Novel analgesics from plant- and animal associated microorganisms
NCCIH - National Center for Complementary and Integrative Health
About This Grant
PROJECT ABSTRACT Pain is a leading cause of disability and there is an urgent need to develop improved therapeutic approaches for affected individuals. Natural products, or compounds isolated from biological organisms, account for a large fraction of clinically approved drugs. The small molecules produced by bacteria and fungi associated with plants and animals are an especially promising source for new drug leads, since they have exceptional chemical diversity and include a broad range of neuroactive compounds. However, challenges associated with current drug discovery strategies have limited prior efforts to identify novel natural products with pain-relieving or analgesic activity. This project overcomes these obstacles using a strategy that leverages newly developed in vivo assays and advanced imaging methods. A zebrafish-based model for nociceptive pain was established and used to identify plant- and animal- associated microbial metabolites with analgesic activity. Aim 1 of this project will identify the active principle from microbial extracts. Aim 2 will identify the mechanism of action of previously isolated lead compounds using a combination of in vitro assays with mammalian cells, and in vivo recordings of neural activity using zebrafish. This project is led by a multi-disciplinary team with expertise in both natural products drug discovery and systems neuroscience. It will identify and characterize natural products with in vivo analgesic activity, which are critically needed as drug leads and molecular probes for developing improved treatment options for pain.
Grant Summary
Novel analgesics from plant- and animal associated microorganisms is a NCCIH - National Center for Complementary and Integrative Health grant providing up to $422K for university, nonprofit, healthcare org. Applications are due 2028-06-30 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $422K
2028-06-30
- 1Confirm your organization is eligible for Novel analgesics from plant- and animal associated microorganisms from NCCIH - National Center for Complementary and Integrative Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NCCIH - National Center for Complementary and Integrative Health before the deadline.
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Novel analgesics from plant- and animal associated microorganisms: Frequently Asked Questions
Who is eligible for the Novel analgesics from plant- and animal associated microorganisms?
Novel analgesics from plant- and animal associated microorganisms is offered by NCCIH - National Center for Complementary and Integrative Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Novel analgesics from plant- and animal associated microorganisms provide?
Novel analgesics from plant- and animal associated microorganisms provides up to $422K per award from NCCIH - National Center for Complementary and Integrative Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Novel analgesics from plant- and animal associated microorganisms deadline?
Applications for Novel analgesics from plant- and animal associated microorganisms are due 2028-06-30 (open). Because deadlines can change, verify the date with the funder, NCCIH - National Center for Complementary and Integrative Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Novel analgesics from plant- and animal associated microorganisms?
To apply for Novel analgesics from plant- and animal associated microorganisms, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NCCIH - National Center for Complementary and Integrative Health.