Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury
NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases
About This Grant
PROJECT SUMMARY Chemical vesicants such as sulfur mustard (SM) and nitrogen mustard (NM) act as alkylating agents causing severe skin injuries characterized by blistering, necrosis, and persistent pathology. Both pose significant threats to civilians and warfighters, yet no approved therapeutics exist for managing vesicant-induced skin injuries. This project addresses this critical medical gap by developing innovative multifunctional wound dressings engineered to simultaneously target cell membrane damage, chronic inflammation, and secondary infection—the primary pathological mechanisms underlying vesicant-induced skin trauma. Our therapeutic approach centers on MG53, a TRIM family protein with demonstrated efficacy in cell membrane repair and wound healing. Beyond its membrane-protective functions, MG53 enhances regenerative capacity in diabetic wounds by revitalizing hair follicle stem cell activity and exerts potent anti-inflammatory effects through NF-κB pathway modulation. Building on these mechanistic insights, we will develop transformative wound dressings that integrate a novel rapid-gelling antimicrobial hydrogel with recombinant human MG53 (rhMG53) protein. We hypothesize that this synergistic combination will dramatically accelerate wound healing and tissue regeneration following chemical vesicant exposure. The goal of this project is to engineer and optimize multifunctional wound dressings combining rapid-gelation antimicrobial hydrogel technology with rhMG53 protein for vesicant-induced cutaneous injuries. Successful completion will yield breakthrough multifunctional wound dressings with integrated tissue repair, anti-inflammatory, and antimicrobial capabilities. These shelf-stable therapeutic platforms can be strategically stockpiled and rapidly deployed as essential medical countermeasures against chemical vesicant exposure, addressing both immediate clinical needs and national security preparedness requirements.
Grant Summary
Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury is a NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases grant providing up to $387K for university, nonprofit, healthcare org. Applications are due 2027-05-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $387K
2027-05-31
- 1Confirm your organization is eligible for Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury from NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases before the deadline.
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Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury: Frequently Asked Questions
Who is eligible for the Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury?
Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury is offered by NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury provide?
Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury provides up to $387K per award from NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury deadline?
Applications for Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury are due 2027-05-31 (open). Because deadlines can change, verify the date with the funder, NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury?
To apply for Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases.