PHAGE IMMUNOPRECIPITATION SEQUENCING (PhIP-SEQ) TO IDENTIFY AUTOANTIBODIES FROM PARTICIPANTS FROM THE SJÖGREN’S INTERNATIONAL COLLABORATIVE CLINICAL ALLIANCE (SICCA)
About This Grant
PROJECT SUMMARY/ABSTRACT Our research aims to advance the understanding and diagnosis of Sjögren’s Disease, particularly its manifestation as dry eye disease (DED), which disproportionately affects women. By refining diagnostic capabilities, we intend to facilitate earlier detection and better therapeutic strategies, which could potentially improve patient outcomes and quality of life. We will utilize a comprehensive human proteome-wide programmable phage display to pinpoint autoantigen targets in tears collected at baseline from participants of the Sjögren’s International Collaborative Clinical Alliance (SICCA). By employing phage immunoprecipitation sequencing (PhIP-Seq), which integrates oligonucleotide library synthesis for encoding peptides in bacteriophages with high-throughput sequencing, to profile the entire antibody repertoire in tear samples. This technique allows for the high-resolution identification of autoantigens associated with Sjögren’s Disease, particularly focusing on distinguish Sjögren’s Disease from other causes of DED, especially female patients. We will also assess the persistence of specific autoantibodies identified at baseline in follow-up samples collected two years later from the SICCA cohort. This cohort includes over 700 participants with baseline and follow-up tear samples collected via Schirmer strips.
Grant Summary
PHAGE IMMUNOPRECIPITATION SEQUENCING (PhIP-SEQ) TO IDENTIFY AUTOANTIBODIES FROM PARTICIPANTS FROM THE SJÖGREN’S INTERNATIONAL COLLABORATIVE CLINICAL ALLIANCE (SICCA) is a NEI - National Eye Institute grant providing up to $451K for university, nonprofit, healthcare org. Applications are due 2028-03-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $451K
2028-03-31
- 1Confirm your organization is eligible for PHAGE IMMUNOPRECIPITATION SEQUENCING (PhIP-SEQ) TO IDENTIFY AUTOANTIBODIES FROM PARTICIPANTS FROM THE SJÖGREN’S INTERNATIONAL COLLABORATIVE CLINICAL ALLIANCE (SICCA) from NEI - National Eye Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NEI - National Eye Institute before the deadline.
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PHAGE IMMUNOPRECIPITATION SEQUENCING (PhIP-SEQ) TO IDENTIFY AUTOANTIBODIES FROM PARTICIPANTS FROM THE SJÖGREN’S INTERNATIONAL COLLABORATIVE CLINICAL ALLIANCE (SICCA): Frequently Asked Questions
Who is eligible for the PHAGE IMMUNOPRECIPITATION SEQUENCING (PhIP-SEQ) TO IDENTIFY AUTOANTIBODIES FROM PARTICIPANTS FROM THE SJÖGREN’S INTERNATIONAL COLLABORATIVE CLINICAL ALLIANCE (SICCA)?
PHAGE IMMUNOPRECIPITATION SEQUENCING (PhIP-SEQ) TO IDENTIFY AUTOANTIBODIES FROM PARTICIPANTS FROM THE SJÖGREN’S INTERNATIONAL COLLABORATIVE CLINICAL ALLIANCE (SICCA) is offered by NEI - National Eye Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the PHAGE IMMUNOPRECIPITATION SEQUENCING (PhIP-SEQ) TO IDENTIFY AUTOANTIBODIES FROM PARTICIPANTS FROM THE SJÖGREN’S INTERNATIONAL COLLABORATIVE CLINICAL ALLIANCE (SICCA) provide?
PHAGE IMMUNOPRECIPITATION SEQUENCING (PhIP-SEQ) TO IDENTIFY AUTOANTIBODIES FROM PARTICIPANTS FROM THE SJÖGREN’S INTERNATIONAL COLLABORATIVE CLINICAL ALLIANCE (SICCA) provides up to $451K per award from NEI - National Eye Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the PHAGE IMMUNOPRECIPITATION SEQUENCING (PhIP-SEQ) TO IDENTIFY AUTOANTIBODIES FROM PARTICIPANTS FROM THE SJÖGREN’S INTERNATIONAL COLLABORATIVE CLINICAL ALLIANCE (SICCA) deadline?
Applications for PHAGE IMMUNOPRECIPITATION SEQUENCING (PhIP-SEQ) TO IDENTIFY AUTOANTIBODIES FROM PARTICIPANTS FROM THE SJÖGREN’S INTERNATIONAL COLLABORATIVE CLINICAL ALLIANCE (SICCA) are due 2028-03-31 (open). Because deadlines can change, verify the date with the funder, NEI - National Eye Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the PHAGE IMMUNOPRECIPITATION SEQUENCING (PhIP-SEQ) TO IDENTIFY AUTOANTIBODIES FROM PARTICIPANTS FROM THE SJÖGREN’S INTERNATIONAL COLLABORATIVE CLINICAL ALLIANCE (SICCA)?
To apply for PHAGE IMMUNOPRECIPITATION SEQUENCING (PhIP-SEQ) TO IDENTIFY AUTOANTIBODIES FROM PARTICIPANTS FROM THE SJÖGREN’S INTERNATIONAL COLLABORATIVE CLINICAL ALLIANCE (SICCA), confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NEI - National Eye Institute.