Enabling improved applicability and transferability of polygenic scores across populations
About This Grant
Abstract The Polygenic Risk Methods Development (PRIMED) Consortium was established to harmonize large-scale genomic and phenotypic data and advance methodological innovation to improve polygenic risk scores (PRS). Within the scope of the PRIMED Consortium, the parent award: Functional and Fine-Mapping Approach to Improve Responsible Risk-modeling of Polygenic Risk Scores (FFAIRR-PRS, U01HG011719) aimed to harmonize and aggregate individual-level data across populations, to share analytic workflows and new statistical genetics frameworks, and to validate these approaches for enhanced polygenic score development, generalizability, and clinical translation. To that end, our team has developed new methods with requisite validation advancing new generalizable frameworks for polygenic risk scoring that have already translated to clinical adoption. Based on these new frameworks and consortium-wide learnings, the goal of this administrative supplement is to complete several ongoing high-impact consortium-wide and site-specific activities that will not yet be finalized within the current project period toward maximal impact for PRIMED. Our research team combines strengths in cardiovascular medicine, statistical genetics, and high throughput genetics and genomics. In Aim 1, we will combine existing PRS from the PGS Catalog using the PRSmix method to enhance cross-trait prediction accuracy and stability and will examine the scale of risk estimation and contextualization effects to optimize fairness in trait-specific PRS modeling across contexts. In Aim 2, we will finalize and disseminate new methodological frameworks, including integrative approaches that involve individual-specific trajectories and rare variant modeling. In Aim 3, we will extend benchmarking and integrative risk modeling efforts across key traits to improve clinical translation. Completion of our aims will further advance PRS accuracy and generalizability and enable methodological advances. We will integrate our learnings to both describe the current state of the field but also provide granular guidance regarding clinical translation and communication with patients.
Grant Summary
Enabling improved applicability and transferability of polygenic scores across populations is a NHGRI - National Human Genome Research Institute grant providing up to $536K for university, nonprofit, healthcare org. Applications are due 2027-03-31 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $536K
2027-03-31
- 1Confirm your organization is eligible for Enabling improved applicability and transferability of polygenic scores across populations from NHGRI - National Human Genome Research Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
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Enabling improved applicability and transferability of polygenic scores across populations: Frequently Asked Questions
Who is eligible for the Enabling improved applicability and transferability of polygenic scores across populations?
Enabling improved applicability and transferability of polygenic scores across populations is offered by NHGRI - National Human Genome Research Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Enabling improved applicability and transferability of polygenic scores across populations provide?
Enabling improved applicability and transferability of polygenic scores across populations provides up to $536K per award from NHGRI - National Human Genome Research Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Enabling improved applicability and transferability of polygenic scores across populations deadline?
Applications for Enabling improved applicability and transferability of polygenic scores across populations are due 2027-03-31 (open). Because deadlines can change, verify the date with the funder, NHGRI - National Human Genome Research Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Enabling improved applicability and transferability of polygenic scores across populations?
To apply for Enabling improved applicability and transferability of polygenic scores across populations, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NHGRI - National Human Genome Research Institute.