Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery
NIBIB - National Institute of Biomedical Imaging and Bioengineering
About This Grant
Significance. Neonates and infants undergoing cardiac surgery face a high risk of postoperative hemodynamic instability, leading to low cardiac output syndrome (LCOS), graft failure, and severe hemodynamic compromise, with mortality rates reaching 50% in transplant cases and 34% for delayed sternal closure (DSC). Despite 40,000 pediatric cardiac surgeries performed annually in the U.S., no real-time, continuous hemodynamic monitoring monitoring solution exists. Current methods are intermittent, indirect, or invasive, making long-term bedside monitoring impractical and delaying early intervention for hemodynamic complications. Objectives. This project aims to develop a disposable wearable ultrasound patch for real-time, noninvasive monitoring of cardiac output and blood pressure in neonates and infants (0–1 year). The ultrasound patch and associated instrumentation and signal processing algorithms will be validated through benchtop experiments and in vivo feasibility will be demonstrated through experiments in an juvenile pig model. Innovation. The proposed project introduces three innovations: (1) a miniaturized disposable ultrasound patch fabricated using additive manufacturing techniques; (2) a novel tunable steering array; and (3) novel signal processing and instrumentation for angle-independent blood velocity and arterial pulse wave velocity assessment. Approach. The disposable ultrasound patch will be fabricated using an innovative one-step laser patterning and 3D printing process. A tunable array will be controlled using stepped frequency modulated continuous wave signals, and the received data will be analyzed using vector Doppler signal processing algorithms. The transducer, instrumentation and signal processing algorithms will be validated against conventional methods for flow and pressure measurements through benchtop acoustic characterization and flow phantom fluid dynamics experiements, and through an in vivo study in an animal model. Impact. By providing a noninvasive continuous hemodynamic monitoring solution, this project has the potential to transform pediatric cardiovascular care by enabling early complication detection, reducing invasive procedures, and improving surgical outcomes. The probe’s innovations extend to vascular and transplant surgeries, where continuous graft perfusion monitoring is critical. Additionally, the pediatric phantom model will serve as a standardized platform for testing next-generation ultrasound-based diagnostic tools. By advancing real-time, noninvasive hemodynamic monitoring, this project supports the NIH’s mission to drive biomedical innovation and improve healthcare outcomes, accelerating the clinical translation of bioelectronic solutions for both pediatric and adult cardiovascular care.
Grant Summary
Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery is a NIBIB - National Institute of Biomedical Imaging and Bioengineering grant providing up to $265K for university, nonprofit, healthcare org. Applications are due 2028-07-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $265K
2028-07-31
- 1Confirm your organization is eligible for Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery from NIBIB - National Institute of Biomedical Imaging and Bioengineering, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIBIB - National Institute of Biomedical Imaging and Bioengineering before the deadline.
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Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery: Frequently Asked Questions
Who is eligible for the Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery?
Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery is offered by NIBIB - National Institute of Biomedical Imaging and Bioengineering and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery provide?
Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery provides up to $265K per award from NIBIB - National Institute of Biomedical Imaging and Bioengineering. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery deadline?
Applications for Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery are due 2028-07-31 (open). Because deadlines can change, verify the date with the funder, NIBIB - National Institute of Biomedical Imaging and Bioengineering, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery?
To apply for Wearable ultrasound patch for noninvasive hemodynamic monitoring after pediatric cardiac surgery, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIBIB - National Institute of Biomedical Imaging and Bioengineering.