mission to Italy

The U.S. Mission to the Republic of Italy s Public Affairs Section (PAS) is pleased to announce that funding is available through its Public Diplomacy Grants Program. This is an Annual Program Statement outlining funding priorities, strategic themes, and the procedures for submitting requests for funding. PA Italy invites proposals for programs that strengthen cultural ties between the United States and Italy through cultural and exchange programming that highlight shared values and promote bilateral cooperation. All programs must include a significant American cultural element, connection with American expert(s), organization(s), OR institution(s) in a specific field that will promote increased understanding of U.S. policy and perspectives. Priority Program Areas: American and Italian voices countering malign influencers and misinformation campaigns Promoting strong transatlantic relations; Creativity and innovation in education and the arts, and problem solving of issues of mutual interest to both countries; American Studies, particularly American History and Literature, to include university linkages; Promoting diversity and inclusion; Empowerment and prosperity through STEM education and entrepreneurship; American English Language Study; Media Literacy.

U.S. Mission to Chile

Funding Opportunity Description The Public Affairs Section of the Embassy of the United States (U.S. Embassy) in Chile is pleased to announce the availability of funding for public diplomacy programs with Chile. This initiative was developed to support projects proposed by U.S. and Chilean cultural, educational, and other non-profit organizations and/or individuals that fulfill U.S. Embassy goals and objectives: to promote greater understanding of the United States and to foster academic, cultural, and other people-to-people exchanges between the United States and Chile. The Public Affairs Section is particularly interested in projects that support increasing academic and cultural exchanges between the United States and Chile, increasing social inclusion, fostering entrepreneurship and innovation, expanding English language proficiency, cooperating in science and technology, and advancing excellence in journalism. We are looking for proposals with outstanding cultural, educational, and exchange merit that involve geographically, demographically, and socio-economically diverse audiences in Chile. In deciding which projects to support, the Public Affairs Section will give consideration to the full range and diversity of U.S. and Chilean non-profit organizations. Government agencies and for-profit institutions, such as those registered as commercial and/or private businesses are not eligible to receive funding. Preference will be given to U.S. and Chilean individuals and institutions with a proven track record of executing superior cultural and educational events and programs. Preference will be given to proposals that demonstrate the long-term sustainability of the project and in-kind and/or in-cash financial commitments from other funding sources. Priority areas for project funding are: Expanding English language proficiency (priority: reaching public schools, higher education students, and young professionals with an emphasis on improving conversational English and STEM fields); Increased social inclusion (priority: equal rights and opportunities for immigrants, LGBTI individuals, people with disabilities, indigenous communities, and racial minorities, as well as civic education); Fostering entrepreneurship and innovation (priority: projects that multiply the number of women and minority small business owners, including social impact investment and philanthropy); U.S.- Chile cooperation in science and technology (priority: renewable energy, women in STEM and regional initiatives); Increasing cultural exchanges between the United States and Chile (priority: reaching underserved audiences outside of Santiago); Increasing academic exchanges between the United States and Chile (priority: higher education students and the 100,000 Strong in the Americas initiative); Advancing excellence in journalism (priority: investigative journalism). Typical activities include: Speaking tours/public talks by U.S. experts or roundtable discussions by U.S. experts with counterparts in Chile; Activities that foster long-term student and academic collaboration between U.S. and Chilean universities, technical schools and community colleges; Joint U.S.-Chile conferences or meetings that produce concrete advances or other results; Projects that showcase a U.S. model or curriculum; Projects that include innovative uses of social media or virtual interaction to expand and amplify the impact; English language focused activities such as conversation clubs, coding camps, academic writing programs and English for specific purposes. Creative projects that advance one or more of the priority areas. Activities that are not typically funded include, but are not limited to: Social welfare projects, acts of charity, or international development projects; Investments that primarily benefit only one or a few businesses or individuals; Scholarships for the study of English outside of specific Department of State programs; Scientific research that does not include exchange of U.S. and Chilean researchers or students; Projects that are inherently political in nature or that contain the appearance of partisanship/support to individual or single party electoral campaigns; Exchange programs with countries other than the U.S. and Chile; Programs or exchanges focused on children under 16 years of age; Political party activities; and, Projects that support specific religious activities.

U.S. Mission to Tajikistan

Purpose of Public Diplomacy Grants: PDS Embassy Dushanbe invites proposals for programs that strengthen ties between the United States and Tajikistan in priority program areas (see below) in order to highlight shared values and promote bilateral cooperation. All proposed programs must include an American element, either through a connection with American expert/s, organization/s, or institutions/s, usage of American educational/informational resources, or any other activities that promote or contribute to increased mutual understanding between the people of the United States and people of Tajikistan. Competitive proposals will promote continued and sustainable cooperation between the people of the United States and Tajikistan even after the project concludes. Competitive proposals will include partnership with Tajik governmental bodies, and to organizations that have a demonstrated track record of implementing such programs. Examples of programs could include, but are not limited to: Academic or professional exchanges, lectures, seminars, trainings, speaker programs, or workshops; and Artistic, cultural, or sports workshops, masterclasses, joint performances, and/or exhibitions. PDS welcomes proposals that support one of the following priority program areas: TOPIC 1: Counter Gender-based Violence (GBV) Domestic violence (DV) and gender-based violence (GBV) remains a serious issue in Tajikistan and much of the world. In a USAID-funded survey in Tajikistan, 97% of men and 60% of women believed spousal abuse was justified. Cases of GBV and DV are underreported because victims wish to avoid humiliation, reprisal, or social stigmatization, or believe it may have been warranted. Further, authorities wishing to promote traditional gender roles frequently dismiss domestic violence as a family matter or only gave a warning or fine. Government resources for survivors are also limited. Project Audience(s) may include: Religiously or socially conservative communities, especially Tajik men (18-50 years old) High school students (14-18 years old.) Youth and emerging leaders (18-35 years old.) University teachers and students. Labor migrants and spouses of labor migrants. Tajik advocacy groups. Government bodies. Independent media including bloggers and vloggers Countering Gender-Based Violence Project Goal: Empower civil society and communities in Tajikistan to prevent and prosecute cases of Domestic Violence (DV) or Gender-Based Violence (GBV) through community-led initiatives. Project Objectives (may address one or more of the following): Messaging campaigns or awareness raising activities, such as sports diplomacy, should engage and target both men and women. Having men as the face of campaigns, or having men speak to men standing against GBV, demonstrates solidarity and emphasizes that eradicating gender-based violence is the collective responsibility of everyone, regardless of gender. Improve collaboration between civil society, independent media, and the government to identify and address gaps in existing laws and policies that criminalize GBV/DV, provide protections for victims, and establish legal frameworks for persecution. Raise awareness among vulnerable populations about laws, rights, and support services concerning early marriage, domestic abuse, harassment, divorce, alimony, and other civil rights. TOPIC 2: Promoting Women s Economic Empowerment and Entrepreneurship Due to the high rate of male labor migration and unemployment, more Tajik women are exploring ways to financially support their households and communities. However, women entrepreneurs' activities are highly dependent on the effectiveness of the business environment in the country. Moreover, the mountainous regions throughout the country challenge the development of entrepreneurship, as does lack of information, limited access to financing for starting a business, and other socio-economic conditions. Nevertheless, successful small business development creates new employment opportunities in Tajikistan and helps women support themselves and their families. Small businesses are fast becoming the main source of income for women in Tajikistan. Proposed projects should enhance women s participation, promotion, and longevity in the Tajik economy and ability to assume leadership positions. Projects should clearly support the protection of economic rights for women and increase respect for women s rights in society to improve their independence and proactive role in Tajik society. Project Audience(s) may include: Women from rural areas (including the spouses of labor migrants) and women entrepreneurs. Small businesses in rural areas. Business associations. Financial and government institutions. Tourism agencies (including guesthouse and small hotels). Community leaders and youth demonstrating leadership potential in these areas. Women s Economic Empowerment Project Goal: Increase the capacity of women from underserved, rural communities, including the spouses of labor migrants, to participate or increase their participation in the Tajik economy. Improve women's economic opportunities in Tajikistan by increasing the capacity of women to start, establish, or expand their own companies. Project Objectives (may address one or more of the following): Develop the business and technical skills of women in rural communities to increase employability, launch and/or improve their own businesses. Establish and conduct activities with a professional network for women from under-represented communities, including the spouses of labor migrants, to support mentorship relationships and collaborative initiatives among network members that go beyond the conclusion of project activities. o Projects could connect women s entrepreneurship in the development of tourism around newly recognized UNESCO heritage sites. o Increase awareness of tourism initiatives and employment opportunities centered around newly designated UNESCO heritage sites. o Projects could seek to increase participation of women from underserved and target communities in the fields of Science, Technology, Engineering, and Mathematics (STEM). Increase women s knowledge and understanding about their legal rights in society and how to advocate for the respect of those rights. o Increase women s knowledge and understanding about their legal rights in the workplace, including rights related to employment, equal pay, job security, and access to economic opportunities. o Equip Tajik women with the ability to advocate for the recognition and enforcement of these rights. Promote women s economic empowerment and entrepreneurship through support from start-up hubs, corporate social responsibility, and/or access to finance. Emphasis should be placed on strengthening chambers of commerce, entrepreneurs, and core private sector industries through interactions or linkages with U.S. counterparts. o Facilitate access to funding resources and financing opportunities for women entrepreneurs to launch and grow their businesses. o Strengthen organizational capacities of chambers of commerce to support business development of aspiring female entrepreneurs. o Facilitate interactions and linkages between women entrepreneurs, chambers of commerce, startup hubs, and private sector industries in Tajikistan and their U.S. counterparts. TOPIC 3: Sharing America with Tajikistan The United States values innovation, creativity, critical thinking, freedom of expression, democratic principles, economic growth, and security. The United States supports a sovereign and independent Tajikistan, which includes support for a well-informed, discerning public who can inoculate itself against disinformation. Both the United States and Tajikistan have rich cultural traditions as shown in literature and storytelling, theater and performing arts, film, music, dance, sport, and education. Educational, cultural, and other exchange activities are a great way to engage the public, especially at-risk youth and those with neutral views or misconceptions about the United States, in order to bridge our cultures, deepen understanding, and discuss topics of mutual importance. Proposed projects should strengthen understanding between the United States and Tajikistan and advance areas of mutual interest by leveraging the experiences and lessons learned from the United States, while respecting cultural differences. Project Audience(s) may include: Tajik audiences who have not had exposure to the United States before. Youth 16-35. Academia, professors, and teachers. Civil society, non-government organizations, and associations/organizations promoting shared values or areas of mutual interest. Information professionals (media outlets, managers, editors, journalists, influencers). Religious and community leaders. Entrepreneurs and business community advocacy organizations. National and subnational government officials. Project Goal: To share American values, such as freedom of expression, respect for human rights, and celebrate/promote respect for diversity and social inclusion, while also improving access to objective information and increase media literacy and critical thinking skills to analyze mis and disinformation aimed at the United States. Project Objectives (may address one or more of the following): Raise awareness about shared U.S.-Tajik values and partnerships through trainings, workshops, masterclasses, joint performances, or other projects by U.S. and/or Tajik experts. Increase access to American content by Tajik audiences (such as book translations) that promote U.S. democratic and rights-based values. Increase collaboration between local, state, and civil society actors/stakeholders on well-defined social issues affecting both the United States and Tajikistan by sharing U.S. models of government-community engagement, or by working with U.S. experts/peers. Increase the effectiveness of individuals, organizations, and coalitions working to advance and/or advocate for respect and the promotion of human rights. Strengthen the ability of Tajik media professionals to develop accurate and fact-based informational media campaigns through digital skills building and training initiatives based on U.S.-best practices. Increase production and publication of objective, fact-based and editorially diverse media content by Tajik media professionals. Increase critical thinking skills, especially for youth and publics with a neutral or view or misconceptions about the United States, to identify and critically analyze sources of misinformation and disinformation. In addition to the specific requirements listed above by program area, all proposals must: 1. Clearly indicate the primary activity area to which it is being submitted for consideration. 2. Focus on the key public diplomacy audiences and activities specified in the areas, provide programs for underserved geographic regions of Tajikistan, as well as non-elite schools (if applicable); 3. Clearly delineate how elements of their program will have a multiplier effect and be sustainable beyond the life of the grant; 4. Provide a traditional and/or social media plan for marketing program activities and outcome, if applicable 5. Identify the cities/districts in which activities will take place. 6. Identify specific outcomes to be achieved by the end of the grant period. 7. Identify any tools (surveys, beneficiary interviews, focus groups, etc.) that will be developed for Monitoring and Evaluation purposes. Applicants must also demonstrate competency to manage all financial aspects of the project, including participant costs and transparent arrangements of sub-grant relationships with partner organizations, if applicable.

U.S. National Science Foundation

The National Science Foundation (NSF) invites investigators at U.S. organizations to submit proposals for Doctoral Dissertation Research Improvement Grants (DDRIGs) to the Arctic Sciences Section, Office of Polar Programs (OPP) to conduct dissertation-level research about and related to the Arctic region. The Programs that are currently accepting DDRIG proposals are the Arctic Social Sciences (ASSP), Arctic System Science (ARCSS), and Arctic Observing Network (AON) Programs. The goal of this solicitation is to attract research proposals that advance a fundamental, process, and systems-level understanding of the Arctic's rapidly changing natural environment and social and cultural systems, and, where appropriate, to improve our capacity to project future change. The Arctic Sciences Section supports research focused on the Arctic region and its connectivity with lower latitudes. The scientific scope is aligned with, but not limited to, research challenges outlined in the Interagency Arctic Research Policy Committee s five-year Arctic research plan (https://www.nsf.gov/geo/opp/arctic/iarpc/start.jsp). Given that this solicitation is designed to support early career scientists, this Program will also advance research capacity in Arctic sciences, promote workforce development in Science, Technology, Engineering, and Math (STEM). The Arctic Sciences Section coordinates with programs across NSF and with other federal and international partners to co-review and co-fund Arctic proposals as appropriate. The Arctic Sciences Section also maintains Arctic logistical infrastructure and field support capabilities that are available to enable research.

Arizona SciTech / Arizona Department of Education

STEM education initiative grants for AZ to expand science, technology, engineering, and mathematics programs in K-12 and postsecondary institutions.

Fort Worth Symphony Orchestra

To support a series of summer community concerts, to be presented in multiple venues and in connection with STEM-based partnership programs.

ASME Foundation

Supports mechanical engineering education, STEM programs, and innovation through grants and fellowships.

NIA - National Institute on Aging

ABSTRACT The ASPIRE: Alzheimer’s Summer Program Inspiring Research Engagement (T35 mechanism) at the Krieger Klein Alzheimer’s Research Center at Rutgers is designed to inspire and prepare medical students to pursue careers in bridging ADRD research and clinical care. This summer program offers 10-week, full-time immersive research experiences to 10 medical students per summer, under the mentorship of 10 accomplished scientists. These mentors, with active NIH funding portfolios and proven mentoring success, ensure trainees receive high-quality guidance and sufficient resources. The program will establish internal and external advisory committees to ensure optimal learning goals for the students in ADRD research. Participants will engage in research projects spanning epidemiological observational studies, lifestyle and medication clinical trials, data analyses of "big data" (including “omics” and medical chart data), digital health innovations, and basic science (animal, cellular/molecular, neural stem cell and human postmortem tissue systems studies). This hands-on experience will be complemented by exposure to data science and biostatistics through dedicated meetings with a program biostatistician, equipping students with basic yet practical analytical skills essential for addressing complex challenges in ADRD research. The program emphasizes the responsible conduct of research, including practices that enhance rigor and transparency in human subjects and animals research. Students will also participate in the ADRD Translational Work in Progress series, engaging in open discussions and critiques of scientific materials such as grant aims and hypothesis development. This interactive environment motivates critical thinking, collaboration, and scientific communication skills. Internal and External Advisory Committees, each including world-class researchers in neurodegeneration and ADRD, will meet annually to monitor program progress and provide recommendations for improvement. This oversight ensures alignment with the highest standards of mentorship while maximizing each student’s research experience. The program culminates in a symposium where trainees present their research findings, further refining their scientific communication skills. By exposing medical students to ADRD research early in their clinician careers, the program addresses the critical need for developing future physician-scientists dedicated to ADRD, a condition that disproportionately affects older adults, the fastest-growing segment of the U.S. population. The program aims to cultivate future leaders who will advance innovative research, ultimately promoting state-of-the-art, compassionate care for ADRD patients and improving health outcomes for the rapidly growing geriatric population.

NCATS - National Center for Advancing Translational Sciences

PROJECT SUMMARY/ABSTRACT Vici syndrome (VS) is a rare pediatric genetic disorder characterized by profound developmental delay, seizures, immunodeficiency, cardiomyopathy, and progressive motor decline, with a median survival of just 42 months, This devastating disorder is caused by pathogenic variants in the EPG5 gene, which encodes a critical regulator in autophagy. Loss of EPG5 function results in the accumulation of toxic intracellular material and progressive cellular dysfunction. VS is a member of a broader class of diseases known as 'Congenital Disorders of Autophagy' (CDAs), in which core components of autophagy are defective. There are essentially no treatment options for children with VS or other CDAs. We hypothesize that agents that induce pharmacological enhancement of autophagy in VS and other CDAs represent a viable therapeutic strategy. In collaboration with VS families, we have developed and characterized critical preclinical models for VS for therapeutic discovery and validation, including patient-derived induced pluripotent stem (iPS) cells and novel genetically engineered mouse models. These Epg5 mutant mice recapitulate a range of neurological phenotypes seen in VS including biochemical deficits in autophagy, progressive motor dysfunction, and a strong molecular and cellular signature indicative of neuroinflammation. In parallel, we have established a novel engineered iPS cell-based platform for high throughput cell-based screens, which has identified rapamycin-related class of compounds (rapalogs) as enhancers of autophagy in the VS cells. This project will evaluate the therapeutic potential of the rapalog everolimus, an FDA-approved drug with over 14 years of safety data, including well-described use in pediatric populations, leveraging the VS mouse models for in vivo preclinical proof-of-principle studies. In Aim 1, we will define the pharmacokinetics (PK) and pharmacodynamics (PD) of everolimus in the VS mouse model, optimizing dosing regimens to sustain autophagy induction in vivo after extended use. In Aim 2, we will assess the ability of everolimus to slow or halt disease progression in vivo using the VS mouse model. Neurological function and inflammatory response in the VS animal model will be monitored during longitudinal treatment with everolimus. Phenotypic monitoring will include whole animal behavioral assays of motor function and molecular and histological biomarkers of neuroinflammation in various CNS tissues. Successful completion of this project will provide critical preclinical data supporting the repurposing of everolimus for clinical proof of concept in VS patients. Our multidisciplinary team, combining expertise in drug discovery, preclinical disease modeling and analysis in mice, clinical treatment of VS patients, and rare disease research, is well-positioned to advance this therapeutic strategy toward clinical translation in partnership with highly engaged VS families.

AT&T Foundation

Funds digital literacy and STEM education programs for underserved communities.