Profiles of Composite Medication Adherence Trajectories in Older Patients with HIV and Multiple Chronic Conditions: A Mixed Methods Study
About This Grant
Project Summary As life expectancy increases in people living with HIV (PLWH), the probability of developing other chronic conditions such as type 2 diabetes (T2DM), hypertension, and cardiovascular disease also increases. PLWH live longer, develop multiple chronic conditions (MCCs), and experience polypharmacy, reinforcing a need to evaluate composite medication adherence across all chronic medications. Suboptimal medication adherence to essential treatments may limit treatment effectiveness, shorten survival, decrease overall population health, and increase health-system costs. Positioned at the nexus of therapeutic intent and success, medication adherence is influenced by myriad system, provider, and person-related factors that cannot be evaluated using claims-based studies alone. Therefore, the overarching goal of this research is to identify a taxonomy of composite medication adherence trajectories (MATs) over a 36-month observation period in older (50-99 years of age) PLWH and MCCs. The taxonomies will inform future research involving development and testing of comprehensive medication adherence interventions and clinical decision support strategies with the highest probability to positively impact medication adherence-related clinical outcomes in older PLWH and MCCs. We propose a mixed-methods explanatory sequential design by combining group-based trajectory modeling (GBTM) of medication refill data followed by 75 semi-structured interviews to fully understand the clinical, social, behavioral, cultural, structural, and economic perspectives that may influence medication adherence decision-making in PLWH and MCCs (i.e., T2DM, hypertension, and/or hyperlipidemia). We propose the following aims: 1. Apply group-based trajectory modeling of medication refill data to identify dynamic profiles of medication adherence behavior over time for older PLWH and MCCs. 2. Use qualitative, semi-structured interviews of older PLWH and MCCs to obtain in-depth understanding of social, behavioral, cultural, structural, and economic perspectives that align with each MAT profile. In contrast to disease-specific (intra-disease), dichotomous summary measures focused on antiretroviral therapy alone, this study uniquely identifies longitudinal MATs across MCCs (inter-disease). Qualitative assessment of lived medication use experiences and array of social, behavioral, cultural, structural, and economic perspectives contributing to MAT profiles advances understanding of needs for PLWH and MCCs to inform optimal, tailored interventions for unique MATs unachievable with claims-only studies.
Grant Summary
Profiles of Composite Medication Adherence Trajectories in Older Patients with HIV and Multiple Chronic Conditions: A Mixed Methods Study is a NIMH - National Institute of Mental Health grant providing up to $418K for university, nonprofit, healthcare org. Applications are due 2028-02-29 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $418K
2028-02-29
- 1Confirm your organization is eligible for Profiles of Composite Medication Adherence Trajectories in Older Patients with HIV and Multiple Chronic Conditions: A Mixed Methods Study from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Profiles of Composite Medication Adherence Trajectories in Older Patients with HIV and Multiple Chronic Conditions: A Mixed Methods Study: Frequently Asked Questions
Who is eligible for the Profiles of Composite Medication Adherence Trajectories in Older Patients with HIV and Multiple Chronic Conditions: A Mixed Methods Study?
Profiles of Composite Medication Adherence Trajectories in Older Patients with HIV and Multiple Chronic Conditions: A Mixed Methods Study is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Profiles of Composite Medication Adherence Trajectories in Older Patients with HIV and Multiple Chronic Conditions: A Mixed Methods Study provide?
Profiles of Composite Medication Adherence Trajectories in Older Patients with HIV and Multiple Chronic Conditions: A Mixed Methods Study provides up to $418K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Profiles of Composite Medication Adherence Trajectories in Older Patients with HIV and Multiple Chronic Conditions: A Mixed Methods Study deadline?
Applications for Profiles of Composite Medication Adherence Trajectories in Older Patients with HIV and Multiple Chronic Conditions: A Mixed Methods Study are due 2028-02-29 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Profiles of Composite Medication Adherence Trajectories in Older Patients with HIV and Multiple Chronic Conditions: A Mixed Methods Study?
To apply for Profiles of Composite Medication Adherence Trajectories in Older Patients with HIV and Multiple Chronic Conditions: A Mixed Methods Study, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.