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Economic Development Administration

Pursuant to the Supplemental Appropriations Act, Pub. L. No. 111-212, 124 Stat. 2302 (2010), EDA announces general policies and application procedures for the FY 2010 Gulf Oil Spill Supplemental Federal Funding Opportunity. This investment assistance will be made available to help devise and implement short or long-term economic redevelopment strategies and for technical assistance activities to address economic development challenges in regions impacted by the discharge of oil stemming from the April 20, 2010, BP Deepwater Horizon drilling rig explosion. The Economic Adjustment Assistance program can offer a wide range of technical, planning, or infrastructure assistance. See 13 C.F.R. 307.3. This program is designed to respond adaptively to pressing economic recovery issues, and is well suited to help address the challenges faced by regions affected by the April 2010 oil spill. Note however, in order to maximize available funding, EDA will consider applications for planning or technical assistance only. That is, no awards will be made under this competitive solicitation for infrastructure improvements or revolving loan fund grants. For purposes of this competition and subject to the availability of funds, EDA will make planning or technical assistance awards that, for example, demonstrate the capacity to support economic recovery by fostering the development of short or long-term economic recovery plans; conduct gap analysis that can identify opportunities for strengthening regional competitiveness; examine opportunities for expanding commercialization programs; or strengthen regional efforts to encourage business expansion and creation efforts. In addition, EDA invites applications to address problems on a larger regional, or multi-State basis, both with respect to the development of a macro-economic analysis of the Gulf Coast region, or the development of a business retention and expansion program for the Gulf region. EDA will administer the Gulf Oil Spill Assistance among its Atlanta and Austin regional offices, which together cover the areas that have felt the greatest impact of the oil spill, specifically the States of Louisiana, Mississippi, Alabama, Florida, and Texas. Please see the FFO, linked below, for more information.

NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases

PROJECT SUMMARY Type 1 diabetes (T1D) results from autoimmune destruction of pancreatic beta cells, causing insulin deficiency and elevated blood glucose levels. Strategies that replace lost beta cells could restore autonomous glucose control in T1D and are in high demand. Patients with type 2 diabetes (T2D) also experience major beta cell loss due to beta cell exhaustion, glucotoxicity and lipotoxicity. Still, there are currently no therapeutic approaches to replace beta cells for people with diabetes. Our long-term goal is to identify durable targets to expand beta cell mass to treat diabetes. The rationale for this project stems from transcriptomic analysis of mouse pancreatic islets during profound beta cell mass expansion that revealed upregulated genes highly enriched with binding sites for the transcription factor GA-binding protein (GABP). Previous studies in other cell types demonstrated GABP is required for mitochondrial biogenesis, oxidative phosphorylation, and cell division1-6. These cellular functions are essential to generate ATP and synthesize key molecular building blocks to support cell division7. Nutrient3 and mitogenic8 signals also converge on GABP, providing further evidence that GABP is a rate limiting transcription factor that responds to increased metabolic demand to ensure cellular energy homeostasis and promote cell division. However, the role of GABP in beta cells is unknown. The goal of this proposal is to define the role of GABP in pancreatic beta cells. To understand the role of GABP in beta cells, we targeted the DNA- binding subunit of GABP (GABPa) to generate beta cell specific Gabpa knockout mice (Ins1-Cre;Gabpa-fl/fl; Gabpabeta-KO) and littermate controls. Unexpectedly, Gabpabeta-KO mice developed polyuria and hyperglycemia, corresponding with reduced serum insulin levels, within the first 2-3 months of life. Pancreatic tissue analysis revealed a dramatic loss of beta cells in Gabpabeta-KO mice at 6 weeks of age compared to controls, likely underlying reduced serum insulin and hyperglycemia. Interestingly, at 3 weeks of age, beta cells were abundant, suggesting a sudden increase in beta cell death soon after weaning. These findings indicate that GABP may play a key role in beta cell survival and turnover in early life. Several studies suggest that beta cell death in diabetes is driven by mitochondrial oxidative stress and dysfunction through cytochrome c release and initiation of caspase-induced apoptosis9-11. GABP is required for mitochondrial function and bioenergetic homeostasis, suggesting that loss of GABP impairs mitochondrial function leading to beta cell death. My central hypothesis is that GABP regulates mitochondrial metabolism to maintain beta cell homeostasis and survival. This hypothesis will be tested using three specific aims: 1) Define the role of GABP in mouse beta cells; 2) Define the role of GABP in human beta cells; 3) Determine the molecular mechanisms of GABP to regulate beta cell mitochondria function. The proposed research is significant, as it will uncover a novel transcriptional mechanism involving GABP regulation of beta cell mitochondrial function integral to cellular energy homeostasis and survival. These findings will direct new therapies to preserve and expand beta cell mass for people with diabetes.

NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases

Project Summary/Abstract: This application requests travel support for early-career investigators, graduate students, and postdoctoral fellows to attend the FASEB Scientific Research Conference “GI Tract XXII: Molecular and Cellular Advances Towards Discovery and Treatment,” to be held August 30–September 3, 2026, in Snowbird, Utah. The meeting is designed to prepare the next generation of researchers focused on GI health and disease and developing new treatments. The organizers include investigators funded by NIDDK that share a commitment to advancing innovative science that improves digestive health. The FASEB GI conference series has been held biennially since 1985, supporting idea exchange, collaboration, and mentoring within the GI research community. The field has advanced rapidly with breakthroughs in multi-omics, organoid systems, single-cell and spatial transcriptomics, stem cell biology, and new therapeutics, and leaders in these areas will serve as keynote and session speakers. A core goal of the meeting is to intentionally include early-career researchers, providing them with oral and poster presentation opportunities, structured career development and networking sessions, and workshops designed to enhance rigor and reproducibility across NIDDK-funded studies. To ensure broad participation, we seek funding to offset travel costs for trainees and early-career investigators. While virtual platforms have expanded opportunities for cross-institutional collaboration, in-person scientific conferences remain essential for initiating new collaborations, fostering mentorship, and strengthening community bonds within the GI research field. As organizers representing both MD and PhD scientists, we are committed to fostering interdisciplinary collaboration and supporting the next generation of digestive disease researchers.

NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases

PROJECT SUMMARY Despite the advances that have been made in the management type 1 diabetes (T1D), exogenous insulin administration with regular monitoring remains the primary treatment for T1D. Imprecise glucose control, which is commonplace, can lead to serious or even fatal complications. Consequently, the social and economic burden of T1D is substantial. Human pluripotent stem cell-derived (hSC) islet therapy has the potential to reduce these costs by providing a one-time, curative treatment that eliminates the need for continuous disease management. In response to NOSI NOT-AI-24-085, which calls for the development of somatic cell gene editing (SCGE) technologies to improve transplantation outcomes, we propose a multidisciplinary strategy to endow stem cell- derived islets (SC-islets) with graft context-based immune evasion, guided by real-time in vivo environment sensing and stimulus-responsive genetic rewiring. Our approach leverages prime editing, integrase-mediated DNA insertion, and machine learning-designed cis-regulatory elements (CREs) to reprogram endogenous loci to achieve these goals. We have assembled a multidisciplinary team, including leaders in T1D biology and stem cell models, genome engineering technologies, and computational genomics. In Aim 1, we will engineer molecular reporters in hiPSC lines to enable real-time, non-invasive monitoring of SC-islet graft inflammation, viability, and functional mass. We will leverage twin prime editing and optimized Bxb1 integrase technology to site-specifically integrate reporters quantifying β cell biomass, stress, apoptosis, and inflammation. We will validate these tools in vitro, and in vivo in humanized NSG MHC-DKO mice in the context of allorejection to establish a framework for high-resolution, longitudinal graft assessment in the context of inflammation and alloimmune attack. In Aim 2, we will rewire regulator elements within the endogenous CD47 locus to enable constitutive immunocloaking in SC-islets. We will design islet-specific synthetic enhancers using computational deep learning (Ledidi) and prime editing CRE interrogation approaches to achieve high levels of CD47 expression in β cells. These engineered SC-islets will be validated for protection in vitro against NK and T cell cytotoxicity, and in vivo in a PBMC-engrafted NSG MHC-DKO allorejection mouse model. In Aim 3, we will rewire the IL10 locus for inflammation-responsive immunosuppression. We will write cytokine-inducible regulatory elements into the regulatory logic of the endogenous IL10 locus to create inflammation adaptive SC-islets that secrete IL10 only in inflamed microenvironments, avoiding systemic effects. Functional assays will assess response kinetics and dynamic range of IL10 expression in response to inflammatory stimuli in vitro, and immunomodulatory capacity in vivo in alloresponse assays. Upon completion, this project will generate genetically engineered, immune-aware SC-islets with dynamic responsiveness to their environment, addressing a central challenge in β cell replacement therapy. If successful, these principles can be applied to other off-the- shelf cellular products to enhance safety, efficacy, and regulatory control of immunomodulation systems.

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

ABSTRACT Infertility remains a global public health challenge, with early developmental failure accounting for a significant proportion of unsuccessful pregnancies. Among the critical processes governing early developmental competence, RNA splicing plays a central role by coordinating transcriptional output, shaping chromatin architecture, and influencing protein synthesis. Yet the mechanisms by which splicing governs these multilayered regulatory systems during the earliest stages of development remain poorly defined. This research investigates the multilayered consequences of splicing dysfunction in an in vitro model of early human development, focusing on how disruptions in RNA processing alter structural genome organization and the regulation of gene expression. Through integrative transcriptomic, epigenomic, and proteomic profiling of cells in vitro, I aim to define how splicing inhibition alters polymerase activity, chromatin architecture, and gene translation. A key objective is to identify the cascade of molecular events—across nuclear and cytoplasmic compartments—that links shifts in RNA splicing efficiency to cell potential. By examining these mechanisms, this project will reveal how splicing regulation safeguards developmental trajectories. Ultimately, this work will advance fundamental knowledge of gene regulation in early development and illuminate molecular mechanisms underlying infertility. These findings hold long-term promise for improving diagnostic strategies and public health interventions aimed at reducing the burden of reproductive failure.

General Motors Foundation

Supports STEM education, community development, and vehicle safety programs in communities where GM operates.

NHLBI - National Heart Lung and Blood Institute

Abstract Support is requested for a Keystone Symposia conference entitled Genetic Medicines to Treat Cardiovascular Disease, organized by Drs. Rick Dewey, Litsa G. Kranias and James S. Ware, with scientific programming input from Keystone Symposia. The meeting will take place Jan 25–28, 2027 at Keystone Resort in Keystone, Colorado, United States. Genetic medicines are paving the way for groundbreaking treatments in cardiovascular diseases (CVD). With advancements in gene therapy, RNA-based therapies, stem cell research, and gene editing, a growing number of clinical trials are underway. This Keystone Symposia meeting on Genetic Medicines to Treat Cardiovascular Disease will bring together diverse groups of basic scientists, clinicians, and industry professionals to foster meaningful discussions of the exciting opportunities emerging from industry-academia collaborations and partnerships. The sessions will explore cutting-edge advancements in identifying new therapeutic targets, translational research and clinical studies aimed at treating CVD. Topics will include breakthroughs in genetic therapies, as well as challenges related to delivery methods, efficacy, safety and cardiac tissue modeling to better understand disease phenotypes. Additionally, the program will feature panel discussions focused on the steps leading from basic discovery to translation, commercialization, FDA approval, and navigating the venture capital landscape. Other key topics will include long-term and off-target effects of therapies, ethical and regulatory considerations, lessons from preclinical and clinical trials, and professional development challenges for early-career researchers. The sessions will highlight latest scientific discoveries but also will explore their translational impacts and emerging challenges, especially in relation to pre-clinical and clinical trial design and the integration of AI technologies to advance genetic medicines. To achieve this, the conference brings together basic researchers, clinicians and industry partners demonstrating the crucial role that interdisciplinary collaborations play in driving growth in this area. Further, the meeting will be held concurrently with our successful joint Keystone Symposia conferences on Precision Genome Engineering and Nucleic Acid Delivery. By placing these three distinct, but related, meetings at the same venue attendees will have access to a broader cross section of talks and attendees that span the scope of genetic medicine research.

Georgia Department of Education

Georgia's STEM Education grants support K-12 schools and districts implementing science, technology, engineering, and mathematics education initiatives, including robotics programs, computer science, and STEM-focused instructional strategies.

Georgia Department of Education

STEM education initiative grants for GA to expand science, technology, engineering, and mathematics programs in K-12 and postsecondary institutions.

U.S. National Science Foundation

The World is facing all minds needed problems, but due to historical systemic structures, all minds have not been fully engaged. Recent research shows that science scholars who are underrepresented in STEM produce higher rates of scientific novelty, yet they do not persist in the systems where the innovation is created (Hofstra et al. 2020). Because the geosciences continue to lag other STEM fields in creating a diverse community of researchers, scholars, and practitioners, disruptive strategies and evidence-based practices are needed to recruit and specifically retain individuals who historically have not been included in geoscience education, research and careers. The National Science Foundation s (NSF) Directorate for Geosciences (GEO) seeks to support activities that will develop unique approaches or bring to scale current efforts to increase and sustain the inclusion of individuals from diverse backgrounds in the geoscience education and research community. Proposals that will address elements in the following two areas are encouraged: Professional Development. GEO encourages projects that will develop efforts and training that focus on the creation of BAJEDI (Belonging Accessibility Justice Equity Diversity and Inclusion) leaders through scaling of model professional development (PD) programs, identifying barriers that exist within academia and/or the geosciences that prevent the development of diversity champions, and the employment of strategies that will create and sustain cohorts of diversity leaders to maximize collective impact in the geoscience ecosystem. Examples of focus areas for PD centered proposals could include: 1) training in BAJEDI for graduate students and postdocs who will soon be on the job market, 2) creation of curriculum and standards for safe, equitable and inclusive education and research practices, 3) development of guidance that would assist geoscience academic and research units in developing or implementing BAJEDI plans, and 4) identification and fostering of practices related to the valuation of BAJEDI leaders and their activities in institutional promotion systems. Geoscience Capacity Building at Minority Serving Institutions (MSIs). With the recognition that Minority Serving Institutions (MSIs) operate with intentionality and holistic support of students (NASEM 2019), GEO also welcomes proposals that envision new efforts to create educational or degree granting geoscience programs at MSIs or scale existing geoscience programs into graduate programs at MSIs with the following elements in mind: Consideration of the necessary steps to create or scale an educational or degree granting geoscience program through partnerships and collaborations, with an emphasis on collaborative infrastructure as defined under the NSF INCLUDES Program. Development of pilot bridge programs (high school to undergraduate, undergraduate to graduate and graduate to workforce) to grow the pool of potential geoscience program majors at MSIs and prepare them to be geoscience professionals. Identification and reduction of barriers (e.g., grants infrastructure or institutional policies) that may hinder the creation and sustainability of educational and degree granting geoscience programs at MSIs. Creation of a coordinating unit to assist in supporting or building grants management infrastructure at MSIs. When developing proposals, the PI team should acknowledge the need for increased engagement from social and behavioral science experts to address issues related to BAJEDI in the geosciences and include these best practices and experts in proposed projects. Proposals could also focus on the dissemination of information on lessons learned from related activities (e.g., GOLD, NSF INCLUDES National Network, etc.) to the geoscience community, and encourage new opportunities for collaboration in the community and across other NSF Broadening Participation Programs. Review Information Competitive funding requests will explicitly describe and demonstrate their alignment and/or connections to the mission and goals of NSF s GOLD Program. Failure to sufficiently demonstrate relevancy to these Programs will result in the funding request being declined.

National Park Service

This program model encourages preservation of public lands through education and stewardship activities. Girl Scout engagement with educational and volunteer-service activities is important for the immediate and future preservation of public lands. The Girl Scout Ranger Program creates opportunities for Girl Scouts to become natural environmental leaders by applying their learning to national parks. This partnership between NPS and GSUSA is a vehicle that will create a pathway for Girl Scouts to experience public land management through field-based learning and exposure to Science, Technology, Engineering, and Math (STEM) careers related to natural resource management, thereby helping to create a land ethic and cultivating environmental stewardship.

NASA Langley Research Center

The National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC) is releasing a Cooperative Agreement Notice (CAN) soliciting proposals for "Global Climate Change Education (GCCE): Research Experiences, Modeling and Data". The objective of the effort is to extend the results of NASA s Earth Science Program to the education community by sponsoring unique and stimulating opportunities for global climate and Earth system science education. GCCE is designed to improve the quality of the Nation s STEM (Science, Technology, Engineering and Mathematics) education and enhance students and teachers literacy about global climate and Earth system change from elementary grades to life-long learners. Each funded proposal is expected to make use of NASA s unique contributions in climate science to enhance learners' academic experiences and/or to improve educators abilities to engage their students. The GCCE project will consider proposals in the following two funding categories: (1) Funding Category R: Global Climate Change Science Research Experiences for Undergraduate or Community College Students and Pre- or In-Service Teachers including those in nontraditional teacher licensure programs; (2) Funding Category D/M: Using NASA Earth system data, interactive models and/or simulations to Strengthen Teaching and Learning about Global Climate Change. The anticipated total amount of funding available for new awards under this solicitation is approximately $8 million. Projects may be proposed for durations of up to 3 years. It is anticipated that approximately 20 - 25 awards will be issued. Participation is open to the following categories of U.S organizations: higher educational institutions, state, local or federally-recognized tribal government agencies, public school districts, nonprofit institutions, Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions (HSI), and Tribal Colleges and Universities (TCU), as well as other minority-serving education al institutions. Notices of intent (NOIs) are strongly encouraged and are to be submitted electronically through NSPIRES at http://nspires.nasaprs.com . Potential offerors are responsible for downloading the CAN and amendments (if any). This solicitation leading to the award of a Cooperative Agreement is issued pursuant to title 14 CFR Part 1260 for educational and nonprofit institutions. Additional questions regarding the solicitation and programmatic information can be obtained from: Dr Lin Chambers, Global Climate Change Education Project Scientist, NASA Langley Research Center, gcce-questions@lists.nasa.gov

NASA Langley Research Center

The National Aeronautics and Space Administration (NASA) Langley Research Center Science Directorate is releasing a Cooperative Agreement Notice (CAN) soliciting proposals for Global Climate Change Education (GCCE): Research Experience, Teaching and Learning . The objective of the effort is to extend the results of NASA s Earth Science Program to the education community by sponsoring unique and stimulating opportunities for global climate and Earth system science education. GCCE is designed to improve the quality of the Nation s STEM (Science, Technology, Engineering and Mathematics) education and enhance the students and teachers literacy about global climate and Earth system change at the elementary, secondary, and undergraduate levels. Each funded proposal is expected to make use of NASA s unique contributions in climate science to enhance students academic experiences and/or to improve educators abilities to engage their students. The GCCE project will consider proposals in the following three funding categories: (1) Funding Category R: Global Climate Change Science Research Experiences for Undergraduate or Community College Students and Pre- or In-Service Teachers including those in nontraditional teacher licensure programs; (2) Funding Category D: Using NASA Earth system data and models to Strengthen Teaching and Learning about Global Climate Change in Formal Education; (3) Funding Category P: Improve Teacher Competency for Global Climate Change Education. The anticipated total amount of funding available for new awards under this solicitation is approximately $8 million. Projects may be proposed for durations of up to 3 years. It is anticipated that approximately 25 awards will be issued. Participation is open to the following categories of U.S organizations: higher educational institutions, state, local or federally-recognized tribal government agencies, public school districts, nonprofit institutions (with proof of nonprofit 501(c)(3) status), Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions (HSI), and Tribal Colleges and Universities (TCU), as well as other minority-serving educational institutions. Notices of intent (NOIs) are strongly encouraged and are to be submitted electronically through NSPIRES at http://nspires.nasaprs.com . The CAN will be available electronically the first week in June 2009 through the NSPIRES website at http: nspires.nasaprs.com. Potential offerors are responsible for downloading the CAN and amendments (if any). This solicitation leading to the award of a Cooperative Agreement is issued pursuant to title 14 CFR Part 1260 for educational and nonprofit institutions. Additional questions regarding the solicitation and programmatic information can be obtained from: Dr Lin Chambers, Global Climate Change Education Program Manager, NASA Langley Research Center, gcce-questions@lists.nasa.gov.

Gowanus Canal Conservancy, Inc.

To incorporate storm water management issues and practices into middle school STEM curriculum and advocate for green infrastructure on school properties.

Gowanus Canal Conservancy, Inc.

To incorporate storm water management issues and practices into middle school STEM curriculum and advocate for green infrastructure on school properties.

Gowanus Canal Conservancy, Inc.

To incorporate stormwater management design and practices into middle and high school STEM curriculum, while working toward long-term viable strategies to construct and maintain green infrastructure on school properties.

Gowanus Canal Conservancy, Inc.

To incorporate stormwater management design and practices into middle and high school STEM curriculum, while working toward long-term viable strategies to construct and maintain green infrastructure on school properties.

National Institute of Standards and Technology

NIST is soliciting proposals from eligible applicants for a Graduate Student Measurement Science and Engineering (GMSE) Fellowship Program that will provide doctoral-level graduate students with opportunities and financial assistance to obtain laboratory experiences within the NIST laboratories in the science, technology, engineering and mathematics (STEM) disciplines. The recipient will work with NIST to foster collaborative research relationships among NIST, doctoral-level graduate students and the students academic institutions in STEM. Review, selection, and award processing is expected to be completed in March 2013. The earliest anticipated start date for awards under this FFO is expected to be May 1, 2013.

NIEHS - National Institute of Environmental Health Sciences

Summary - Growing Clean- Partnering with Plants For Public Health Leaders: International PhytoScholars Program – 2026 Overview: We will train and inspire the next generation of professionals and academic researchers in public health protection as part of the 19th Annual International Phytotechnologies Conference. We plan to support student participation in the International Phytotechnologies Scholars Program to be held in October 2026 in Providence Rhode Island. The conference is hosted by the International Phytotechnology Society (IPS), that also develops and executes the PhytoScholars Program. PhytoScholars is a unique student-oriented scholars program for green solutions for public health protection with the overarching goal to inspire and train future leaders in green solutions. Intellectual Merit: The IPS conference has the goal to advance knowledge in areas of protecting human health and advancing sustainable solutions that can be broadly applicable. The resulting knowledge exchange and publications explicitly advance the intellectual exchange and knowledge generation, with merit for our scholarly community. PhytoScholars program feeds into this mission, and promotes the next generation with the following objectives: - To increases knowledge of the broader roles of phytotechnologies in the concurrent protection of public health, risk assessment and the improvement of ecosystem function; - To provide students with professional skills and development opportunities and the chance to network with international professionals working in the field of phytotechnologies; - To directly support student training, active mentorship, and education in phytotechnologies and sustainable technologies as strategies for environmental remediation and stewardship. Broader Impacts: As part of this program, students will be supported to attend the conference by offering support for partial coverage of travel and lodging fees for an expected 12 – 20 selected scholars. PhytoScholars will be offered the opportunity to travel and will directly interact with international leaders in public health protection to learn scientifically and grow professionally. All PhytoScholars will be tasked to offer a presentation, meet professional leaders, offer specified feedback, and meet learning objectives, which include not only scientific objectives but also cultural and professional development objectives. All PhytoScholars’ presentations will be evaluated by a minimum of two professional leaders. The selection process will aim to invite applicants from across the range of STEM fields involved in public health and environmental quality. The selection committee will cover a range of fields and is a group of accomplished scholars that has interacted with past conferences and can benefit from the PhytoScholars programs. All selection committee members will be attending the conference to offer talks and engage with the PhytoScholars as mentors and role models and provide guidance and advice toward impactful careers.

U.S. National Science Foundation

NSF GRANTED supports innovative models of research enterprise administrative development and workforce training infrastructure that promote sustainable research capacity and opportunities for economic impactin U.S. organizations. The research enterprise, broadly defined, includes research development and administration, research analytics, technology transfer and commercialization, corporate relations/public-private partnerships, research integrity, compliance and security, research policy, administration of student research training, and research leadership. Strengthening and transforming this administrative infrastructure is necessary to fully utilize the Nation's research talent and capabilities and empower America's organizations that engage in or support research and its outcomes, to participate in a globally competitive research enterprise. Program Description Maintaining U.S. global leadership demands a research enterprise that is competitive, effective, sustainable and contributes to the Nation's economic growth goals. A strong national research enterprise relies on more than funding for the research itself. It also requires robust administrative support-and-service infrastructure, which is often unseen, yet includes critical components to ensure a competitive research environment regardless of organization or location. Research enterprise infrastructure enables the development of proposals and management of awards and supports research translation through technology transfer and public-private partnerships. Research compliance enables the security and integrity of research approaches. Research analytics and communication, managing the training of the U.S. scientific workforce, and harnessing the creativity and drive of research leadership, and more, are also fundamental components of the infrastructure. TheGRANTED initiativeprovides unique opportunities to realize a broad and collaborative vision for research enterprise infrastructure. Proposals in response to this GRANTED program description should engage the professional, administrative research support-and-service workforce in project leadership roles described within proposals.Proposed projects should look beyond individual and discipline-specific research needs and focus on activities that create organization-wide impact and potential for regional and national impact. Projects should propose scalable approaches and models to build and sustain research enterprise infrastructure.Competitive proposals will recognize structural and organizational challenges and include goals to implement interventions, solutions, and/or strategies that will mitigate the challenges. Proposals must be centered around one or more of the three main themes of GRANTED: Innovating and enhancing practices and processes within the research enterprise; Developing and strengthening human capital within the research enterprise; and Translating effective practices related to the research enterprise into a broad range of organizational contexts. The GRANTED program utilizes general proposal requirements, including eligibility, as outlined in the current NSF Proposal and Award Policies and Procedures Guide (PAPPG). Prospective PIs are strongly encouraged to contact GRANTED initiative personnel (GRANTED@nsf.gov) with inquiries prior to developing and submitting a proposal to this program description. The project budget and duration should be determined by the scope of the proposed activities and presented in accordance with the PAPPG.GRANTED is not intended to fund discipline-specific STEM research and training projects. Collectively, proposals funded through this Program Description will advance transformation of the national research enterprise, measured through 1) generating scalable models that improve research capacity and competitiveness, 2) creating collaborations, partnerships, and communities centered around strengthening the Nation's research enterprise, 3) increasing the range of project leadership, organizations, ideas, and approaches that NSF funds, especially related to developing areas aligned to agency priorities, and 4) strengthening engagement across the Nation s research enterprise.

U.S. National Science Foundation

NSF GRANTED supports innovative models of research enterprise administrative development and workforce training infrastructure that promote sustainable research capacity and opportunities for economic impactin U.S. organizations. The research enterprise, broadly defined, includes research development and administration, research analytics, technology transfer and commercialization, corporate relations/public-private partnerships, research integrity, compliance and security, research policy, administration of student research training, and research leadership. Strengthening and transforming this administrative infrastructure is necessary to fully utilize the Nation's research talent and capabilities and empower America's organizations that engage in or support research and its outcomes, to participate in a globally competitive research enterprise. Program Description Maintaining U.S. global leadership demands a research enterprise that is competitive, effective, sustainable <span>a</span>nd contributes to the Nation's economic growth goals. A strong national research enterprise relies on more than funding for the research itself. It also requires robust administrative support-and-service infrastructure, which is often unseen, yet includes critical components to ensure a competitive research environment regardless of organization or location. Research enterprise infrastructure enables the development of proposals and management of awards and supports research translation through technology transfer and public-private partnerships. Research compliance enables the security and integrity of research approaches. Research analytics and communication, managing the training of the U.S. scientific workforce, and harnessing the creativity and drive of research leadership, and more, are also fundamental components of the infrastructure. The<a href="https://new.nsf.gov/funding/initiatives/broadening-participation/granted">GRANTED initiative</a>provides unique opportunities to realize a broad and collaborative vision for research enterprise infrastructure. Proposals in response to this GRANTED program description should engage the professional, administrative research support-and-service workforce in project leadership roles described within proposals.Proposed projects should look beyond individual and discipline-specific research needs and focus on activities that create organization-wide impact and potential for regional and national impact. Projects should propose scalable approaches and models to build and sustain research enterprise infrastructure.Competitive proposals will recognize structural and organizational challenges and include goals to implement interventions, solutions, and/or strategies that will mitigate the challenges. Proposals must be centered around one or more of the three main themes of GRANTED: <ul type="disc"> <li>Innovating and enhancing practices and processes within the research enterprise;</li> <li>Developing and strengthening human capital within the research enterprise; and</li> <li>Translating effective practices related to the research enterprise into a broad range of organizational contexts.</li> </ul> The GRANTED program utilizes general proposal requirements, including eligibility, as outlined in the current NSF Proposal and Award Policies and Procedures Guide (PAPPG). Prospective PIs are strongly encouraged to contact GRANTED initiative personnel (<a href="mailto:granted@nsf.gov">GRANTED@nsf.gov</a>) with inquiries prior to developing and submitting a proposal to this program description. The project budget and duration should be determined by the scope of the proposed activities and presented in accordance with the PAPPG.GRANTED is not intended to fund discipline-specific STEM research and training projects. Collectively, proposals funded through this Program Description will advance transformation of the national research enterprise, measured through 1) generating scalable models that improve research capacity and competitiveness, 2) creating collaborations, partnerships, and communities centered around strengthening the Nation's research enterprise, 3) increasing the range of project leadership, organizations, ideas, and approaches that NSF funds, especially related to developing areas aligned to agency priorities, and 4) strengthening engagement across the Nation&rsquo;s research enterprise.

National Park Service

A.Project Goals - Historically, Lake Tuendae, which hosts one of the primary populations of Mohave tui chub (fish), had to be dredged every 10 years to remove cattail and aquatic ditchgrass (Ruppia maritime) detritus. This activity leads to substantial tui chub mortality just to maintain its habitat. This requires lengthy Section 7 formal consultation with the US Fish and Wildlife Service. After the last dredging action in 2001, members of the interagency recovery team have been able to postpone the need for dredging by over five years due through conducting annual cattail control actions. However, in the past two years several key participants have retired or been reassigned. As a result, cattail control has been minimal and growth has expanded by over 30 square meters in Lake Tuendae and MC Spring due to the inability of MOJA staff alone to keep up. Thus, to minimize the need for dredging, cattail control needs to continue and transplant of native plants completed to prevent re-establishment of cattails. B.Project Objectives - MOJA staff has identified by completing these three objectives towards the endangered Mohave Tui Chub habitat enhancement in Lake Tuendae, MC Spring, West Pond and Morning Star Mine Lake, should help with their survival rates. a. Objective one, involves obtaining water body dimensions such as depth, width and vegetation cover along with water quality measurements of temperature, dissolved oxygen and total dissolved solids (TDS). Results will be compared with previous data. b. For Objective two, the cattail will be cut with cutters with handles of varying length and a flat bottom boat to access cattail stems for cutting as close to soil level as possible. Cutting will be done monthly and continue monthly during the cooler part of the year, to control any regrowth. Some dead mats of Ruppia spp. will be raked from the water to reduce its extent across open water. c. For Objective three, dig up local stocks of bulrush and Cooper s rush from non-tui chub bearing waters and transplant immediately to cattail infested areas at the water s edge. Follow up visits to cutback cattails from around the transplants will be conducted until the transplants have established. It is anticipated 250 to 300 individuals of each species would be needed to cover the required area. This project should further minimize the need for any future dredging of the habitat that results in mortality of tui chub (fish). The Research Associate (RA) will be able to conduct about half of the tasks independently and the rest with existing MOJA staff.

NIAID - National Institute of Allergy and Infectious Diseases

ABSTRACT Monoclonal antibodies have found enormous clinical utility for treatment of infectious diseases, autoimmunity and cancer. While there are four human IgG subclasses, only IgG1, 2 and 4 have been deployed as therapeutics. IgG1 is the most abundant subclass and is the go-to molecule when target cell killing is desired, i.e the cancer drugs anti-HER-2 (trastuzumab) that kills breast cancer cells and anti-CD20 (rituximab) that depletes B cell tumors. IgG2 in contrast has very low affinity for FcgR, is a poor activator of complement and cell mediated killing, and is often used for receptor blocking or neutralizing mAbs, ie the EGFR blocker panitumumab. IgG4 is used for chronic diseases and for immune check-point inhibitors, such as nivolumab (PD1 blockade). IgG4 does not activate complement and binds poorly to FcgR making it a preferred choice when cell death or inflammation is not the goal. In contrast, IgG3 has not found widespread use clinically, with only one human trial of an IgG3 antibody exist in the literature. The paucity of interest in IgG3 for development of therapeutics, despite its potency with regards to antibody effector functions, and optimal ability to engage antigens through its flexible hinge region, mainly stems from its very short in vivo half-life. There are some additional technical challenges such as the existence of multiple allotypes, practical obstacles to effective purification, and pH stability. Due to its superior range of effector mechanism potency, and flexible binding properties, we propose that revisiting IgG3 as a therapeutic agent is warranted. Herein we will employ protein engineering to optimize the FcRn interaction of IgG3 to expand its in vivo half-life, and the FcR interactions to define the full range of effector mechanism activation that can be achieved through IgG3. We propose that if harnessed appropriately, IgG3 can be developed for therapeutic clinical use, with the benefits of improved binding profiles and a broader dynamic range of effector function potency.

NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases

This proposal seeks external funding for a recently launched internship program for undergraduate trainees who are passionate about improving metabolic health. Our program aims to help outstanding undergraduates achieve their goals of becoming the next generation of nurses, physician assistants, physicians, and scientists by providing research experience, clinical exposure, career development training, and community outreach opportunities over the course of a 10-week summer program. Our training offers exposure to the metabolic underpinnings of chronic kidney disease (CKD), diabetes, obesity, hypertension, heart failure, cardiovascular disease and stroke. These comorbid conditions have increased in parallel with the epidemic proportions of diabetes and obesity, which are strong risk factors for these chronic health conditions. With overwhelming support from UofU administration, colleagues, and community leaders, we created and implemented the Utah Summer Undergraduate Mentored Metabolism Immersive Training (SUMMIT) Program, a 10-week summer research internship which provides: i) hands-on research experience (basic, clinical, or translational) with established scientists; ii) professional and career development; iii) clinical shadowing; iv) cultural mentoring; and v) community outreach. With NIH support, we aim to continue annual research experiences and educational training in metabolic disease (with an emphasis on diabetes, obesity, endocrinology, and metabolism) through the Utah SUMMIT Program. We will: 1) Execute a summer research internship centered on metabolic health for undergraduates that includes comprehensive and lifelong academic, career, and educational support through mentored research and the development of a strong, supportive cohort experience; 2) provide Summit Scholars outreach opportunities with Utahns at high risk for metabolic disease; and 3) Evaluate the effectiveness of the SUMMIT Program on increasing trainee trajectories toward STEM careers and the endocrine-related biomedical workforce.