Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries
About This Grant
Abstract Large-scale genome wide association studies (GWAS) have identified a large number of genetic variants associated with complex diseases. The aggregation of all the variants that are known to contribute to the disease in the form of polygenic risk scores (PRS) improves the prediction of a range of complex diseases. Most PRS have been developed within European ancestry study samples and have shown to perform poorly in other ancestry groups, further exaggerating differences in treatment quality across ancestries. As genetic approaches for precision medicine become more popular, there is a critical need to responsively and proactively expand access to accurate PRS. Specifically, diabetes, and its associated complications are one of the biggest health problems of the 21st century. In fact, type 1 and type 2 diabetes (T1D and T2D), gestational diabetes (GDM) and related complications are excellent disease models to study the utility of PRS for predicting heterogenous and complex health outcomes in a setting where differences in access to healthcare exist. Not only are PRS useful to predict T1D and T2D, but they can distinguish between T1D and T2D, and between T2D subtypes. The wealth of existing GWAS data from diabetes subtypes, complications, and quantitative traits recently generated provides a unique opportunity for constructing highly transferable PRS across populations. To address the differences in accuracy in PRS across ancestries, we have assembled a multi-disciplinary team to aggregate and analyze the largest existing genetic data from more than 1.8 M individuals (49% non-European) with T1D, T2D, GDM and glycemia-related complications and quantitative traits to improve the PRS prediction of diabetes and progression across lifespan in multiple ancestries with these Aims: (1) Collection, harmonization and integration of large-scale, multi-ancestry cohorts with diabetes traits across the life-span and genomics for development, training and testing PRS for multiple ancestries; (2) Development of methods to improve PRS prediction in non-European populations by using Bayesian approaches that allow integration of linkage disequilibrium and summary statistics from several ancestries. (3) Development, testing, and comparing performance of PRS for each trait, development of risk prediction tools that integrate clinical and genetic risk factors, and assessment of scenarios where PRS improve the prediction. Accomplishing the aims of this proposal will demonstrate how genomic data can inform more efficient and targeted preventive strategies within healthcare systems and across multiple populations. Findings are expected to advance precision care of patients with diabetes and related conditions in people of multiple ancestral backgrounds and serve as a paradigm for many other complex diseases.
Grant Summary
Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries is a NHGRI - National Human Genome Research Institute grant providing up to $876K for university, nonprofit, healthcare org. Applications are due 2027-03-31 (open). Check eligibility and apply with FindGrants.
Not quite the right fit?
Search 9,000+ open grants, or get matches ranked for your organization — free.
Focus Areas
Eligibility
How to Apply
Up to $876K
2027-03-31
- 1Confirm your organization is eligible for Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries from NHGRI - National Human Genome Research Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NHGRI - National Human Genome Research Institute before the deadline.
Don't want to draft it yourself?
We'll draft the complete application against NHGRI - National Human Genome Research Institute's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
AI Requirement Analysis
Detailed requirements not yet analyzed
Have the NOFO? Paste it below for AI-powered requirement analysis.
Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries: Frequently Asked Questions
Who is eligible for the Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries?
Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries is offered by NHGRI - National Human Genome Research Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries provide?
Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries provides up to $876K per award from NHGRI - National Human Genome Research Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries deadline?
Applications for Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries are due 2027-03-31 (open). Because deadlines can change, verify the date with the funder, NHGRI - National Human Genome Research Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries?
To apply for Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple Ancestries, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NHGRI - National Human Genome Research Institute.