Contributions of nociceptive nerves in the HSC niche
NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
About This Grant
PROJECT SUMMARY Hematopoietic stem cells (HSCs) reside in specialized microenvironments in the bone marrow (BM) that comprise multiple cellular constituents, including nerves, with vital regulatory functions. Our previous studies established that the nociceptive nervous system is an essential BM niche component controlling HSC mobilization from the bone marrow into the peripheral blood. Our new preliminary resutls reveal that aging is associated with a progressive loss of nociceptive innvervation in the bone marrow, and that supplementaiton of nociceptive nerve-derived CGRP attenuates the expansion and BM HSCs in aged mice, restores their engraftment ability, and reverses the myeloid-biased differentiation. Based on these findings, we hypothesize that nociceptive nerve-derived CGRP is a critical rejuvenating signal for aged HSCs, and that targeted chemogenetic activation of BM nociceptive neurons using DREADDs can be harnessed to reverse HSC aging in vivo. In the Specific Aim 1, we will determine whether CGRP administration reverses bona fide aging hallmarks and identify the downstream molecular programs that mediate this rejuvenation. In Specific Aim 2, we will investigate whether local activation of BM nociceptive neurons using DREADDs rejuvaentes old HSC in vivo. Together, these proposed studies will shed light into the critical functions of an under-appreciated component of the HSC niche and uncover novel therapeutic strategies for age-associated hematopoietic diseases.
Grant Summary
Contributions of nociceptive nerves in the HSC niche is a NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases grant providing up to $250K for university, nonprofit, healthcare org. Applications are due 2027-06-30 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $250K
2027-06-30
- 1Confirm your organization is eligible for Contributions of nociceptive nerves in the HSC niche from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases before the deadline.
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Contributions of nociceptive nerves in the HSC niche: Frequently Asked Questions
Who is eligible for the Contributions of nociceptive nerves in the HSC niche?
Contributions of nociceptive nerves in the HSC niche is offered by NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Contributions of nociceptive nerves in the HSC niche provide?
Contributions of nociceptive nerves in the HSC niche provides up to $250K per award from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Contributions of nociceptive nerves in the HSC niche deadline?
Applications for Contributions of nociceptive nerves in the HSC niche are due 2027-06-30 (open). Because deadlines can change, verify the date with the funder, NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Contributions of nociceptive nerves in the HSC niche?
To apply for Contributions of nociceptive nerves in the HSC niche, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases.