EHR-based Genome-Informed Risk Assessment and Communication
About This Grant
PROJECT SUMMARY/ABSTRACT Genomic sequencing has been rapidly integrated into research and clinical care for common chronic diseases, yet robust evidence remains limited on how genome-informed risk information affects health planning and behaviors and short-term or long-term health outcomes. Returning such information to patients and providers promises to enable earlier, targeted screening, risk-reducing interventions, and tailored disease management. However, if implemented poorly, it can introduce confusion, anxiety, and unnecessary testing. Health systems, providers, payers, and professional societies are being asked to decide which genomic findings to return, how to communicate results, how to check risk updates, and how to support follow- up care—often without real-world outcomes data to guide those decisions. In addition, the rapid pace of advances in genomic analyses presents new translational challenges, which have not been adequately studied in the context of genome informed risks for common chronic diseases that place substantial burdens on individuals, healthcare systems, and society. This proposed research will fill these gaps. As an eMERGE IV site, we have previously developed and validated methods for comprehensive Genome-Informed Risk Assessment (GIRA) for 10 common complex diseases; led risk prediction efforts for two phenotypes (i.e., breast cancer and chronic kidney disease); recruited and returned GIRA risk to 2,536 participants at the Columbia Site; and led the network effort to develop patient- and clinician-facing education, return of results approaches, and ELSI work to consider impacts of GIRAs on patient behaviors and follow up care. We also established standardized and portable clinical decision support infrastructure and data flows in the EHR to support tailored return of GIRA reports. For the 1-year supplement, we proposed to use the time to complete the following activities of the project: (1) Continue the extraction and evaluation of the key study outcome— uptake of pre-specified care recommendations across the ten eMERGE-IV conditions; (2) Assess the impact of GIRA return on multiple condition-specific outcomes, including diagnosis of disease, initiation or intensification of care, and clinical outcomes among high-risk vs. not high-risk participants; and (3) Test the performance of updated genome informed risks compared to legacy risk scores and assess risk status re- classification using in-silico analysis of the eMERGE-IV cohort. Our proposed study will address critical knowledge gaps in the clinical translation of genome-informed risk scores and improve our methods for longitudinal outcome extraction from the EHR and for genetic risk stratification.
Grant Summary
EHR-based Genome-Informed Risk Assessment and Communication is a NHGRI - National Human Genome Research Institute grant providing up to $935K for university, nonprofit, healthcare org. Applications are due 2027-04-30 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $935K
2027-04-30
- 1Confirm your organization is eligible for EHR-based Genome-Informed Risk Assessment and Communication from NHGRI - National Human Genome Research Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NHGRI - National Human Genome Research Institute before the deadline.
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EHR-based Genome-Informed Risk Assessment and Communication: Frequently Asked Questions
Who is eligible for the EHR-based Genome-Informed Risk Assessment and Communication?
EHR-based Genome-Informed Risk Assessment and Communication is offered by NHGRI - National Human Genome Research Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the EHR-based Genome-Informed Risk Assessment and Communication provide?
EHR-based Genome-Informed Risk Assessment and Communication provides up to $935K per award from NHGRI - National Human Genome Research Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the EHR-based Genome-Informed Risk Assessment and Communication deadline?
Applications for EHR-based Genome-Informed Risk Assessment and Communication are due 2027-04-30 (open). Because deadlines can change, verify the date with the funder, NHGRI - National Human Genome Research Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the EHR-based Genome-Informed Risk Assessment and Communication?
To apply for EHR-based Genome-Informed Risk Assessment and Communication, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NHGRI - National Human Genome Research Institute.