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Application for a Light Sheet Microscope for Cleared Tissue for the Center for Advanced Microscopy

OD - NIH Office of the Director

open
OpenLast verified: 2026-07-17

About This Grant

Project Summary/Abstract This application is to purchase an AxL Cleared Tissue LightSheet (AxL CTLS) from 3i for imaging of optically cleared samples. The Center for Advanced Microscopy is the only microscopy based core facility on the Chicago Campus and supports approximately 750 users from 300 laboratories annually. The Center for Advanced Microscopy has been supporting light sheet microscopy for 8 years with a Miltenyi UltraMicroscope II system. Light sheet microscopy has been very successfully incorporated into the workflows of many researchers at Northwestern University. Our UltraMicroscope II has been heavily used, but it has reached end-of-life and will no longer be supported by the manufacturer. The instrument is beginning to fail and in the past year we had 4 months of downtime for repairs. We seek to replace this instrument with a new light sheet that has higher resolution, faster speeds and can accommodate a wider range of samples. After testing several systems, we chose the AxL CTLS. Fifteen NIH-funded investigators are Major Users of this instrument and the success of their 26 NIH funded research is dependent on light sheet technology being available at CAM. Their research has a broad range of impacts across basic and applied science fields from fields including surgery, infectious diseases and microbiology, immunology, cardiovascular biology, developmental biology, neurosciences, and nephrology. Acquisition of the AxL CTLS would enhance the research of these investigators and offer improved image capabilities than the current instrument. The AxL CTLS would be a valuable acquisition not only for research carried out at Northwestern University and the Chicago scientific community.

Grant Summary

Application for a Light Sheet Microscope for Cleared Tissue for the Center for Advanced Microscopy is a OD - NIH Office of the Director grant providing up to $437K for university, nonprofit, healthcare org. Applications are due 2027-05-14 (open). Check eligibility and apply with FindGrants.

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Focus Areas

health research

Eligibility

universitynonprofithealthcare org

How to Apply

Funding Range

Up to $437K

Deadline

2027-05-14

Complexity
Medium
  1. 1Confirm your organization is eligible for Application for a Light Sheet Microscope for Cleared Tissue for the Center for Advanced Microscopy from OD - NIH Office of the Director, checking organization type, location, and any population or project requirements.
  2. 2Gather the required documents and information, including your organization details, project plan, and budget figures.
  3. 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
  4. 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to OD - NIH Office of the Director before the deadline.
This record is a past award, contract, or funder profile — useful for research, but not an open grant application. Check the original source for current opportunities from this funder.

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Application for a Light Sheet Microscope for Cleared Tissue for the Center for Advanced Microscopy: Frequently Asked Questions

Who is eligible for the Application for a Light Sheet Microscope for Cleared Tissue for the Center for Advanced Microscopy?

Application for a Light Sheet Microscope for Cleared Tissue for the Center for Advanced Microscopy is offered by OD - NIH Office of the Director and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.

How much funding does the Application for a Light Sheet Microscope for Cleared Tissue for the Center for Advanced Microscopy provide?

Application for a Light Sheet Microscope for Cleared Tissue for the Center for Advanced Microscopy provides up to $437K per award from OD - NIH Office of the Director. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.

When is the Application for a Light Sheet Microscope for Cleared Tissue for the Center for Advanced Microscopy deadline?

Applications for Application for a Light Sheet Microscope for Cleared Tissue for the Center for Advanced Microscopy are due 2027-05-14 (open). Because deadlines can change, verify the date with the funder, OD - NIH Office of the Director, and give yourself enough time to prepare a complete, competitive application before the close date.

How do you apply for the Application for a Light Sheet Microscope for Cleared Tissue for the Center for Advanced Microscopy?

To apply for Application for a Light Sheet Microscope for Cleared Tissue for the Center for Advanced Microscopy, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from OD - NIH Office of the Director.