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About This Grant
We request funds to acquire a state-of-the-art microGRID-MALDI2-timsTOF fleX imaging mass spectrometer from Bruker Daltonics to establish the Center for Single-Cell and Spatial Metabolomics & Multi-Omics (S²M²) at the University of California San Diego (UCSD). This new Center, led by a recently recruited expert in imaging mass spectrometry, will address a critical gap in lacking high-resolution spatial metabolomics infrastructure at UCSD, in San Diego, and across Southern California, and will be the first shared facility in the United States offering single-cell metabolomics. The requested instrument enables high-sensitivity, high-throughput mass spectrometry imaging at the single-cell spatial resolution, powered by MALDI-2 post-ionization, Trapped Ion Mobility Spectrometry (TIMS), and microGRID laser optics. These capabilities are essential for meeting the growing demand for spatial and single-cell omics, particularly in studies of metabolism, which is increasingly recognized as a key driver of cell identity, immune function, and disease progression. The instrument will catalyze NIH-funded research in cancer biology, aging, developmental biology, infectious diseases, drug metabolism, and tissue regeneration. The Center will leverage METASPACE, an open-source cloud platform for metabolite annotation and spatial data interpretation developed by the PI’s team and used by over 4000 scientists worldwide. By combining cutting-edge instrumentation with intuitive, accessible software, S²M² will provide a seamless workflow for biologists and clinicians, dramatically reducing the technical barrier to high-resolution spatial metabolomics. The PI brings extensive experience in directing centers, having previously founded and led two shared facilities for metabolomics and imaging mass spectrometry in Europe. With strong institutional support, a strong enthusiasm among UCSD scientists, high-end equipment, and unique software, the S²M² Center is positioned to become a regional and national leader in single-cell metabolomics. The instrument will be housed in a dedicated, fully equipped laboratory in the Biomedical Sciences Building and operated under a financially sustainable, service-oriented model. This investment will have immediate and lasting impact by enabling next-generation spatial metabolomics at UC San Diego and establishing a unique national resource for spatial and single-cell analysis in biomedical research.
Grant Summary
microGRID-MALDI2-timsTOF fleX mass spectrometry imaging system is a OD - NIH Office of the Director grant providing up to $1.8M for university, nonprofit, healthcare org. Applications are due 2027-06-14 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $1.8M
2027-06-14
- 1Confirm your organization is eligible for microGRID-MALDI2-timsTOF fleX mass spectrometry imaging system from OD - NIH Office of the Director, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to OD - NIH Office of the Director before the deadline.
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microGRID-MALDI2-timsTOF fleX mass spectrometry imaging system: Frequently Asked Questions
Who is eligible for the microGRID-MALDI2-timsTOF fleX mass spectrometry imaging system?
microGRID-MALDI2-timsTOF fleX mass spectrometry imaging system is offered by OD - NIH Office of the Director and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the microGRID-MALDI2-timsTOF fleX mass spectrometry imaging system provide?
microGRID-MALDI2-timsTOF fleX mass spectrometry imaging system provides up to $1.8M per award from OD - NIH Office of the Director. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the microGRID-MALDI2-timsTOF fleX mass spectrometry imaging system deadline?
Applications for microGRID-MALDI2-timsTOF fleX mass spectrometry imaging system are due 2027-06-14 (open). Because deadlines can change, verify the date with the funder, OD - NIH Office of the Director, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the microGRID-MALDI2-timsTOF fleX mass spectrometry imaging system?
To apply for microGRID-MALDI2-timsTOF fleX mass spectrometry imaging system, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from OD - NIH Office of the Director.