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View full policyAdvancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models
About This Grant
Project Summary/Abstract Cardiac disease remains the leading cause of mortality, yet existing models fail to capture the complexity necessary for effective therapeutic development. COIN (Cardiac Organoids in Niches) integrates in silico, in chemico, and in vitro methodologies to engineer patient-specific cardiac niches, enhancing disease fidelity and therapeutic screening. By leveraging AI-driven modeling, biomaterials engineering, and multi-omics analysis, COIN establishes a scalable, reproducible NAMs platform for disease modeling and drug discovery. COIN’s AI- powered niche design tailors cardiac microenvironments to genetic, sex, and age profiles, improving disease relevance and therapeutic predictability. Innovations in biomaterials engineering refine extracellular matrix (ECM) properties to replicate human cardiac physiology, while organoid villages enhance translational accuracy. Multi- scale validation ensures COIN models faithfully reproduce patient-specific disease phenotypes, supporting regulatory qualification and preclinical safety assessment. COIN collaborates with the VQN to establish regulatory validation benchmarks and with the NDHCC to facilitate FAIR-compliant multi-omics data-sharing. Supported by the nation’s largest academic iPSC biobank and the Stanford Center for Genomics and Personalized Medicine, COIN unites leading experts in bioinformatics, AI, biomaterials, and organoid engineering to develop standardized, regulatory-ready NAMs models. Comprehensive technical characterization ensures functional validation, disease fidelity, and industry readiness. Training and outreach initiatives drive interdisciplinary collaboration and workforce development, fostering broad industry adoption. By integrating multi-scale modeling, high-throughput biomaterials engineering, and AI-driven analytics, COIN reduces reliance on animal models, advances precision drug discovery, and establishes a gold-standard NAMs platform for cardiac medicine.
Grant Summary
Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models is a OD - NIH Office of the Director grant providing up to $3.1M for university, nonprofit, healthcare org. Applications are due 2030-12-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $3.1M
2030-12-31
- 1Confirm your organization is eligible for Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models from OD - NIH Office of the Director, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to OD - NIH Office of the Director before the deadline.
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Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models: Frequently Asked Questions
Who is eligible for the Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models?
Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models is offered by OD - NIH Office of the Director and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models provide?
Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models provides up to $3.1M per award from OD - NIH Office of the Director. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models deadline?
Applications for Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models are due 2030-12-31 (open). Because deadlines can change, verify the date with the funder, OD - NIH Office of the Director, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models?
To apply for Advancing Personalized Cardiac Organoids - Converging In Vitro, In Chemico, and In Silico Models, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from OD - NIH Office of the Director.