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View full policyAcquisition of an Orbitrap Astral Mass Spectrometer System for Proteomics and Metabolomics Facility of Cornell University
About This Grant
Advanced mass spectrometry (MS) technologies unlock exceptional opportunities towards transformative applications and groundbreaking discoveries for life science research. We are requesting funding to purchase the latest Orbitrap Astral mass spectrometer interfaced with a Vanquish Neo ultra-high-performance liquid chromatography system from Thermo Fisher Scientific. This state-of-the-art system will be housed, operated and maintained in the Proteomics and Metabolomics Facility (PMF) at the Cornell University Biotechnology Resource Center (BRC). The BRC will provide administrative support to the PMF team with a proven track-record in managing shared resources for the biomedical and life science research community. Implementation of the instrument in the BRC as a university-wide shared research resource will enable cost-effective and flexible access to this vital technology for a broad range of NIH-funded research. There is a growing demand for proteomics and metabolomics applications at Cornell, as observed by the continuous growth in the number of facility users and processed samples by the facility over the past decade, and evidenced by the recently founded Center for Innovative Proteomics (CIP), which promotes campus-wide collaboration to develop cutting-edge proteomics methodologies for research. The proposed Orbitrap Astral system will replace the aging Orbitrap Fusion instrument, offering new capabilities as no such instrument is available across all Cornell campuses. It will also expand the capacity and capabilities of the facility on the existing instrumentation, which is currently utilized at near full capacity. The need for the increased performance and capacity is particularly critical with respect to applications involving analysis of complex samples with limited sample input (e.g. single-cell proteomics and affinity-enriched samples) for many NIH-funded projects, which require fast scan speed, ultra-high sensitivity and resolution, and highly accurate mass measurements. The requested instrument provides >5 orders of magnitude dynamic range, enabling confident identification of peptides from low abundance proteins and low stoichiometry modifications in complex samples. It will uniquely leverage the PMF’s and CIP’s expertise to support proteomics discovery studies at the single-cell level by developing and implementing high-throughput single-cell and spatial proteomics technologies, enabling Cornell PIs to propose and competitively undertake new research projects that are currently not feasible with our existing instrumentation. The BRC PMF has extensive experience in running LC-MS instruments and providing MS solutions to effectively advance research. The proposed instrument will be readily integrated into the facility’s established proteomics pipelines. Placement of the proposed system in the BRC will enable a large group of NIH-funded investigators to undertake research projects that would not otherwise be economically or technically feasible. This proposal describes 31 projects from 15 NIH-funded investigator groups that will utilize the proposed system. The requested instrument will benefit a wide range of current and future NIH-funded projects and other projects.
Grant Summary
Acquisition of an Orbitrap Astral Mass Spectrometer System for Proteomics and Metabolomics Facility of Cornell University is a OD - NIH Office of the Director grant providing up to $750K for university, nonprofit, healthcare org. Applications are due 2027-06-30 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $750K
2027-06-30
- 1Confirm your organization is eligible for Acquisition of an Orbitrap Astral Mass Spectrometer System for Proteomics and Metabolomics Facility of Cornell University from OD - NIH Office of the Director, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to OD - NIH Office of the Director before the deadline.
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Acquisition of an Orbitrap Astral Mass Spectrometer System for Proteomics and Metabolomics Facility of Cornell University: Frequently Asked Questions
Who is eligible for the Acquisition of an Orbitrap Astral Mass Spectrometer System for Proteomics and Metabolomics Facility of Cornell University?
Acquisition of an Orbitrap Astral Mass Spectrometer System for Proteomics and Metabolomics Facility of Cornell University is offered by OD - NIH Office of the Director and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Acquisition of an Orbitrap Astral Mass Spectrometer System for Proteomics and Metabolomics Facility of Cornell University provide?
Acquisition of an Orbitrap Astral Mass Spectrometer System for Proteomics and Metabolomics Facility of Cornell University provides up to $750K per award from OD - NIH Office of the Director. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Acquisition of an Orbitrap Astral Mass Spectrometer System for Proteomics and Metabolomics Facility of Cornell University deadline?
Applications for Acquisition of an Orbitrap Astral Mass Spectrometer System for Proteomics and Metabolomics Facility of Cornell University are due 2027-06-30 (open). Because deadlines can change, verify the date with the funder, OD - NIH Office of the Director, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Acquisition of an Orbitrap Astral Mass Spectrometer System for Proteomics and Metabolomics Facility of Cornell University?
To apply for Acquisition of an Orbitrap Astral Mass Spectrometer System for Proteomics and Metabolomics Facility of Cornell University, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from OD - NIH Office of the Director.