A Vessel-on-a-Chip Platform to Study Schistosome Egg-Induced Endothelial Remodeling and Macrophage Polarization
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
PROJECT SUMMARY / ABSTRACT Schistosomiasis affects over 200 million people worldwide and is driven by granulomatous inflammation and fibrotic remodeling in response to schistosome eggs trapped in host tissues. While macrophages are key contributors to this pathology, the role of vascular endothelial cells (VECs)-the first host cells to encounter deposited eggs-remains understudied due to limitations in current models. To address this, we propose a 3D Schistosomal vessel-on-a-chip (Schisto- VoC) platform that mimics key features of the human vascular microenvironment, including physiologic flow, endothelial-macrophage co-culture, and controlled delivery of egg-secreted products (ESP). Preliminary data indicate that VECs respond to eggs and ESP with inflammatory activation and partial endothelial-to-mesenchymal transition (EndMT), suggesting a role in guiding macrophage polarization. In Aim 1, we will engineer a perfusable microvascular network and integrate tunable hydrogel microspheres and live eggs to dissect biomechanical and biochemical cues that drive VEC remodeling. In Aim 2, we will assess how ESP-activated VECs influence macrophage polarization by evaluating M2 polarization markers, cytokine secretion, and 3D migration phenotypes. Pharmacologic inhibition of key pathways: NF-κB, Notch4-DLL, and TGF- β will clarify their contributions to EndMT and immune crosstalk. This work will uncover novel immune-endothelial mechanisms in granuloma formation and fibrosis and establish a standardized platform for antifibrotic drug discovery.
Grant Summary
A Vessel-on-a-Chip Platform to Study Schistosome Egg-Induced Endothelial Remodeling and Macrophage Polarization is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $274K for university, nonprofit, healthcare org. Applications are due 2028-04-30 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $274K
2028-04-30
- 1Confirm your organization is eligible for A Vessel-on-a-Chip Platform to Study Schistosome Egg-Induced Endothelial Remodeling and Macrophage Polarization from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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A Vessel-on-a-Chip Platform to Study Schistosome Egg-Induced Endothelial Remodeling and Macrophage Polarization: Frequently Asked Questions
Who is eligible for the A Vessel-on-a-Chip Platform to Study Schistosome Egg-Induced Endothelial Remodeling and Macrophage Polarization?
A Vessel-on-a-Chip Platform to Study Schistosome Egg-Induced Endothelial Remodeling and Macrophage Polarization is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the A Vessel-on-a-Chip Platform to Study Schistosome Egg-Induced Endothelial Remodeling and Macrophage Polarization provide?
A Vessel-on-a-Chip Platform to Study Schistosome Egg-Induced Endothelial Remodeling and Macrophage Polarization provides up to $274K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the A Vessel-on-a-Chip Platform to Study Schistosome Egg-Induced Endothelial Remodeling and Macrophage Polarization deadline?
Applications for A Vessel-on-a-Chip Platform to Study Schistosome Egg-Induced Endothelial Remodeling and Macrophage Polarization are due 2028-04-30 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the A Vessel-on-a-Chip Platform to Study Schistosome Egg-Induced Endothelial Remodeling and Macrophage Polarization?
To apply for A Vessel-on-a-Chip Platform to Study Schistosome Egg-Induced Endothelial Remodeling and Macrophage Polarization, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.