Center for Virtual Imaging Trial - Accelerated Validation Supplement

About This Grant

ABSTRACT The Center for Virtual Imaging Trials (CVIT) serves as a premier national resource for in silico imaging research, providing advanced computational phantoms, physics-based imaging simulators, and AI development tools to support hundreds of users across academia, industry, and regulatory agencies. Virtual imaging trials (VITs) enable efficient, rigorous evaluation of imaging technologies and protocols under controlled conditions with known ground truth, offering a powerful complement to traditional clinical trials. Maintaining this capability is critical for advancing diagnostic innovation, regulatory science, and precision medicine. This administrative supplement provides essential gap funding to sustain CVIT operations during a transition period and to launch key advancements aligned with the Center’s original aims. These initiatives, which address high-priority needs identified by the community, represent the first steps toward the next renewal phase and focus on three areas of biologically realistic lesion modeling (a sub-aim from the anticipated TRD1 renewal), integrated PET-CT simulation (a sub-aim from the anticipated TRD2 renewal), and hybrid AI training resources (a sub-aim from the anticipated TRD3 renewal). Collectively, these efforts will sustain critical CVIT infrastructure while delivering tangible scientific advances that expand its capabilities, enhance translational relevance, and position the Center for its next phase of innovation. The proposed developments will ensure continued national access and leadership in simulation- based imaging research and accelerate the development and evaluation of imaging technologies and AI tools.