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Rockport Center for the Arts

Artistic fee subsidy for State Artist Marcia Ball to perform at the Rockport Conference Center in Rockport, 09/08/23 - 09/08/23.

Humble Elementary/Humble ISD

Artistic fee subsidy for Creativity Shell to provide arts instruction at Humble Elementary in Humble, 09/01/23 - 12/15/23.

Irving Symphony Association

Artistic fee subsidy for Mexico 2000 Ballet Folklórico to perform at Carpenter Performance Hall-Irving Arts Center in Irving, 02/09/24 - 02/10/24.

Playhouse 2000

Artistic fee subsidy for Glass Half Full Theatre to perform at Kathleen C. Cailloux City Center for the Performing Arts in Kerrville, 01/19/24 - 01/19/24.

Piney Woods Fine Arts Association

Artistic fee subsidy for Dallas String Quartet to perform at Crockett Civic Center in Crockett, 12/14/23 - 12/14/23.

Dobie West Performing Arts Theatre

Artistic fee subsidy for Laughter League to perform at Dobie West Performing Arts Theatre in George West, 07/19/24 - 07/19/24.

Guadalupe Cultural Arts Center

Artistic fee subsidy for Los Texmaniacs to perform at Rosedale Park in San Antonio, 05/19/24 - 05/19/24.

Performing Arts Journal, Inc.

Performing Arts Journal

Operation Unite New York

Performing Arts Music Program

The Bronx Museum of the Arts

Permanent Collection Catalogue

FIC - John E. Fogarty International Center for Advanced Study in the Health Sciences

Modified Project Summary/Abstract Section The widespread access to antiretroviral therapy (ART) has converted HIV infection into a chronic and manageable condition. To date, PWH who have stable access to ART mostly maintain stable HIV suppression and achieve a more comparable life expectancy as people without HIV (PWoH), constituting an aging population of PWH. However, PWH continue to incur residual effects of persistent immune and metabolic dysfunction, resulting in a higher risk of developing non-communicable diseases (NCDs) when compared to PWoH. Among NCDs, cardiovascular disease (CVD) and neurocognitive impairment (NCI) are not only contributing factors to morbidity and mortality but also two of the most disabling conditions that compromise perceived ratings of life satisfaction. In PWoH, extensive research has established vascular disease as a key contributor to cognitive decline and NCI. Vascular brain injury (VBI) is a crucial risk factor for cognitive decline in all forms of dementia. Considering the persistently elevated risk of CVD in PWH despite suppressive ART, there is a compelling rationale that CVD and VBI are accentuated in older PWH. Notably, our understanding between CVD risks, vascular dysfunction, and cognitive outcomes in older PWH on ART is essentially derived from studies from high-income countries (HICs), with effectively no empirical evidence regarding complex interplay between persistence of inflammation and vascular dysfunction in older PWH residing in low- to middle-income countries (LMICs). Research findings from the global north cannot be extrapolated into LMICs given the significant differences in HIV subtype, as well as the unique genetic and environmental risks on vascular dysfunction. Moreover, cognitive studies in Asia have been limited by the use of screening measures for cognitive impairment, as well as by an inadequate focus on older PWH on stable ART. This R21 proposal leverages the robust HIV research infrastructure of the HIV Netherlands Australia Thailand Research Collaboration (HIVNAT) of the Thai Red Cross AIDS Research Centre (TRCARC) in Bangkok, Thailand. We will enrol older PWH, along with age- and sex-matched PWoH. Participants will undergo blood sampling for immune activation and vascular dysfunction biomarker measurement, optical coherence tomography angiography (OCTA) and comprehensive cognitive assessment. Through a biological-structural cognitive framework, this proposed study aims to address the aforementioned knowledge gaps by examining the potential link between persistent inflammation, vascular dysfunction, and cognitive performance in older PWH on stable ART in LMICs. In addition to providing potential mechanistic insight and intervention targets to NCI in older PWH, this proposed work will enhance research capacity building at HIVNAT to support future studies aimed at deeper phenotyping of cognitive outcomes and discovery of risk determinants, including modifiable factors that can be targeted in future studies.

OD - NIH Office of the Director

The seismic wave of precision medicine is reaching research laboratories. Imaging is an essential component of that paradigm shift. Clinically applicable modalities are becoming an avant-garde of translational efforts relying on seamless transition between preclinical and clinical scenario. For decades imaging scientists and clinicians had to choose between outstanding anatomical information offered by magnetic resonance imaging (MRI) and high sensitivity of positron emission tomography (PET) as moving animals or patients between scanners is too cumbersome with time delay and image registration compounding the difficulties. The advent of an era of integrated PET/MR scanners solved this long-lasting obstacle. University of Maryland, Baltimore (UMB) made impressive investment in research infrastructure, along with the construction of a brand new Health Science Building (HSF) III in 2019. The basement of the building is equipped with state-of-the-art imaging devices. Among others it features clinical Biograph PET/MR system (Siemens), and small animal wide-bore 9.4 T Bruker MR scanner. Moreover, University of Maryland recently recruited a group of investigators from the Johns Hopkins University (including the PI of this proposal), who have an outstanding expertise in both MRI and PET, including many publications and patents in both imaging modalities. They have established a Program in Image Guided Neurointerventions (PIGN), with unique resources dedicated to imaging science radiation-ready space in HSF III and approved protocols for radiolabeling of a various molecules and compounds. This resource is now open to offer the radiolabeling expertise to the entire UMB community. Notably, there is growing demand for simultaneous MRI and PET imaging during the same imaging session. Excellent example is core application of PIGN where MRI is used to predict and assess brain territory targeted by IA injection while PET component reports in real-time on drug accumulation and dose at the target. Until now scientists at UMB had only access to clinical PET/MR scanner, although to fully unlock the potential of that system it is essential to also be able to perform experiments in small animals. Importantly, dedicated small animal 9.4 T Bruker MR scanner is available, which can be easily upgraded by PET insert to serve as a fully functional PET/MR scanner. It is also worth mentioning that currently available small animal PET/CT scanner (Siemens Inveon) will be decommissioned next year as the manufacturer discontinued its production and its support will expire, therefore UMB campus will be devoid of any access to PET imaging. At the same time the radiolabeling expertise and support from PIGN, energized a number of UMB scientists across many disciplines including radiology, neurosurgery, immunology, pharmacology, oncology and human virology who enthusiastically support this proposal. Therefore, the proposed PET insert will be an excellent and much needed addition to an outstanding research infrastructure recently acquired by the UMB to serve local research community.

New York Foundation for the Arts

Peter Friedman - Beyond Belief: The Power of Things

City of Richmond

Chinese Martial Arts

Petersen Automotive Museum Foundation

Petersen Automotive Museum Foundation is an active grantmaking foundation based in Los Angeles, CA. Focus: arts. Contact the foundation directly for current funding opportunities.

NSF

The broader impact/commercial potential of this PFI project is to develop improved social media tools to keep teens safer online. A multidisciplinary team of researchers, clinicians, and industry partners will build, evaluate, and commercialize state-of-the-art technologies that proactively detect adolescent online risk behaviors, including mental health issues, sexual solicitations, and online harassment, for the purpose of mitigating these risks and preventing harm. The team plans to release two separate technology offerings: First, an open source project that shares our risk detection algorithms with developers, so that they can build upon these solutions and form a community dedicated to promoting adolescent online safety. Second, a commercial product that combines these risk detection algorithms into an easy-to-use and accessible service that provides needed support and infrastructure to internet-based companies, who ultimately facilitate the risks teens encounter online, so that they can share in the joint responsibility of protecting the teens who use their platforms. It is imperative that as a society we become more proactive about protect teens from online risks, especially the most vulnerable teens who are at highest risk of engaging in online activities that can lead to physical harm or even death. The proposed project addresses the critical and timely problem of adolescent online safety by leveraging a multi-disciplinary approach of human-centered machine learning to accurately detect risks teen encounter online. The work will be accomplished in four stages: 1) a user-centered phase that examines the types of online risk exposure that matter most to teens and their families. With this insight, the team will build evidence-based adolescent online risk models that identify key dimensions and patterns of risk. 2) a data-driven phase that draws upon these models to establish ground truth and annotate a rich training set of teen social media data, 3) a machine-learning phase that improves existing and builds new risk detection algorithms that are contextualized to teens and able to detect behavioral changes over time, and 4) a technology development phase that evaluates our solution and commercializes it within two separate product lines. The end result will be a suite of algorithms tailored to adolescents that detect objectionable content within social media and identify problematic behavioral patterns or changes that are indicative of impending risks over time. This work will enable real-time online safety interventions that protect and empower teen internet users. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

ABSTRACT Sub-Saharan Africa's (SSA) 400 million adolescent girls and young women (AGYW, age 15-24) face disproportionate rates of HIV acquisition and suboptimal HIV care engagement. Despite the widespread availability of oral PrEP at public health facilities, uptake is impeded by low awareness, socio-cultural and access barriers, provider bias, and user dissatisfaction. Moreover, among PrEP-aware AGYW, uptake and continuation of PrEP is low due to side effects, fear of being seen with medicines, and low adherence support, undermining PrEP's preventative effects and leaving AGYW in need of critical HIV prevention. Our team and others have demonstrated that AGYW are interested in PrEP, especially newer modalities such as injectables, and that they prefer to seek HIV care at locations that foster privacy, are convenient, and are girl-friendly. Given the growing recognition that pharmacies, staffed by health workers who can be trained to provide expanded services, outnumber health facilities, can promote beneficial health behaviors, bridge gaps in health services, and mitigate health workforce shortages, we aim to expand this body of research to conduct an implementation science study on potential implementation models of pharmacy-based PrEP provision and adherence support for AGYW. In Uganda, the Community Retail Private Pharmacy Drug Distribution Point (CRPDDP) already provides pharmacy-based anti-retroviral therapy (ART) to over 48,000 clients across 160+ pharmacies (and increasing). Given the Uganda Ministry of Health's interest to expand this pharmacy-based differentiated service delivery model for increased reach and extended prevention offerings, we propose a mixed-methods study to garner foundational evidence to evaluate how this cadre of pharmacies already providing ART refills to PLHIV can include PrEP services generally and specifically tailored to AGYW. We hypothesize that these pharmacies can be well-equipped to reach AGYW with PrEP, given the critical role they already play in the community providing expanded care. As such, we propose to conduct formative research among CRPDDP pharmacies and their AGYW clients to advance implementation of pharmacy-based PrEP and adherence support. Guided by participatory processes of human-centered design, including in-depth interviews with AGYW who are potential PrEP users, pharmacists, and focus groups with pharmacy and youth advisory boards and MOH stakeholders, we will conduct formative research to understand barriers, facilitators, and desires for pharmacy-based PrEP to inform a discrete choice experiment (DCE) (Aim 1). We will then evaluate a series of implementation science outcomes—willingness, acceptability, feasibility, and readiness—among CRPDDP pharmacists (n=~160) (Aim 2), and conduct parallel DCE surveys among CRPDDP pharmacists and their AGYW clients (n=300) to evaluate preferences for pharmacy-based PrEP implementation models (Aim 3). By the end of the study, we will understand how a potentially ready platform of pharmacies can be expanded to provide PrEP care to a key population, and will have identified potential implementation gaps from user, provider, and policy perspectives .

NIAID - National Institute of Allergy and Infectious Diseases

Modified Project Summary/Abstract Section HIV disproportionately affects the Southern United States with the highest burden of new infections. While biomedical HIV prevention strategies, such as pre-exposure prophylaxis (PrEP) and treatment as prevention can effectively prevent HIV acquisition and transmission, innovative strategies are still needed to ensure these tools are employed in the communities most impacted by the epidemic. Alabama, one of seven priority states in the U.S. Department of Health and Human Services Ending the HIV Epidemic initiative, recently permitted collaborative practice agreements between physicians and pharmacists. Over half of all pharmacies operating in Alabama are community-based with many operating in areas of the state of higher HIV incidence. Rapid status neutral approaches can improve linkage to HIV service delivery, and pharmacy-based HIV testing in pharmacies has been effective in other regions. However, critical gaps remain in understanding how to effectively incorporate HIV testing and service delivery in pharmacy settings in Alabama and other regions of the Southern US. To close that gap, this proposed study will pursue two specific aims: (1) Evaluate key determinants for implementation of a test-to-treat, status neutral rapid antiretroviral (ARV) intervention into independent pharmacy settings through concurrent mixed-methods; (2) Develop and refine a multi-component implementation strategy to integrate HIV testing, PrEP, and ART in routine pharmacy-based practice. Upon completion of our proposed research, our inter-disciplinary team, which includes experts in infectious diseases and HIV PrEP/ARV service delivery, implementation science, community-engaged research, and pharmacy care delivery, will lead to a multi-site type III implementation trial of PrEP service delivery at community pharmacies across the South.

NSF

Nontechnical description: Hybrid material systems allow for harnessing physical interactions from crystal structures, magnetism, and material defects across the interfaces to achieve novel electronic and magnetic properties that are otherwise absent in each individual system. Exploiting magnetic interactions at the interface is a particularly attractive approach due to their high efficiency and tunability. By designing, synthesizing, and characterizing magnetic multilayers that integrate two dissimilar magnets and an interface, this project, via integrated computational and experimental efforts, aims to understand the complex interplay among the different types of fast (up to gigahertz) magnetic interactions that coexist at the interface. In fulfilling these goals, the research team will exploit state-of-the-art material engineering strategies including thin-film synthesis with precise control of composition and film thickness, and local electrical current injection. Upon completion, the project will develop new understanding towards harnessing cooperative physical interactions at interfaces for fast and reliable signal transmission and conversion, which plays a central role in the study of a wide variety of quantum materials and systems. The project will also increase participation of high-school students in STEM related careers. Technical description: The collective spin excitations (magnons) have received increased attention in novel constructions of hybrid systems exhibiting coherent phenomena. To date, investigation of hybrid magnonic systems has largely focused on using the non-propagating, ferromagnetic resonance modes. This scheme, however, leaves out the use of magnon wavevectors and their precessional phases as a potential state variable or control knobs. This project will design and create novel phase-controlled magnonic systems that operate on tailored, cavity magnon modes with finite wavelengths. By using magnetic heterostructures comprising a composite interlayer sandwiched by two dissimilar magnets, the team will explore tailored magnon-magnon coupling arising from synergistic interfacial spin-spin interactions. Such systems will exemplify a route towards the selective excitation, amplification, and on-demand phase control of short-wavelength (100 nm or less) magnon modes, and fill in a critical knowledge gap of coherent phenomena involving short-wavelength magnons. Technically, the project will explore competing magnon excitation channels from symmetric and antisymmetric spin coupling schemes, and deconvolute the magnon phase contributions from the intrinsic, wavevector-dependent characteristics and the extrinsic, angular momentum injections. This project will advance the fundamental understanding of competing spin-spin interactions from conventional static regime to a transformatively new dynamic regime. By synthesizing the novel magnon-magnon coupled cavity heterostructure, both the finite wavevector and magnon precession phase can be enabled as new state variables for signal transmission and transduction. The magnon-magnon coupling parameters along with the new theory and simulation capabilities will facilitate the understanding, prediction, and design of many other hybrid coherent/quantum systems involving magnons coupled to other solid-state quasiparticles. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

Philippine Cultural Foundation Inc

Philippine Cultural Foundation Inc is an active grantmaking foundation based in Tampa, FL. Focus: arts. Contact the foundation directly for current funding opportunities.

NIDCR - National Institute of Dental and Craniofacial Research

PROJECT SUMMARY/ABSTRACT Temporomandibular joint (TMJ) osteoarthritis (OA) is characterized by chronic inflammation, resulting in cartilage degradation and subchondral bone erosion, leading to jaw pain and a compromised quality of life. With no effective treatment currently available, there is a pressing need for new clinical approaches to the problem. Our innovative approach, which could potentially prevent the progression of TMJ-OA to more advanced stages, has the potential to reduce the need for complex and costly surgical procedures. Photocrosslinking tissue proteins (i.e., collagen) is a straightforward and clinically advantageous procedure. It involves applying an aqueous Rose Bengal (RB) solution to the tissue and exposure to green light. Protein crosslinking has been investigated for wound closure, anastomosis, nerve repair, and enhanced wound healing in many tissues. It has also been shown to reduce inflammatory responses in treated tissues, hence the term photochemical tissue passivation (PTP). Published data from our group shows that the network formed by extracellular protein crosslinking prevents inflammatory markers from infiltrating the treatment site. We also showed in rodent knee and shoulder models of fibrosis and post-traumatic arthritis that PTP reduces inflammation in the joint capsule. PTP was initially applied in other tissues by Dr. Redmond’s group. Only after collaborations with Dr. Guastaldi the leap was made to TMJ and this proposal. Dr. Redmond is a pioneer of photocrosslinking therapeutics, and Dr. Guastaldi has extensive experience with animal models, TMJ disease, and regeneration. We believe this innovative approach is only possible due to this partnership's unique combination of expertise. In addition, utilizing state-of-the-art optical diagnostic imaging techniques via Dr. Redmond’s and Dr. Guastaldi’s collaborators at the Wellman Center for Photomedicine (MGH) is another powerful and innovative step in assessing TMJ disease progression and therapeutic efficacy. Polarization- sensitive optical coherence tomography (PS-OCT) is an optical technique that has recently demonstrated the ability to measure cartilage fiber structure and orientation. Dr. Vakoc is a leader in the field of PS-OCT, and his lab is well-equipped to conduct rapid volumetric PS-OCT imaging. We propose to apply to the TMJ for the first time. The overall goal is to explore the potential of PTP to reduce inflammation and prevent the progression of TMJ-OA. A well-established rat model of TMJ-OA will be used to achieve this goal. We hypothesize that PTP of the TMJ capsule offers a promising, minimally invasive approach to halting TMJ-OA progression by reducing inflammation within the TMJ. The following specific aims will address the hypothesis: SA1) To assess the effect of PTP on the whole TMJ structure. PS-OCT imaging, micro-CT, histology, and pain assessment will assess the impact of PTP on the whole TMJ structure. SA2) To assess the efficacy of PTP to reduce TMJ-OA-related inflammation. Whole TMJ specimens tissues will undergo quantitative (Q-PCR) and qualitative (IHC staining) assessment for the presence of inflammatory markers.

NSF

Pathogen contamination of water is an important public health threat around the world. This project will develop a low-cost and highly effective method to disinfect water., The research will create new single-atom photocatalysts (SAPs) that work as powerful antimicrobial agents under light. The SAPs are metal atoms spread out at the atomic level onto a supporting material. The interactions between the metal and the support improve light absorption and charge separation, which boost their ability to kill microbes. The research will use laboratory experiments and computer simulations to explore different transition metals that bond with nitrogen or oxygen atoms in the support material. Along with scientific discovery, this project will provide strong learning experiences to help train the next generation of STEM professionals. The research will also be integrated into several educational outreach programs. Infection by waterborne pathogenic microorganisms poses a significant threat to human and environmental health. Development of effective technologies for water disinfection is of both fundamental and technological significance in environmental remediation. The proposed research is focused on the rational design and engineering of carbon-supported single (metal) atom nanocomposites as high-performance photodynamic antimicrobial agents, a critical step in environmental cleanup through the elimination of waterborne pathogens. In these single-atom photocatalysts (SAPs), the metal centers are embedded within the supporting substrates by strong coordination bonds. The metal-support interactions can be exploited as a unique powerful variable in the manipulation of the materials' optical and electronic properties, leading to optimal photodynamic activity. The project will focus on three tasks and three unique SAPs: (a) atomic dispersion of select transition-metal species within nitrogen-doped carbon scaffold, where the photodynamic performance will be systematically examined within the context of metal-nitrogen coordination interactions; (b) structural engineering of metal oxide nanoparticle-supported single atom catalysts for enhanced photocatalytic bactericidal performance, by taking advantage of the formation of new electronic states within the oxide bandgap, such that the photodynamic activity can be enhanced and extended to the visible range; and (c) select doping of the B sites of perovskite-type ABO3 metal oxide nanoparticle for enhanced photodynamic performance due to manipulation of the electronic band structures. The materials' structures will be meticulously examined by state-of-the art microscopy and spectroscopy measurements and carefully correlated to the bactericidal activity in conjunction with first principles calculations. The ultimate goal is to establish an unambiguous structure-property-activity framework within which the antimicrobial performance of the SAPs can be manipulated and optimized. The proposed research will offer a unique educational framework that helps nurture the next-generation STEM workforce. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

NYC Department of Cultural Affairs

Pioneer Works Art Foundation

Pipeline Arts Foundation

Pipeline Arts Foundation is an active grantmaking foundation based in Greenwood Vlg, CO. Focus: arts. Contact the foundation directly for current funding opportunities.