Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases
NIBIB - National Institute of Biomedical Imaging and Bioengineering
About This Grant
Project Abstract Atherosclerosis, the leading cause of cardiovascular diseases, occurs with compositional and mechanical changes in arterial walls that narrow and stiffen the artery. These mechanical changes are a warning sign for vascular health and predictors of heart attacks and strokes. Specifically, arterial stiffness and viscoelasticity may be used as mechanical biomarkers. Current measurement methods often rely on imaging or catheterization techniques that provide incomplete information, are unsuitable for long-term monitoring, and are often limited to superficial arteries. The primary limitation is the inability to simultaneously measure local arterial pressure and arterial strain. Despite the potential to use mechanical changes of artery walls as biomarkers for vascular diseases, there is currently no technology to enable daily monitoring of mechanical biomarkers. To address current shortcomings, we propose an implantable, vascular stent-based sensing platform to monitor arterial stiffness and viscoelasticity. Notably, the proposed system adapts the design of conventional vascular stents, which are already implanted several million times per year, to offer monitoring of vascular health biomarkers. Soft strain and pressure sensors will be printed and integrated with a stent platform for wireless monitoring from arteries. Capacitive sensors will be optimized for high sensitivity and integration with the stent. The stent is laser machined to act as an inductor for wireless communication while providing mechanics identical to conventional stents. The integrated device is wirelessly interrogated via inductive coupling, allowing for a passive and battery-free implant. The sensor system will be compatible with conventional catheter implantation and replicate the performance of conventional stents, but with the added benefit of providing insights into the patient’s vascular health. Wireless connectivity will be tuned to enable high sample rates at communication distances representative of implantation in coronary arteries. The device will be applied to measure mechanical changes in an artery model. Silicone arterial models with tunable viscoelasticity will be designed and fabricated to mimic atherosclerotic and restenosis conditions. The device will enable wireless recordings of pressure-diameter curves and arterial viscoelastic parameters, which will provide a means to remotely estimate arterial wall composition and disease progression. The long- term objective of this project is to enable at-home, daily monitoring of mechanical biomarkers of vascular diseases to improve patient outcomes. Moreover, the proposed device is expected to enable future studies on mechanical biomarkers, arterial wall remodeling, and mechanical homeostasis, which will enhance the understanding of vascular disease progression and treatment design.
Grant Summary
Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases is a NIBIB - National Institute of Biomedical Imaging and Bioengineering grant providing up to $143K for university, nonprofit, healthcare org. Applications are due 2028-03-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $143K
2028-03-31
- 1Confirm your organization is eligible for Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases from NIBIB - National Institute of Biomedical Imaging and Bioengineering, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIBIB - National Institute of Biomedical Imaging and Bioengineering before the deadline.
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Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases: Frequently Asked Questions
Who is eligible for the Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases?
Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases is offered by NIBIB - National Institute of Biomedical Imaging and Bioengineering and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases provide?
Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases provides up to $143K per award from NIBIB - National Institute of Biomedical Imaging and Bioengineering. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases deadline?
Applications for Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases are due 2028-03-31 (open). Because deadlines can change, verify the date with the funder, NIBIB - National Institute of Biomedical Imaging and Bioengineering, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases?
To apply for Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIBIB - National Institute of Biomedical Imaging and Bioengineering.