1/2 Self-directed mobile mindfulness to address ICU survivors' psychological distress: the Lift RCT
NCCIH - National Center for Complementary and Integrative Health
About This Grant
Cardiorespiratory conditions such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis are among the most common causes of mortality and morbidity. They are also notable for high rates of persistent psychological distress symptoms including depression, anxiety, and PTSD that worsen quality of life and outcomes of the underlying conditions. Yet there are few effective strategies able to overcome barriers of limited access to mental health care. To address this gap, we developed Lift, a completely automated and self-directed mindfulness training intervention, from the ground up with patient input. First, Lift reduced depression symptoms and improved quality of life compared to an education program control in a multicenter pilot RCT (R34 AT008819) among those recently hospitalized with serious cardiorespiratory conditions. Next, a 247-person multicenter 2x2x2 factorial optimization trial (U01 AT00974) compared 8 intervention versions differing by program introduction (app vs. therapist), dose (standard vs. high), and approach to in-the-moment symptom management (app vs. therapist). This trial demonstrated that while all versions had a strong effect on depression, anxiety, and PTSD symptoms, the high dose, app-only version was optimized for effect, adherence, and retention. Given these promising findings, a formal test of the optimized Lift mobile mindfulness intervention’s efficacy is needed. Therefore, we propose a 4-site multicenter RCT with 6-month follow up among 450 cardiorespiratory failure survivors with elevated post-discharge symptoms of psychological distress. Our specific aims will: (1) Test Lift vs. an education program control delivered by similar platforms on symptoms of depression, anxiety, PTSD, and quality of life; (2a) Determine patient-level characteristics associated with a greater treatment response among a priori-defined subgroups using a heterogeneity of treatment effects analysis; (2b) Explore novel adherence metrics and outcomes; and (3) Ensure off-the-shelf intervention readiness with an exploratory mixed-methods hybrid type 1 implementation framework analysis that integrates quantitative trial implementation data with semi-structured trial participant interviews. Innovative and unique elements include a fully automated mobile health delivery system that personalizes content in response to changes in symptom trajectories, a focus on enrolling a population representative of the US, and strong community engagement with formalized roles. This project addresses national research priorities and could advance the field with a personalizable yet population-scalable therapy that has the potential to broadly improve mental health access.
Grant Summary
1/2 Self-directed mobile mindfulness to address ICU survivors' psychological distress: the Lift RCT is a NCCIH - National Center for Complementary and Integrative Health grant providing up to $989K for university, nonprofit, healthcare org. Applications are due 2027-03-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $989K
2027-03-31
- 1Confirm your organization is eligible for 1/2 Self-directed mobile mindfulness to address ICU survivors' psychological distress: the Lift RCT from NCCIH - National Center for Complementary and Integrative Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NCCIH - National Center for Complementary and Integrative Health before the deadline.
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1/2 Self-directed mobile mindfulness to address ICU survivors' psychological distress: the Lift RCT: Frequently Asked Questions
Who is eligible for the 1/2 Self-directed mobile mindfulness to address ICU survivors' psychological distress: the Lift RCT?
1/2 Self-directed mobile mindfulness to address ICU survivors' psychological distress: the Lift RCT is offered by NCCIH - National Center for Complementary and Integrative Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the 1/2 Self-directed mobile mindfulness to address ICU survivors' psychological distress: the Lift RCT provide?
1/2 Self-directed mobile mindfulness to address ICU survivors' psychological distress: the Lift RCT provides up to $989K per award from NCCIH - National Center for Complementary and Integrative Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the 1/2 Self-directed mobile mindfulness to address ICU survivors' psychological distress: the Lift RCT deadline?
Applications for 1/2 Self-directed mobile mindfulness to address ICU survivors' psychological distress: the Lift RCT are due 2027-03-31 (open). Because deadlines can change, verify the date with the funder, NCCIH - National Center for Complementary and Integrative Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the 1/2 Self-directed mobile mindfulness to address ICU survivors' psychological distress: the Lift RCT?
To apply for 1/2 Self-directed mobile mindfulness to address ICU survivors' psychological distress: the Lift RCT, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NCCIH - National Center for Complementary and Integrative Health.