PIEZO1-Mediated Mechanotransduction in Neural Development
NINDS - National Institute of Neurological Disorders and Stroke
About This Grant
Project Summary Mechanical forces are essential for neural development, and their dysregulation leads to neurodevelopmental defects. The mechanically-activated ion channel PIEZO1 plays critical roles in neural development, but the mechanisms by which it detects and transduces mechanical signals into cellular responses remain poorly understood. This proposal aims to elucidate how PIEZO1 mechanotransduction shapes early neural development through three specific aims: (1) Decipher the mechanistic links between cell-generated forces, membrane tension, and PIEZO1 in Neural Stem Cells (NSCs); (2) Determine the molecular mechanism underlying PIEZO1-mediated regulation of cholesterol biosynthesis in neural development; and (3) Elucidate the role of PIEZO1 in NSC and neuronal migration. The research employs innovative approaches including: quantitative imaging of endogenous PIEZO1 activity using PIEZO1-HaloTag human induced pluripotent stem cells, micropatterned substrates to control cellular mechanics, neural rosette models that recapitulate early human neural development, genetically-engineered mice, and bioengineered scaffolds that mimic radial glial tracks guiding neuronal migration. This systematic investigation spanning single molecules to developing tissue models will reveal fundamental mechanisms by which PIEZO1 coordinates cellular responses to mechanical cues during neural development. Understanding these pathways has therapeutic potential for neurodevelopmental disorders where mechanical signal transduction is disrupted.
Grant Summary
PIEZO1-Mediated Mechanotransduction in Neural Development is a NINDS - National Institute of Neurological Disorders and Stroke grant providing up to $621K for university, nonprofit, healthcare org. Applications are due 2031-04-30 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $621K
2031-04-30
- 1Confirm your organization is eligible for PIEZO1-Mediated Mechanotransduction in Neural Development from NINDS - National Institute of Neurological Disorders and Stroke, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NINDS - National Institute of Neurological Disorders and Stroke before the deadline.
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PIEZO1-Mediated Mechanotransduction in Neural Development: Frequently Asked Questions
Who is eligible for the PIEZO1-Mediated Mechanotransduction in Neural Development?
PIEZO1-Mediated Mechanotransduction in Neural Development is offered by NINDS - National Institute of Neurological Disorders and Stroke and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the PIEZO1-Mediated Mechanotransduction in Neural Development provide?
PIEZO1-Mediated Mechanotransduction in Neural Development provides up to $621K per award from NINDS - National Institute of Neurological Disorders and Stroke. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the PIEZO1-Mediated Mechanotransduction in Neural Development deadline?
Applications for PIEZO1-Mediated Mechanotransduction in Neural Development are due 2031-04-30 (open). Because deadlines can change, verify the date with the funder, NINDS - National Institute of Neurological Disorders and Stroke, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the PIEZO1-Mediated Mechanotransduction in Neural Development?
To apply for PIEZO1-Mediated Mechanotransduction in Neural Development, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NINDS - National Institute of Neurological Disorders and Stroke.