Retinoic acid signaling and uterine epithelial cell fate
NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development
About This Grant
Project Summary The mammalian female reproductive tract (FRT), consisting of the oviducts, uterus, cervix and vagina, is essential for pregnancy establishment and a frequent site of human disease, including infertility and cancer. The embryonic origin of FRT is the Müllerian ducts, a pair of epithelial tubes with a surrounding mesenchyme. Once formed, the Müllerian duct regionally divides into segments along the anterior- posterior axis with each segment developing into distinct structure (oviduct, uterus, cervix and upper vagina). Classical tissue recombination experiments have shown that the Müllerian duct epithelial cell fate determination along the anterior-posterior axis is mediated by signals from the underlying stroma and retinoic acid (RA) signaling has been proposed to be the stromal cue for uterine epithelial cell fate determination. Despite advances in the molecular understanding of MDE specification during FRT development, there remains a striking knowledge gap in our understanding of how adult uterine cell fate is maintained. Recently a group of uterine epithelial cells at the intersection of luminal and glandular epithelium has been proposed to be a uterine stem cell population capable of differentiating into either luminal or glandular cells. However, little is known how these stem/progenitor cells acquire and maintain uterine cell fate and whether stromal signals are required for their specification. Our preliminary studies provide strong genetic data supporting the idea that RA signaling is continually required to maintain uterine epithelial cell fate during adult uterine homeostasis. In addition, our data suggest a model in which an antagonistic relationship between RA and estrogen signaling regulates Müllerian duct epithelial cytodifferentiation. These hypotheses will be tested in two aims. Aim 1 will examine the cell-autonomous function of retinoic acid receptors in FRT development and in adult uterine cell fate determination. Aim 2 will test the hypothesis that an RA-estrogen antagonism drives FRT cell fate determination both in mouse and in human. Successful completion of these studies may provide novel insights into female infertility and uterine cancer as a result of signaling imbalance between RA and estrogen, which could have a long-lasting impact in multiple research fields including development, fertility and cancer research.
Grant Summary
Retinoic acid signaling and uterine epithelial cell fate is a NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development grant providing up to $428K for university, nonprofit, healthcare org. Applications are due 2028-05-31 (open). Check eligibility and apply with FindGrants.
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Up to $428K
2028-05-31
- 1Confirm your organization is eligible for Retinoic acid signaling and uterine epithelial cell fate from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development before the deadline.
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Retinoic acid signaling and uterine epithelial cell fate: Frequently Asked Questions
Who is eligible for the Retinoic acid signaling and uterine epithelial cell fate?
Retinoic acid signaling and uterine epithelial cell fate is offered by NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Retinoic acid signaling and uterine epithelial cell fate provide?
Retinoic acid signaling and uterine epithelial cell fate provides up to $428K per award from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Retinoic acid signaling and uterine epithelial cell fate deadline?
Applications for Retinoic acid signaling and uterine epithelial cell fate are due 2028-05-31 (open). Because deadlines can change, verify the date with the funder, NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Retinoic acid signaling and uterine epithelial cell fate?
To apply for Retinoic acid signaling and uterine epithelial cell fate, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development.