Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease
About This Grant
SUMMARY The functions of long-noncoding RNAs (lncRNAs) as crucial regulators of transcription, epigenetic modifications, mRNA stability, localization, and translation indicate their potential involvement in Alzheimer's disease (AD) pathogenesis. Given the impairment of these fundamental cellular processes in AD, lncRNAs emerge as plausible targets. Consistent with this possibility, several studies have demonstrated altered expression of specific lncRNAs in various AD models. However, the precise roles, mechanisms, and cell-specific contributions of these lncRNAs in AD development remain unclear. This exploratory/developmental R21 proposal aims to systematically investigate the regulation of expression and function of lncRNA SLAMR in the pathogenesis of AD. SLAMR lncRNA was discovered from an unbiased screen of learning regulated lncRNAs. We find that SLAMR lncRNA in mouse CA1 is critical for synapse density, morphology, plasticity and memory. Importantly, we find that SLAMR functions as a key modulator of translation and structural plasticity. Gain of function of SLAMR resulted in enhanced translation and functional synapses. Our preliminary data show that SLAMR expression is impaired in APP knock-in (App NL-G-F) mouse model of AD. We will now assess the role of SLAMR mediated translation in App NL-G-F model and Tau model (PS19) of AD. Our systematic functional experiments are anticipated to unveil the role of SLAMR in the progression of AD pathogenesis. Successful completion of this proposal will shed light on the significance of lncRNAs in AD pathogenesis and influence the development of lncRNA-based therapeutics for AD.
Grant Summary
Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease is a NIA - National Institute on Aging grant providing up to $507K for university, nonprofit, healthcare org. Applications are due 2028-01-31 (open). Check eligibility and apply with FindGrants.
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Up to $507K
2028-01-31
- 1Confirm your organization is eligible for Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease from NIA - National Institute on Aging, checking organization type, location, and any population or project requirements.
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Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease: Frequently Asked Questions
Who is eligible for the Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease?
Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease is offered by NIA - National Institute on Aging and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease provide?
Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease provides up to $507K per award from NIA - National Institute on Aging. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease deadline?
Applications for Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease are due 2028-01-31 (open). Because deadlines can change, verify the date with the funder, NIA - National Institute on Aging, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease?
To apply for Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIA - National Institute on Aging.