The impact of chronic low dose cadmium exposure on skeletal growth and maintenance in mice models
NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development
About This Grant
PROJECT SUMMARY/ABSTRACT Osteoporosis is a debilitating skeletal disease affecting over 50% of women and 25% of men over the age of 50, often resulting in painful and disabling fractures that significantly reduce quality of life and increase mortality. Achieving optimal peak bone mass and strength during early life is one of the most critical factors in reducing lifetime fracture risk. Cadmium (Cd) is a toxic heavy metal increasingly present in the environment due to industrial uses as a metal lubricant, in battery production, pigments, and plastics. Critically, Cd bioaccumulates in the body with a biological half-life of approximately 30 years, raising serious concerns about its effects during key developmental windows such as skeletal modeling in early life. This proposal aims to investigate the long- term skeletal consequences of Cd bioaccumulation during early skeletal growth and attainment of peak bone density, at doses that have previously been considered safe. We will assess effects of Cd on lumbar spine and femur during early skeletal development in mice up to time of peak bone density using advanced high resolution micro-computed tomography imaging, histomorphometry, evaluate biochemical markers of bone turnover and perform assays of bone strength and fracture resistance. This study will provide critical data on how environmentally relevant, chronic Cd exposures during development may compromise skeletal health. This work will inform public health policy and environmental safety standards, particularly as Cd exposure continues to rise globally. Moreover, it will highlight the vulnerability of developing skeletal systems to toxic environmental insults.
Grant Summary
The impact of chronic low dose cadmium exposure on skeletal growth and maintenance in mice models is a NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development grant providing up to $157K for university, nonprofit, healthcare org. Applications are due 2028-05-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $157K
2028-05-31
- 1Confirm your organization is eligible for The impact of chronic low dose cadmium exposure on skeletal growth and maintenance in mice models from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development before the deadline.
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The impact of chronic low dose cadmium exposure on skeletal growth and maintenance in mice models: Frequently Asked Questions
Who is eligible for the The impact of chronic low dose cadmium exposure on skeletal growth and maintenance in mice models?
The impact of chronic low dose cadmium exposure on skeletal growth and maintenance in mice models is offered by NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the The impact of chronic low dose cadmium exposure on skeletal growth and maintenance in mice models provide?
The impact of chronic low dose cadmium exposure on skeletal growth and maintenance in mice models provides up to $157K per award from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the The impact of chronic low dose cadmium exposure on skeletal growth and maintenance in mice models deadline?
Applications for The impact of chronic low dose cadmium exposure on skeletal growth and maintenance in mice models are due 2028-05-31 (open). Because deadlines can change, verify the date with the funder, NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the The impact of chronic low dose cadmium exposure on skeletal growth and maintenance in mice models?
To apply for The impact of chronic low dose cadmium exposure on skeletal growth and maintenance in mice models, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development.